Gene: PTGER4 (prostaglandin E receptor 4 (subtype EP4)) Homo sapiens
Symbol: PTGER4
Name: prostaglandin E receptor 4 (subtype EP4)
Description: The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: EP4; EP4R; MGC126583; OTTHUMP00000119996; PGE receptor EP4 subtype; PGE receptor, EP4 subtype; PGE2 receptor EP4 subtype; prostaglandin E2 receptor EP4 subtype; prostanoid EP4 receptor
Related Pseudogenes: PTGER4P1   PTGER4P2-CDK2AP2P2   PTGER4P3  
Latest Assembly: Human Genome Assembly GRCh37
Human Genome Assembly GRCh38540,679,498 - 40,741,764+NCBI
Human Alternate Assembly CHM1_1540,681,992 - 40,695,797+NCBI
Human Genome Assembly HuRef540,632,020 - 40,645,825+NCBI
Human Genome Assembly GRCh37540,680,032 - 40,696,962+NCBI
Human Celera Assembly540,568,598 - 40,582,403+NCBI
Human Genome Assembly Build 36540,715,789 - 40,729,594+NCBI
Human Cytogenetic Map5p13.1 NCBI
Human Genome Assembly540,715,788 - 40,729,592 NCBI

Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19)
Launch JBrowse : build 36 (hg18) build 37 (hg19)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Human Genome Assembly GRCh37)
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PTGER4
Entrez Gene
Ensembl Gene
GBrowse: hg18 hg19
JBrowse: hg18 hg19
HGNC Report
NCBI Map Viewer
Vista + UCSC

RGD Object Information
RGD ID: 736498
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2015-07-21
Status: ACTIVE