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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of PDX1 mRNA | CTD | PMID:22946080 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:736368 | 6480464 | Tetrachlorodibenzodioxin affects the expression of PDX1 mRNA | CTD | PMID:21570461 | 9-cis-retinoic acid | decreases expression | ISO | RGD:736368 | 6480464 | alitretinoin results in decreased expression of PDX1 mRNA | CTD | PMID:21670153 | 9-cis-retinoic acid | decreases expression | EXP | | 6480464 | alitretinoin results in decreased expression of PDX1 mRNA | CTD | PMID:21115832 | all-trans-retinoic acid | increases expression | ISO | RGD:736368 | 6480464 | Tretinoin results in increased expression of PDX1 protein | CTD | PMID:17244022 | all-trans-retinol | multiple interactions | ISO | RGD:736368 | 6480464 | [Vitamin A co-treated with INHBA protein] results in increased expression of PDX1 mRNA | CTD | PMID:17244017 | amiloride | decreases uptake | ISO | RGD:736367 | 6480464 | Amiloride results in decreased uptake of PDX1 protein | CTD | PMID:16405074 | benzene | increases expression | EXP | | 6480464 | Benzene results in increased expression of PDX1 protein | CTD | PMID:15468289 | benzo[a]pyrene | increases expression | ISO | RGD:736367 | 6480464 | Benzo(a)pyrene results in increased expression of PDX1 mRNA | CTD | PMID:22316170 | bezafibrate | multiple interactions | EXP | | 6480464 | Diazoxide inhibits the reaction [Bezafibrate results in decreased expression of PDX1 mRNA] | CTD | PMID:11527545 | bezafibrate | decreases expression | EXP | | 6480464 | Bezafibrate results in decreased expression of PDX1 mRNA | CTD | PMID:11527545 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of PDX1 mRNA | CTD | PMID:22946080 | capsaicin | decreases expression | EXP | | 6480464 | Capsaicin results in decreased expression of PDX1 mRNA | CTD | PMID:16278290 | choline | multiple interactions | ISO | RGD:736368 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PDX1 gene | CTD | PMID:20938992 | cytochalasin D | decreases uptake | ISO | RGD:736367 | 6480464 | Cytochalasin D results in decreased uptake of PDX1 protein | CTD | PMID:16405074 | D-glucose | multiple interactions | ISO | RGD:736367 | 6480464 | calyculin A inhibits the reaction [Glucose affects the localization of PDX1 protein]; more ... | CTD | PMID:11574405 | D-glucose | multiple interactions | EXP | | 6480464 | lipopolysaccharide, Escherichia coli 0111 B4 inhibits the reaction [Glucose results in increased expression of PDX1 mRNA] | CTD | PMID:22558381 | D-glucose | increases expression | EXP | | 6480464 | Glucose results in increased expression of PDX1 mRNA | CTD | PMID:22558381 | D-glucose | increases expression | ISO | RGD:736368 | 6480464 | Glucose results in increased expression of PDX1 mRNA | CTD | PMID:22558381 | D-glucose | multiple interactions | ISO | RGD:736368 | 6480464 | IL1B protein inhibits the reaction [Glucose results in increased expression of PDX1 mRNA]; more ... | CTD | PMID:22558381 | D-glucose | affects localization | ISO | RGD:736367 | 6480464 | Glucose affects the localization of PDX1 protein | CTD | PMID:11574405 PMID:22558381 | D-glucose | multiple interactions | ISO | RGD:736367 | 6480464 | Palmitic Acid inhibits the reaction [Glucose affects the localization of PDX1 protein] | CTD | PMID:22558381 | D-glucose | multiple interactions | ISO | RGD:736368 | 6480464 | [Metformin co-treated with Glucose] affects the localization of PDX1 protein; more ... | CTD | PMID:16489446 | D-glucose | increases activity | ISO | RGD:736368 | 6480464 | Glucose results in increased activity of PDX1 promoter | CTD | PMID:16489446 | D-glucose | affects localization | ISO | RGD:736368 | 6480464 | Glucose affects the localization of PDX1 protein | CTD | PMID:11574405 | D-glucose | multiple interactions | ISO | RGD:736368 | 6480464 | calyculin A inhibits the reaction [Glucose affects the localization of PDX1 protein]; more ... | CTD | PMID:11574405 | D-glucose | affects localization | ISO | RGD:736367 | 6480464 | Glucose affects the localization of PDX1 protein | CTD | PMID:11574405 | diazoxide | multiple interactions | EXP | | 6480464 | Diazoxide inhibits the reaction [Bezafibrate results in decreased expression of PDX1 mRNA] | CTD | PMID:11527545 | diethylstilbestrol | decreases expression | EXP | | 6480464 | Diethylstilbestrol results in decreased expression of PDX1 mRNA | CTD | PMID:22946080 | folic acid | multiple interactions | ISO | RGD:736368 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PDX1 gene | CTD | PMID:20938992 | fonofos | increases methylation | ISO | RGD:736367 | 6480464 | Fonofos results in increased methylation of PDX1 promoter | CTD | PMID:22847954 | glucose | affects localization | ISO | RGD:736367 | 6480464 | Glucose affects the localization of PDX1 protein | CTD | PMID:11574405 | glucose | multiple interactions | EXP | | 6480464 | lipopolysaccharide, Escherichia coli 0111 B4 inhibits the reaction [Glucose results in increased expression of PDX1 mRNA] | CTD | PMID:22558381 | glucose | increases expression | EXP | | 6480464 | Glucose results in increased expression of PDX1 mRNA | CTD | PMID:22558381 | glucose | increases expression | ISO | RGD:736368 | 6480464 | Glucose results in increased expression of PDX1 mRNA | CTD | PMID:22558381 | glucose | multiple interactions | ISO | RGD:736368 | 6480464 | IL1B protein inhibits the reaction [Glucose results in increased expression of PDX1 mRNA]; more ... | CTD | PMID:22558381 | glucose | affects localization | ISO | RGD:736367 | 6480464 | Glucose affects the localization of PDX1 protein | CTD | PMID:11574405 PMID:22558381 | glucose | multiple interactions | ISO | RGD:736367 | 6480464 | Palmitic Acid inhibits the reaction [Glucose affects the localization of PDX1 protein] | CTD | PMID:22558381 | glucose | multiple interactions | ISO | RGD:736368 | 6480464 | [Metformin co-treated with Glucose] affects the localization of PDX1 protein; more ... | CTD | PMID:16489446 | glucose | increases activity | ISO | RGD:736368 | 6480464 | Glucose results in increased activity of PDX1 promoter | CTD | PMID:16489446 | glucose | multiple interactions | ISO | RGD:736367 | 6480464 | calyculin A inhibits the reaction [Glucose affects the localization of PDX1 protein]; more ... | CTD | PMID:11574405 | glucose | affects localization | ISO | RGD:736368 | 6480464 | Glucose affects the localization of PDX1 protein | CTD | PMID:11574405 | glucose | multiple interactions | ISO | RGD:736368 | 6480464 | calyculin A inhibits the reaction [Glucose affects the localization of PDX1 protein]; more ... | CTD | PMID:11574405 | L-methionine | multiple interactions | ISO | RGD:736368 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PDX1 gene | CTD | PMID:20938992 | metformin | multiple interactions | ISO | RGD:736368 | 6480464 | [Metformin co-treated with Glucose] affects the localization of PDX1 protein | CTD | PMID:16489446 | metformin | increases expression | ISO | RGD:736368 | 6480464 | Metformin results in increased expression of PDX1 protein | CTD | PMID:16489446 | okadaic acid | multiple interactions | ISO | RGD:736367 | 6480464 | Okadaic Acid inhibits the reaction [Glucose affects the localization of PDX1 protein] | CTD | PMID:11574405 | okadaic acid | multiple interactions | ISO | RGD:736368 | 6480464 | Okadaic Acid inhibits the reaction [Glucose affects the localization of PDX1 protein] | CTD | PMID:11574405 | palmitic acid | decreases expression | ISO | RGD:736367 | 6480464 | Palmitic Acid results in decreased expression of PDX1 mRNA | CTD | PMID:18155663 | palmitic acid | multiple interactions | EXP | | 6480464 | geniposide inhibits the reaction [Palmitic Acid results in decreased expression of PDX1 protein] | CTD | PMID:22819839 | palmitic acid | decreases expression | EXP | | 6480464 | Palmitic Acid results in decreased expression of PDX1 protein | CTD | PMID:22819839 | palmitic acid | multiple interactions | ISO | RGD:736367 | 6480464 | Palmitic Acid inhibits the reaction [Glucose affects the localization of PDX1 protein] | CTD | PMID:22558381 | palmitic acid | multiple interactions | ISO | RGD:736368 | 6480464 | Palmitic Acid inhibits the reaction [Glucose results in increased expression of PDX1 mRNA] | CTD | PMID:22558381 | parathion | increases methylation | ISO | RGD:736367 | 6480464 | Parathion results in increased methylation of PDX1 promoter | CTD | PMID:22847954 | resveratrol | multiple interactions | ISO | RGD:736367 | 6480464 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein promotes the reaction [resveratrol results in increased expression of PDX1 mRNA]] | CTD | PMID:21163946 | resveratrol | increases expression | ISO | RGD:736367 | 6480464 | resveratrol results in increased expression of PDX1 mRNA | CTD | PMID:21163946 | rosiglitazone | multiple interactions | ISO | RGD:736368 | 6480464 | rosiglitazone promotes the reaction [Glucose results in increased activity of PDX1 promoter] | CTD | PMID:16489446 | rosiglitazone | increases expression | ISO | RGD:736368 | 6480464 | rosiglitazone results in increased expression of PDX1 protein | CTD | PMID:16489446 | rosiglitazone | affects localization | ISO | RGD:736368 | 6480464 | rosiglitazone affects the localization of PDX1 protein | CTD | PMID:16489446 | terbufos | increases methylation | ISO | RGD:736367 | 6480464 | terbufos results in increased methylation of PDX1 promoter | CTD | PMID:22847954 | trans-resveratrol | multiple interactions | ISO | RGD:736367 | 6480464 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein promotes the reaction [resveratrol results in increased expression of PDX1 mRNA]] | CTD | PMID:21163946 | trans-resveratrol | increases expression | ISO | RGD:736367 | 6480464 | resveratrol results in increased expression of PDX1 mRNA | CTD | PMID:21163946 | wortmannin | multiple interactions | ISO | RGD:736367 | 6480464 | [wortmannin co-treated with INS protein] inhibits the reaction [Glucose affects the localization of PDX1 protein]; more ... | CTD | PMID:11574405 | wortmannin | multiple interactions | ISO | RGD:736368 | 6480464 | wortmannin inhibits the reaction [Glucose affects the localization of PDX1 protein] | CTD | PMID:11574405 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Insulin secretion |
| Maturity onset diabetes of the young | |
| Type II diabetes mellitus | |
| Pathway Interaction Database | FOXA2 and FOXA3 transcription factor networks (PID:200087) |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Insulin secretion |
| Maturity onset diabetes of the young | |
| Type II diabetes mellitus | |
| Pathway Interaction Database | FOXA2 and FOXA3 transcription factor networks (PID:200087) |
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RGD Disease Portals| Pdx1 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Pdx1 (Rattus norvegicus) |
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| PDX1 (Homo sapiens) |
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| Pdx1 (Mus musculus) |
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Position Markers| RH94684 |
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| RH94789 |
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| Pdx1 |
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Nucleotide Sequences| Nucleotide RefSeqs | NM_022852 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06070295 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01071051 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH474012 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U04833 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U39640 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_022852 | |||||||||||||||
| RefSeq Status: | PROVISIONAL | |||||||||||||||
| Type: | CODING | |||||||||||||||
| Protein Acc Id: | NP_074043 | |||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_074043 | (Get FASTA) |
| GenBank Protein | AAA18355 | (Get FASTA) |
| EDL89565 | (Get FASTA) | |
| P52947 | (Get FASTA) |
External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000046458 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000066935 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000071942 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 29535 | ENTREZGENE |
| Gene3D-CATH | Homeodomain-rel | UniProtKB/Swiss-Prot |
| InterPro | Homeobox | UniProtKB/Swiss-Prot |
| Homeobox_antennapedia | UniProtKB/Swiss-Prot | |
| Homeobox_CS | UniProtKB/Swiss-Prot | |
| Homeobox_region | UniProtKB/Swiss-Prot | |
| Homeodomain-like | UniProtKB/Swiss-Prot | |
| IPI | IPI00327500 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:29535 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Pfam | Homeobox | UniProtKB/Swiss-Prot |
| PRINTS | ANTENNAPEDIA | UniProtKB/Swiss-Prot |
| HOMEOBOX | UniProtKB/Swiss-Prot | |
| PROSITE | ANTENNAPEDIA; FALSE_NEG | UniProtKB/Swiss-Prot |
| HOMEOBOX_1 | UniProtKB/Swiss-Prot | |
| HOMEOBOX_2 | UniProtKB/Swiss-Prot | |
| SMART | HOX | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | Homeodomain_like | UniProtKB/Swiss-Prot |
| UniGene | Rn.54603 | ENTREZGENE |
| UniProt | PDX1_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2008-02-18 | Pdx1 | pancreatic and duodenal homeobox 1 | Pdx1 | pancreatic and duodenal homeobox gene 1 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2002-06-10 | Pdx1 | pancreatic and duodenal homeobox gene 1 | Symbol and Name status set to approved | 1490 | APPROVED | ||
| 2001-06-12 | Ipf1 | Insulin promoter factor 1 | Symbol withdrawn, duplicate entry of Pdx1(RGD:62387) | 434 | WITHDRAWN |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_process | involved in maintenance of differentiated beta-cell functions | 70227 |
| gene_regulation | activity inhibited by cytokines such as interteukine1-beta and interferon-gamma, inhibitory effect prevented by blocking NF-kappaB activation or NO production | 70227 |
| gene_regulation | inhibitory effect can be prevented by blocking NF-kappaB activation or NO production | 70227 |
| More on Pdx1 | |
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Entrez Gene |
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Ensembl Gene |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 62387 |
| Created: | 2001-04-26 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-30 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




