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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | affects expression | EXP | | 6480464 | Ethinyl Estradiol affects the expression of STC1 mRNA | CTD | PMID:20170705 | 17beta-estradiol | multiple interactions | ISO | RGD:730961 | 6480464 | [Progesterone co-treated with Estradiol] results in decreased expression of STC1 mRNA | CTD | PMID:17404688 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:734316 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of STC1 mRNA | CTD | PMID:19933214 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of STC1 mRNA | CTD | PMID:22808131 | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | RGD:734316 | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of STC1 mRNA | CTD | PMID:20188158 | 4,4'-diaminodiphenylmethane | decreases expression | ISO | RGD:734316 | 6480464 | 4,4'-diaminodiphenylmethane results in decreased expression of STC1 mRNA | CTD | PMID:18648102 | 7,9-dihydro-1H-purine-2,6,8(3H)-trione | affects abundance | ISO | RGD:730961 | 6480464 | STC1 gene SNP affects the abundance of Uric Acid | CTD | PMID:23263486 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of STC1 mRNA | CTD | PMID:16483693 | ammonium hexachloroplatinate | affects expression | ISO | RGD:730961 | 6480464 | ammonium hexachloroplatinate affects the expression of STC1 mRNA | CTD | PMID:19527780 | bisphenol A | affects expression | ISO | RGD:730961 | 6480464 | bisphenol A affects the expression of STC1 mRNA | CTD | PMID:20170705 | carmustine | affects response to substance | ISO | RGD:730961 | 6480464 | STC1 mRNA affects the susceptibility to Carmustine | CTD | PMID:16365179 | coumestrol | decreases expression | ISO | RGD:730961 | 6480464 | Coumestrol results in decreased expression of STC1 mRNA | CTD | PMID:19167446 | crocidolite asbestos | increases expression | ISO | RGD:730961 | 6480464 | Asbestos, Crocidolite results in increased expression of STC1 mRNA | CTD | PMID:18687144 | cyclosporin A | decreases expression | ISO | RGD:730961 | 6480464 | Cyclosporine results in decreased expression of STC1 mRNA | CTD | PMID:20106945 | daidzein | multiple interactions | ISO | RGD:730961 | 6480464 | [Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of STC1 mRNA | CTD | PMID:16963248 | dasatinib (anhydrous) | decreases expression | ISO | RGD:730961 | 6480464 | dasatinib results in decreased expression of STC1 mRNA | CTD | PMID:20579391 | diazoxide | increases expression | ISO | RGD:734316 | 6480464 | Isoproterenol results in increased expression of STC1 mRNA | CTD | PMID:20003209 | dibutyl phthalate | increases expression | ISO | RGD:734316 | 6480464 | Dibutyl Phthalate results in increased expression of STC1 mRNA | CTD | PMID:21266533 | dibutyl phthalate | increases expression | ISO | RGD:734316 | 6480464 | Dibutyl Phthalate results in increased expression of STC1 mRNA | CTD | PMID:17361019 PMID:21266533 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of STC1 mRNA | CTD | PMID:21266533 | divanadium pentaoxide | increases expression | ISO | RGD:730961 | 6480464 | vanadium pentoxide results in increased expression of STC1 mRNA | CTD | PMID:17459161 | fluoxetine | increases expression | EXP | | 6480464 | Fluoxetine results in increased expression of STC1 mRNA | CTD | PMID:17033635 | genistein | multiple interactions | ISO | RGD:730961 | 6480464 | [Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of STC1 mRNA | CTD | PMID:16963248 | genistein | increases expression | EXP | | 6480464 | Genistein results in increased expression of STC1 mRNA | CTD | PMID:12075121 | glycerol 2-phosphate | decreases expression | EXP | | 6480464 | beta-glycerophosphoric acid results in decreased expression of STC1 mRNA | CTD | PMID:17438129 | hexamethylene diisocyanate | affects expression | ISO | RGD:730961 | 6480464 | 1,6-hexamethylene diisocyanate affects the expression of STC1 mRNA | CTD | PMID:19527780 | indomethacin | decreases expression | ISO | RGD:730961 | 6480464 | Indomethacin results in decreased expression of STC1 mRNA | CTD | PMID:17401462 | isoprenaline | increases expression | ISO | RGD:734316 | 6480464 | Isoproterenol results in increased expression of STC1 mRNA | CTD | PMID:20003209 | mono(2-ethylhexyl) phthalate | increases expression | EXP | | 6480464 | mono-(2-ethylhexyl)phthalate results in increased expression of STC1 mRNA | CTD | PMID:16809437 | nickel dichloride | increases expression | ISO | RGD:730961 | 6480464 | nickel chloride results in increased expression of STC1 mRNA | CTD | PMID:21455298 | ochratoxin A | increases expression | ISO | RGD:730961 | 6480464 | ochratoxin A results in increased expression of STC1 mRNA | CTD | PMID:22124623 | oxaliplatin | decreases expression | ISO | RGD:730961 | 6480464 | oxaliplatin results in decreased expression of STC1 mRNA | CTD | PMID:17762391 | paclitaxel | affects response to substance | ISO | RGD:730961 | 6480464 | STC1 protein affects the susceptibility to Paclitaxel | CTD | PMID:16217747 | paracetamol | decreases expression | ISO | RGD:730961 | 6480464 | Acetaminophen results in decreased expression of STC1 mRNA | CTD | PMID:21420995 | phenylephrine | affects expression | EXP | | 6480464 | Phenylephrine affects the expression of STC1 mRNA | CTD | PMID:18158353 | phosphonoformic acid | increases expression | EXP | | 6480464 | Foscarnet results in increased expression of STC1 mRNA | CTD | PMID:17438129 | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of STC1 mRNA | CTD | PMID:12832660 | progesterone | multiple interactions | ISO | RGD:730961 | 6480464 | [Progesterone co-treated with Estradiol] results in decreased expression of STC1 mRNA | CTD | PMID:17404688 | progesterone | decreases expression | ISO | RGD:730961 | 6480464 | Progesterone results in decreased expression of STC1 mRNA | CTD | PMID:17404688 | quercetin | increases expression | ISO | RGD:730961 | 6480464 | Quercetin results in increased expression of STC1 mRNA | CTD | PMID:19729006 | temozolomide | affects response to substance | ISO | RGD:730961 | 6480464 | STC1 mRNA affects the susceptibility to temozolomide | CTD | PMID:16365179 | tert-butyl hydroperoxide | increases expression | ISO | RGD:730961 | 6480464 | tert-Butylhydroperoxide results in increased expression of STC1 mRNA | CTD | PMID:15336504 | topotecan | affects response to substance | ISO | RGD:730961 | 6480464 | STC1 protein affects the susceptibility to Topotecan | CTD | PMID:16217747 | trimellitic anhydride | decreases expression | ISO | RGD:734316 | 6480464 | trimellitic anhydride results in decreased expression of STC1 mRNA | CTD | PMID:19042947 | trimellitic anhydride | affects expression | ISO | RGD:730961 | 6480464 | trimellitic anhydride affects the expression of STC1 mRNA | CTD | PMID:19527780 | troglitazone | increases expression | ISO | RGD:730961 | 6480464 | troglitazone results in increased expression of STC1 mRNA | CTD | PMID:19140230 | uric acid | affects abundance | ISO | RGD:730961 | 6480464 | STC1 gene SNP affects the abundance of Uric Acid | CTD | PMID:23263486 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsDisease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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References - curated| 1. |
GOA data from the GO Consortium |
| 2. |
Ito D, etal., Mol Cell Biol. 2004 Nov;24(21):9456-69. |
| 3. |
Johnson KJ, etal., Biol Reprod. 2007 Dec;77(6):978-89. Epub 2007 Sep 19. |
| 4. |
Li L and Wong CK, Mol Cell Endocrinol. 2008 Feb 13;283(1-2):96-103. Epub 2007 Dec 3. |
| 5. |
MGD data from the GO Consortium |
| 6. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 7. |
Ookata K, etal., Exp Nephrol. 2001;9(6):428-35. |
| 8. |
Paciga M, etal., Endocrinology 2002 Oct;143(10):3925-34. |
| 9. |
Ratkovic S, etal., Brain Res. 2008 Jul 7;1218:141-50. Epub 2008 May 3. |
| 10. |
RGD automated data pipeline |
| 11. |
RGD automated import pipeline for gene-chemical interactions |
| 12. |
RGD comprehensive gene curation |
| 13. |
Strausberg RL, etal., Proc Natl Acad Sci U S A 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11. |
| 14. |
Tanuma J, etal., Cancer Res 1998 Apr 15;58(8):1660-4 |
| 15. |
Xiao LJ, etal., Reproduction. 2006 Jun;131(6):1137-49. |
| 16. |
Yoshiko Y, etal., Endocrinology 2003 Sep;144(9):4134-43. |
References - uncuratedRGD Disease Portals| Stc1 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Stc1 (Rattus norvegicus) |
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| STC1 (Homo sapiens) |
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| Stc1 (Mus musculus) |
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Position Markers| D15Got53 |
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| D15Wox14 |
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| D19Mit9 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_031123 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06083921 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01083662 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC078803 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473951 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U62667 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_031123 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_112385 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_112385 | (Get FASTA) |
| GenBank Protein | AAB39541 | (Get FASTA) |
| AAH78803 | (Get FASTA) | |
| EDM02180 | (Get FASTA) | |
| P97574 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000015075 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000020728 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000020728 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 81801 | ENTREZGENE |
| Germonline | ENSRNOG00000015075 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 2374 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:7123665 | IMAGE-MGC_LOAD |
| InterPro | Stanniocalcin | UniProtKB/Swiss-Prot |
| IPI | IPI00205597 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:81801 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:93378 | IMAGE-MGC_LOAD |
| PANTHER | Stanniocalcin | UniProtKB/Swiss-Prot |
| Pfam | Stanniocalcin | UniProtKB/Swiss-Prot |
| UniGene | Rn.10647 | ENTREZGENE |
| UniProt | STC1_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2004-09-10 | Stc1 | stanniocalcin 1 | Symbol and Name status set to approved | 10779 | APPROVED | ||
| 2002-08-07 | Stc1 | stanniocalcin 1 | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
RGD Curation Notes| Note Type | Note | Reference |
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| gene_drugs | forskolin significantly increased expression levels | 628359 |
| gene_expression | highly expressed in ovary, in particular in androgen-producing thecal and interstitial cells with a 15-fold increase in expression found during pregnancy | 628359 |
| gene_process | calcium and phosphate regulating hormone | 628359 |
| gene_process | increases both sodium-dependent phosphate uptake and Pit1 gene expression in nodule formation stage fetal rat calvaria (RC) cell cultures | 737672 |
| gene_protein | protein expressed in ovaries is larger than 50-kDa homodimer found in other tissues | 628359 |
| gene_regulation | human chorioinc gonadotropin, independently and in combination with phosphodiesterase inhibitors enhanced expression levels while protein kinase A inhibitors decreased expression levels | 628359 |
| More on Stc1 | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 621776 |
| Created: | 2002-08-06 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.