Gene: Il23r (interleukin 23 receptor)
Mus musculus |
| Symbol: |
Il23r
|
| Name: |
interleukin 23 receptor
|
| Description: |
ENCODES a protein that exhibits interleukin-23 binding (ortholog); interleukin-23 receptor activity (ortholog); INVOLVED IN cytokine-mediated signaling pathway (ortholog); interleukin-23-mediated signaling pathway (ortholog); JAK-STAT cascade (ortholog); PARTICIPATES IN interleukin-23 signaling pathway; Jak-Stat signaling pathway; ASSOCIATED WITH abnormal CD4-positive T cell differentiation; abnormal CD4-positive T cell physiology; abnormal response/metabolism to endogenous compounds; ASSOCIATED WITH Asthma; Hypertension, Pulmonary (ortholog); Inflammatory Bowel Disease 17 (ortholog); FOUND IN integral to plasma membrane (ortholog); interleukin-23 receptor complex (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-amino-2-deoxy-D-glucopyranose (ortholog); aldehydo-D-glucosamine (ortholog) |
| Type: |
protein-coding
|
| RefSeq Status: |
VALIDATED
|
| Also known as: |
IL-23 receptor; IL-23R; interleukin-23 receptor; OTTMUSP00000038453
|
| Orthologs: |
Homo sapiens : IL23R
(interleukin 23 receptor)
HGNC
Rattus norvegicus : Il23r
(interleukin 23 receptor)
|
| Latest Assembly: |
Mouse Genome Assembly Build 37
|
| Position: |
| Map | Chr | Position | Strand | Source |
|---|
Mouse Genome Assembly GRCm38 | 6 | 67,422,932 - 67,491,855 | - | NCBI | Mouse cM Map | 6 | | - | NCBI | Mouse Celera Assembly | 6 | 69,541,500 - 69,610,484 | - | NCBI | Mouse Genome Assembly Build 37 | 6 | 67,372,926 - 67,441,849 | - | NCBI | Mouse Genome Assembly Build 36.1 | 6 | 67,372,926 - 67,441,849 | - | NCBI | Mouse Cytogenetic Map | 6 | C1 | | NCBI |
|
| Model |
|
 Disease Annotations |
 Gene-Chemical Interaction Annotations
| 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of IL23R mRNA | CTD | PMID:21570461 | | 2-amino-2-deoxy-D-glucopyranose | multiple interactions | ISO | RGD:1586368 | 6480464 | Glucosamine inhibits the reaction [IL1B results in increased expression of IL23R mRNA] | CTD | PMID:17109745 | | aldehydo-D-glucosamine | multiple interactions | ISO | RGD:1586368 | 6480464 | Glucosamine inhibits the reaction [IL1B results in increased expression of IL23R mRNA] | CTD | PMID:17109745 | | beta-D-glucosamine | multiple interactions | ISO | RGD:1586368 | 6480464 | Glucosamine inhibits the reaction [IL1B results in increased expression of IL23R mRNA] | CTD | PMID:17109745 | | mercaptopurine | increases expression | ISO | RGD:1586368 | 6480464 | 6-Mercaptopurine results in increased expression of IL23R mRNA | CTD | PMID:23358152 | | N-acetyl-1,4-benzoquinone imine | affects response to substance | ISO | RGD:1351657 | 6480464 | IL23R gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine | CTD | PMID:21177773 | | purine-6-thiol | increases expression | ISO | RGD:1586368 | 6480464 | 6-Mercaptopurine results in increased expression of IL23R mRNA | CTD | PMID:23358152 | | zinc sulfate | decreases expression | ISO | RGD:1351657 | 6480464 | Zinc Sulfate results in decreased expression of IL23R mRNA | CTD | PMID:16330358 | |
Biological Process
| cytokine-mediated signaling pathway | | ISO | EMBL:AF461422 | 2290270 | MGI:MGI:2180423|PMID:12023369 | MGI | MGI:MGI:2180423 PMID:12023369 |
| inflammatory response | | IEA | UniProtKB-KW:KW-0395 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| innate immune response | | IEA | UniProtKB-KW:KW-0399 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| interleukin-23-mediated signaling pathway | | ISO | UniProtKB:Q5VWK5 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| JAK-STAT cascade | | ISO | EMBL:AF461422 | 2290270 | MGI:MGI:2180423|PMID:12023369 | MGI | MGI:MGI:2180423 PMID:12023369 |
| leukocyte mediated immunity | | ISO | EMBL:AF461422 | 2290270 | MGI:MGI:2180423|PMID:12023369 | MGI | MGI:MGI:2180423 PMID:12023369 |
| negative regulation of interleukin-10 production | | ISO | UniProtKB:Q5VWK5 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| positive regulation of defense response to virus by host | | ISO | UniProtKB:Q5VWK5 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| positive regulation of interferon-gamma production | | ISO | UniProtKB:Q5VWK5 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| positive regulation of interleukin-12 production | | ISO | UniProtKB:Q5VWK5 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| positive regulation of T-helper 1 type immune response | | ISO | UniProtKB:Q5VWK5 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| response to interferon-gamma | | ISO | UniProtKB:Q5VWK5 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| response to lipopolysaccharide | | ISO | UniProtKB:Q5VWK5 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
Cellular Component
| integral to membrane | | IEA | UniProtKB-KW:KW-0812 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| integral to plasma membrane | | ISO | EMBL:AF461422 | 2290270 | MGI:MGI:2180423|PMID:12023369 | MGI | MGI:MGI:2180423 PMID:12023369 |
| interleukin-23 receptor complex | | ISO | UniProtKB:Q5VWK5 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| membrane | | IEA | UniProtKB-KW:KW-0472 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| plasma membrane | | IEA | UniProtKB-KW:KW-1003 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
Molecular Function
| interleukin-23 binding | | ISO | EMBL:AF461422 | 2290270 | MGI:MGI:2180423|PMID:12023369 | MGI | MGI:MGI:2180423 PMID:12023369 |
| interleukin-23 receptor activity | | ISO | EMBL:AF461422 | 2290270 | MGI:MGI:2180423|PMID:12023369 | MGI | MGI:MGI:2180423 PMID:12023369 |
| 1300959 | Lxw2_m | lupus BXSB x NZW 2 (mouse) | | | Not determined | | 6 | 33845280 | 67845419 | Mouse |
| 1558984 | Cplaq9_m | circadian period of locomotor activity 9 (mouse) | | | Not determined | | 6 | 34112078 | 68112202 | Mouse |
| 1300767 | Aliq4_m | acute lung injury QTL 4 (mouse) | | | Not determined | | 6 | 36246341 | 70246444 | Mouse |
| 1357539 | Bsbob3_m | BSB obesity 3 (mouse) | | | Not determined | | 6 | 36421465 | 70421585 | Mouse |
| 4141108 | Ramls2_m | radiation-induced acute myeloid leukemia sensitivity 2 (mouse) | | | Not determined | | 6 | 38149860 | 72149984 | Mouse |
| 1302144 | Oriq3_m | ovulation rate QTL 3 (mouse) | | | Not determined | | 6 | 38505943 | 72506037 | Mouse |
| 1301266 | Lmr4_m | leishmaniasis resistance 4 (mouse) | | | Not determined | | 6 | 42066367 | 76066509 | Mouse |
| 1558811 | Scc13_m | colon tumor susceptibility 13 (mouse) | | | Not determined | | 6 | 42066367 | 76066509 | Mouse |
| 1302131 | Bmd8_m | bone mineral density 8 (mouse) | | | Not determined | | 6 | 52111712 | 116105285 | Mouse |
| 1300556 | Cia6_m | collagen induced arthritis QTL 6 (mouse) | | | Not determined | | 6 | 58397577 | 92397704 | Mouse |
| 4141287 | Bmd20_m | bone mineral density 20 (mouse) | | | Not determined | | 6 | 58494350 | 92494483 | Mouse |
| 1301369 | Im4_m | immunoregulatory 4 (mouse) | | | Not determined | | 6 | 63434732 | 97434899 | Mouse |
| 1300546 | Ssta3_m | susceptibility to Salmonella typhimurium antigens 3 (mouse) | | | Not determined | | 6 | 66421193 | 100421316 | Mouse |
| 1300650 | Bw18_m | body weight QTL 18 (mouse) | | | Not determined | | 6 | 66663863 | 100664025 | Mouse |