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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of PIK3R1 protein | CTD | PMID:22142692 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:731958 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PIK3R1 mRNA | CTD | PMID:17101203 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:11103 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PIK3R1 mRNA | CTD | PMID:19770486 PMID:22666406 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:11103 | 6480464 | Tetrachlorodibenzodioxin affects the expression of PIK3R1 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:731958 | 6480464 | Tetrachlorodibenzodioxin affects the expression of PIK3R1 mRNA | CTD | PMID:22298810 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PIK3R1 mRNA | CTD | PMID:21215274 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | AHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of PIK3R1 mRNA] | CTD | PMID:21215274 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:11103 | 6480464 | Tetrachlorodibenzodioxin affects the reaction [AHR protein binds to PIK3R1 promoter] | CTD | PMID:19654925 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:11103 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PIK3R1 mRNA | CTD | PMID:19770486 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:11103 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PIK3R1 mRNA | CTD | PMID:18691609 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:731958 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PIK3R1 mRNA | CTD | PMID:20106945 | 2-butoxyethanol | increases expression | ISO | RGD:11103 | 6480464 | n-butoxyethanol results in increased expression of PIK3R1 mRNA | CTD | PMID:19812364 | 3,3',4,4'-tetrachlorobiphenyl | multiple interactions | ISO | RGD:11103 | 6480464 | 3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of PIK3R1 mRNA] | CTD | PMID:19467301 | 3-methylcholanthrene | multiple interactions | ISO | RGD:731958 | 6480464 | Methylcholanthrene promotes the reaction [AHR protein binds to PIK3R1 promoter] | CTD | PMID:20348232 | 3H-1,2-dithiole-3-thione | decreases expression | EXP | | 6480464 | 1,2-dithiol-3-thione results in decreased expression of PIK3R1 mRNA | CTD | PMID:19162173 | 4-coumaric acid | increases expression | ISO | RGD:11103 | 6480464 | 4-coumaric acid results in increased expression of PIK3R1 mRNA | CTD | PMID:21870829 | 9-cis-retinoic acid | increases expression | ISO | RGD:11103 | 6480464 | alitretinoin results in increased expression of PIK3R1 mRNA; more ... | CTD | PMID:16288212 | acetylsalicylic acid | decreases expression | ISO | RGD:731958 | 6480464 | Aspirin results in decreased expression of PIK3R1 mRNA | CTD | PMID:20457246 | aflatoxin B1 | increases expression | ISO | RGD:11103 | 6480464 | Aflatoxin B1 results in increased expression of PIK3R1 mRNA | CTD | PMID:19770486 | all-trans-retinoic acid | multiple interactions | ISO | RGD:11103 | 6480464 | PIK3R1 protein promotes the reaction [Tretinoin results in increased activity of AKT1 protein] | CTD | PMID:16288212 | all-trans-retinoic acid | increases expression | ISO | RGD:11103 | 6480464 | Tretinoin results in increased expression of PIK3R1 mRNA; more ... | CTD | PMID:16288212 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of PIK3R1 mRNA | CTD | PMID:16483693 | arsenic atom | decreases expression | ISO | RGD:731958 | 6480464 | Arsenic results in decreased expression of PIK3R1 mRNA | CTD | PMID:19945496 | arsenite(3-) | multiple interactions | ISO | RGD:11103 | 6480464 | arsenite promotes the reaction [PIK3R1 protein results in increased expression of HIF1A mRNA]; more ... | CTD | PMID:20835880 | ATP | multiple interactions | ISO | RGD:731958 | 6480464 | Adenosine Triphosphate inhibits the reaction [resveratrol results in decreased activity of [PIK3R1 protein binds to PIK3CA protein]] | CTD | PMID:17550345 | benzo[a]pyrene | multiple interactions | ISO | RGD:11103 | 6480464 | Benzo(a)pyrene promotes the reaction [AHR protein binds to PIK3R1 promoter] | CTD | PMID:19654925 | benzo[a]pyrene | decreases expression | ISO | RGD:11103 | 6480464 | Benzo(a)pyrene results in decreased expression of PIK3R1 mRNA | CTD | PMID:19770486 PMID:22228805 | benzo[a]pyrene | decreases expression | ISO | RGD:11103 | 6480464 | Benzo(a)pyrene results in decreased expression of PIK3R1 mRNA | CTD | PMID:19770486 | benzo[a]pyrene | multiple interactions | ISO | RGD:11103 | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of PIK3R1 mRNA | CTD | PMID:21715664 | bilirubin | decreases expression | ISO | RGD:731958 | 6480464 | Bilirubin results in decreased expression of PIK3R1 mRNA | CTD | PMID:20196124 | bis(2-chloroethyl) sulfide | decreases expression | ISO | RGD:11103 | 6480464 | Mustard Gas results in decreased expression of PIK3R1 mRNA | CTD | PMID:18955075 | bisphenol A | increases expression | ISO | RGD:731958 | 6480464 | bisphenol A results in increased expression of PIK3R1 mRNA | CTD | PMID:21890461 | bisphenol A | decreases expression | ISO | RGD:731958 | 6480464 | bisphenol A results in decreased expression of PIK3R1 mRNA | CTD | PMID:22576693 | bisphenol A | increases methylation | ISO | RGD:731958 | 6480464 | bisphenol A results in increased methylation of PIK3R1 gene | CTD | PMID:22576693 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of PIK3R1 protein | CTD | PMID:22142692 | cadmium atom | decreases expression | ISO | RGD:11103 | 6480464 | Cadmium results in decreased expression of PIK3R1 mRNA | CTD | PMID:22666406 | capsaicin | multiple interactions | ISO | RGD:11103 | 6480464 | PIK3R1 gene mutant form inhibits the reaction [NGF protein results in increased susceptibility to Capsaicin] | CTD | PMID:17324588 | celastrol | decreases expression | ISO | RGD:731958 | 6480464 | tripterine results in decreased expression of PIK3R1 mRNA | CTD | PMID:17010675 | chlorogenic acid | increases expression | ISO | RGD:11103 | 6480464 | Chlorogenic Acid results in increased expression of PIK3R1 mRNA | CTD | PMID:21870829 | ciguatoxin CTX1B | affects expression | ISO | RGD:11103 | 6480464 | Ciguatoxins affects the expression of PIK3R1 mRNA | CTD | PMID:18353800 | cinnamic acid | increases expression | ISO | RGD:11103 | 6480464 | cinnamic acid results in increased expression of PIK3R1 mRNA | CTD | PMID:21870829 | cis-caffeic acid | increases expression | ISO | RGD:11103 | 6480464 | caffeic acid results in increased expression of PIK3R1 mRNA | CTD | PMID:21870829 | cisplatin | decreases response to substance | ISO | RGD:731958 | 6480464 | PIK3R1 results in decreased susceptibility to Cisplatin | CTD | PMID:21571862 | cobalt dichloride | decreases expression | ISO | RGD:731958 | 6480464 | cobaltous chloride results in decreased expression of PIK3R1 mRNA | CTD | PMID:19320972 | coenzyme Q10 | multiple interactions | EXP | | 6480464 | coenzyme Q10 inhibits the reaction [APP protein results in decreased expression of PIK3R1 protein] | CTD | PMID:22186599 | cyclosporin A | decreases expression | ISO | RGD:731958 | 6480464 | Cyclosporine results in decreased expression of PIK3R1 mRNA | CTD | PMID:20106945 | cyclosporin A | decreases expression | ISO | RGD:11103 | 6480464 | Cyclosporine results in decreased expression of PIK3R1 mRNA | CTD | PMID:19770486 | D-glucose | multiple interactions | ISO | RGD:731958 | 6480464 | Glucose promotes the reaction [PIK3R1 protein binds to IRS1 protein] | CTD | PMID:10430617 | daunorubicin | affects response to substance | ISO | RGD:731958 | 6480464 | PIK3R1 affects the susceptibility to Daunorubicin | CTD | PMID:17545624 | dexamethasone | increases expression | ISO | RGD:731958 | 6480464 | Dexamethasone results in increased expression of PIK3R1 protein | CTD | PMID:15576458 | dexamethasone | increases expression | EXP | | 6480464 | Dexamethasone results in increased expression of PIK3R1 mRNA | CTD | PMID:20032058 | dexamethasone | multiple interactions | EXP | | 6480464 | Testosterone inhibits the reaction [Dexamethasone results in increased expression of PIK3R1 mRNA] | CTD | PMID:20032058 | diazoxide | increases expression | ISO | RGD:11103 | 6480464 | Isoproterenol results in increased expression of PIK3R1 mRNA | CTD | PMID:20003209 | dioxygen | multiple interactions | ISO | RGD:731958 | 6480464 | PIK3R1 protein promotes the reaction [Oxygen deficiency results in increased expression of CD36 mRNA]; more ... | CTD | PMID:19640849 | dioxygen | increases expression | ISO | RGD:731958 | 6480464 | Oxygen deficiency results in increased expression of PIK3R1 mRNA | CTD | PMID:19640849 | disodium selenite | increases expression | EXP | | 6480464 | Sodium Selenite results in increased expression of PIK3R1 mRNA | CTD | PMID:14714311 | diuron | decreases expression | EXP | | 6480464 | Diuron results in decreased expression of PIK3R1 mRNA | CTD | PMID:21551480 | ethanol | affects expression | EXP | | 6480464 | Ethanol affects the expression of PIK3R1 mRNA | CTD | PMID:11772933 | ethanol | increases expression | ISO | RGD:11103 | 6480464 | Ethanol results in increased expression of PIK3R1 protein | CTD | PMID:22459179 | ethanol | multiple interactions | EXP | | 6480464 | N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid inhibits the reaction [Ethanol results in increased expression of PIK3R1 mRNA] | CTD | PMID:20655511 | ethanol | increases expression | EXP | | 6480464 | Ethanol results in increased expression of PIK3R1 mRNA | CTD | PMID:20655511 | eugenol | increases expression | EXP | | 6480464 | Eugenol results in increased expression of PIK3R1 mRNA | CTD | PMID:20724125 | eugenol | increases expression | ISO | RGD:11103 | 6480464 | Eugenol results in increased expression of PIK3R1 mRNA | CTD | PMID:21870829 | ferulic acid | increases expression | ISO | RGD:11103 | 6480464 | ferulic acid results in increased expression of PIK3R1 mRNA | CTD | PMID:21870829 | folic acid | affects expression | ISO | RGD:731958 | 6480464 | Folic Acid affects the expression of PIK3R1 mRNA | CTD | PMID:16361273 | fonofos | increases methylation | ISO | RGD:731958 | 6480464 | Fonofos results in increased methylation of PIK3R1 promoter | CTD | PMID:22847954 | formaldehyde | decreases expression | ISO | RGD:731958 | 6480464 | Formaldehyde results in decreased expression of PIK3R1 mRNA | CTD | PMID:20655997 | gedunin | decreases expression | ISO | RGD:731958 | 6480464 | gedunin results in decreased expression of PIK3R1 mRNA | CTD | PMID:17010675 | glucose | multiple interactions | ISO | RGD:731958 | 6480464 | Glucose promotes the reaction [PIK3R1 protein binds to IRS1 protein] | CTD | PMID:10430617 | gold atom | multiple interactions | ISO | RGD:11103 | 6480464 | [Gold co-treated with Polyethylene Glycols] results in increased expression of PIK3R1 mRNA | CTD | PMID:19695318 | gold(0) | multiple interactions | ISO | RGD:11103 | 6480464 | [Gold co-treated with Polyethylene Glycols] results in increased expression of PIK3R1 mRNA | CTD | PMID:19695318 | imatinib | decreases expression | ISO | RGD:731958 | 6480464 | imatinib results in decreased expression of PIK3R1 mRNA; more ... | CTD | PMID:19208803 | indole-3-methanol | affects expression | EXP | | 6480464 | indole-3-carbinol affects the expression of PIK3R1 mRNA | CTD | PMID:21396975 | iron atom | multiple interactions | EXP | | 6480464 | Iron promotes the reaction [MAP3K7 protein binds to HRAS protein binds to PIK3R1 protein]; more ... | CTD | PMID:17172471 | isoprenaline | increases expression | ISO | RGD:11103 | 6480464 | Isoproterenol results in increased expression of PIK3R1 mRNA | CTD | PMID:20003209 | L-ascorbic acid | decreases expression | EXP | | 6480464 | Ascorbic Acid results in decreased expression of PIK3R1 mRNA | CTD | PMID:15372504 | melphalan | decreases expression | ISO | RGD:731958 | 6480464 | Melphalan results in decreased expression of PIK3R1 mRNA | CTD | PMID:22363485 | mercury atom | decreases expression | EXP | | 6480464 | Mercury results in decreased expression of PIK3R1 mRNA | CTD | PMID:12730625 | mercury(0) | decreases expression | EXP | | 6480464 | Mercury results in decreased expression of PIK3R1 mRNA | CTD | PMID:12730625 | metformin | increases expression | ISO | RGD:11103 | 6480464 | Metformin results in increased expression of PIK3R1 mRNA | CTD | PMID:21870829 | methotrexate | affects expression | ISO | RGD:11103 | 6480464 | Methotrexate affects the expression of PIK3R1 mRNA | CTD | PMID:18502557 | methylmercury chloride | affects expression | EXP | | 6480464 | methylmercuric chloride affects the expression of PIK3R1 mRNA | CTD | PMID:20864626 | paraquat | increases expression | ISO | RGD:11103 | 6480464 | Paraquat results in increased expression of PIK3R1 mRNA | CTD | PMID:12595580 | parathion | increases methylation | ISO | RGD:731958 | 6480464 | Parathion results in increased methylation of PIK3R1 promoter | CTD | PMID:22847954 | phenobarbital | increases expression | EXP | | 6480464 | Phenobarbital results in increased expression of PIK3R1 mRNA | CTD | PMID:12082028 | phenobarbital | decreases expression | ISO | RGD:11103 | 6480464 | Phenobarbital results in decreased expression of PIK3R1 mRNA | CTD | PMID:23091169 | pirinixic acid | multiple interactions | ISO | RGD:731958 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PIK3R1 mRNA | CTD | PMID:19710929 | pirinixic acid | increases expression | ISO | RGD:11103 | 6480464 | pirinixic acid results in increased expression of PIK3R1 mRNA | CTD | PMID:18445702 | propiconazole | decreases expression | ISO | RGD:11103 | 6480464 | propiconazole results in decreased expression of PIK3R1 mRNA | CTD | PMID:21278054 | resveratrol | decreases expression | ISO | RGD:11103 | 6480464 | resveratrol results in decreased expression of PIK3R1 mRNA | CTD | PMID:22610192 | resveratrol | increases expression | ISO | RGD:731958 | 6480464 | resveratrol results in increased expression of PIK3R1 protein; more ... | CTD | PMID:18089832 | resveratrol | multiple interactions | EXP | | 6480464 | resveratrol inhibits the reaction [INS1 protein promotes the reaction [IRS1 protein binds to PIK3R1 protein]] | CTD | PMID:16626303 | resveratrol | multiple interactions | ISO | RGD:731958 | 6480464 | Adenosine Triphosphate inhibits the reaction [resveratrol results in decreased activity of [PIK3R1 protein binds to PIK3CA protein]]; more ... | CTD | PMID:17550345 | retinyl acetate | increases expression | ISO | RGD:11103 | 6480464 | retinol acetate results in increased expression of PIK3R1 mRNA | CTD | PMID:16772331 | rosiglitazone | multiple interactions | ISO | RGD:731958 | 6480464 | bexarotene promotes the reaction [rosiglitazone results in increased expression of PIK3R1 mRNA] | CTD | PMID:10548525 | rosiglitazone | increases expression | ISO | RGD:731958 | 6480464 | rosiglitazone results in increased expression of PIK3R1 mRNA | CTD | PMID:10548525 | silicon dioxide | decreases expression | ISO | RGD:11103 | 6480464 | Silicon Dioxide results in decreased expression of PIK3R1 mRNA | CTD | PMID:19073995 | sirolimus | multiple interactions | ISO | RGD:731958 | 6480464 | Sirolimus promotes the reaction [IRS1 protein binds to PIK3R1 protein] | CTD | PMID:17908691 | succimer | multiple interactions | ISO | RGD:11103 | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of PIK3R1 mRNA | CTD | PMID:21641980 | tamoxifen | increases expression | ISO | RGD:11103 | 6480464 | Tamoxifen results in increased expression of PIK3R1 mRNA | CTD | PMID:20937368 | terbufos | increases methylation | ISO | RGD:731958 | 6480464 | terbufos results in increased methylation of PIK3R1 promoter | CTD | PMID:22847954 | tert-butyl hydroperoxide | decreases expression | ISO | RGD:731958 | 6480464 | tert-Butylhydroperoxide results in decreased expression of PIK3R1 mRNA | CTD | PMID:15336504 | testosterone | multiple interactions | EXP | | 6480464 | Testosterone inhibits the reaction [Dexamethasone results in increased expression of PIK3R1 mRNA] | CTD | PMID:20032058 | trans-4-coumaric acid | increases expression | ISO | RGD:11103 | 6480464 | 4-coumaric acid results in increased expression of PIK3R1 mRNA | CTD | PMID:21870829 | trans-resveratrol | decreases expression | ISO | RGD:11103 | 6480464 | resveratrol results in decreased expression of PIK3R1 mRNA | CTD | PMID:22610192 | trans-resveratrol | increases expression | ISO | RGD:731958 | 6480464 | resveratrol results in increased expression of PIK3R1 protein; more ... | CTD | PMID:18089832 | trans-resveratrol | multiple interactions | EXP | | 6480464 | resveratrol inhibits the reaction [INS1 protein promotes the reaction [IRS1 protein binds to PIK3R1 protein]] | CTD | PMID:16626303 | trans-resveratrol | multiple interactions | ISO | RGD:731958 | 6480464 | Adenosine Triphosphate inhibits the reaction [resveratrol results in decreased activity of [PIK3R1 protein binds to PIK3CA protein]]; more ... | CTD | PMID:17550345 | tunicamycin | decreases expression | ISO | RGD:11103 | 6480464 | Tunicamycin results in decreased expression of PIK3R1 mRNA | CTD | PMID:17127020 | uranium atom | affects expression | ISO | RGD:731958 | 6480464 | Uranium affects the expression of PIK3R1 mRNA | CTD | PMID:15672453 | valproic acid | affects expression | ISO | RGD:11103 | 6480464 | Valproic Acid affects the expression of PIK3R1 mRNA | CTD | PMID:17292431 | wortmannin | decreases activity | ISO | RGD:731958 | 6480464 | wortmannin results in decreased activity of PIK3R1 protein | CTD | PMID:19036708 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations
Disease Annotations
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Gene-Chemical Interaction Annotations
Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Acute myeloid leukemia |
| Aldosterone-regulated sodium reabsorption | |
| Amoebiasis | |
| Apoptosis | |
| B cell receptor signaling pathway | |
| Bacterial invasion of epithelial cells | |
| Carbohydrate digestion and absorption | |
| Chagas disease (American trypanosomiasis) | |
| Chemokine signaling pathway | |
| Cholinergic synapse | |
| Chronic myeloid leukemia | |
| Colorectal cancer | |
| Endometrial cancer | |
| Epstein-Barr virus infection | |
| ErbB signaling pathway | |
| Fc epsilon RI signaling pathway | |
| Fc gamma R-mediated phagocytosis | |
| Focal adhesion | |
| Glioma | |
| Hepatitis B | |
| Hepatitis C | |
| HIF-1 signaling pathway | |
| HTLV-I infection | |
| Influenza A | |
| Insulin signaling pathway | |
| Jak-STAT signaling pathway | |
| Leukocyte transendothelial migration | |
| Measles | |
| Melanoma | |
| mTOR signaling pathway | |
| Natural killer cell mediated cytotoxicity | |
| Neurotrophin signaling pathway | |
| Non-small cell lung cancer | |
| Osteoclast differentiation | |
| Pancreatic cancer | |
| Pathways in cancer | |
| Phosphatidylinositol signaling system | |
| PI3K-Akt signaling pathway | |
| Progesterone-mediated oocyte maturation | |
| Prostate cancer | |
| Regulation of actin cytoskeleton | |
| Renal cell carcinoma | |
| Small cell lung cancer | |
| T cell receptor signaling pathway | |
| Toll-like receptor signaling pathway | |
| Toxoplasmosis | |
| Type II diabetes mellitus | |
| VEGF signaling pathway | |
| Viral carcinogenesis | |
| Pathway Interaction Database | a6b1 and a6b4 Integrin signaling (PID:200190) |
| Angiopoietin receptor Tie2-mediated signaling (PID:200079) | |
| Atypical NF-kappaB pathway (PID:200021) | |
| BCR signaling pathway (PID:200006) | |
| CDC42 signaling events (PID:200069) | |
| Class I PI3K signaling events (PID:200116) | |
| CXCR3-mediated signaling events (PID:200175) | |
| CXCR4-mediated signaling events (PID:200099) | |
| E-cadherin signaling in keratinocytes (PID:200147) | |
| E-cadherin signaling in the nascent adherens junction (PID:200124) | |
| EGF receptor (ErbB1) signaling pathway (PID:200101) | |
| EPHA2 forward signaling (PID:200216) | |
| EPHB forward signaling (PID:200052) | |
| Ephrin B reverse signaling (PID:200204) | |
| EPO signaling pathway (PID:200183) | |
| ErbB1 downstream signaling (PID:200133) | |
| ErbB2/ErbB3 signaling events (PID:200140) | |
| ErbB4 signaling events (PID:200011) | |
| FAS (CD95) signaling pathway (PID:200080) | |
| Fc-epsilon receptor I signaling in mast cells (PID:200004) | |
| FGF signaling pathway (PID:200220) | |
| GMCSF-mediated signaling events (PID:200019) | |
| IFN-gamma pathway (PID:200129) | |
| IGF1 pathway (PID:200100) | |
| IL1-mediated signaling events (PID:200089) | |
| IL2 signaling events mediated by PI3K (PID:200118) | |
| IL2 signaling events mediated by STAT5 (PID:200184) | |
| IL2-mediated signaling events (PID:200098) | |
| IL23-mediated signaling events (PID:200154) | |
| IL3-mediated signaling events (PID:200145) | |
| IL4-mediated signaling events (PID:200022) | |
| IL5-mediated signaling events (PID:200107) | |
| IL6-mediated signaling events (PID:200146) | |
| Insulin Pathway (PID:200014) | |
| Integrins in angiogenesis (PID:200128) | |
| Internalization of ErbB1 (PID:200171) | |
| LPA receptor mediated events (PID:200013) | |
| N-cadherin signaling events (PID:200209) | |
| Nectin adhesion pathway (PID:200065) | |
| Nephrin/Neph1 signaling in the kidney podocyte (PID:200152) | |
| Netrin-mediated signaling events (PID:200088) | |
| Neurotrophic factor-mediated Trk receptor signaling (PID:200150) | |
| Nongenotropic Androgen signaling (PID:200170) | |
| Osteopontin-mediated events (PID:200053) | |
| p75(NTR)-mediated signaling (PID:200122) | |
| PAR1-mediated thrombin signaling events (PID:200189) | |
| PDGFR-alpha signaling pathway (PID:200162) | |
| PDGFR-beta signaling pathway (PID:200149) | |
| Plasma membrane estrogen receptor signaling (PID:200034) | |
| Reelin signaling pathway (PID:200062) | |
| SHP2 signaling (PID:200083) | |
| Signaling events mediated by focal adhesion kinase (PID:200224) | |
| Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) (PID:200041) | |
| Signaling events mediated by PTP1B (PID:200042) | |
| Signaling events mediated by Stem cell factor receptor (c-Kit) (PID:200181) | |
| Signaling events mediated by TCPTP (PID:200078) | |
| Signaling events mediated by the Hedgehog family (PID:200168) | |
| Signaling events mediated by VEGFR1 and VEGFR2 (PID:200188) | |
| Signaling events regulated by Ret tyrosine kinase (PID:200070) | |
| TRAIL signaling pathway (PID:200068) | |
| Trk receptor signaling mediated by PI3K and PLC-gamma (PID:200214) | |
| VEGFR1 specific signals (PID:200177) | |
| VEGFR3 signaling in lymphatic endothelium (PID:200218) | |
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References - uncurated| PubMed | 10437794 |
| 11278339 | |
| 12408866 | |
| 12594288 | |
| 12960006 | |
| 16569213 | |
| 16717100 | |
| 16960657 | |
| 18417706 | |
| 18828053 | |
| 19298529 | |
| 19689064 | |
| 20042608 | |
| 20669351 | |
| 21671003 | |
| 21704119 | |
| 8183574 | |
| 8402898 | |
| 8550620 | |
| 8628286 | |
| 8781294 | |
| 9748281 | |
| 9791008 |
RGD Disease Portals| Pik3r1 has been annotated in the following RGD Disease Portals. |
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Candidate Gene Status
Comparative Map Data| Pik3r1 (Rattus norvegicus) |
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| PIK3R1 (Homo sapiens) |
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| Pik3r1 (Mus musculus) |
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Position Markers| U50413 |
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| RH94812 |
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| BF390857 |
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| Pik3r1 |
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| RH138083 |
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| RH138178 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_013005 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06012403 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06012404 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01012553 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01012554 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01012555 | (Get FASTA) | Search GEO for Microarray Profiles | |
| D63325 | (Get FASTA) | Search GEO for Microarray Profiles | |
| D64045 | (Get FASTA) | Search GEO for Microarray Profiles | |
| D64048 | (Get FASTA) | Search GEO for Microarray Profiles | |
| D78486 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U50412 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_013005 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_037137 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_037137 | (Get FASTA) |
| GenBank Protein | AAC52846 | (Get FASTA) |
| BAA18932 | (Get FASTA) | |
| BAA18933 | (Get FASTA) | |
| BAA24030 | (Get FASTA) | |
| BAA24426 | (Get FASTA) | |
| Q63787 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000018903 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000025687 | ENTREZGENE, UniProtKB/TrEMBL |
| ENSRNOP00000060575 | UniProtKB/TrEMBL | |
| ENSRNOP00000067155 | UniProtKB/TrEMBL | |
| Ensembl Transcript | ENSRNOT00000025687 | ENTREZGENE, UniProtKB/TrEMBL |
| ENSRNOT00000065301 | UniProtKB/TrEMBL | |
| ENSRNOT00000075057 | UniProtKB/TrEMBL | |
| Entrez Gene | 25513 | ENTREZGENE |
| Gene3D-CATH | RhoGAP | UniProtKB/Swiss-Prot |
| SH2 | UniProtKB/Swiss-Prot | |
| HomoloGene Group ID | 7889 | ENTREZGENE |
| InterPro | PI3kinase_P85 | UniProtKB/Swiss-Prot |
| Rho_GTPase_activation_prot | UniProtKB/Swiss-Prot | |
| RhoGAP | UniProtKB/Swiss-Prot | |
| SH2 | UniProtKB/Swiss-Prot | |
| SH3_2 | UniProtKB/Swiss-Prot | |
| SH3_domain | UniProtKB/Swiss-Prot | |
| IPI | IPI00211946 | UniProtKB/Swiss-Prot |
| IPI00231820 | UniProtKB/Swiss-Prot | |
| IPI00231821 | UniProtKB/Swiss-Prot | |
| IPI00949639 | UniProtKB/TrEMBL | |
| KEGG Report | rno:25513 | ENTREZGENE, UniProtKB/Swiss-Prot |
| PANTHER | PI3kinase_P85 | UniProtKB/Swiss-Prot |
| Pfam | RhoGAP | UniProtKB/Swiss-Prot |
| SH2 | UniProtKB/Swiss-Prot | |
| SH3_2 | UniProtKB/Swiss-Prot | |
| PRINTS | PI3KINASEP85 | UniProtKB/Swiss-Prot |
| SH2DOMAIN | UniProtKB/Swiss-Prot | |
| PROSITE | RHOGAP | UniProtKB/Swiss-Prot |
| SH2 | UniProtKB/Swiss-Prot | |
| SH3 | UniProtKB/Swiss-Prot | |
| SMART | RhoGAP | UniProtKB/Swiss-Prot |
| SH2 | UniProtKB/Swiss-Prot | |
| SH3 | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | Rho_GAP | UniProtKB/Swiss-Prot |
| SH3 | UniProtKB/Swiss-Prot | |
| TIGR | TC228818 | |
| UniGene | Rn.10599 | ENTREZGENE |
| UniProt | F1LNG1_RAT | UniProtKB/TrEMBL |
| F1LNG5_RAT | UniProtKB/TrEMBL | |
| M0RC47_RAT | UniProtKB/TrEMBL | |
| O55168_RAT | UniProtKB/TrEMBL | |
| P85A_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2008-09-09 | Pik3r1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | Pik3r1 | phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2008-02-14 | Pik3r1 | phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) | Pik3r1 | phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2001-05-08 | Pik3r1 | Phosphoinositide 3-kinase p85 | Name withdrawn, does not match Human and Mouse nomenclature | 434 | WITHDRAWN | ||
| 2001-05-08 | Pik3r1 | Phosphoinositide 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) | Name changed to reflect Human and Mouse nomenclature | 434 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_domains | contains SH2 domains | 729673 |
| gene_expression | expressed in hepatic, brain and renal tissues | 729673 |
| gene_function | activation is strongly induced by insulin | 729673 |
| gene_function | activation is required for insulin-stimulated glucose transport and insulin-dependent p70S6K activation | 68289 |
| gene_function | phosphorylates a variety of lipids and proteins to activate specific signaling cascades | 729503 |
| gene_homology | alternative splice product of 55 kDa, p55alpha, has homology to p55 gamma (Pik3r3) | 68289 |
| gene_physical_interaction | tyrosine kinase receptor binding | 729673 |
| gene_physical_interaction | binds to and is stimulated by phosphorylated substrates | 729673 |
| gene_physical_interaction | binds to insulin receptor | 729673 |
| gene_physical_interaction | forms a heterodimer with the p110 catalytic subunit | 729673 |
| gene_regulation | regulatory subunit of holoprotein p85 | 729673 |
| gene_transcript | three splice variants, p85, p55 and p50 | 68289 |
| More on Pik3r1 | |
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Entrez Gene |
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Ensembl Gene |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 3329 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




