Gene: CDC42 (cell division cycle 42) Homo sapiens
Symbol: CDC42
Name: cell division cycle 42
Description: The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CDC42Hs; cell division control protein 42 homolog; cell division cycle 42 (GTP binding protein, 25kDa); dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD)); dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD)); G25K; G25K GTP-binding protein; growth-regulating protein; GTP binding protein, 25kDa; GTP-binding protein, 25kD; OTTHUMP00000002834; OTTHUMP00000002926; OTTHUMP00000002927; small GTP binding protein CDC42; TKS
Related Pseudogenes: CDC42P1   CDC42P2   CDC42P3   CDC42P4   CDC42P5   CDC42P6  
Latest Assembly: Human Genome Assembly GRCh37
Human Genome Assembly GRCh38122,052,627 - 22,092,943+NCBI
Human Alternate Assembly CHM1_1122,491,651 - 22,531,931+NCBI
Human Genome Assembly HuRef120,622,960 - 20,663,212+NCBI
Human Genome Assembly GRCh37122,379,120 - 22,419,439+NCBI
Human Celera Assembly120,702,109 - 20,742,389+NCBI
Human Genome Assembly Build 36122,251,707 - 22,292,023+NCBI
Human Cytogenetic Map1p36.1 NCBI
Human Genome Assembly122,124,487 - 22,164,741 NCBI

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Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Human Genome Assembly GRCh37)
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CDC42
Entrez Gene
Ensembl Gene
GBrowse: hg18 hg19
JBrowse: hg18 hg19
HGNC Report
NCBI Map Viewer
Vista + UCSC

RGD Object Information
RGD ID: 730976
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2016-02-02
Status: ACTIVE