Gene: WT1 (Wilms tumor 1)  Homo sapiens Symbol: WT1 Name: Wilms tumor 1 Description: This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilm's tumors. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation site upstream of and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Oct 2010] Type: protein-coding RefSeq Status: REVIEWED Also known as: amino-terminal domain of EWS|last three zinc fingers of the DNA-binding domain of WT1; AWT1; EWS-WT1; GUD; NPHS4; OTTHUMP00000037553; OTTHUMP00000037554; OTTHUMP00000037555; OTTHUMP00000037556; OTTHUMP00000238018; WAGR; Wilms tumor protein; WIT-2; WT33 Orthologs: Mus musculus : Wt1 (Wilms tumor 1 homolog)  MGI Rattus norvegicus : Wt1 (Wilms tumor 1) Latest Assembly: Human Genome Assembly GRCh37 Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 11 32,338,667 - 32,386,515 - NCBI Human Genome Assembly HuRef 11 32,104,249 - 32,152,010 - NCBI Human Genome Assembly GRCh37 11 32,409,321 - 32,457,081 - NCBI Human Genome Assembly Build 36 11 32,365,901 - 32,413,663 - NCBI Human Cytogenetic Map 11 p13   NCBI Human Genome Assembly 11 32,365,896 - 32,413,653   NCBI Model Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19) Annotation    (Toggle Detail/Summary View) Disease Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) Alzheimer Disease   IED   1580623   RGD   Breast Neoplasms Disease_progression IEP   2315543   RGD   Denys-Drash Syndrome   IAGP   1580624   RGD   Denys-Drash Syndrome   IEA   7240710   OMIM   Endometrial Neoplasms Disease_progression IEP   2315542   RGD   Frasier Syndrome   IEA   7240710   OMIM   Genital Neoplasms, Male   IEP   2315541   RGD   Meacham Winn Culler syndrome   IEA   7240710   OMIM   NEPHROTIC SYNDROME, TYPE 4   IEA   7240710   OMIM   Ovarian Neoplasms   IEP   2315539   RGD   WAGR Syndrome   IEA   1331525   RGD   Wilms Tumor   IAGP   2315545 DNA:point mutations:exon:1084C>T; more ... RGD   Wilms Tumor   IEA   7240710   OMIM   Wilms Tumor   IEP   2315544   RGD   Wilms Tumor   IEA   1331525   RGD   Gene-Chemical Interaction Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) 17beta-estradiol decreases response to substance EXP   6480464 WT1 protein results in decreased susceptibility to Estradiol CTD PMID:20204298 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:11493 6480464 Tetrachlorodibenzodioxin results in decreased expression of WT1 mRNA CTD PMID:19933214 2-ethoxyethanol increases expression ISO RGD:3974 6480464 2-ethoxyethanol results in increased expression of WT1 mRNA CTD PMID:19643169 2-methoxyethanol increases expression ISO RGD:3974 6480464 methyl cellosolve results in increased expression of WT1 mRNA CTD PMID:19643169 5-fluorouracil decreases expression ISO RGD:11493 6480464 Fluorouracil results in decreased expression of WT1 protein CTD PMID:21296659 acetic acid increases expression ISO RGD:11493 6480464 Acetic Acid results in increased expression of WT1 protein CTD PMID:21296659 all-trans-retinoic acid multiple interactions EXP   6480464 PDCD4 protein promotes the reaction [Tretinoin results in decreased expression of WT1 protein] CTD PMID:17259349 all-trans-retinoic acid decreases expression EXP   6480464 Tretinoin results in decreased expression of WT1 mRNA CTD PMID:15749674 more ... all-trans-retinoic acid increases expression EXP   6480464 Tretinoin results in increased expression of WT1 mRNA CTD PMID:21934132 PMID:14646600 all-trans-retinoic acid decreases expression EXP   6480464 Tretinoin results in decreased expression of WT1 mRNA CTD PMID:15770638 PMID:15749674 all-trans-retinoic acid increases expression EXP   6480464 Tretinoin results in increased expression of WT1 mRNA CTD PMID:14646600 PMID:21934132 all-trans-retinoic acid increases expression ISO RGD:11493 6480464 Tretinoin results in increased expression of WT1 mRNA CTD PMID:16604517 all-trans-retinoic acid decreases expression ISO RGD:11493 6480464 Tretinoin results in decreased expression of WT1 protein CTD PMID:15855632 all-trans-retinoic acid increases expression EXP   6480464 Tretinoin results in increased expression of WT1 protein CTD PMID:12644474 all-trans-retinoic acid decreases expression EXP   6480464 Tretinoin results in decreased expression of WT1 protein CTD PMID:15770638 all-trans-retinoic acid increases expression EXP   6480464 Tretinoin results in increased expression of WT1 mRNA CTD PMID:14646600 all-trans-retinoic acid decreases expression EXP   6480464 Tretinoin results in decreased expression of WT1 mRNA CTD PMID:15749674 PMID:15770638 all-trans-retinoic acid decreases expression EXP   6480464 Tretinoin results in decreased expression of WT1 mRNA alternative form CTD PMID:15749674 ammonium chloride affects expression ISO RGD:3974 6480464 Ammonium Chloride affects the expression of WT1 mRNA CTD PMID:16483693 benzo[a]pyrene multiple interactions ISO RGD:11493 6480464 AHR affects the reaction [Benzo(a)pyrene affects the splicing of WT1 mRNA] CTD PMID:21803694 benzo[a]pyrene affects splicing ISO RGD:11493 6480464 Benzo(a)pyrene affects the splicing of WT1 mRNA CTD PMID:21803694 bisdemethoxycurcumin decreases expression EXP   6480464 bis(4-hydroxycinnamoyl)methane results in decreased expression of WT1 protein; more ... CTD PMID:18034345 bromochloroacetic acid decreases expression ISO RGD:11493 6480464 bromochloroacetic acid results in decreased expression of WT1 protein CTD PMID:21296659 carmustine decreases response to substance EXP   6480464 WT1 results in decreased susceptibility to Carmustine CTD PMID:20820871 cisplatin decreases response to substance EXP   6480464 WT1 results in decreased susceptibility to Cisplatin CTD PMID:20820871 cobalt dichloride multiple interactions EXP   6480464 [cobaltous chloride co-treated with Deferoxamine] results in increased expression of WT1 mRNA CTD PMID:12738801 copper atom multiple interactions EXP   6480464 [NSC 689534 binds to Copper] which results in decreased expression of WT1 mRNA CTD PMID:20971185 copper(0) multiple interactions EXP   6480464 [NSC 689534 binds to Copper] which results in decreased expression of WT1 mRNA CTD PMID:20971185 curcumin decreases expression EXP   6480464 Curcumin results in decreased expression of WT1 mRNA; more ... CTD PMID:18034345 PMID:19196508 curcumin decreases expression EXP   6480464 Curcumin results in decreased expression of WT1 protein; more ... CTD PMID:19196508 PMID:18034345 demethoxycurcumin decreases expression EXP   6480464 demethoxycurcumin results in decreased expression of WT1 mRNA; more ... CTD PMID:18034345 desferrioxamine B multiple interactions EXP   6480464 [cobaltous chloride co-treated with Deferoxamine] results in increased expression of WT1 mRNA CTD PMID:12738801 diarsenic trioxide decreases expression EXP   6480464 arsenic trioxide results in decreased expression of WT1 mRNA CTD PMID:16966277 PMID:20471514 diarsenic trioxide increases expression EXP   6480464 arsenic trioxide results in increased expression of WT1 mRNA CTD PMID:11940349 diarsenic trioxide decreases expression EXP   6480464 arsenic trioxide results in decreased expression of WT1 protein CTD PMID:16966277 diarsenic trioxide decreases expression EXP   6480464 arsenic trioxide results in decreased expression of WT1 mRNA CTD PMID:20471514 PMID:16966277 dioxygen increases expression EXP   6480464 Oxygen deficiency results in increased expression of WT1 mRNA CTD PMID:12738801 dioxygen decreases expression EXP   6480464 Oxygen deficiency results in decreased expression of WT1 mRNA CTD PMID:17175027 diuron decreases expression ISO RGD:3974 6480464 Diuron results in decreased expression of WT1 mRNA CTD PMID:21551480 formaldehyde increases expression ISO RGD:3974 6480464 Formaldehyde results in increased expression of WT1 mRNA CTD PMID:12679049 fulvestrant decreases response to substance EXP   6480464 WT1 protein results in decreased susceptibility to fulvestrant CTD PMID:20204298 heptadecafluorononanoic acid increases expression ISO RGD:3974 6480464 perfluoro-n-nonanoic acid results in increased expression of WT1 mRNA; more ... CTD PMID:20580666 imatinib decreases expression EXP   6480464 imatinib results in decreased expression of WT1 mRNA CTD PMID:15329907 manganese atom decreases expression EXP   6480464 Manganese results in decreased expression of WT1 mRNA CTD PMID:17175027 manganese(0) decreases expression EXP   6480464 Manganese results in decreased expression of WT1 mRNA CTD PMID:17175027 manganese(II) chloride decreases expression EXP   6480464 manganese chloride results in decreased expression of WT1 mRNA CTD PMID:17175027 nitric oxide increases expression ISO RGD:3974 6480464 Nitric Oxide results in increased expression of WT1 mRNA CTD PMID:21443142 paraquat increases expression ISO RGD:11493 6480464 Paraquat results in increased expression of WT1 mRNA CTD PMID:16797015 progesterone increases expression EXP   6480464 Progesterone results in increased expression of WT1 mRNA; more ... CTD PMID:14662165 rosuvastatin increases expression ISO RGD:3974 6480464 rosuvastatin results in increased expression of WT1 mRNA CTD PMID:21443142 sirolimus decreases expression EXP   6480464 Sirolimus results in decreased expression of WT1 protein; more ... CTD PMID:18927120 sirolimus decreases expression EXP   6480464 Sirolimus results in decreased expression of WT1 protein mutant form CTD PMID:15782132 staurosporine increases expression EXP   6480464 Staurosporine results in increased expression of WT1 protein CTD PMID:12914969 tamoxifen decreases response to substance EXP   6480464 WT1 protein results in decreased susceptibility to Tamoxifen CTD PMID:20944147 PMID:20204298 tamoxifen decreases response to substance EXP   6480464 WT1 protein results in decreased susceptibility to Tamoxifen CTD PMID:20204298 PMID:20944147 tetrachloromethane affects expression ISO RGD:11493 6480464 Carbon Tetrachloride affects the expression of WT1 mRNA CTD PMID:17484886 Gene Ontology Annotations Biological Process Term Qualifier Evidence With Reference Notes Source Original Reference(s) adrenal cortex formation   ISS UniProtKB:P22561 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 adrenal gland development   IGI UniProtKB:P22561 2290271 PMID:10101119 UniProtKB PMID:10101119 branching involved in ureteric bud morphogenesis   IGI UniProtKB:P22561 2290271 PMID:10101119 UniProtKB PMID:10101119 camera-type eye development   ISS UniProtKB:P22561 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 camera-type eye development   IEA Ensembl:ENSMUSP00000117891 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 cardiac muscle cell fate commitment   ISS UniProtKB:P22561 2290271 GO_REF:0000024 BHF-UCL GO_REF:0000024 cellular response to cAMP   IEP   2290271 PMID:15961562 UniProtKB PMID:15961562 cellular response to gonadotropin stimulus   IDA   2290271 PMID:15961562 UniProtKB PMID:15961562 diaphragm development   ISS UniProtKB:P22561 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 epithelial cell differentiation   ISS UniProtKB:P22561 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 germ cell development   ISS UniProtKB:P22561 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 germ cell development   IEA Ensembl:ENSMUSP00000117891 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 glomerular basement membrane development   IMP   2290271 PMID:19205749 UniProtKB PMID:19205749 glomerular visceral epithelial cell differentiation   ISS UniProtKB:P22561 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 glomerulus development   IGI UniProtKB:P22561 2290271 PMID:10101119 UniProtKB PMID:10101119 gonad development   ISS UniProtKB:P22561 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 heart development   IGI UniProtKB:P22561 2290271 PMID:10101119 UniProtKB PMID:10101119 induction of apoptosis   IDA   2290271 PMID:7588596 UniProtKB PMID:7588596 kidney development   IGI UniProtKB:P22561 2290271 PMID:11912180 UniProtKB PMID:11912180 male genitalia development   ISS UniProtKB:P22561 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 male gonad development   IEP   2290271 PMID:17848411 UniProtKB PMID:17848411 male gonad development   IEA Ensembl:ENSMUSP00000117891 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 mesenchymal to epithelial transition   ISS UniProtKB:P22561 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 mesonephros development   IEA Ensembl:ENSMUSP00000117891 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 metanephric epithelium development   IEP   2290271 PMID:7856737 UniProtKB PMID:7856737 metanephric mesenchyme development   ISS UniProtKB:P22561 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 metanephric S-shaped body morphogenesis   IGI UniProtKB:P22561 2290271 PMID:10101119 UniProtKB PMID:10101119 metanephros development   IEA Ensembl:ENSMUSP00000117891 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 negative regulation of apoptotic process   IGI UniProtKB:P22561 2290271 PMID:10101119 UniProtKB PMID:10101119 negative regulation of cell growth   IDA   2290271 PMID:9553041 UniProtKB PMID:9553041 negative regulation of cell growth   IDA   2290271 PMID:7588596 UniProtKB PMID:7588596 negative regulation of cell growth   IDA   2290271 PMID:9765217 UniProtKB PMID:9765217 negative regulation of cell proliferation   IDA   2290271 PMID:9553041 UniProtKB PMID:9553041 negative regulation of cell proliferation   IDA   2290271 PMID:9765217 UniProtKB PMID:9765217 negative regulation of female gonad development   ISS UniProtKB:P22561 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 negative regulation of metanephric glomerular mesangial cell proliferation   ISS UniProtKB:P22561 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 negative regulation of transcription from RNA polymerase II promoter   IDA   2290271 PMID:7585606 MGI PMID:7585606 negative regulation of transcription, DNA-dependent   IDA   2290271 PMID:12802290 UniProtKB PMID:12802290 negative regulation of transcription, DNA-dependent   IDA   2290271 PMID:7588596 UniProtKB PMID:7588596 negative regulation of transcription, DNA-dependent   IDA   2290271 PMID:9815658 UniProtKB PMID:9815658 negative regulation of transcription, DNA-dependent   IDA   2290271 PMID:8119964 UniProtKB PMID:8119964 negative regulation of transcription, DNA-dependent   IDA   2290271 PMID:7720589 UniProtKB PMID:7720589 negative regulation of transcription, DNA-dependent   IDA   2290271 PMID:7585606 UniProtKB PMID:7585606 negative regulation of transcription, DNA-dependent   IDA   2290271 PMID:19050011 UniProtKB PMID:19050011 negative regulation of transcription, DNA-dependent   IDA   2290271 PMID:14701728 UniProtKB PMID:14701728 negative regulation of transcription, DNA-dependent   IDA   2290271 PMID:1332065 UniProtKB PMID:1332065 negative regulation of translation   IDA   2290271 PMID:7588596 UniProtKB PMID:7588596 positive regulation of heart growth   ISS UniProtKB:P22561 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 positive regulation of male gonad development   ISS UniProtKB:P22561 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 positive regulation of metanephric ureteric bud development   ISS UniProtKB:P22561 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 positive regulation of transcription from RNA polymerase II promoter   IEA Ensembl:ENSMUSP00000117891 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of transcription, DNA-dependent NOT IDA   2290271 PMID:9815658 UniProtKB PMID:9815658 positive regulation of transcription, DNA-dependent   IDA   2290271 PMID:7588596 UniProtKB PMID:7588596 positive regulation of transcription, DNA-dependent   IDA   2290271 PMID:9815658 UniProtKB PMID:9815658 positive regulation of transcription, DNA-dependent   IDA   2290271 PMID:9765217 UniProtKB PMID:9765217 positive regulation of transcription, DNA-dependent   IDA   2290271 PMID:9553041 UniProtKB PMID:9553041 positive regulation of transcription, DNA-dependent   IDA   2290271 PMID:9178767 UniProtKB PMID:9178767 positive regulation of transcription, DNA-dependent   IDA   2290271 PMID:8132626 UniProtKB PMID:8132626 positive regulation of transcription, DNA-dependent   IDA   2290271 PMID:21390327 UniProtKB PMID:21390327 positive regulation of transcription, DNA-dependent   IDA   2290271 PMID:16467207 UniProtKB PMID:16467207 positive regulation of transcription, DNA-dependent   IDA   2290271 PMID:14701728 UniProtKB PMID:14701728 positive regulation of transcription, DNA-dependent   IDA   2290271 PMID:12802290 UniProtKB PMID:12802290 positive regulation of transcription, DNA-dependent   IGI UniProtKB:P22561 2290271 PMID:11912180 UniProtKB PMID:11912180 posterior mesonephric tubule development   ISS UniProtKB:P22561 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 regulation of organ formation   ISS UniProtKB:P22561 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 regulation of transcription from RNA polymerase II promoter   ISS UniProtKB:P22561 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 regulation of transcription, DNA-dependent   ISS UniProtKB:P22561 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 regulation of transcription, DNA-dependent   IEA InterPro:IPR000976 2290271 GO_REF:0000002 InterPro GO_REF:0000002 regulation of transcription, DNA-dependent   NAS   2290271 PMID:8393820 UniProtKB PMID:8393820 regulation of transcription, DNA-dependent   NAS   2290271 PMID:7862533 UniProtKB PMID:7862533 RNA splicing   ISS UniProtKB:P22561 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 sex determination   IDA   2290271 PMID:9815658 UniProtKB PMID:9815658 sex determination   IEA Ensembl:ENSMUSP00000117891 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 thorax and anterior abdomen determination   ISS UniProtKB:P22561 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 tissue development   ISS UniProtKB:P22561 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 tissue development   IEA Ensembl:ENSMUSP00000117891 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 ureteric bud development   ISS UniProtKB:P22561 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 vasculogenesis   ISS UniProtKB:P22561 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 vasculogenesis   IEA Ensembl:ENSMUSP00000117891 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 visceral serous pericardium development   IGI UniProtKB:P22561 2290271 PMID:10101119 UniProtKB PMID:10101119 Cellular Component Term Qualifier Evidence With Reference Notes Source Original Reference(s) cytoplasm   ISS UniProtKB:P22561 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 cytoplasm   IEA Ensembl:ENSMUSP00000117891 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 nuclear speck   IDA   2290271 PMID:16934801 UniProtKB PMID:16934801 nuclear speck   IDA   2290271 PMID:15520190 UniProtKB PMID:15520190 nuclear speck   IDA   2290271 PMID:9553041 UniProtKB PMID:9553041 nucleolus   IEA UniProtKB-SubCell:SL-0188 2290271 GO_REF:0000039 UniProtKB GO_REF:0000039 nucleoplasm   IDA   2290271 PMID:15520190 UniProtKB PMID:15520190 nucleus   IDA   2290271 PMID:14701728 UniProtKB PMID:14701728 nucleus   IEA InterPro:IPR000976 2290271 GO_REF:0000002 InterPro GO_REF:0000002 nucleus   IDA   2290271 PMID:8306891 UniProtKB PMID:8306891 nucleus   IDA   2290271 PMID:7588596 UniProtKB PMID:7588596 nucleus   IDA   2290271 PMID:16934801 UniProtKB PMID:16934801 nucleus   IDA   2290271 PMID:1662794 UniProtKB PMID:1662794 nucleus   IDA   2290271 PMID:15961562 UniProtKB PMID:15961562 Molecular Function Term Qualifier Evidence With Reference Notes Source Original Reference(s) C2H2 zinc finger domain binding   IPI UniProtKB:P19544 2290271 PMID:8119964 UniProtKB PMID:8119964 double-stranded DNA binding   IEA Ensembl:ENSMUSP00000117891 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 nucleic acid binding   IEA InterPro:IPR013087 2290271 GO_REF:0000002 InterPro GO_REF:0000002 protein binding   IPI UniProtKB:P80723 2290271 PMID:14701728 UniProtKB PMID:14701728 protein binding   IPI UniProtKB:P08107 2290271 PMID:9553041 UniProtKB PMID:9553041 protein binding   IPI UniProtKB:Q02962 2290271 PMID:9178767 UniProtKB PMID:9178767 protein binding   IPI UniProtKB:P19544 2290271 PMID:8119964 UniProtKB PMID:8119964 protein binding   IPI UniProtKB:P32114 2290271 PMID:7720589 UniProtKB PMID:7720589 protein binding   IPI UniProtKB:P48059 2290271 PMID:21390327 UniProtKB PMID:21390327 protein binding   IPI UniProtKB:Q9BWF3 2290271 PMID:16934801 UniProtKB PMID:16934801 RNA binding   IEA UniProtKB-KW:KW-0694 2290271 GO_REF:0000037 UniProtKB GO_REF:0000037 RNA binding   IEA Ensembl:ENSMUSP00000117891 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription   ISS UniProtKB:P22561 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 sequence-specific DNA binding   IDA   2290271 PMID:1662794 UniProtKB PMID:1662794 sequence-specific DNA binding   IDA   2290271 PMID:8119964 UniProtKB PMID:8119964 sequence-specific DNA binding   IDA   2290271 PMID:7720589 UniProtKB PMID:7720589 sequence-specific DNA binding transcription factor activity   ISS UniProtKB:P22561 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 sequence-specific DNA binding transcription factor activity   NAS   2290271 PMID:8393820 UniProtKB PMID:8393820 sequence-specific DNA binding transcription factor activity   NAS   2290271 PMID:7862533 UniProtKB PMID:7862533 transcription regulatory region DNA binding   IDA   2290271 PMID:1332065 UniProtKB PMID:1332065 transcription regulatory region DNA binding   IDA   2290271 PMID:9815658 UniProtKB PMID:9815658 transcription regulatory region DNA binding   IDA   2290271 PMID:7588596 UniProtKB PMID:7588596 transcription regulatory region DNA binding   IDA   2290271 PMID:7585606 UniProtKB PMID:7585606 transcription regulatory region DNA binding   IDA   2290271 PMID:16467207 UniProtKB PMID:16467207 zinc ion binding   IDA   2290271 PMID:15518539 UniProtKB PMID:15518539 zinc ion binding   IEA InterPro:IPR007087 2290271 GO_REF:0000002 InterPro GO_REF:0000002 Molecular Pathway Annotations External Database Links KEGG Pathway Transcriptional misregulation in cancer Pathway Interaction Database p73 transcription factor network (PID:200017) Regulation of Telomerase (PID:200086) Disease Annotations Alzheimer Disease  (IED) Breast Neoplasms  (IEP) Denys-Drash Syndrome  (IAGP,IEA) Endometrial Neoplasms  (IEP) Frasier Syndrome  (IEA) Genital Neoplasms, Male  (IEP) Meacham Winn Culler syndrome  (IEA) NEPHROTIC SYNDROME, TYPE 4  (IEA) Ovarian Neoplasms  (IEP) WAGR Syndrome  (IEA) Wilms Tumor  (IAGP,IEA,IEP) Gene-Chemical Interaction Annotations 17beta-estradiol  (EXP) 2,3,7,8-tetrachlorodibenzodioxine  (ISO) 2-ethoxyethanol  (ISO) 2-methoxyethanol  (ISO) 5-fluorouracil  (ISO) acetic acid  (ISO) all-trans-retinoic acid  (EXP,ISO) ammonium chloride  (ISO) benzo[a]pyrene  (ISO) bisdemethoxycurcumin  (EXP) bromochloroacetic acid  (ISO) carmustine  (EXP) cisplatin  (EXP) cobalt dichloride  (EXP) copper atom  (EXP) copper(0)  (EXP) curcumin  (EXP) demethoxycurcumin  (EXP) desferrioxamine B  (EXP) diarsenic trioxide  (EXP) dioxygen  (EXP) diuron  (ISO) formaldehyde  (ISO) fulvestrant  (EXP) heptadecafluorononanoic acid  (ISO) imatinib  (EXP) manganese atom  (EXP) manganese(0)  (EXP) manganese(II) chloride  (EXP) nitric oxide  (ISO) paraquat  (ISO) progesterone  (EXP) rosuvastatin  (ISO) sirolimus  (EXP) staurosporine  (EXP) tamoxifen  (EXP) tetrachloromethane  (ISO) Gene Ontology Annotations Biological Process adrenal cortex formation  (ISS) adrenal gland development  (IGI) branching involved in ureteric bud morphogenesis  (IGI) camera-type eye development  (IEA,ISS) cardiac muscle cell fate commitment  (ISS) cellular response to cAMP  (IEP) cellular response to gonadotropin stimulus  (IDA) diaphragm development  (ISS) epithelial cell differentiation  (ISS) germ cell development  (IEA,ISS) glomerular basement membrane development  (IMP) glomerular visceral epithelial cell differentiation  (ISS) glomerulus development  (IGI) gonad development  (ISS) heart development  (IGI) induction of apoptosis  (IDA) kidney development  (IGI) male genitalia development  (ISS) male gonad development  (IEA,IEP) mesenchymal to epithelial transition  (ISS) mesonephros development  (IEA) metanephric epithelium development  (IEP) metanephric mesenchyme development  (ISS) metanephric S-shaped body morphogenesis  (IGI) metanephros development  (IEA) negative regulation of apoptotic process  (IGI) negative regulation of cell growth  (IDA) negative regulation of cell proliferation  (IDA) negative regulation of female gonad development  (ISS) negative regulation of metanephric glomerular mesangial cell proliferation  (ISS) negative regulation of transcription from RNA polymerase II promoter  (IDA) negative regulation of transcription, DNA-dependent  (IDA) negative regulation of translation  (IDA) positive regulation of heart growth  (ISS) positive regulation of male gonad development  (ISS) positive regulation of metanephric ureteric bud development  (ISS) positive regulation of transcription from RNA polymerase II promoter  (IEA) positive regulation of transcription, DNA-dependent  (IDA,IGI) posterior mesonephric tubule development  (ISS) regulation of organ formation  (ISS) regulation of transcription from RNA polymerase II promoter  (ISS) regulation of transcription, DNA-dependent  (IEA,ISS,NAS) RNA splicing  (ISS) sex determination  (IDA,IEA) thorax and anterior abdomen determination  (ISS) tissue development  (IEA,ISS) ureteric bud development  (ISS) vasculogenesis  (IEA,ISS) visceral serous pericardium development  (IGI) Cellular Component cytoplasm  (IEA,ISS) nuclear speck  (IDA) nucleolus  (IEA) nucleoplasm  (IDA) nucleus  (IDA,IEA) Molecular Function C2H2 zinc finger domain binding  (IPI) double-stranded DNA binding  (IEA) nucleic acid binding  (IEA) protein binding  (IPI) RNA binding  (IEA) RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription  (ISS) sequence-specific DNA binding  (IDA) sequence-specific DNA binding transcription factor activity  (ISS,NAS) transcription regulatory region DNA binding  (IDA) zinc ion binding  (IDA,IEA) Molecular Pathway Annotations External Database Links KEGG Pathway Transcriptional misregulation in cancer Pathway Interaction Database p73 transcription factor network (PID:200017) Regulation of Telomerase (PID:200086) References - curated 1. Becker KG, etal., Nat Genet 2004 May;36(5):431-2. 2. Coppes MJ, etal., Proc Natl Acad Sci U S A. 1993 Feb 15;90(4):1416-9. 3. Fukuzawa R, etal., J Med Genet. 2002 Aug;39(8):e48. 4. Gerald WL, etal., Am J Pathol. 1992 May;140(5):1031-7. 5. GOA_HUMAN data from the GO Consortium 6. Han L, etal., Diagn Cytopathol. 2009 Oct 23. 7. Li JH and Man YG, Cancer Biomark. 2009;5(3):109-16. 8. Lovell MA, etal., Brain Res. 2003 Sep 5;983(1-2):84-96. 9. Ohno S, etal., Anticancer Res. 2009 May;29(5):1691-5. 10. RGD automated import pipeline for gene-chemical interactions 11. RGD Automated Pipelines 12. Sangoi AR, etal., Mod Pathol. 2009 Sep;22(9):1228-35. Epub 2009 Jun 19. 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Biological Process Cancer Diseases Biological Process Neurological Diseases Genomics Comparative Map Data WT1   (Homo sapiens) Map Chr Position Strand Source Human Alternate Assembly CHM1_1 11 32,338,667 - 32,386,515 - NCBI Human Genome Assembly HuRef 11 32,104,249 - 32,152,010 - NCBI Human Genome Assembly GRCh37 11 32,409,321 - 32,457,081 - NCBI Human Genome Assembly Build 36 11 32,365,901 - 32,413,663 - NCBI Human Cytogenetic Map 11 p13   NCBI Human Genome Assembly 11 32,365,896 - 32,413,653   NCBI Wt1   (Mus musculus) Map Chr Position Strand Source Mouse Genome Assembly GRCm38 2 105,126,529 - 105,173,614 + NCBI Mouse cM Map 2 55.06   NCBI Mouse Celera Assembly 2 106,361,212 - 106,408,919 + NCBI Mouse Genome Assembly Build 37 2 104,966,686 - 105,013,771 + NCBI Mouse Genome Assembly Build 36.1 2 104,966,686 - 105,013,771 + NCBI Mouse Cytogenetic Map 2 E   NCBI Wt1   (Rattus norvegicus) Map Chr Position Strand Source Rat Cytogenetic Map 3 q32   NCBI RGSC Genome Assembly v5.0 3 101,756,493 - 101,802,601 + NCBI RGSC Genome Assembly v3.4 3 90,529,704 - 90,577,280 + NCBI Rat Celera Assembly 3 90,623,287 - 90,669,803 + NCBI Genome Assembly 3.1 3 90,463,925 - 90,472,651 + NCBI RH 3.4 3 720.19   RGD Position Markers WT1   Map Chr Position Strand Source Human NCBI RH Map 11 209.7   UniSTS Human GeneMap99-GB4 RH Map 11 114.29   UniSTS Human Genome Assembly HuRef 11 32,104,991 - 32,105,489   UniSTS Human Genome Assembly GRCh37 11 32,410,063 - 32,410,561   UniSTS Human Celera Assembly 11 32,556,798 - 32,557,296   RGD Human Genome Assembly Build 36 11 32,366,639 - 32,367,137   RGD Human Cytogenetic Map 11 p13   UniSTS G15888   Map Chr Position Strand Source Human Genome Assembly HuRef 11 32,104,330 - 32,104,547   UniSTS Human Genome Assembly GRCh37 11 32,409,402 - 32,409,619   UniSTS Human Celera Assembly 11 32,556,137 - 32,556,354   RGD Human Genome Assembly Build 36 11 32,365,978 - 32,366,195   RGD Human Cytogenetic Map 11 p13   UniSTS G59663   Map Chr Position Strand Source Human TNG Radiation Hybrid Map 11 15330.0   UniSTS Human Genome Assembly HuRef 11 32,112,816 - 32,112,928   UniSTS Human Genome Assembly GRCh37 11 32,417,888 - 32,418,000   UniSTS Human Celera Assembly 11 32,564,623 - 32,564,735   RGD Human Genome Assembly Build 36 11 32,374,464 - 32,374,576   RGD Human Cytogenetic Map 11 p13   UniSTS D11S3501   Map Chr Position Strand Source Human Genome Assembly HuRef 11 32,110,715 - 32,110,868   UniSTS Human Genome Assembly GRCh37 11 32,415,787 - 32,415,940   UniSTS Human Celera Assembly 11 32,562,522 - 32,562,675   RGD Human Genome Assembly Build 36 11 32,372,363 - 32,372,516   RGD Human Cytogenetic Map 11 p13   UniSTS GDB:178695   Map Chr Position Strand Source Human Genome Assembly HuRef 11 32,104,414 - 32,105,369   UniSTS Human Genome Assembly GRCh37 11 32,409,486 - 32,410,441   UniSTS Human Celera Assembly 11 32,556,221 - 32,557,176   RGD Human Genome Assembly Build 36 11 32,366,062 - 32,367,017   RGD Human Cytogenetic Map 11 p13   UniSTS GDB:186603   Map Chr Position Strand Source Human Genome Assembly HuRef 11 32,104,416 - 32,104,548   UniSTS Human Genome Assembly GRCh37 11 32,409,488 - 32,409,620   UniSTS Human Celera Assembly 11 32,556,223 - 32,556,355   RGD Human Genome Assembly Build 36 11 32,366,064 - 32,366,196   RGD Human Cytogenetic Map 11 p13   UniSTS GDB:250580   Map Chr Position Strand Source Human Genome Assembly GRCh37 11 32,456,533 - 32,456,710   UniSTS Human Celera Assembly 11 32,603,265 - 32,603,442   RGD Human Genome Assembly Build 36 11 32,413,109 - 32,413,286   RGD Human Cytogenetic Map 11 p13   UniSTS GDB:250581   Map Chr Position Strand Source Human Genome Assembly HuRef 11 32,144,398 - 32,144,568   UniSTS Human Genome Assembly GRCh37 11 32,449,467 - 32,449,637   UniSTS Human Celera Assembly 11 32,596,202 - 32,596,372   RGD Human Genome Assembly Build 36 11 32,406,043 - 32,406,213   RGD Human Cytogenetic Map 11 p13   UniSTS GDB:250582   Map Chr Position Strand Source Human Genome Assembly HuRef 11 32,116,803 - 32,117,203   UniSTS Human Genome Assembly GRCh37 11 32,421,875 - 32,422,275   UniSTS Human Celera Assembly 11 32,568,610 - 32,569,010   RGD Human Genome Assembly Build 36 11 32,378,451 - 32,378,851   RGD Human Cytogenetic Map 11 p13   UniSTS GDB:250583   Map Chr Position Strand Source Human Genome Assembly HuRef 11 32,112,689 - 32,112,920   UniSTS Human Genome Assembly GRCh37 11 32,417,761 - 32,417,992   UniSTS Human Celera Assembly 11 32,564,496 - 32,564,727   RGD Human Genome Assembly Build 36 11 32,374,337 - 32,374,568   RGD Human Cytogenetic Map 11 p13   UniSTS GDB:250584   Map Chr Position Strand Source Human Genome Assembly HuRef 11 32,112,159 - 32,112,670   UniSTS Human Genome Assembly GRCh37 11 32,417,231 - 32,417,742   UniSTS Human Celera Assembly 11 32,563,966 - 32,564,477   RGD Human Genome Assembly Build 36 11 32,373,807 - 32,374,318   RGD Human Cytogenetic Map 11 p13   UniSTS GDB:250585   Map Chr Position Strand Source Human Genome Assembly HuRef 11 32,105,514 - 32,105,854   UniSTS Human Genome Assembly GRCh37 11 32,410,586 - 32,410,926   UniSTS Human Celera Assembly 11 32,557,321 - 32,557,661   RGD Human Genome Assembly Build 36 11 32,367,162 - 32,367,502   RGD Human Cytogenetic Map 11 p13   UniSTS GDB:250586   Map Chr Position Strand Source Human Genome Assembly HuRef 11 32,104,412 - 32,104,555   UniSTS Human Genome Assembly GRCh37 11 32,409,484 - 32,409,627   UniSTS Human Celera Assembly 11 32,556,219 - 32,556,362   RGD Human Genome Assembly Build 36 11 32,366,060 - 32,366,203   RGD Human Cytogenetic Map 11 p13   UniSTS GDB:316186   Map Chr Position Strand Source Human Genome Assembly HuRef 11 32,108,310 - 32,108,658   UniSTS Human Genome Assembly GRCh37 11 32,413,382 - 32,413,730   UniSTS Human Celera Assembly 11 32,560,117 - 32,560,465   RGD Human Genome Assembly Build 36 11 32,369,958 - 32,370,306   RGD Human Cytogenetic Map 11 p13   UniSTS GDB:371622   Map Chr Position Strand Source Human Genome Assembly HuRef 11 32,152,089 - 32,152,292   UniSTS Human Genome Assembly GRCh37 11 32,457,160 - 32,457,363   UniSTS Human Celera Assembly 11 32,603,892 - 32,604,095   RGD Human Genome Assembly Build 36 11 32,413,736 - 32,413,939   RGD Human Cytogenetic Map 11 p13   UniSTS GDB:371627   Map Chr Position Strand Source Human Genome Assembly HuRef 11 32,151,902 - 32,152,106   UniSTS Human Genome Assembly GRCh37 11 32,456,973 - 32,457,177   UniSTS Human Celera Assembly 11 32,603,705 - 32,603,909   RGD Human Genome Assembly Build 36 11 32,413,549 - 32,413,753   RGD Human Cytogenetic Map 11 p13   UniSTS GDB:371630   Map Chr Position Strand Source Human Genome Assembly HuRef 11 32,151,787 - 32,151,973   UniSTS Human Genome Assembly GRCh37 11 32,456,858 - 32,457,044   UniSTS Human Celera Assembly 11 32,603,590 - 32,603,776   RGD Human Genome Assembly Build 36 11 32,413,434 - 32,413,620   RGD Human Cytogenetic Map 11 p13   UniSTS GDB:371633   Map Chr Position Strand Source Human Genome Assembly HuRef 11 32,151,612 - 32,151,817   UniSTS Human Genome Assembly GRCh37 11 32,456,683 - 32,456,888   UniSTS Human Celera Assembly 11 32,603,415 - 32,603,620   RGD Human Genome Assembly Build 36 11 32,413,259 - 32,413,464   RGD Human Cytogenetic Map 11 p13   UniSTS GDB:371636   Map Chr Position Strand Source Human Genome Assembly HuRef 11 32,151,469 - 32,151,635   UniSTS Human Genome Assembly GRCh37 11 32,456,540 - 32,456,706   UniSTS Human Celera Assembly 11 32,603,272 - 32,603,438   RGD Human Genome Assembly Build 36 11 32,413,116 - 32,413,282   RGD Human Cytogenetic Map 11 p13   UniSTS GDB:371639   Map Chr Position Strand Source Human Genome Assembly HuRef 11 32,151,349 - 32,151,516   UniSTS Human Genome Assembly GRCh37 11 32,456,420 - 32,456,587   UniSTS Human Celera Assembly 11 32,603,152 - 32,603,319   RGD Human Genome Assembly Build 36 11 32,412,996 - 32,413,163   RGD Human Cytogenetic Map 11 p13   UniSTS GDB:371642   Map Chr Position Strand Source Human Genome Assembly HuRef 11 32,151,158 - 32,151,397   UniSTS Human Genome Assembly GRCh37 11 32,456,229 - 32,456,468   UniSTS Human Celera Assembly 11 32,602,961 - 32,603,200   RGD Human Genome Assembly Build 36 11 32,412,805 - 32,413,044   RGD Human Cytogenetic Map 11 p13   UniSTS GDB:371645   Map Chr Position Strand Source Human Genome Assembly HuRef 11 32,144,885 - 32,145,148   UniSTS Human Genome Assembly GRCh37 11 32,449,954 - 32,450,217   UniSTS Human Celera Assembly 11 32,596,689 - 32,596,952   RGD Human Genome Assembly Build 36 11 32,406,530 - 32,406,793   RGD Human Cytogenetic Map 11 p13   UniSTS GDB:371654   Map Chr Position Strand Source Human Genome Assembly HuRef 11 32,132,928 - 32,133,043   UniSTS Human Genome Assembly GRCh37 11 32,437,999 - 32,438,114   UniSTS Human Celera Assembly 11 32,584,734 - 32,584,849   RGD Human Genome Assembly Build 36 11 32,394,575 - 32,394,690   RGD Human Cytogenetic Map 11 p13   UniSTS GDB:371660   Map Chr Position Strand Source Human Genome Assembly HuRef 11 32,112,688 - 32,112,918   UniSTS Human Genome Assembly GRCh37 11 32,417,760 - 32,417,990   UniSTS Human Celera Assembly 11 32,564,495 - 32,564,725   RGD Human Genome Assembly Build 36 11 32,374,336 - 32,374,566   RGD Human Cytogenetic Map 11 p13   UniSTS GDB:371667   Map Chr Position Strand Source Human Genome Assembly HuRef 11 32,108,382 - 32,108,591   UniSTS Human Genome Assembly GRCh37 11 32,413,454 - 32,413,663   UniSTS Human Celera Assembly 11 32,560,189 - 32,560,398   RGD Human Genome Assembly Build 36 11 32,370,030 - 32,370,239   RGD Human Cytogenetic Map 11 p13   UniSTS GDB:371673   Map Chr Position Strand Source Human Genome Assembly HuRef 11 32,105,448 - 32,105,643   UniSTS Human Genome Assembly GRCh37 11 32,410,520 - 32,410,715   UniSTS Human Celera Assembly 11 32,557,255 - 32,557,450   RGD Human Genome Assembly Build 36 11 32,367,096 - 32,367,291   RGD Human Cytogenetic Map 11 p13   UniSTS GDB:371676   Map Chr Position Strand Source Human Genome Assembly HuRef 11 32,105,224 - 32,105,503   UniSTS Human Genome Assembly GRCh37 11 32,410,296 - 32,410,575   UniSTS Human Celera Assembly 11 32,557,031 - 32,557,310   RGD Human Genome Assembly Build 36 11 32,366,872 - 32,367,151   RGD Human Cytogenetic Map 11 p13   UniSTS GDB:371679   Map Chr Position Strand Source Human Genome Assembly HuRef 11 32,104,934 - 32,105,256   UniSTS Human Genome Assembly GRCh37 11 32,410,006 - 32,410,328   UniSTS Human Celera Assembly 11 32,556,741 - 32,557,063   RGD Human Genome Assembly Build 36 11 32,366,582 - 32,366,904   RGD Human Cytogenetic Map 11 p13   UniSTS GDB:371682   Map Chr Position Strand Source Human Genome Assembly HuRef 11 32,104,739 - 32,104,991   UniSTS Human Genome Assembly GRCh37 11 32,409,811 - 32,410,063   UniSTS Human Celera Assembly 11 32,556,546 - 32,556,798   RGD Human Genome Assembly Build 36 11 32,366,387 - 32,366,639   RGD Human Cytogenetic Map 11 p13   UniSTS GDB:371686   Map Chr Position Strand Source Human Genome Assembly HuRef 11 32,104,258 - 32,104,435   UniSTS Human Genome Assembly GRCh37 11 32,409,330 - 32,409,507   UniSTS Human Celera Assembly 11 32,556,065 - 32,556,242   RGD Human Genome Assembly Build 36 11 32,365,906 - 32,366,083   RGD Human Cytogenetic Map 11 p13   UniSTS GDB:512306   Map Chr Position Strand Source Human Genome Assembly HuRef 11 32,151,465 - 32,151,741   UniSTS Human Genome Assembly GRCh37 11 32,456,536 - 32,456,812   UniSTS Human Celera Assembly 11 32,603,268 - 32,603,544   RGD Human Genome Assembly Build 36 11 32,413,112 - 32,413,388   RGD Human Cytogenetic Map 11 p13   UniSTS GDB:512315   Map Chr Position Strand Source Human Genome Assembly HuRef 11 32,151,082 - 32,151,741   UniSTS Human Genome Assembly GRCh37 11 32,456,153 - 32,456,812   UniSTS Human Celera Assembly 11 32,602,885 - 32,603,544   RGD Human Genome Assembly Build 36 11 32,412,729 - 32,413,388   RGD Human Cytogenetic Map 11 p13   UniSTS GDB:595974   Map Chr Position Strand Source Human Genome Assembly HuRef 11 32,152,980 - 32,153,171   UniSTS Human Genome Assembly GRCh37 11 32,458,051 - 32,458,242   UniSTS Human Celera Assembly 11 32,604,783 - 32,604,974   RGD Human Genome Assembly Build 36 11 32,414,627 - 32,414,818   RGD Human Cytogenetic Map 11 p13   UniSTS GDB:595983   Map Chr Position Strand Source Human Genome Assembly HuRef 11 32,152,797 - 32,153,023   UniSTS Human Genome Assembly GRCh37 11 32,457,868 - 32,458,094   UniSTS Human Celera Assembly 11 32,604,600 - 32,604,826   RGD Human Genome Assembly Build 36 11 32,414,444 - 32,414,670   RGD Human Cytogenetic Map 11 p13   UniSTS GDB:595991   Map Chr Position Strand Source Human Genome Assembly HuRef 11 32,152,602 - 32,152,842   UniSTS Human Genome Assembly GRCh37 11 32,457,673 - 32,457,913   UniSTS Human Celera Assembly 11 32,604,405 - 32,604,645   RGD Human Genome Assembly Build 36 11 32,414,249 - 32,414,489   RGD Human Cytogenetic Map 11 p13   UniSTS GDB:596004   Map Chr Position Strand Source Human Genome Assembly HuRef 11 32,152,383 - 32,152,648   UniSTS Human Genome Assembly GRCh37 11 32,457,454 - 32,457,719   UniSTS Human Celera Assembly 11 32,604,186 - 32,604,451   RGD Human Genome Assembly Build 36 11 32,414,030 - 32,414,295   RGD Human Cytogenetic Map 11 p13   UniSTS GDB:596045   Map Chr Position Strand Source Human Genome Assembly HuRef 11 32,151,932 - 32,152,115   UniSTS Human Genome Assembly GRCh37 11 32,457,003 - 32,457,186   UniSTS Human Celera Assembly 11 32,603,735 - 32,603,918   RGD Human Genome Assembly Build 36 11 32,413,579 - 32,413,762   RGD Human Cytogenetic Map 11 p13   UniSTS WT   Map Chr Position Strand Source Human Genome Assembly HuRef 11 32,104,435 - 32,104,608   UniSTS Human Genome Assembly GRCh37 11 32,409,507 - 32,409,680   UniSTS Human Celera Assembly 11 32,556,242 - 32,556,415   RGD Human Genome Assembly Build 36 11 32,366,083 - 32,366,256   RGD Human Cytogenetic Map 11 p13   UniSTS PMC20552P1   Map Chr Position Strand Source Human Genome Assembly HuRef 11 32,144,400 - 32,144,558   UniSTS Human Genome Assembly GRCh37 11 32,449,469 - 32,449,627   UniSTS Human Celera Assembly 11 32,596,204 - 32,596,362   RGD Human Genome Assembly Build 36 11 32,406,045 - 32,406,203   RGD Human Cytogenetic Map 11 p13   UniSTS WT1_1108   Map Chr Position Strand Source Human Genome Assembly HuRef 11 32,104,062 - 32,104,927   UniSTS Human Genome Assembly GRCh37 11 32,409,134 - 32,409,999   UniSTS Human Celera Assembly 11 32,555,869 - 32,556,734   RGD Human Genome Assembly Build 36 11 32,365,710 - 32,366,575   RGD RH18097   Map Chr Position Strand Source Human GeneMap99-GB4 RH Map 11 120.2   UniSTS Human Genome Assembly HuRef 11 32,104,414 - 32,104,628   UniSTS Human Genome Assembly GRCh37 11 32,409,486 - 32,409,700   UniSTS Human Celera Assembly 11 32,556,221 - 32,556,435   RGD Human Genome Assembly Build 36 11 32,366,062 - 32,366,276   RGD Human Cytogenetic Map 11 p13   UniSTS GDB:568832   Map Chr Position Strand Source Human Cytogenetic Map 11 p13   UniSTS G54575   Map Chr Position Strand Source Human Genome Assembly GRCh37 11 32,417,913 - 32,418,007   UniSTS Human Celera Assembly 11 32,564,648 - 32,564,742   UniSTS Human Cytogenetic Map 11 p13   UniSTS GDB:313098   Map Chr Position Strand Source Human Cytogenetic Map 11 p13   UniSTS GDB:316182   Map Chr Position Strand Source Human Genome Assembly HuRef 11 32,112,593 - 32,112,848   UniSTS Human Cytogenetic Map 11 p13   UniSTS GDB:371670   Map Chr Position Strand Source Human Genome Assembly HuRef 11 32,105,515 - 32,105,700   UniSTS Human Cytogenetic Map 11 p13   UniSTS WT1-2   Map Chr Position Strand Source Human Cytogenetic Map 11 p13   UniSTS UniSTS:148287   Map Chr Position Strand Source Human Genome Assembly HuRef 11 32,104,418 - 32,105,032   UniSTS Human Genome Assembly GRCh37 11 32,409,490 - 32,410,104   UniSTS Human Celera Assembly 11 32,556,225 - 32,556,839   UniSTS D11S813E   Map Chr Position Strand Source Human Cytogenetic Map 11 p13   UniSTS QTLs in Region (Human Genome Assembly GRCh37) The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer RGD ID Symbol Name LOD P Value Trait Sub Trait Chr Start Stop Species 1358830 MULTSCL21_H Multiple sclerosis susceptibility QTL 21 (human) Multiple sclerosis susceptibility 11 12852167 38852167 Human 2293388 PRSTS222_H Prostate tumor susceptibility QTL 222 (human) 3.02 Prostate tumor susceptibility 11 12937065 38937065 Human 1559250 SCL60_H Serum cholesterol level QTL 60 (human) 1.84 Lipid level total cholesterol 11 13680696 39680696 Human 2315778 GLUCO160_H Glucose level QTL 160 (human) 1.65 .003 Glucose level 11 13680696 39680696 Human 1576345 LVC1_H Left ventricular contractility QTL 1 (human) 3.93 Left ventricular contractility 11 16817071 70403343 Human 1559104 SCL15_H Serum cholesterol level QTL 15 (human) 2.6 .06 Lipid level hyperlipidemia susceptibility 11 17086204 79965640 Human 1559116 SCL24_H Serum cholesterol level QTL 24 (human) 2.11 .000009 Lipid level triglyceride 11 21640179 47640179 Human 2293464 PRSTS303_H Prostate tumor susceptibility QTL 303 (human) .015 Prostate tumor susceptibility 11 21640179 47640179 Human 2316031 GLUCO215_H Glucose level QTL 215 (human) .07 Glucose level 11 23023320 49023320 Human 2316050 GLUCO209_H Glucose level QTL 209 (human) .046 Glucose level 11 23023320 49023320 Human 2316340 GLUCO222_H Glucose level QTL 222 (human) .0013 Glucose level 11 27974426 53974426 Human 1559107 SCL32_H Serum cholesterol level QTL 32 (human) 3.27 Lipid level LDL cholesterol 11 28913978 70403233 Human 1559113 SCL31_H Serum cholesterol level QTL 31 (human) 3.72 Lipid level LDL cholesterol 11 28913978 70403233 Human 1643364 BW338_H Body weight QTL 338 (human) 2.21 Body fat amount percent body fat 11 30610207 56610207 Human 2315893 GLUCO189_H Glucose level QTL 189 (human) 2.25 Glucose level 11 30610207 56610207 Human Sequence Nucleotide Sequences Nucleotide RefSeqs NG_009272 (Get FASTA) Search GEO for Microarray Profiles   NM_000378 (Get FASTA) Search GEO for Microarray Profiles   NM_001198551 (Get FASTA) Search GEO for Microarray Profiles   NM_001198552 (Get FASTA) Search GEO for Microarray Profiles   NM_024424 (Get FASTA) Search GEO for Microarray Profiles   NM_024426 (Get FASTA) Search GEO for Microarray Profiles GenBank Nucleotide ABBA01060912 (Get FASTA) Search GEO for Microarray Profiles   AK093168 (Get FASTA) Search GEO for Microarray Profiles   AK291736 (Get FASTA) Search GEO for Microarray Profiles   AL049692 (Get FASTA) Search GEO for Microarray Profiles   AMYH01003478 (Get FASTA) Search GEO for Microarray Profiles   AMYH01003479 (Get FASTA) Search GEO for Microarray Profiles   AY245105 (Get FASTA) Search GEO for Microarray Profiles   BC032861 (Get FASTA) Search GEO for Microarray Profiles   BC046461 (Get FASTA) Search GEO for Microarray Profiles   BG718348 (Get FASTA) Search GEO for Microarray Profiles   CH471064 (Get FASTA) Search GEO for Microarray Profiles   M30393 (Get FASTA) Search GEO for Microarray Profiles   M80217 (Get FASTA) Search GEO for Microarray Profiles   M80232 (Get FASTA) Search GEO for Microarray Profiles   S60755 (Get FASTA) Search GEO for Microarray Profiles   S61515 (Get FASTA) Search GEO for Microarray Profiles   S74529 (Get FASTA) Search GEO for Microarray Profiles   S75264 (Get FASTA) Search GEO for Microarray Profiles   S77896 (Get FASTA) Search GEO for Microarray Profiles   U06486 (Get FASTA) Search GEO for Microarray Profiles   U77682 (Get FASTA) Search GEO for Microarray Profiles   X51630 (Get FASTA) Search GEO for Microarray Profiles   X61631 (Get FASTA) Search GEO for Microarray Profiles   X72314 (Get FASTA) Search GEO for Microarray Profiles   X74840 (Get FASTA) Search GEO for Microarray Profiles   X77549 (Get FASTA) Search GEO for Microarray Profiles Reference Sequences RefSeq Acc Id: NM_000378 RefSeq Status: REVIEWED Type: CODING Protein Acc Id: NP_000369 Peptide Label: isoform A Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 11 32,338,667 - 32,386,515 - NCBI Human Genome Assembly HuRef 11 32,104,249 - 32,152,010 - ENTREZGENE Human Genome Assembly GRCh37 11 32,409,321 - 32,457,081 - ENTREZGENE Human Genome Assembly Build 36 11 32,365,901 - 32,413,663 - NCBI Archive RefSeq Acc Id: NM_024424 RefSeq Status: REVIEWED Type: CODING Protein Acc Id: NP_077742 Peptide Label: isoform B Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 11 32,338,667 - 32,386,515 - NCBI Human Genome Assembly HuRef 11 32,104,249 - 32,152,010 - ENTREZGENE Human Genome Assembly GRCh37 11 32,409,321 - 32,457,081 - ENTREZGENE Human Genome Assembly Build 36 11 32,365,901 - 32,413,663 - NCBI Archive RefSeq Acc Id: NM_024426 RefSeq Status: REVIEWED Type: CODING Protein Acc Id: NP_077744 Peptide Label: isoform D Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 11 32,338,667 - 32,386,515 - NCBI Human Genome Assembly HuRef 11 32,104,249 - 32,152,010 - ENTREZGENE Human Genome Assembly GRCh37 11 32,409,321 - 32,457,081 - ENTREZGENE Human Genome Assembly Build 36 11 32,365,901 - 32,413,663 - NCBI Archive RefSeq Acc Id: NM_001198552 RefSeq Status: REVIEWED Type: CODING Protein Acc Id: NP_001185481 Peptide Label: isoform F Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 11 32,338,667 - 32,386,515 - NCBI Human Genome Assembly HuRef 11 32,104,249 - 32,152,010 - ENTREZGENE Human Genome Assembly GRCh37 11 32,409,321 - 32,457,081 - ENTREZGENE RefSeq Acc Id: NM_001198551 RefSeq Status: REVIEWED Type: CODING Protein Acc Id: NP_001185480 Peptide Label: isoform E Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 11 32,338,667 - 32,386,515 - NCBI Human Genome Assembly HuRef 11 32,104,249 - 32,152,010 - ENTREZGENE Human Genome Assembly GRCh37 11 32,409,321 - 32,457,081 - ENTREZGENE RefSeq Acc Id: NM_024425 RefSeq Status: Type: CODING Position: Map Chr Position Strand Source Human Genome Assembly Build 36 11 32,365,901 - 32,413,663 - NCBI Archive Protein Sequences Protein RefSeqs NP_000369 (Get FASTA)   NP_001185480 (Get FASTA)   NP_001185481 (Get FASTA)   NP_077742 (Get FASTA)   NP_077744 (Get FASTA) GenBank Protein AAA36810 (Get FASTA)   AAA61299 (Get FASTA)   AAA62865 (Get FASTA)   AAB20110 (Get FASTA)   AAB33427 (Get FASTA)   AAB33443 (Get FASTA)   AAC60605 (Get FASTA)   AAD14879 (Get FASTA)   AAH32861 (Get FASTA)   AAH46461 (Get FASTA)   AAO61088 (Get FASTA)   ADZ15874 (Get FASTA)   BAF84425 (Get FASTA)   BAG52667 (Get FASTA)   CAA35956 (Get FASTA)   CAA43819 (Get FASTA)   CAA51057 (Get FASTA)   EAW68220 (Get FASTA)   EAW68221 (Get FASTA)   EAW68222 (Get FASTA)   EAW68223 (Get FASTA)   EAW68224 (Get FASTA)   EAW68225 (Get FASTA)   EAW68226 (Get FASTA)   P19544 (Get FASTA) Promoters RGD ID: 6789584 Promoter ID: HG_KWN:12574 Type: CpG-Island SO ACC ID: SO:0000170 Source: MPROMDB Tissues & Cell Lines: NB4 Transcripts: ENST00000379079,   UC001MTM.1 Position: Map Chr Position Strand Source Human Genome Assembly Build 36 11 32,409,121 - 32,409,621 - MPROMDB RGD ID: 6853646 Promoter ID: EP58019 Type: initiation region Name: HS_WT1 Description: Wilm's tumor, WT1 gene. SO ACC ID: SO:0000170 Source: EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/) Tissues & Cell Lines: fetal kidney, immature hematop. cells Experiment Methods: Primer extension Position: Map Chr Position Strand Source Human Genome Assembly Build 36 11 32,413,876 - 32,413,936   EPD Additional Information External Database Links Database Acc Id Source(s) COSMIC WT1 COSMIC Ensembl Genes ENSG00000184937 ENTREZGENE Ensembl Protein ENSP00000331327 ENTREZGENE   ENSP00000368370 ENTREZGENE   ENSP00000415516 ENTREZGENE   ENSP00000435307 ENTREZGENE Ensembl Transcript ENST00000332351 ENTREZGENE   ENST00000379079 ENTREZGENE   ENST00000452863 ENTREZGENE   ENST00000530998 ENTREZGENE Entrez Gene 7490 ENTREZGENE Gene3D-CATH Znf_C2H2/integrase_DNA-bd UniProtKB/Swiss-Prot Germonline ENSG00000184937 HGNC ID 12796 ENTREZGENE HomoloGene Group ID 11536 ENTREZGENE HPRD ID 06163 ENTREZGENE InterPro Wilms_tumour UniProtKB/Swiss-Prot   Wilms_tumour_N UniProtKB/Swiss-Prot   Znf_C2H2 UniProtKB/Swiss-Prot   Znf_C2H2-like UniProtKB/Swiss-Prot   Znf_C2H2/integrase_DNA-bd UniProtKB/Swiss-Prot IPI IPI00019517 UniProtKB/Swiss-Prot   IPI00374173 UniProtKB/Swiss-Prot   IPI00550100 UniProtKB/Swiss-Prot   IPI00853526 UniProtKB/Swiss-Prot   IPI00935507 UniProtKB/Swiss-Prot   IPI00935900 UniProtKB/Swiss-Prot   IPI00936595 UniProtKB/Swiss-Prot   IPI00974284 UniProtKB/TrEMBL   IPI00977686 UniProtKB/TrEMBL   IPI01009246 UniProtKB/Swiss-Prot KEGG Report hsa:7490 ENTREZGENE, UniProtKB/Swiss-Prot OMIM 136680 OMIM   194070 OMIM   194080 OMIM   256370 OMIM   607102 OMIM   608978 OMIM Pfam WT1 UniProtKB/Swiss-Prot PharmGKB PA37395 PharmGKB PRINTS WILMSTUMOUR UniProtKB/Swiss-Prot PROSITE ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot   ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot SMART ZnF_C2H2 UniProtKB/Swiss-Prot UniGene Hs.591980 ENTREZGENE UniProt E9PKS2_HUMAN UniProtKB/TrEMBL   E9PPW3_HUMAN UniProtKB/TrEMBL   H0Y3F0_HUMAN UniProtKB/TrEMBL   H0Y7K5_HUMAN UniProtKB/TrEMBL   H0YED9_HUMAN UniProtKB/TrEMBL   J3KNN9_HUMAN UniProtKB/TrEMBL   Q6PI38_HUMAN UniProtKB/TrEMBL   WT1_HUMAN UniProtKB/Swiss-Prot Nomenclature History Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status 2011-08-16 WT1  Wilms tumor 1  WT1  Wilms tumor 1  Symbol and/or name change 39860 APPROVED 2011-07-27 WT1  Wilms tumor 1  WT1  Wilms tumor 1  Symbol and/or name change 39860 APPROVED

More on WT1 Entrez Gene Ensembl Gene Genome Browser: (hg18) (hg19) HGNC Report NCBI Map Viewer Vista Vista + UCSC RGD Object Information RGD ID: 69122 Created: 2001-11-08 Species: Homo sapiens Last Modified: 2013-04-30 Status: ACTIVE