Gene: ARFGEF2 (ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)) Homo sapiens
Symbol: ARFGEF2
Name: ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
Description: ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BIG2; brefeldin A-inhibited GEP 2; brefeldin A-inhibited guanine nucleotide-exchange protein 2; dJ1164I10.1; FLJ23723; OTTHUMP00000031231; PVNH2
Latest Assembly: Human Genome Assembly GRCh37
Human Genome Assembly GRCh382048,921,721 - 49,036,693+NCBI
Human Alternate Assembly CHM1_12047,442,300 - 47,557,463+NCBI
Human Genome Assembly HuRef2044,289,793 - 44,403,088+NCBI
Human Genome Assembly GRCh372047,538,250 - 47,653,230+NCBI
Human Celera Assembly2044,242,891 - 44,357,843+NCBI
Human Genome Assembly Build 362046,971,682 - 47,086,637+NCBI
Human Cytogenetic Map20q13.13 NCBI
Human Genome Assembly2046,971,833 - 47,083,645 NCBI

Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19)
Launch JBrowse : build 36 (hg18) build 37 (hg19)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
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References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Human Genome Assembly GRCh37)
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ARFGEF2
Entrez Gene
Ensembl Gene
GBrowse: hg18 hg19
JBrowse: hg18 hg19
HGNC Report
NCBI Map Viewer
Vista + UCSC

RGD Object Information
RGD ID: 736641
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2015-10-06
Status: ACTIVE