Heart Failure, Congestive Gene, QTL, and Strain Annotations - Disease Ontology

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Keyword

ONTOLOGY REPORT

Heart Failure, Congestive (D006333)

A complication of HEART DISEASES. Defective cardiac filling and/or impaired contraction and emptying, resulting in the heart's inability to pump a sufficient amount of blood to meet the needs of the body tissues or to be able to do so only with an elevated filling pressure. (from Braunwald, Heart Disease, 5th ed)

There is 1 path(s) and 75 annotation(s) to this term. Annotations to this term and its descendants total 183.

ANNOTATIONS

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Heart Failure, Congestive

183

Gene Symbol	Gene Name	Evidence	Reference
ADM	adrenomedullin	ISS	RGD:704370
ADRA2C	adrenergic, alpha-2C-, receptor	ISS	RGD:1300355
ADRB1	adrenergic, beta-1-, receptor	ISS	RGD:737774
ADRBK1	adrenergic, beta, receptor kinase 1	ISS	RGD:737776
ADRBK1	adrenergic, beta, receptor kinase 1	ISS (from RGD:2062)	RGD:1625790
AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	IAGP	RGD:1601140
AOC3	amine oxidase, copper containing 3 (vascular adhesion protein 1)	IEP	RGD:2313827
APLN	apelin	ISS (from RGD:620672)	RGD:1626171
APLN	apelin	IEP	RGD:1626175
APLN	apelin	ISS (from RGD:620672)	RGD:1626186
Adm	adrenomedullin	ISS	RGD:704370
Adm	adrenomedullin	IED	RGD:704370
Adra2c	adrenergic, alpha-2C-, receptor	ISS	RGD:1300355
Adrb1	adrenergic receptor, beta 1	IAGP	RGD:737774
Adrb1	adrenergic, beta-1-, receptor	ISS	RGD:737774
Adrbk1	adrenergic, beta, receptor kinase 1	ISS	RGD:737776
Adrbk1	adrenergic, beta, receptor kinase 1	IEP	RGD:1625790
Adrbk1	adrenergic receptor kinase, beta 1	ISS (from RGD:2062)	RGD:1625790
Adrbk1	adrenergic receptor kinase, beta 1	IAGP	RGD:737776
Agt	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	ISS (from RGD:731070)	RGD:1601140
Agt	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	ISS (from RGD:731070)	RGD:1601140
Aoc3	amine oxidase, copper containing 3	ISS (from RGD:1347849)	RGD:2313827
Aoc3	amine oxidase, copper containing 3 (vascular adhesion protein 1)	ISS (from RGD:1347849)	RGD:2313827
Apln	apelin	ISS (from RGD:620672)	RGD:1626186
Apln	apelin	IED	RGD:1626171
Apln	apelin	ISS (from RGD:1351986)	RGD:1626175
Apln	apelin	ISS (from RGD:1351986)	RGD:1626175
Apln	apelin	IEP	RGD:1626186
Apln	apelin	ISS (from RGD:620672)	RGD:1626171
Birc5	baculoviral IAP repeat-containing 5	IEP	RGD:2293134
CASP12	caspase 12 (gene/pseudogene)	ISS (from RGD:621758)	RGD:2311453
CAT	catalase	IEP	RGD:1581151
CCL2	chemokine (C-C motif) ligand 2	ISS	RGD:1581156
CCNA2	cyclin A2	ISS (from RGD:1550849)	RGD:2293348
CCR2	chemokine (C-C motif) receptor 2	IAGP	RGD:1581177
CD40LG	CD40 ligand	IEP	RGD:2314219
CHEK2	CHK2 checkpoint homolog (S. pombe)	IEP	RGD:2289708
CORIN	corin, serine peptidase	ISS	RGD:1581217
CORIN	corin, serine peptidase	ISS	RGD:1581218
CST3	cystatin C	IEP	RGD:2314311
Casp12	caspase 12	ISS (from RGD:621758)	RGD:2311453
Casp12	caspase 12	IEP	RGD:2311453
Cat	catalase	ISS	RGD:1581151
Cat	catalase	ISS	RGD:1581151
Ccl2	chemokine (C-C motif) ligand 2	IEP	RGD:1581156
Ccl2	chemokine (C-C motif) ligand 2	ISS	RGD:1581156
Ccna2	cyclin A2	ISS (from RGD:1550849)	RGD:2293348
Ccna2	cyclin A2	IPM	RGD:2293348
Ccr2	chemokine (C-C motif) receptor 2	ISS	RGD:1581177
Ccr2	chemokine (C-C motif) receptor 2	ISS	RGD:1581177
Cd40lg	CD40 ligand	ISS (from RGD:1352959)	RGD:2314219
Cd40lg	CD40 ligand	ISS (from RGD:1352959)	RGD:2314219
Chek2	CHK2 checkpoint homolog (S. pombe)	ISS (from RGD:732861)	RGD:2289708
Chek2	CHK2 checkpoint homolog (S. pombe)	ISS (from RGD:732861)	RGD:2289708
Corin	corin	ISS	RGD:1581218
Corin	corin	ISS	RGD:1581217
Corin	corin, serine peptidase	IEP	RGD:1581217
Corin	corin, serine peptidase	IEP	RGD:1581218
Cst3	cystatin C	ISS (from RGD:736914)	RGD:2314311
Cst3	cystatin C	ISS (from RGD:736914)	RGD:2314311
DDR1	discoidin domain receptor tyrosine kinase 1	ISS (from RGD:2252)	RGD:1642301
DIO3	deiodinase, iodothyronine, type III	ISS (from RGD:68420)	RGD:2303417
Ddr1	discoidin domain receptor family, member 1	ISS (from RGD:2252)	RGD:1642301
Ddr1	discoidin domain receptor tyrosine kinase 1	IEP	RGD:1642301
Dio3	deiodinase, iodothyronine, type III	IEP	RGD:2303417
Dio3	deiodinase, iodothyronine type III	ISS (from RGD:68420)	RGD:2303417
ECE1	endothelin converting enzyme 1	IEP	RGD:1580911
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	ISS (from RGD:2561)	RGD:1580989
ERBB4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	ISS (from RGD:620486)	RGD:1580989
EYA4	eyes absent homolog 4 (Drosophila)	IAGP	RGD:1598455
Ece1	endothelin converting enzyme 1	ISS (from RGD:731823)	RGD:1580911
Ece1	endothelin converting enzyme 1	ISS (from RGD:731823)	RGD:1580911
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	IEP	RGD:1580989
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	ISS (from RGD:2561)	RGD:1580989
Erbb4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	ISS (from RGD:620486)	RGD:1580989
Erbb4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	IEP	RGD:1580989
Eya4	eyes absent 4 homolog (Drosophila)	ISS	RGD:1598455
Eya4	eyes absent homolog 4 (Drosophila)	ISS	RGD:1598455
FKBP1B	FK506 binding protein 1B, 12.6 kDa	ISS (from RGD:61835)	RGD:2302075
FOS	FBJ murine osteosarcoma viral oncogene homolog	ISS (from RGD:2626)	RGD:2293777
FOSL1	FOS-like antigen 1	ISS (from RGD:2627)	RGD:2293777
FOXC1	forkhead box C1	IEP	RGD:1582564
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	IEP	RGD:1582564
FOXO1	forkhead box O1	ISS	RGD:704404
FOXO1	forkhead box O1	IEP	RGD:1582564
FOXP1	forkhead box P1	IEP	RGD:1582564
FOXP4	forkhead box P4	IEP	RGD:1582564
Fkbp1b	FK506 binding protein 1b	ISS (from RGD:61835)	RGD:2302075
Fkbp1b	FK506 binding protein 1b	IEP	RGD:2302075
Fos	FBJ osteosarcoma oncogene	IEP	RGD:2293777
Fos	FBJ osteosarcoma oncogene	ISS (from RGD:2626)	RGD:2293777
Fosl1	fos-like antigen 1	ISS (from RGD:2627)	RGD:2293777
Fosl1	fos-like antigen 1	IEP	RGD:2293777
Foxc2	forkhead box C2	ISS (from RGD:1347315)	RGD:1582564
Foxo1	forkhead box O1	ISS (from RGD:737155)	RGD:1582564
Foxo1	forkhead box O1	ISS (from RGD:737155)	RGD:1582564
Foxo1	forkhead box O1	ISS	RGD:704404
Foxp1	forkhead box P1	ISS (from RGD:1318576)	RGD:1582564
Foxp1	forkhead box P1	ISS (from RGD:1318576)	RGD:1582564
Foxp4	forkhead box P4	ISS (from RGD:1322820)	RGD:1582564
Foxp4	forkhead box P4	ISS (from RGD:1322820)	RGD:1582564
GRK1	G protein-coupled receptor kinase 1	ISS (from RGD:619712)	RGD:1600002
Grk1	G protein-coupled receptor kinase 1	IED	RGD:1600002
Grk1	G protein-coupled receptor kinase 1	ISS (from RGD:619712)	RGD:1600002
HTR2A	5-hydroxytryptamine (serotonin) receptor 2A	ISS (from RGD:61800)	RGD:1600503
Htr2a	5-hydroxytryptamine (serotonin) receptor 2A	IED	RGD:1600503
Htr2a	5-hydroxytryptamine (serotonin) receptor 2A	ISS (from RGD:61800)	RGD:1600503
IGF1	insulin-like growth factor 1 (somatomedin C)	ISS (from RGD:2868)	RGD:1598415
IL10	interleukin 10	IEP (from RGD:2886)	RGD:1598465
IL6	interleukin 6 (interferon, beta 2)	ISS (from RGD:2901)	RGD:2307285
IL6R	interleukin 6 receptor	ISS (from RGD:2902)	RGD:1625433
Igf1	insulin-like growth factor 1	IEP	RGD:1598415
Igf1	insulin-like growth factor 1	ISS (from RGD:2868)	RGD:1598415
Il10	interleukin 10	IEP (from RGD:2886)	RGD:1598465
Il10	interleukin 10	IEP	RGD:1598465
Il6	interleukin 6	IED	RGD:2307285
Il6	interleukin 6	ISS (from RGD:2901)	RGD:2307285
Il6ra	interleukin 6 receptor, alpha	ISS (from RGD:2902)	RGD:1625433
Il6ra	interleukin 6 receptor, alpha	IEP	RGD:1625433
MAPK14	mitogen-activated protein kinase 14	ISS	RGD:1302548
MDH2	malate dehydrogenase 2, NAD (mitochondrial)	ISS (from RGD:619719)	RGD:1582470
MMP1	matrix metallopeptidase 1 (interstitial collagenase)	IED	RGD:1582539
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	ISS (from RGD:621316)	RGD:2290467
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	IEP	RGD:1582647
MSTN	myostatin	ISS (from RGD:3115)	RGD:2303554
MYH6	myosin, heavy chain 6, cardiac muscle, alpha	IEP	RGD:1580923
Mapk14	mitogen activated protein kinase 14	ISS	RGD:1302548
Mdh2	malate dehydrogenase 2, NAD (mitochondrial)	IED	RGD:1582470
Mdh2	malate dehydrogenase 2, NAD (mitochondrial)	ISS (from RGD:619719)	RGD:1582470
Mmp1a	matrix metallopeptidase 1a (interstitial collagenase)	ISS (from RGD:1317388)	RGD:1582539
Mmp1a	matrix metallopeptidase 1a (interstitial collagenase)	ISS (from RGD:1317388)	RGD:1582539
Mmp2	matrix metallopeptidase 2	ISS (from RGD:621316)	RGD:2290467
Mmp2	matrix metallopeptidase 2	IEP	RGD:2290467
Mmp9	matrix metallopeptidase 9	ISS (from RGD:1348437)	RGD:1582647
Mmp9	matrix metallopeptidase 9	ISS (from RGD:1348437)	RGD:1582647
Mstn	myostatin	IEP	RGD:2303554
Mstn	myostatin	ISS (from RGD:3115)	RGD:2303554
Myh6	myosin, heavy polypeptide 6, cardiac muscle, alpha	ISS	RGD:1580923
Myh6	myosin, heavy chain 6, cardiac muscle, alpha	ISS	RGD:1580923
NOS1	nitric oxide synthase 1 (neuronal)	ISS	RGD:1581144
NPPB	natriuretic peptide precursor B	ISS	RGD:1580140
NPPB	natriuretic peptide precursor B	ISS	RGD:1580139
NPR1	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	ISS	RGD:737701
NPTXR	neuronal pentraxin receptor	ISS (from RGD:628898)	RGD:1642301
Nos1	nitric oxide synthase 1, neuronal	IEP	RGD:1581144
Nos1	nitric oxide synthase 1, neuronal	ISS	RGD:1581144
Nppb	natriuretic peptide precursor B	IAGP	RGD:1580140
Nppb	natriuretic peptide precursor type B	ISS	RGD:1580139
Nppb	natriuretic peptide precursor type B	ISS (from RGD:69139)	RGD:1642196
Nppb	natriuretic peptide precursor B	ISS (from RGD:69139)	RGD:1642196
Nppb	natriuretic peptide precursor B	IAGP	RGD:1580139
Nppb	natriuretic peptide precursor type B	ISS	RGD:1580140
Npr1	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	ISS	RGD:737701
Nptxr	neuronal pentraxin receptor	IEP	RGD:1642301
Nptxr	neuronal pentraxin receptor	ISS (from RGD:628898)	RGD:1642301
PLCD1	phospholipase C, delta 1	ISS (from RGD:3346)	RGD:2300431
PLD2	phospholipase D2	ISS (from RGD:3350)	RGD:2299908
PPP1CA	protein phosphatase 1, catalytic subunit, alpha isoform	ISS	RGD:737728
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	IED	RGD:1580714
PRKAR2A	protein kinase, cAMP-dependent, regulatory, type II, alpha	IED	RGD:1580714
PRKCA	protein kinase C, alpha	ISS (from RGD:3395)	RGD:2292480
PRKCB	protein kinase C, beta	ISS (from RGD:3396)	RGD:1625516
Plcd1	phospholipase C, delta 1	IED	RGD:2300431
Plcd1	phospholipase C, delta 1	ISS (from RGD:3346)	RGD:2300431
Pld2	phospholipase D2	IEP	RGD:2299908
Pld2	phospholipase D2	ISS (from RGD:3350)	RGD:2299908
Ppp1ca	protein phosphatase 1, catalytic subunit, alpha isoform	ISS	RGD:737728
Prkaca	protein kinase, cAMP dependent, catalytic, alpha	ISS (from RGD:1344608)	RGD:1580714
Prkaca	protein kinase, cAMP-dependent, catalytic, alpha	ISS (from RGD:1344608)	RGD:1580714
Prkar2a	protein kinase, cAMP dependent regulatory, type II alpha	ISS (from RGD:732434)	RGD:1580714
Prkar2a	protein kinase, cAMP dependent regulatory, type II alpha	ISS (from RGD:732434)	RGD:1580714
Prkca	protein kinase C, alpha	IEP	RGD:2292480
Prkca	protein kinase C, alpha	ISS (from RGD:3395)	RGD:2292480
Prkcb	protein kinase C, beta	IEP	RGD:1625516
Prkcb	protein kinase C, beta	ISS (from RGD:3396)	RGD:1625516
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	ISS (from RGD:619755)	RGD:1581295
RAMP2	receptor (G protein-coupled) activity modifying protein 2	ISS (from RGD:61872)	RGD:704370
RRAD	Ras-related associated with diabetes	IEP	RGD:2311701
RYR2	ryanodine receptor 2 (cardiac)	ISS (from RGD:620314)	RGD:1599251
Rac1	RAS-related C3 botulinum substrate 1	ISS (from RGD:619755)	RGD:1581295
Rac1	ras-related C3 botulinum toxin substrate 1	IAGP	RGD:1581295
Ramp2	receptor (G protein-coupled) activity modifying protein 2	IEP	RGD:704370
Ramp2	receptor (calcitonin) activity modifying protein 2	ISS (from RGD:61872)	RGD:704370
Rrad	Ras-related associated with diabetes	ISS (from RGD:736416)	RGD:2311701
Rrad	Ras-related associated with diabetes	ISS (from RGD:736416)	RGD:2311701
Ryr2	ryanodine receptor 2, cardiac	ISS (from RGD:620314)	RGD:1599251
Ryr2	ryanodine receptor 2, cardiac	IED	RGD:1599251
SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	ISS (from RGD:3656)	RGD:2312309
SIRT1	sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)	IEP	RGD:1580423
SLC2A4	solute carrier family 2 (facilitated glucose transporter), member 4	IEP	RGD:2313624
SLC8A1	solute carrier family 8 (sodium/calcium exchanger), member 1	ISS (from RGD:3717)	RGD:1642720
SRF	serum response factor (c-fos serum response element-binding transcription factor)	IED	RGD:1581426
Selp	selectin, platelet	ISS (from RGD:3656)	RGD:2312309
Selp	selectin, platelet	IEP	RGD:2312309
Sirt1	sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)	ISS	RGD:1580423
Sirt1	sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)	ISS	RGD:1580423
Slc2a4	solute carrier family 2 (facilitated glucose transporter), member 4	ISS (from RGD:731478)	RGD:2313624
Slc2a4	solute carrier family 2 (facilitated glucose transporter), member 4	ISS (from RGD:731478)	RGD:2313624
Slc8a1	solute carrier family 8 (sodium/calcium exchanger), member 1	ISS (from RGD:3717)	RGD:1642720
Slc8a1	solute carrier family 8 (sodium/calcium exchanger), member 1	IEP	RGD:1642720
Srf	serum response factor	ISS (from RGD:1321393)	RGD:1581426
Srf	serum response factor (c-fos serum response element-binding transcription factor)	ISS (from RGD:1321393)	RGD:1581426
TH	tyrosine hydroxylase	ISS	RGD:737737
TIMP1	TIMP metallopeptidase inhibitor 1	ISS (from RGD:621675)	RGD:2290467
TIMP2	TIMP metallopeptidase inhibitor 2	ISS (from RGD:61312)	RGD:2290467
TIMP4	TIMP metallopeptidase inhibitor 4	ISS (from RGD:69077)	RGD:2290467
TNF	tumor necrosis factor (TNF superfamily, member 2)	TAS	RGD:1580317
TNFRSF11B	tumor necrosis factor receptor superfamily, member 11b	ISS (from RGD:619802)	RGD:1624176
Th	tyrosine hydroxylase	ISS	RGD:737737
Timp1	TIMP metallopeptidase inhibitor 1	IEP	RGD:2290467
Timp1	tissue inhibitor of metalloproteinase 1	ISS (from RGD:621675)	RGD:2290467
Timp2	TIMP metallopeptidase inhibitor 2	IEP	RGD:2290467
Timp2	tissue inhibitor of metalloproteinase 2	ISS (from RGD:61312)	RGD:2290467
Timp4	tissue inhibitor of metalloproteinase 4	IEP	RGD:2290467
Timp4	tissue inhibitor of metalloproteinase 4	ISS (from RGD:69077)	RGD:2290467
Tnf	tumor necrosis factor (TNF superfamily, member 2)	IED	RGD:1580213
Tnf	tumor necrosis factor	ISS (from RGD:3876)	RGD:1580213
Tnfrsf11b	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	ISS (from RGD:619802)	RGD:1624176
Tnfrsf11b	tumor necrosis factor receptor superfamily, member 11b	IEP	RGD:1624176
UTS2	urotensin 2	IEP	RGD:1580809
UTS2	urotensin 2	IEP	RGD:2306804
Uts2	urotensin 2	ISS (from RGD:737599)	RGD:2306804
Uts2	urotensin 2	ISS (from RGD:737599)	RGD:1580809
Uts2	urotensin 2	ISS (from RGD:737599)	RGD:1580809
Uts2	urotensin 2	ISS (from RGD:737599)	RGD:2306804

Strain Symbol	Evidence	Reference
F344-Tg(Cyp1a1-Ren2)10Jmul	IAGP	RGD:2313695
LEW.F344-(D10Rat99-D10Rat11)/Jmul	IAGP	RGD:2313695
SHHF/Bbb	IED	RGD:2293766

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Term	C	T
Disease Ontology	0	8271
Cardiovascular Diseases	49	3188
Heart Diseases	52	1471
Heart Failure, Congestive +	75	183

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