Gene: GCK (glucokinase (hexokinase 4)) Homo sapiens
Symbol: GCK
Name: glucokinase (hexokinase 4)
Description: Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). [provided by RefSeq, Apr 2009]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ATP:D-hexose 6-phosphotransferase; FGQTL3; GK; GLK; glucokinase; hexokinase D, pancreatic isozyme; hexokinase type IV; hexokinase-4; hexokinase-D; HHF3; HK IV; HK4; HKIV; HXKP; LGLK; MODY2; OTTHUMP00000159306; OTTHUMP00000159307; OTTHUMP00000159308; OTTHUMP00000209239
Orthologs:
Mus musculus : Gck (glucokinase)  MGI
Rattus norvegicus : Gck (glucokinase)
more info ...
Latest Assembly: Human Genome Assembly GRCh37
Position:
MapChrPositionStrandSource
Human Genome Assembly GRCh38744,144,271 - 44,189,423-NCBI
Human Alternate Assembly CHM1_1744,187,724 - 44,232,886-NCBI
Human Alternate Assembly CRA_TCAGchr7v2744,223,370 - 44,268,527-NCBI
Human Genome Assembly HuRef744,069,141 - 44,114,301-NCBI
Human Genome Assembly GRCh37744,183,870 - 44,229,022-NCBI
Human Celera Assembly744,281,829 - 44,326,987-NCBI
Human Genome Assembly Build 36744,150,395 - 44,195,563-NCBI
Human Cytogenetic Map7p15.3-p15.1 NCBI
Human Genome Assembly743,957,109 - 43,972,127 NCBI
Model

Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19)


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Human Genome Assembly GRCh37)

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on GCK
Entrez Gene
Ensembl Gene
Genome Browser: (hg18) (hg19)
HGNC Report
NCBI Map Viewer
Vista
Vista + UCSC

RGD Object Information
RGD ID: 735697
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2014-10-22
Status: ACTIVE