Atp1a1 Rat Gene (ATPase, Na+/K+ transporting, alpha 1 polypeptide)

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Keyword

Gene:
Atp1a1 ( Rattus norvegicus )
ATPase, Na+/K+ transporting, alpha 1 polypeptide
Description: mediates Na+ and K+ transport; may play a role in regulation of blood pressure
Synonyms: ATPase, Na+K+ transporting, alpha 1 ; Nkaa1b;  (details...)
ArrayIDs: M28647_at; M74494_g_at; rc_AI072060_s_at; M74494_at; 1367585_a_at; M28647_g_at; 1371108_a_at;  (details...)
Gene Type: protein-coding
Strain: SS.MNS-(Mme-D2Mit14)/Ayd  SS.MNS-(Mme-Gca)/Ayd  SS.MNS-(D2Mit6-Adh1)/Ayd

Additional Data

Candidate gene for: Bp16 - Blood pressure QTL 16
Bp132 - Blood pressure QTL 132

Markers: D2Arb18 D2Mgh11 D2Wox26

primer pair: 70112

Homologs
Homo sapiens: ATP1A1     See the Human gene in context in:     UCSC     NCBI MapViewer

Mus musculus: Atp1a1     See the Mouse gene in context in:     UCSC     NCBI MapViewer

Comparative Map Data
Species Symbol Map Name Chr. Position
Rattus norvegicus Atp1a1 genome assembly 3.1 2 196620502 - 196649996
Rat Celera Assembly 2 181455492 - 181483650
RGSC genome assembly v3.4 2 196657749 - 196687237
Cytogenetic 2 q34
Mus musculus Atp1a1 Mouse genome assembly build 36.1 3 101380146 - 101408582
Cytogenetic 3 3 F3
Homo sapiens ATP1A1 human genome assembly 1 116627877 - 116659436
Human genome assembly build 36.2 1 116717359 - 116748919
Cytogenetic 1 p21

View comparative maps:      NCBI MapViewer

Genome
View:

Browsers:

Other Map Data:
Associated SSLP Map Locations
STS D2Arb18 SHRSP x BN 2 72.7698
Rat cytogenetic map 2
STS D2Mgh11 RH 2.0 2 967
SHRSP x BN 2 72.7598
RH 3.4 2 1294.1
STS D2Wox26 RH 2.0 2 969.2
RH 3.4 2 1294.3
Rat cytogenetic map 2

Annotation
Molecular Function

Note Reference

transports Na+ from the cell and accumulates K+ 628463

catalytic subunit of Apt1 enzyme 628463

Gene Ontology

potassium ion binding,  nucleotide binding,  monovalent inorganic cation transmembrane transporter activity ... (details...)
Biological Process

Note Reference

mediates ionic gradients across the plasma membrane 628463

required in maintaining ionic homeostasis in the kidney 70519

Gene Ontology

potassium ion import,  negative regulation of heart contraction,  response to drug ... (details...)
Cellular Component

Gene Ontology

endosome,  melanosome,  integral to membrane ... (details...)
Disease

Ontology

Hypertension (details...)
Expression

Note Reference

expressed ubiquitously in fetal and adult tissues 61043

Protein

Note Reference

contains binding sites for ions and substrates 628463

Domain

Note Reference

central isoform-specific region (ISR) mediates PKC response but not K+ deocclusion 628463

Mutation/over- and underexpression

Note Reference

A1079T mutation that had been proposed to be related to hypertension was not found in any of several hypertension-prone rats 70519

External Links
Databases
DATABASE ID SOURCE
SMART: Cation_ATPase_N IPI
PROSITE: ATPASE_E1_E2 IPI
UNIPARC: UPI00000E85B2 IPI
UNIPARC: UPI00000619F2 IPI
KEGG Report: rno:24211 ENTREZGENE
HomoloGene Group ID: 564 ENTREZGENE
Germonline: 2167
Pfam: Hydrolase IPI
Pfam: E1-E2_ATPase IPI
Pfam: Cation_ATPase_C IPI
Pfam: Cation_ATPase_N IPI
InterPro: Dehalogen-like_hydro. IPI
InterPro: ATPase_P-typ_P_site. IPI
InterPro: ATPase_P-typ_ion-transptr. IPI
InterPro: ATPase_P-typ_cation-transptr_N. IPI
InterPro: ATPase_P-typ_cation-transptr_C. IPI
InterPro: ATPase_P-typ_cation-ex_asu_euk. IPI
InterPro: ATPase_P-typ_cation-exchng_asu. IPI
InterPro: ATPase_P-typ_ATPase-assoc-reg. IPI
Ensembl Protein: ENSRNOP00000045650 IPI
IPI: IPI00326305 IPI
IPI: IPI00558343 IPI
Entrez Gene: Atp1a1 ENTREZGENE
IMAGE_CLONE: IMAGE:5598014 IMAGE-MGC_LOAD
MGC_CLONE: MGC:72546 IMAGE-MGC_LOAD
Ensembl Genes: ENSRNOG00000030019 IPI
TIGR: TC216770
UniProt: AT1A1_RAT IPI
UniProt: Q64608_RAT IPI
RatMap: 87 ENTREZGENE
PANTHER: ATPase_P IPI
TIGRFAMs: ATPase_P-type IPI
TIGRFAMs: ATPase-IIC_X-K IPI
PRINTS: NAKATPASE. IPI
PRINTS: CATATPASE. IPI
Sequences
Nucleotide: BC061968 Get FASTA Search GEO Profiles
Nucleotide: M74494 Get FASTA Search GEO Profiles
Nucleotide: M28647 Get FASTA Search GEO Profiles
Nucleotide: M14511 Get FASTA Search GEO Profiles
Nucleotide: M11733 Get FASTA Search GEO Profiles
Nucleotide: X05882 Get FASTA Search GEO Profiles
Nucleotide: X53234 Get FASTA Search GEO Profiles
Nucleotide: X53233 Get FASTA Search GEO Profiles
Nucleotide: CH474015 Get FASTA Search GEO Profiles
Nucleotide: NM_012504 Get FASTA Search GEO Profiles
(View all 10 Nucleotide Accessions)
Protein: AAA41671 Get FASTA
Protein: AAA41670 Get FASTA
Protein: CAA29306 Get FASTA
Protein: P06685 Get FASTA
Protein: Q64608 Get FASTA
Protein: CAA37326 Get FASTA
Protein: CAA37325 Get FASTA
Protein: AAA40775 Get FASTA
Protein: AAA40783 Get FASTA
Protein: NP_036636 Get FASTA
Protein: AAH61968 Get FASTA
Protein: EDL85522 Get FASTA
Protein: EDL85523 Get FASTA
(View all 13 Protein Accessions)
Clusters
UniGene: 2992
UniGene: 217534

References
Curated References
26 references in RGD related to Atp1a1

Other References
73 other references at PubMed related to Atp1a1

Database Information
RGD ID 2167
History

Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference

10-SEP-04: Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide ATPase, Na+K+ transporting, alpha 1 APPROVED Name updated 1299863

10-JUN-02: Atp1a1 ATPase, Na+K+ transporting, alpha 1 PROVISIONAL Name updated 70585