Gene: WT1 (Wilms tumor 1) Homo sapiens
Symbol: WT1
Name: Wilms tumor 1
Description: This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilm's tumors. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation site upstream of and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Oct 2010]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: amino-terminal domain of EWS|last three zinc fingers of the DNA-binding domain of WT1; AWT1; EWS-WT1; GUD; NPHS4; OTTHUMP00000037553; OTTHUMP00000037554; OTTHUMP00000037555; OTTHUMP00000037556; OTTHUMP00000238018; WAGR; Wilms tumor protein; WIT-2; WT33
Orthologs:
Latest Assembly: Human Genome Assembly GRCh37
Position:
MapChrPositionStrandSource
Human Genome Assembly GRCh381132,387,775 - 32,435,535-NCBI
Human Alternate Assembly CHM1_11132,409,251 - 32,457,017-NCBI
Human Genome Assembly HuRef1132,104,249 - 32,152,010-NCBI
Human Genome Assembly GRCh371132,408,789 - 32,457,104-NCBI
Human Celera Assembly1132,556,060 - 32,603,819-NCBI
Human Genome Assembly Build 361132,365,901 - 32,413,663-NCBI
Human Cytogenetic Map11p13 NCBI
Human Genome Assembly1132,365,896 - 32,413,653 NCBI
Model

Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19)


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Human Genome Assembly GRCh37)

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on WT1
Entrez Gene
Ensembl Gene
Genome Browser: (hg18) (hg19)
HGNC Report
NCBI Map Viewer
Vista
Vista + UCSC

RGD Object Information
RGD ID: 69122
Created: 2001-11-08
Species: Homo sapiens
Last Modified: 2014-10-22
Status: ACTIVE