Gene: GCK (glucokinase) Homo sapiens
Symbol: GCK
Name: glucokinase
Description: Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). [provided by RefSeq, Apr 2009]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ATP:D-hexose 6-phosphotransferase; FGQTL3; GK; GLK; glucokinase (hexokinase 4); hexokinase D, pancreatic isozyme; hexokinase type IV; hexokinase-4; hexokinase-D; HHF3; HK IV; HK4; HKIV; HXKP; LGLK; MODY2; OTTHUMP00000159306; OTTHUMP00000159307; OTTHUMP00000159308; OTTHUMP00000209239
Mus musculus : Gck (glucokinase)  MGI
Rattus norvegicus : Gck (glucokinase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38744,143,213 - 44,189,439 (-)NCBIGRCh38hg38GRCh38
GRCh37744,183,870 - 44,229,022 (-)NCBIGRCh37hg19GRCh37
Build 36744,150,395 - 44,195,563 (-)NCBINCBI36hg18NCBI36
Build 34743,957,109 - 43,972,127NCBI
Celera744,281,829 - 44,326,987 (-)NCBI
Cytogenetic Map7p13NCBImapview
HuRef744,069,141 - 44,114,301 (-)NCBI
CHM1_1744,187,724 - 44,232,886 (-)NCBI
CRA_TCAGchr7v2744,223,370 - 44,268,527 (-)NCBI

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on GCK
Entrez Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Map Viewer
Vista + UCSC

RGD Object Information
RGD ID: 735697
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2016-10-11
Status: ACTIVE