Strain: BB/OK
Symbol:
BB/OK
Strain:
BB
Substrain:
OK
Ontology ID:
N/A
Also known as:
MDC-02-70;
Type:
inbred
Source:
Central Institute for Diabetes, Karlsburg, Germany, National BioResource Project for the Rat in Japan
Origin:
This colony was established in 1983, these rats were originally from an outbred colony from Ottawa, Canada.
Coat Color:
White
Inbred Generations:
F62
Annotation
Disease Annotations
Phenotype Annotations
RGD Disease Portals
BB/OK has been annotated in the following RGD Disease Portals.
References - curated
1.
Kloting I, etal., Ann N Y Acad Sci 1997 Sep 20;827:64-84.
2.
Kovacs P and Kloting I, Arch Biochem Biophys 1998 Jun 1;354(1):139-43.
3.
Jackerott M, etal., J Autoimmun 1997 Feb;10(1):35-41.
4.
Kloting I, etal., Biochem Biophys Res Commun 1998 Apr 17;245(2):483-6
5.
Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
6.
Jacob HJ, etal., Nat Genet 1992 Sep;2(1):56-60
7.
Kovacs P, etal., Biochem Biophys Res Commun 1997 Jun 18;235(2):343-8
Region
Strain QTL Data
Symbol
Name
Trait
Subtrait
Iddm4
Insulin dependent diabetes mellitus QTL 4
Glucose level
insulin-dependent
Bp42
Blood pressure QTL 42
Blood pressure
null
Bp43
Blood pressure QTL 43
Blood pressure
null
Bp44
Blood pressure QTL 44
Blood pressure
null
Bp45
Blood pressure QTL 45
Blood pressure
null
Bp46
Blood pressure QTL 46
Blood pressure
null
Bp47
Blood pressure QTL 47
Blood pressure
null
Bp48
Blood pressure QTL 48
Blood pressure
null
Bw18
Body weight QTL 18
Body weight
null
Bw20
Body weight QTL 20
Body weight
null
Bw22
Body weight QTL 22
Body weight
null
Iddm8
Insulin dependent diabetes mellitus QTL 8
Insulin level
null
Bp80
Blood pressure QTL 80
Blood pressure
systolic
Bp79
Blood pressure QTL 79
Blood pressure
systolic
Scl22
Serum cholesterol level QTL 22
Lipid level
cholesterol
Spl3
Serum phospholipid level QTL 3
Protein level
null
Stl2
Serum triglyceride level QTL 2
Lipid level
triglyceride
Stl3
Serum triglyceride level QTL 3
Lipid level
triglyceride
Iddm5
Insulin dependent diabetes mellitus QTL 5
Insulin level
null
Iddm6
Insulin dependent diabetes mellitus QTL 6
Insulin level
null
Iddm9
Insulin dependent diabetes mellitus QTL 9
Insulin level
null
Iddm10
Insulin dependent diabetes mellitus QTL 10
Insulin level
null
Iddm16
Insulin dependent diabetes mellitus QTL 16
Insulin level
null
Scl4
Serum cholesterol level QTL 4
Lipid level
cholesterol
Scl5
Serum cholesterol level QTL 5
Lipid level
cholesterol
Bw39
Body weight QTL 39
Body weight
null
Bw40
Body weight QTL 40
Body weight
null
Additional Information
RGD Curation Notes
Note Type
Note
Reference
strain_life_disease
These animals develop insulin-dependent diabetes.
619667
strain_life_disease
These animals develop insulin-dependent diabetes.
619684
strain_characteristics
80-100% of male and female BB/OK rats develop spontaneously insulin-dependent type 1 diabetes mellitus at an age of about 90 days; first autoantobodies are detectable at an age of 10 days; first sign of insulitis at an age of 30 days; all animals develop insulitis up to an age of 30 weeks.
1549690
strain_reproduction
Average litter size at weaning 6.5 pups for diabetic-prone and 7.2 pups for the diabetic-resistant colonies.
61077
RGD Object Information
RGD ID:
61107
Created:
2001-01-05
Species:
Rattus norvegicus
Last Modified:
2009-06-18
Status:
ACTIVE