Insulin Resistance Gene, QTL, and Strain Annotations - Disease Ontology

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Keyword

ONTOLOGY REPORT

Insulin Resistance (D007333)

Diminished effectiveness of INSULIN in lowering blood sugar levels: Requiring the use of 200 units or more of insulin per day to prevent hyperglycemia or ketosis. It is usually due to insulin binding by antibodies (INSULIN ANTIBODIES), but abnormalities in insulin receptors (RECEPTOR, INSULIN) on cell surfaces also occur. It is associated with obesity, ketoacidosis, infection, and certain rare conditions. (from Stedman, 25th ed)

There is 1 path(s) and 38 annotation(s) to this term. Annotations to this term and its descendants total 90.

ANNOTATIONS

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Insulin Resistance

Gene Symbol	Gene Name	Evidence	Reference
ACACA	acetyl-Coenzyme A carboxylase alpha	ISS (from RGD:621248)	RGD:1625727
ACACB	acetyl-Coenzyme A carboxylase beta	ISS (from RGD:620500)	RGD:1625727
ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	ISS	RGD:1331525
ACP1	acid phosphatase 1, soluble	ISS (from RGD:10068)	RGD:2313180
ACSL1	acyl-CoA synthetase long-chain family member 1	IEP	RGD:1625735
ADFP	adipose differentiation-related protein	ISS (from RGD:730883)	RGD:1625752
ADIPOQ	adiponectin, C1Q and collagen domain containing	ISS (from RGD:628748)	RGD:1599150
ADIPOR1	adiponectin receptor 1	IAGP	RGD:1625762
ADORA1	adenosine A1 receptor	ISS (from RGD:2048)	RGD:1625243
ADORA1	adenosine A1 receptor	IPM	RGD:2313807
ADRA1B	adrenergic, alpha-1B-, receptor	ISS (from RGD:10096)	RGD:1625772
ADRB2	adrenergic, beta-2-, receptor, surface	IAGP	RGD:1601125
ADRB2	adrenergic, beta-2-, receptor, surface	ISS (from RGD:2060)	RGD:1598757
ADRB3	adrenergic, beta-3-, receptor	IAGP	RGD:1559326
ADRB3	adrenergic, beta-3-, receptor	IAGP	RGD:2313158
ADRBK1	adrenergic, beta, receptor kinase 1	ISS (from RGD:10111)	RGD:1625791
AHSG	alpha-2-HS-glycoprotein	ISS (from RGD:10128)	RGD:1625793
AHSG	alpha-2-HS-glycoprotein	IEP	RGD:1625794
AKT2	v-akt murine thymoma viral oncogene homolog 2	IAGP	RGD:1601155
APLN	apelin	ISS (from RGD:620672)	RGD:1626170
APOA2	apolipoprotein A-II	ISS (from RGD:732677)	RGD:2313957
APOC1	apolipoprotein C-I	IPM	RGD:2313951
APOC3	apolipoprotein C-III	ISS (from RGD:10179)	RGD:1601226
AR	androgen receptor	IAGP	RGD:2306773
AR	androgen receptor	IED	RGD:1601244
ATP1A2	ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide	IED	RGD:1601252
Acaca	acetyl-coenzyme A carboxylase alpha	IED	RGD:1625727
Acaca	acetyl-Coenzyme A carboxylase alpha	ISS (from RGD:621248)	RGD:1625727
Acacb	acetyl-Coenzyme A carboxylase beta	ISS (from RGD:620500)	RGD:1625727
Acacb	acetyl-Coenzyme A carboxylase beta	IED	RGD:1625727
Ace	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	ISS	RGD:1331525
Ace	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	ISS	RGD:1331525
Acp1	acid phosphatase 1, soluble	IPM	RGD:2313180
Acp1	acid phosphatase 1, soluble	ISS (from RGD:10068)	RGD:2313180
Acsl1	acyl-CoA synthetase long-chain family member 1	ISS (from RGD:1342971)	RGD:1625735
Acsl1	acyl-CoA synthetase long-chain family member 1	ISS (from RGD:1342971)	RGD:1625735
Adfp	adipose differentiation related protein	ISS (from RGD:730883)	RGD:1625752
Adipoq	adiponectin, C1Q and collagen domain containing	ISS (from RGD:628748)	RGD:1599150
Adipoq	adiponectin, C1Q and collagen domain containing	IEP	RGD:1599150
Adipor1	adiponectin receptor 1	ISS (from RGD:1344545)	RGD:1625762
Adipor1	adiponectin receptor 1	ISS (from RGD:1344545)	RGD:1625762
Adipor1	adiponectin receptor 1	ISS	RGD:1331376
Adora1	adenosine A1 receptor	ISS (from RGD:730817)	RGD:2313807
Adora1	adenosine A1 receptor	IED	RGD:1625243
Adora1	adenosine A1 receptor	ISS (from RGD:730817)	RGD:2313807
Adora1	adenosine A1 receptor	ISS (from RGD:2048)	RGD:1625243
Adra1b	adrenergic, alpha-1B-, receptor	ISS (from RGD:10096)	RGD:1625772
Adra1b	adrenergic receptor, alpha 1b	IAGP	RGD:1625772
Adrb2	adrenergic receptor, beta 2	ISS (from RGD:733595)	RGD:1601125
Adrb2	adrenergic receptor, beta 2	ISS (from RGD:2060)	RGD:1598757
Adrb2	adrenergic, beta-2-, receptor, surface	ISS (from RGD:733595)	RGD:1601125
Adrb2	adrenergic, beta-2-, receptor, surface	IED	RGD:1598757
Adrb3	adrenergic receptor, beta 3	ISS	RGD:1559326
Adrb3	adrenergic, beta-3-, receptor	ISS	RGD:1559326
Adrb3	adrenergic, beta-3-, receptor	ISS (from RGD:737467)	RGD:2313158
Adrb3	adrenergic receptor, beta 3	ISS (from RGD:737467)	RGD:2313158
Adrbk1	adrenergic, beta, receptor kinase 1	ISS (from RGD:10111)	RGD:1625791
Adrbk1	adrenergic receptor kinase, beta 1	IED	RGD:1625791
Ahsg	alpha-2-HS-glycoprotein	ISS (from RGD:736027)	RGD:1625794
Ahsg	alpha-2-HS-glycoprotein	ISS (from RGD:736027)	RGD:1625794
Ahsg	alpha-2-HS-glycoprotein	ISS (from RGD:10128)	RGD:1625793
Ahsg	alpha-2-HS-glycoprotein	IAGP	RGD:1625793
Akt2	thymoma viral proto-oncogene 2	ISS (from RGD:732407)	RGD:1601155
Akt2	v-akt murine thymoma viral oncogene homolog 2	ISS (from RGD:732407)	RGD:1601155
Apln	apelin	ISS (from RGD:620672)	RGD:1626170
Apln	apelin	IEP	RGD:1626170
Apoa2	apolipoprotein A-II	IPM	RGD:2313957
Apoa2	apolipoprotein A-II	ISS (from RGD:732677)	RGD:2313957
Apoc1	apolipoprotein C-I	ISS (from RGD:735472)	RGD:2313951
Apoc1	apolipoprotein C-I	ISS (from RGD:735472)	RGD:2313951
Apoc3	apolipoprotein C-III	ISS (from RGD:10179)	RGD:1601226
Apoc3	apolipoprotein C-III	IAGP	RGD:1601226
Apoe	apolipoprotein E	IAGP	RGD:1601230
Ar	androgen receptor	ISS (from RGD:735652)	RGD:1601244
Ar	androgen receptor	ISS (from RGD:735652)	RGD:1601244
Ar	androgen receptor	ISS (from RGD:735652)	RGD:2306773
Ar	androgen receptor	ISS (from RGD:735652)	RGD:2306773
Atp1a2	ATPase, Na+/K+ transporting, alpha 2 polypeptide	ISS (from RGD:736008)	RGD:1601252
Atp1a2	ATPase, Na+/K+ transporting, alpha 2 polypeptide	ISS (from RGD:736008)	RGD:1601252
BCHE	butyrylcholinesterase	IEP	RGD:2306776
Bche	butyrylcholinesterase	ISS (from RGD:732174)	RGD:2306776
Bche	butyrylcholinesterase	ISS (from RGD:732174)	RGD:2306776
C1R	complement component 1, r subcomponent	IEP	RGD:1600551
C1r	complement component 1, r subcomponent	ISS (from RGD:1319235)	RGD:1600551
C1ra	complement component 1, r subcomponent A	ISS (from RGD:1319235)	RGD:1600551
CBLB	Cas-Br-M (murine) ecotropic retroviral transforming sequence b	ISS (from RGD:733799)	RGD:2314038
CCL2	chemokine (C-C motif) ligand 2	IAGP	RGD:2306985
CD36	CD36 molecule (thrombospondin receptor)	ISS (from RGD:2301)	RGD:70461
CD36	CD36 molecule (thrombospondin receptor)	ISS (from RGD:2301)	RGD:2307217
CD36	CD36 molecule (thrombospondin receptor)	ISS (from RGD:2301)	RGD:68930
CNTF	ciliary neurotrophic factor	TAS	RGD:1626122
CPB2	carboxypeptidase B2 (plasma)	IEP	RGD:2313645
CST3	cystatin C	IEP	RGD:2314305
Cblb	Casitas B-lineage lymphoma b	IAGP	RGD:2314038
Cblb	Cas-Br-M (murine) ecotropic retroviral transforming sequence b	ISS (from RGD:733799)	RGD:2314038
Ccl2	chemokine (C-C motif) ligand 2	ISS (from RGD:731046)	RGD:2306985
Ccl2	chemokine (C-C motif) ligand 2	ISS (from RGD:731046)	RGD:2306985
Cd36	CD36 antigen	ISS (from RGD:2301)	RGD:68930
Cd36	CD36 molecule (thrombospondin receptor)	IED	RGD:68930
Cd36	CD36 antigen	ISS (from RGD:2301)	RGD:2307217
Cd36	CD36 molecule (thrombospondin receptor)	IPM	RGD:2307217
Cd36	CD36 molecule (thrombospondin receptor)	IAGP	RGD:70461
Cd36	CD36 antigen	ISS (from RGD:2301)	RGD:70461
Cntf	ciliary neurotrophic factor	TAS	RGD:1626122
Cntf	ciliary neurotrophic factor	TAS	RGD:1626122
Cpb2	carboxypeptidase B2 (plasma)	ISS (from RGD:731734)	RGD:2313645
Cpb2	carboxypeptidase B2 (plasma)	ISS (from RGD:731734)	RGD:2313645
Cst3	cystatin C	ISS (from RGD:736914)	RGD:2314305
Cst3	cystatin C	ISS (from RGD:736914)	RGD:2314305
DIO2	deiodinase, iodothyronine, type II	IAGP	RGD:2313698
DRD1	dopamine receptor D1	ISS (from RGD:2518)	RGD:2302119
Dio2	deiodinase, iodothyronine, type II	ISS (from RGD:735779)	RGD:2313698
Dio2	deiodinase, iodothyronine, type II	ISS (from RGD:735779)	RGD:2313698
Drd1a	dopamine receptor D1A	IEP	RGD:2302119
Drd1a	dopamine receptor D1A	ISS (from RGD:2518)	RGD:2302119
ENPP1	ectonucleotide pyrophosphatase/phosphodiesterase 1	IAGP	RGD:1601043
Enpp1	ectonucleotide pyrophosphatase/phosphodiesterase 1	ISS (from RGD:1351327)	RGD:1601043
Enpp1	ectonucleotide pyrophosphatase/phosphodiesterase 1	ISS (from RGD:1351327)	RGD:1601043
F7	coagulation factor VII	ISS (from RGD:1345586)	RGD:2312406
F7	coagulation factor VII (serum prothrombin conversion accelerator)	ISS (from RGD:1345586)	RGD:2312406
F7	coagulation factor VII (serum prothrombin conversion accelerator)	IEP	RGD:2312406
FABP2	fatty acid binding protein 2, intestinal	IAGP	RGD:1626407
FABP2	fatty acid binding protein 2, intestinal	IAGP	RGD:1626400
FABP2	fatty acid binding protein 2, intestinal	IAGP	RGD:1578456
FABP3	fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)	ISS (from RGD:69088)	RGD:1578459
FABP4	fatty acid binding protein 4, adipocyte	ISS (from RGD:69309)	RGD:1625407
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	IAGP	RGD:1601219
FXN	frataxin	IAGP	RGD:2307049
Fabp2	fatty acid binding protein 2, intestinal	ISS (from RGD:735842)	RGD:1626400
Fabp2	fatty acid binding protein 2, intestinal	ISS (from RGD:735842)	RGD:1626400
Fabp2	fatty acid binding protein 2, intestinal	ISS (from RGD:735842)	RGD:1626407
Fabp2	fatty acid binding protein 2, intestinal	ISS (from RGD:735842)	RGD:1578456
Fabp2	fatty acid binding protein 2, intestinal	ISS	RGD:1578456
Fabp2	fatty acid binding protein 2, intestinal	ISS (from RGD:735842)	RGD:1626407
Fabp3	fatty acid binding protein 3, muscle and heart	IAGP	RGD:1578459
Fabp3	fatty acid binding protein 3, muscle and heart	ISS (from RGD:69088)	RGD:1578459
Fabp4	fatty acid binding protein 4, adipocyte	IEP	RGD:1625407
Fabp4	fatty acid binding protein 4, adipocyte	ISS (from RGD:69309)	RGD:1625407
Foxc2	forkhead box C2	ISS (from RGD:1347315)	RGD:1601219
Fxn	frataxin	ISS (from RGD:1604403)	RGD:2307049
Fxn	frataxin	ISS (from RGD:1604403)	RGD:2307049
GFPT1	glutamine-fructose-6-phosphate transaminase 1	IED	RGD:1625423
GYS1	glycogen synthase 1 (muscle)	IAGP	RGD:2313176
Gfpt1	glutamine fructose-6-phosphate transaminase 1	ISS (from RGD:1353383)	RGD:1625423
Gfpt1	glutamine fructose-6-phosphate transaminase 1	ISS (from RGD:1353383)	RGD:1625423
Gys1	glycogen synthase 1, muscle	ISS (from RGD:1320086)	RGD:2313176
Gys1	glycogen synthase 1, muscle	ISS (from RGD:1320086)	RGD:2313176
HMOX1	heme oxygenase (decycling) 1	IEP	RGD:1601621
HNF1A	HNF1 homeobox A	IEP	RGD:1601482
HTR2A	5-hydroxytryptamine (serotonin) receptor 2A	IEP	RGD:1624367
Hmox1	heme oxygenase (decycling) 1	ISS (from RGD:730901)	RGD:1601621
Hmox1	heme oxygenase (decycling) 1	ISS (from RGD:730901)	RGD:1601621
Hnf1a	HNF1 homeobox A	ISS (from RGD:737153)	RGD:1601482
Hnf1a	HNF1 homeobox A	ISS (from RGD:737153)	RGD:1601482
Htr2a	5-hydroxytryptamine (serotonin) receptor 2A	ISS (from RGD:61800)	RGD:1624367
Htr2a	5-hydroxytryptamine (serotonin) receptor 2A	ISS (from RGD:61800)	RGD:1624367
ICAM1	intercellular adhesion molecule 1	IEP	RGD:2313467
IGFBP2	insulin-like growth factor binding protein 2, 36kDa	IMP	RGD:1626479
IGFBP3	insulin-like growth factor binding protein 3	IED	RGD:2313762
IGFBP6	insulin-like growth factor binding protein 6	IED	RGD:2301717
IGFBP7	insulin-like growth factor binding protein 7	IEP	RGD:1626516
IL1B	interleukin 1, beta	ISS (from RGD:10790)	RGD:1626632
IL6	interleukin 6 (interferon, beta 2)	ISS (from RGD:2901)	RGD:2307252
IL6R	interleukin 6 receptor	IEP	RGD:1625431
INPPL1	inositol polyphosphate phosphatase-like 1	ISS (from RGD:68396)	RGD:2312440
INPPL1	inositol polyphosphate phosphatase-like 1	ISS (from RGD:68396)	RGD:2312442
INS	insulin	IEP	RGD:2311112
INSR	insulin receptor	ISS (from RGD:2917)	RGD:2307333
INSR	insulin receptor	ISS	RGD:1302523
IRS1	insulin receptor substrate 1	IAGP	RGD:1624973
IRS2	insulin receptor substrate 2	IAGP	RGD:1625025
Icam1	intercellular adhesion molecule 1	ISS (from RGD:69659)	RGD:2313467
Icam1	intercellular adhesion molecule 1	ISS (from RGD:69659)	RGD:2313467
Igfbp2	insulin-like growth factor binding protein 2	ISS (from RGD:737357)	RGD:1626479
Igfbp2	insulin-like growth factor binding protein 2	ISS (from RGD:737357)	RGD:1626479
Igfbp3	insulin-like growth factor binding protein 3	ISS (from RGD:736042)	RGD:2313762
Igfbp3	insulin-like growth factor binding protein 3	ISS (from RGD:736042)	RGD:2313762
Igfbp6	insulin-like growth factor binding protein 6	ISS (from RGD:735616)	RGD:2301717
Igfbp6	insulin-like growth factor binding protein 6	ISS (from RGD:735616)	RGD:2301717
Igfbp7	insulin-like growth factor binding protein 7	ISS (from RGD:1314683)	RGD:1626516
Igfbp7	insulin-like growth factor binding protein 7	ISS (from RGD:1314683)	RGD:1626516
Il1b	interleukin 1 beta	IEP	RGD:1626632
Il1b	interleukin 1 beta	ISS (from RGD:10790)	RGD:1626632
Il6	interleukin 6	IED	RGD:2307252
Il6	interleukin 6	ISS (from RGD:2901)	RGD:2307252
Il6ra	interleukin 6 receptor, alpha	ISS (from RGD:736525)	RGD:1625431
Il6ra	interleukin 6 receptor, alpha	ISS (from RGD:736525)	RGD:1625431
Inppl1	inositol polyphosphate phosphatase-like 1	ISS (from RGD:68396)	RGD:2312440
Inppl1	inositol polyphosphate phosphatase-like 1	IPM	RGD:2312440
Inppl1	inositol polyphosphate phosphatase-like 1	ISS (from RGD:68396)	RGD:2312442
Inppl1	inositol polyphosphate phosphatase-like 1	IPM	RGD:2312442
Ins2	insulin 2	ISS (from RGD:731056)	RGD:2311112
Ins2	insulin II	ISS (from RGD:731056)	RGD:2311112
Insr	insulin receptor	ISS (from RGD:2917)	RGD:2307333
Insr	insulin receptor	ISS	RGD:1302523
Insr	insulin receptor	IAGP	RGD:2307333
Irs1	insulin receptor substrate 1	ISS (from RGD:733473)	RGD:1624973
Irs1	insulin receptor substrate 1	ISS (from RGD:733473)	RGD:1624973
Irs2	insulin receptor substrate 2	ISS (from RGD:736204)	RGD:1625025
Irs2	insulin receptor substrate 2	ISS (from RGD:736204)	RGD:1625025
KLF11	Kruppel-like factor 11	IAGP	RGD:2311539
KLK1	kallikrein 1	IED	RGD:1641794
Klf11	Kruppel-like factor 11	ISS (from RGD:1605424)	RGD:2311539
Klf11	Kruppel-like factor 11	ISS (from RGD:1605424)	RGD:2311539
Klk1	kallikrein 1	ISS (from RGD:1349866)	RGD:1641794
LEP	leptin	IEP	RGD:2311127
LEPR	leptin receptor	IAGP	RGD:2311142
LEPR	leptin receptor	IAGP	RGD:2311138
LPIN1	lipin 1	IEP	RGD:1641822
LPL	lipoprotein lipase	ISS (from RGD:10876)	RGD:2313300
LTA	lymphotoxin alpha (TNF superfamily, member 1)	IAGP	RGD:1625035
Lep	leptin	ISS (from RGD:69123)	RGD:2311127
Lep	leptin	ISS (from RGD:69123)	RGD:2311127
Lepr	leptin receptor	ISS (from RGD:735832)	RGD:2311138
Lepr	leptin receptor	ISS (from RGD:735832)	RGD:2311142
Lepr	leptin receptor	ISS (from RGD:735832)	RGD:2311142
Lepr	leptin receptor	ISS (from RGD:735832)	RGD:2311138
Lpin1	lipin 1	ISS (from RGD:1316957)	RGD:1641822
Lpin1	lipin 1	ISS (from RGD:1316957)	RGD:1641822
Lpl	lipoprotein lipase	IAGP	RGD:2313300
Lpl	lipoprotein lipase	ISS (from RGD:10876)	RGD:2313300
Lta	lymphotoxin alpha (TNF superfamily, member 1)	ISS (from RGD:1345394)	RGD:1625035
Lta	lymphotoxin A	ISS (from RGD:1345394)	RGD:1625035
MIF	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	IEP	RGD:1641955
Mif	macrophage migration inhibitory factor	ISS (from RGD:734203)	RGD:1641955
Mif	macrophage migration inhibitory factor	ISS (from RGD:734203)	RGD:1641955
NAMPT	nicotinamide phosphoribosyltransferase	IEP	RGD:1642341
NOS3	nitric oxide synthase 3 (endothelial cell)	ISS (from RGD:3186)	RGD:2292098
NPPB	natriuretic peptide precursor B	IEP	RGD:1642192
NR1H4	nuclear receptor subfamily 1, group H, member 4	ISS (from RGD:734104)	RGD:1625076
Nampt	nicotinamide phosphoribosyltransferase	ISS (from RGD:1351636)	RGD:1642341
Nampt	nicotinamide phosphoribosyltransferase	ISS (from RGD:1351636)	RGD:1642341
Nos3	nitric oxide synthase 3, endothelial cell	IEP	RGD:2292098
Nos3	nitric oxide synthase 3, endothelial cell	ISS (from RGD:3186)	RGD:2292098
Nppb	natriuretic peptide precursor type B	ISS (from RGD:69139)	RGD:1642192
Nppb	natriuretic peptide precursor B	ISS (from RGD:69139)	RGD:1642192
Nr1h4	nuclear receptor subfamily 1, group H, member 4	IAGP	RGD:1625076
Nr1h4	nuclear receptor subfamily 1, group H, member 4	ISS (from RGD:734104)	RGD:1625076
PDE3A	phosphodiesterase 3A, cGMP-inhibited	ISS (from RGD:61942)	RGD:2300415
PDX1	pancreatic and duodenal homeobox 1	ISS (from RGD:62387)	RGD:2311223
PDX1	pancreatic and duodenal homeobox 1	ISS (from RGD:736368)	RGD:2311222
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	ISS (from RGD:3329)	RGD:1625262
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	IED	RGD:1625212
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	ISS (from RGD:11103)	RGD:1625211
PKLR	pyruvate kinase, liver and RBC	ISS (from RGD:11113)	RGD:1625583
PMCH	pro-melanin-concentrating hormone	ISS (from RGD:3358)	RGD:1642484
PON1	paraoxonase 1	IAGP	RGD:1642617
PPARD	peroxisome proliferator-activated receptor delta	ISS (from RGD:731946)	RGD:2313780
PPARG	peroxisome proliferator-activated receptor gamma	IAGP	RGD:1601446
PPARGC1B	peroxisome proliferator-activated receptor gamma, coactivator 1 beta	IEP	RGD:1642499
PPP1R3A	protein phosphatase 1, regulatory (inhibitor) subunit 3A	IAGP	RGD:1601468
PPP1R3A	protein phosphatase 1, regulatory (inhibitor) subunit 3A	ISS (from RGD:1558275)	RGD:1601446
PRKAA2	protein kinase, AMP-activated, alpha 2 catalytic subunit	IAGP	RGD:1625266
PRKCB	protein kinase C, beta	ISS (from RGD:3396)	RGD:1625515
PRKCD	protein kinase C, delta	ISS (from RGD:69027)	RGD:1642527
PRKCD	protein kinase C, delta	ISS (from RGD:67383)	RGD:729667
PRKCQ	protein kinase C, theta	ISS (from RGD:620968)	RGD:1625603
PRKCQ	protein kinase C, theta	ISS (from RGD:620968)	RGD:1625604
PRKCZ	protein kinase C, zeta	IED	RGD:1642650
PRL	prolactin	IEP	RGD:1642560
PTEN	phosphatase and tensin homolog	ISS (from RGD:61995)	RGD:2292521
PTGDS	prostaglandin D2 synthase 21kDa (brain)	ISS (from RGD:11182)	RGD:1642581
PTK2B	PTK2B protein tyrosine kinase 2 beta	ISS (from RGD:733599)	RGD:1642605
PTPN1	protein tyrosine phosphatase, non-receptor type 1	IAGP	RGD:1625240
PTPRF	protein tyrosine phosphatase, receptor type, F	IED	RGD:1642735
PTPRF	protein tyrosine phosphatase, receptor type, F	IEP	RGD:1642733
PYY	peptide YY	IAGP	RGD:1625281
Pde3a	phosphodiesterase 3A, cGMP inhibited	IEP	RGD:2300415
Pde3a	phosphodiesterase 3A, cGMP inhibited	ISS (from RGD:61942)	RGD:2300415
Pdx1	pancreatic and duodenal homeobox 1	ISS (from RGD:62387)	RGD:2311223
Pdx1	pancreatic and duodenal homeobox 1	IEP	RGD:2311222
Pdx1	pancreatic and duodenal homeobox 1	IEP	RGD:2311223
Pdx1	pancreatic and duodenal homeobox 1	ISS (from RGD:736368)	RGD:2311222
Pik3r1	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)	IAGP	RGD:1625211
Pik3r1	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)	ISS (from RGD:731958)	RGD:1625212
Pik3r1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	ISS (from RGD:11103)	RGD:1625211
Pik3r1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	ISS (from RGD:731958)	RGD:1625212
Pik3r1	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)	ISS (from RGD:3329)	RGD:1625262
Pik3r1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	IED	RGD:1625262
Pklr	pyruvate kinase, liver and RBC	ISS (from RGD:11113)	RGD:1625583
Pklr	pyruvate kinase liver and red blood cell	IEP	RGD:1625583
Plin2	perilipin 2	IED	RGD:1625752
Pmch	pro-melanin-concentrating hormone	ISS (from RGD:3358)	RGD:1642484
Pmch	pro-melanin-concentrating hormone	IED	RGD:1642484
Pon1	paraoxonase 1	ISS (from RGD:1349272)	RGD:1642617
Pon1	paraoxonase 1	ISS (from RGD:1349272)	RGD:1642617
Ppard	peroxisome proliferator activator receptor delta	IED	RGD:2313780
Ppard	peroxisome proliferator-activated receptor delta	ISS (from RGD:731946)	RGD:2313780
Pparg	peroxisome proliferator activated receptor gamma	ISS (from RGD:69168)	RGD:1601446
Pparg	peroxisome proliferator-activated receptor gamma	ISS (from RGD:69168)	RGD:1601446
Ppargc1b	peroxisome proliferative activated receptor, gamma, coactivator 1 beta	ISS (from RGD:1350671)	RGD:1642499
Ppargc1b	peroxisome proliferator-activated receptor gamma, coactivator 1 beta	ISS (from RGD:1350671)	RGD:1642499
Ppp1r3a	protein phosphatase 1, regulatory (inhibitor) subunit 3A	IAGP	RGD:1601446
Ppp1r3a	protein phosphatase 1, regulatory (inhibitor) subunit 3A	ISS (from RGD:1343572)	RGD:1601468
Ppp1r3a	protein phosphatase 1, regulatory (inhibitor) subunit 3A	ISS (from RGD:1343572)	RGD:1601468
Ppp1r3a	protein phosphatase 1, regulatory (inhibitor) subunit 3A	ISS (from RGD:1558275)	RGD:1601446
Prkaa2	protein kinase, AMP-activated, alpha 2 catalytic subunit	ISS (from RGD:730888)	RGD:1625266
Prkaa2	protein kinase, AMP-activated, alpha 2 catalytic subunit	ISS (from RGD:730888)	RGD:1625266
Prkcb	protein kinase C, beta	ISS (from RGD:3396)	RGD:1625515
Prkcb	protein kinase C, beta	IED	RGD:1625515
Prkcd	protein kinase C, delta	ISS (from RGD:67383)	RGD:729667
Prkcd	protein kinase C, delta	IPM	RGD:1642527
Prkcd	protein kinase C, delta	ISS (from RGD:69027)	RGD:1642527
Prkcd	protein kinase C, delta	IEP	RGD:729667
Prkcq	protein kinase C, theta	IEP	RGD:1625603
Prkcq	protein kinase C, theta	ISS (from RGD:620968)	RGD:1625603
Prkcq	protein kinase C, theta	ISS (from RGD:620968)	RGD:1625604
Prkcq	protein kinase C, theta	IEP	RGD:1625604
Prkcz	protein kinase C, zeta	ISS (from RGD:736361)	RGD:1642650
Prkcz	protein kinase C, zeta	ISS (from RGD:736361)	RGD:1642650
Prl	prolactin	ISS (from RGD:736187)	RGD:1642560
Prl	prolactin	ISS (from RGD:736187)	RGD:1642560
Pten	phosphatase and tensin homolog	ISS (from RGD:61995)	RGD:2292521
Pten	phosphatase and tensin homolog	IED	RGD:2292521
Ptgds	prostaglandin D2 synthase (brain)	IAGP	RGD:1642581
Ptgds	prostaglandin D2 synthase (brain)	ISS (from RGD:11182)	RGD:1642581
Ptk2b	PTK2B protein tyrosine kinase 2 beta	ISS (from RGD:733599)	RGD:1642605
Ptk2b	PTK2 protein tyrosine kinase 2 beta	IAGP	RGD:1642605
Ptpn1	protein tyrosine phosphatase, non-receptor type 1	ISS (from RGD:1343639)	RGD:1625240
Ptpn1	protein tyrosine phosphatase, non-receptor type 1	ISS (from RGD:1343639)	RGD:1625240
Ptprf	protein tyrosine phosphatase, receptor type, F	ISS (from RGD:734202)	RGD:1642735
Ptprf	protein tyrosine phosphatase, receptor type, F	ISS (from RGD:734202)	RGD:1642733
Ptprf	protein tyrosine phosphatase, receptor type, F	ISS (from RGD:734202)	RGD:1642733
Ptprf	protein tyrosine phosphatase, receptor type, F	ISS (from RGD:734202)	RGD:1642735
Pyy	peptide YY (mapped)	ISS (from RGD:1348512)	RGD:1625281
Pyy	peptide YY	ISS (from RGD:1348512)	RGD:1625281
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	ISS (from RGD:727889)	RGD:2298860
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	ISS (from RGD:1551095)	RGD:2298857
RETN	resistin	IEP	RGD:2313499
RRAD	Ras-related associated with diabetes	IPM	RGD:2311703
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	IEP	RGD:2298860
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	ISS (from RGD:1551095)	RGD:2298857
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	ISS (from RGD:727889)	RGD:2298860
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	IEP	RGD:2298857
Retn	resistin	ISS (from RGD:1346963)	RGD:2313499
Retn	resistin	ISS (from RGD:1346963)	RGD:2313499
Rrad	Ras-related associated with diabetes	ISS (from RGD:736416)	RGD:2311703
Rrad	Ras-related associated with diabetes	ISS (from RGD:736416)	RGD:2311703
SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	IEP	RGD:1601202
SERPINF1	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1	IEP	RGD:2312339
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	IEP	RGD:1643171
SI	sucrase-isomaltase (alpha-glucosidase)	ISS (from RGD:3675)	RGD:1625544
SLC27A4	solute carrier family 27 (fatty acid transporter), member 4	IEP	RGD:1625638
SLC2A3	solute carrier family 2 (facilitated glucose transporter), member 3	IEP	RGD:1642802
SLC2A4	solute carrier family 2 (facilitated glucose transporter), member 4	IEP	RGD:2313624
SOCS1	suppressor of cytokine signaling 1	ISS (from RGD:732457)	RGD:1625677
SOCS3	suppressor of cytokine signaling 3	ISS (from RGD:730834)	RGD:2313789
SOCS3	suppressor of cytokine signaling 3	ISS (from RGD:730834)	RGD:1625677
SOD3	superoxide dismutase 3, extracellular	IEP	RGD:1625698
SORBS1	sorbin and SH3 domain containing 1	ISS (from RGD:1320081)	RGD:1642731
SOX6	SRY (sex determining region Y)-box 6	ISS (from RGD:1319099)	RGD:1581307
SREBF1	sterol regulatory element binding transcription factor 1	IAGP	RGD:2308809
SREBF1	sterol regulatory element binding transcription factor 1	ISS (from RGD:728328)	RGD:2308807
STK11	serine/threonine kinase 11	ISS (from RGD:1308653)	RGD:1601389
Scd1	stearoyl-Coenzyme A desaturase 1	IED	RGD:1580005
Scd1	stearoyl-Coenzyme A desaturase 1	ISS	RGD:1580005
Serpina1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	ISS (from RGD:1349357)	RGD:1601202
Serpinf1	serine (or cysteine) peptidase inhibitor, clade F, member 1	ISS (from RGD:1342519)	RGD:2312339
Serpinf1	serine (or cysteine) peptidase inhibitor, clade F, member 1	ISS (from RGD:1342519)	RGD:2312339
Shc1	src homology 2 domain-containing transforming protein C1	ISS (from RGD:1346921)	RGD:1643171
Shc1	SHC (Src homology 2 domain containing) transforming protein 1	ISS (from RGD:1346921)	RGD:1643171
Si	sucrase-isomaltase (alpha-glucosidase)	IEP	RGD:1625544
Si	silver	ISS (from RGD:3675)	RGD:1625544
Slc27a1	solute carrier family 27 (fatty acid transporter), member 1	IED	RGD:1642795
Slc27a4	solute carrier family 27 (fatty acid transporter), member 4	ISS (from RGD:1316551)	RGD:1625638
Slc27a4	solute carrier family 27 (fatty acid transporter), member 4	ISS (from RGD:1316551)	RGD:1625638
Slc2a3	solute carrier family 2 (facilitated glucose transporter), member 3	ISS (from RGD:737055)	RGD:1642802
Slc2a3	solute carrier family 2 (facilitated glucose transporter), member 3	ISS (from RGD:737055)	RGD:1642802
Slc2a4	solute carrier family 2 (facilitated glucose transporter), member 4	ISS (from RGD:731478)	RGD:2313624
Slc2a4	solute carrier family 2 (facilitated glucose transporter), member 4	ISS (from RGD:731478)	RGD:2313624
Socs1	suppressor of cytokine signaling 1	ISS (from RGD:732457)	RGD:1625677
Socs1	suppressor of cytokine signaling 1	IPM	RGD:1625677
Socs3	suppressor of cytokine signaling 3	ISS (from RGD:730834)	RGD:2313789
Socs3	suppressor of cytokine signaling 3	IPM	RGD:1625677
Socs3	suppressor of cytokine signaling 3	IAGP	RGD:2313789
Socs3	suppressor of cytokine signaling 3	ISS (from RGD:730834)	RGD:1625677
Sod3	superoxide dismutase 3, extracellular	ISS (from RGD:736515)	RGD:1625698
Sod3	superoxide dismutase 3, extracellular	ISS (from RGD:736515)	RGD:1625698
Sorbs1	sorbin and SH3 domain containing 1	IAGP	RGD:1642731
Sorbs1	sorbin and SH3 domain containing 1	ISS (from RGD:1320081)	RGD:1642731
Sox6	SRY-box containing gene 6	IED	RGD:1581307
Sox6	SRY (sex determining region Y)-box 6	ISS (from RGD:1319099)	RGD:1581307
Srebf1	sterol regulatory element binding transcription factor 1	ISS (from RGD:69473)	RGD:2308809
Srebf1	sterol regulatory element binding transcription factor 1	ISS (from RGD:728328)	RGD:2308807
Srebf1	sterol regulatory element binding transcription factor 1	IEP	RGD:2308807
Srebf1	sterol regulatory element binding transcription factor 1	ISS (from RGD:69473)	RGD:2308809
Srebf1_v2	sterol regulatory element binding factor 1, variant 2	ISS (from RGD:69473)	RGD:2308809
Srebf1_v2	sterol regulatory element binding factor 1, variant 2	IEP	RGD:2308807
Stk11	serine/threonine kinase 11	ISS (from RGD:1308653)	RGD:1601389
Stk11	serine/threonine kinase 11	IEP	RGD:1601389
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	IAGP	RGD:2312433
TF	transferrin	ISS (from RGD:3845)	RGD:1601515
TFAP2B	transcription factor AP-2 beta (activating enhancer binding protein 2 beta)	IED	RGD:1601544
THBD	thrombomodulin	IEP	RGD:2312460
TLR4	toll-like receptor 4	IEP	RGD:2312489
TLR4	toll-like receptor 4	ISS (from RGD:737014)	RGD:2312483
TLR4	toll-like receptor 4	ISS (from RGD:737014)	RGD:1620681
TNF	tumor necrosis factor (TNF superfamily, member 2)	IAGP	RGD:1580312
TNFRSF11B	tumor necrosis factor receptor superfamily, member 11b	IEP	RGD:1620889
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	IEP	RGD:1624180
TSC1	tuberous sclerosis 1	ISS (from RGD:733994)	RGD:1624197
Tcf7l2	transcription factor 7-like 2 (T-cell specific, HMG-box)	ISS (from RGD:1317786)	RGD:2312433
Tcf7l2	transcription factor 7-like 2, T-cell specific, HMG-box	ISS (from RGD:1317786)	RGD:2312433
Tcfap2b	transcription factor AP-2 beta	ISS (from RGD:1314875)	RGD:1601544
Tcfap2b	transcription factor AP-2 beta	ISS (from RGD:1314875)	RGD:1601544
Tf	transferrin	IEP	RGD:1601515
Thbd	thrombomodulin	ISS (from RGD:1349382)	RGD:2312460
Thbd	thrombomodulin	ISS (from RGD:1349382)	RGD:2312460
Tlr4	toll-like receptor 4	ISS (from RGD:737013)	RGD:2312489
Tlr4	toll-like receptor 4	ISS (from RGD:737014)	RGD:1620681
Tlr4	toll-like receptor 4	IAGP	RGD:1620681
Tlr4	toll-like receptor 4	ISS (from RGD:737014)	RGD:2312483
Tlr4	toll-like receptor 4	IAGP	RGD:2312483
Tlr4	toll-like receptor 4	ISS (from RGD:737013)	RGD:2312489
Tnf	tumor necrosis factor	ISS (from RGD:3876)	RGD:1580214
Tnf	tumor necrosis factor (TNF superfamily, member 2)	IED	RGD:1580214
Tnfrsf11b	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	ISS (from RGD:730969)	RGD:1620889
Tnfrsf11b	tumor necrosis factor receptor superfamily, member 11b	ISS (from RGD:730969)	RGD:1620889
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	ISS (from RGD:737288)	RGD:1624180
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	ISS (from RGD:737288)	RGD:1624180
Trf	transferrin	ISS (from RGD:3845)	RGD:1601515
Tsc1	tuberous sclerosis 1	ISS (from RGD:733994)	RGD:1624197
Tsc1	tuberous sclerosis 1	IAGP	RGD:1624197
UCP1	uncoupling protein 1 (mitochondrial, proton carrier)	IAGP	RGD:1624979
UCP2	uncoupling protein 2 (mitochondrial, proton carrier)	IAGP	RGD:2313512
UCP3	uncoupling protein 3 (mitochondrial, proton carrier)	IAGP	RGD:2313512
UCP3	uncoupling protein 3 (mitochondrial, proton carrier)	IPM	RGD:2313515
Ucp1	uncoupling protein 1 (mitochondrial, proton carrier)	ISS (from RGD:735821)	RGD:1624979
Ucp1	uncoupling protein 1 (mitochondrial, proton carrier)	ISS (from RGD:735821)	RGD:1624979
Ucp2	uncoupling protein 2 (mitochondrial, proton carrier)	ISS (from RGD:69170)	RGD:2313512
Ucp2	uncoupling protein 2 (mitochondrial, proton carrier)	ISS (from RGD:69170)	RGD:2313512
Ucp3	uncoupling protein 3 (mitochondrial, proton carrier)	ISS (from RGD:733835)	RGD:2313512
Ucp3	uncoupling protein 3 (mitochondrial, proton carrier)	ISS (from RGD:733835)	RGD:2313515
Ucp3	uncoupling protein 3 (mitochondrial, proton carrier)	ISS (from RGD:733835)	RGD:2313515
Ucp3	uncoupling protein 3 (mitochondrial, proton carrier)	ISS (from RGD:733835)	RGD:2313512
VCAM1	vascular cell adhesion molecule 1	IEP	RGD:1580351
VWF	von Willebrand factor	IEP	RGD:1625711
Vcam1	vascular cell adhesion molecule 1	ISS (from RGD:730988)	RGD:1580351
Vcam1	vascular cell adhesion molecule 1	ISS (from RGD:730988)	RGD:1580351
Vwf	von Willebrand factor homolog	ISS (from RGD:1347936)	RGD:1625711
Vwf	Von Willebrand factor homolog	ISS (from RGD:1347936)	RGD:1625711

Qtl Symbol	Qtl Name	Evidence	Reference
Gluco11	Glucose level QTL 11	IAGP	RGD:1357415
Gluco12	Glucose level QTL12	IAGP	RGD:1357415
Gluco16	Glucose level QTL 16	IED	RGD:61078
Gluco17	Glucose level QTL 17	IED	RGD:61078
Gluco6	Glucose level QTL 6	IAGP	RGD:619533
Insglur1	Insulin/glucose ratio QTL 1	IAGP	RGD:619533
Insglur2	Insulin/glucose ratio QTL 2	IAGP	RGD:619533
Niddm58	Non-insulin dependent diabetes mellitus QTL 58	IAGP	RGD:619683

Strain Symbol	Evidence	Reference
BN.PD-(D8Rat39-D8Rat35),SHR-(D4Mgh2-Cd36),SHR-(D20Wox3-D20Mgh5)/Cub	QTM	RGD:632347
BN.SHR-(Il6-Cd36)/Cub	QTM	RGD:632347
LH/Mav	IED	RGD:1302893
OLETF/Got	IED	RGD:619679
SD	TAS	RGD:68927
SHR-Tg(Ef1a-Cd36)106Ipcv	IED	RGD:1600636
SHR-Tg(Ef1a-Cd36)10Ipcv	IED	RGD:68930
SHR-Tg(Ef1a-Cd36)19Ipcv	IED	RGD:68930
SHR-Tg(Ef1a-Cd36)93Ipcv	IED	RGD:1600636
SHR.PD-(D8Rat42-D8Arb23)/Cub	IED	RGD:1580747
SHR/OlaIpcv	IED	RGD:68930
SS/Jr	TAS	RGD:727992
SS/JrHsdMcwi	TAS	RGD:727992
WIAR-Tg(Wap-GH1)1Mni	TAS	RGD:1302502
WOKA	IED	RGD:619689

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in the second column. The C column indicates the number of objects annotated to the term, while the T column indicates the number of annotations to the term and its decendants.

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Term	C	T
Disease Ontology	0	8271
Nutritional and Metabolic Diseases	0	1369
Metabolic Diseases	1	1101
Insulin Resistance +	38	90

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