Gene: GCK (glucokinase) Homo sapiens
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Symbol: GCK
Name: glucokinase
Description: This gene encodes a member of the hexokinase family of proteins. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. The use of multiple promoters and alternative splicing of this gene result in distinct protein isoforms that exhibit tissue-specific expression in the pancreas and liver. In the pancreas, this enzyme plays a role in glucose-stimulated insulin secretion, while in the liver, this enzyme is important in glucose uptake and conversion to glycogen. Mutations in this gene that alter enzyme activity have been associated with multiple types of diabetes and hyperinsulinemic hypoglycemia. [provided by RefSeq, Aug 2017]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ATP:D-hexose 6-phosphotransferase; FGQTL3; GK; GLK; glucokinase (hexokinase 4); hexokinase D, pancreatic isozyme; hexokinase type IV; hexokinase-4; hexokinase-D; HHF3; HK IV; HK4; HKIV; HXKP; LGLK; MODY2; OTTHUMP00000159306; OTTHUMP00000159307; OTTHUMP00000159308; OTTHUMP00000209239
Orthologs:
Mus musculus (house mouse) : Gck (glucokinase)  MGI
Rattus norvegicus (Norway rat) : Gck (glucokinase)  AGR
Chinchilla lanigera (long-tailed chinchilla) : Gck (glucokinase)
Pan paniscus (bonobo/pygmy chimpanzee) : GCK (glucokinase)
Canis lupus familiaris (dog) : GCK (glucokinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gck (glucokinase)
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Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38744,143,213 - 44,189,439 (-)NCBIGRCh38hg38GRCh38
GRCh37744,183,870 - 44,229,022 (-)NCBIGRCh37hg19GRCh37
Build 36744,150,395 - 44,195,563 (-)NCBINCBI36hg18NCBI36
Build 34743,957,109 - 43,972,127NCBI
Celera744,281,829 - 44,326,987 (-)NCBI
Cytogenetic Map7p13NCBImapview
HuRef744,069,141 - 44,114,301 (-)NCBI
CHM1_1744,187,724 - 44,232,886 (-)NCBI
CRA_TCAGchr7v2744,223,370 - 44,268,527 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Genomics

Comparative Map Data
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miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
Nomenclature History
 
More on GCK
AGR Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Map Viewer
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Vista + UCSC

RGD Object Information
RGD ID: 735697
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2017-10-10
Status: ACTIVE