GCK (glucokinase (hexokinase 4)) - Rat Genome Database

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Keyword

Gene: GCK (glucokinase (hexokinase 4)) Homo sapiens

Symbol:

GCK

Name:

glucokinase (hexokinase 4)

Description:

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). [provided by RefSeq, Apr 2009]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

ATP:D-hexose 6-phosphotransferase; FGQTL3; GK; GLK; glucokinase; hexokinase D, pancreatic isozyme; hexokinase type IV; hexokinase-4; hexokinase-D; HHF3; HK IV; HK4; HKIV; HXKP; LGLK; MODY2; OTTHUMP00000159306; OTTHUMP00000159307; OTTHUMP00000159308; OTTHUMP00000209239

Orthologs:

Mus musculus : Gck (glucokinase) MGI
Rattus norvegicus : Gck (glucokinase)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	7	44,159,372 - 44,204,538	-	NCBI
Human Alternate Assembly CRA_TCAGchr7v2	7	44,223,370 - 44,268,527	-	NCBI
Human Genome Assembly HuRef	7	44,069,141 - 44,114,301	-	NCBI
Human Genome Assembly GRCh37	7	44,183,870 - 44,229,022	-	NCBI
Human Genome Assembly Build 36	7	44,150,395 - 44,195,563	-	NCBI
Human Cytogenetic Map	7	p15.3-p15.1		NCBI
Human Genome Assembly	7	43,957,109 - 43,972,127		NCBI