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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | increases expression | ISO | RGD:736533 | 6480464 | Ethinyl Estradiol results in increased expression of SLC11A1 mRNA | CTD | PMID:12072388 | 17beta-estradiol | affects expression | ISO | RGD:736533 | 6480464 | Estradiol affects the expression of SLC11A1 mRNA | CTD | PMID:16684588 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:736533 | 6480464 | Tetrachlorodibenzodioxin affects the expression of SLC11A1 mRNA | CTD | PMID:21570461 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of SLC11A1 mRNA | CTD | PMID:16483693 | benzo[a]pyrene | increases expression | ISO | RGD:736533 | 6480464 | Benzo(a)pyrene results in increased expression of SLC11A1 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | affects expression | ISO | RGD:736533 | 6480464 | Benzo(a)pyrene affects the expression of SLC11A1 mRNA | CTD | PMID:22342234 | clofibrate | multiple interactions | ISO | RGD:736533 | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of SLC11A1 mRNA; more ... | CTD | PMID:17585979 | copper atom | multiple interactions | ISO | RGD:736533 | 6480464 | SLC11A1 protein affects the reaction [manganese chloride results in increased uptake of Copper]; more ... | CTD | PMID:22465424 | copper(0) | multiple interactions | ISO | RGD:736533 | 6480464 | SLC11A1 protein affects the reaction [manganese chloride results in increased uptake of Copper]; more ... | CTD | PMID:22465424 | D-penicillamine | increases expression | EXP | | 6480464 | Penicillamine results in increased expression of SLC11A1 mRNA | CTD | PMID:19575532 | diarsenic trioxide | increases expression | ISO | RGD:736532 | 6480464 | arsenic trioxide results in increased expression of SLC11A1 mRNA | CTD | PMID:20458559 | ferric ammonium citrate | increases expression | ISO | RGD:736533 | 6480464 | ferric ammonium citrate results in increased expression of SLC11A1 mRNA | CTD | PMID:11054110 | iron atom | multiple interactions | ISO | RGD:736533 | 6480464 | [CP gene mutant form results in increased abundance of Iron] which results in increased expression of SLC11A1 mRNA | CTD | PMID:16988052 | isoniazide | affects expression | EXP | | 6480464 | Isoniazid affects the expression of SLC11A1 mRNA | CTD | PMID:20623750 | manganese(II) chloride | multiple interactions | ISO | RGD:736533 | 6480464 | [manganese chloride results in increased expression of SLC11A1 mRNA] which results in increased uptake of Copper; more ... | CTD | PMID:22465424 | manganese(II) chloride | increases expression | ISO | RGD:736533 | 6480464 | manganese chloride results in increased expression of SLC11A1 mRNA | CTD | PMID:22465424 | mercury atom | increases expression | ISO | RGD:736532 | 6480464 | Mercury results in increased expression of SLC11A1 mRNA | CTD | PMID:19937285 | mercury(0) | increases expression | ISO | RGD:736532 | 6480464 | Mercury results in increased expression of SLC11A1 mRNA | CTD | PMID:19937285 | methotrexate | decreases expression | ISO | RGD:736532 | 6480464 | Methotrexate results in decreased expression of SLC11A1 mRNA | CTD | PMID:17400583 | paracetamol | multiple interactions | ISO | RGD:736533 | 6480464 | PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SLC11A1 mRNA] | CTD | PMID:17585979 | paracetamol | affects expression | ISO | RGD:736533 | 6480464 | Acetaminophen affects the expression of SLC11A1 mRNA | CTD | PMID:17562736 | paraquat | increases expression | ISO | RGD:736533 | 6480464 | Paraquat results in increased expression of SLC11A1 mRNA | CTD | PMID:21371552 | succimer | multiple interactions | ISO | RGD:736533 | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in increased expression of SLC11A1 mRNA | CTD | PMID:21641980 | tetrachloromethane | affects expression | ISO | RGD:736533 | 6480464 | Carbon Tetrachloride affects the expression of SLC11A1 mRNA | CTD | PMID:17484886 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Lysosome |
| Mineral absorption | |
| Pathway Interaction Database | Validated targets of C-MYC transcriptional repression (PID:200200) |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Lysosome |
| Mineral absorption | |
| Pathway Interaction Database | Validated targets of C-MYC transcriptional repression (PID:200200) |
References - curated| 1. |
Akcakaya P, etal., Mol Biol Rep. 2011 Dec 8. |
| 2. |
Alcais A, etal., J Infect Dis. 2000 Jan;181(1):302-8. |
| 3. |
Ates O, etal., J Clin Immunol. 2008 Jan;28(1):73-7. Epub 2007 Sep 18. |
| 4. |
Ates O, etal., Rheumatol Int. 2009 May;29(7):787-91. Epub 2008 Nov 8. |
| 5. |
Barshes NR, etal., Transpl Infect Dis. 2006 Jun;8(2):108-12. |
| 6. |
Borrego A, etal., Microbes Infect. 2006 Oct;8(12-13):2766-71. Epub 2006 Sep 7. |
| 7. |
Castellucci L, etal., BMC Med Genet. 2010 Jan 20;11:10. |
| 8. |
Champion OL, etal., Microbes Infect. 2008 Jul;10(8):922-7. Epub 2008 May 14. |
| 9. |
Chermesh I, etal., Dig Dis Sci. 2007 Jul;52(7):1632-5. Epub 2007 Mar 24. |
| 10. |
Comabella M, etal., Mult Scler. 2004 Dec;10(6):618-20. |
| 11. |
Crawford NP, etal., BMC Med Genet. 2005 Mar 9;6:10. |
| 12. |
Decobert M, etal., J Urol. 2006 Apr;175(4):1506-11. |
| 13. |
El-Safi S, etal., C R Biol. 2006 Nov;329(11):863-70. Epub 2006 Aug 22. |
| 14. |
Ferreira FR, etal., Int J Lepr Other Mycobact Dis. 2004 Dec;72(4):457-67. |
| 15. |
Gazouli M, etal., Can J Neurol Sci. 2008 Sep;35(4):491-4. |
| 16. |
Gazouli M, etal., Inflamm Bowel Dis. 2008 Oct;14(10):1323-30. |
| 17. |
Jiang HR, etal., J Leukoc Biol. 2009 Apr;85(4):703-10. Epub 2008 Dec 30. |
| 18. |
Kissler S, etal., Nat Genet. 2006 Apr;38(4):479-83. Epub 2006 Mar 19. |
| 19. |
Kojima Y, etal., Tissue Antigens. 2001 Dec;58(6):379-84. |
| 20. |
Kotlowski R, etal., Inflamm Bowel Dis. 2008 Aug;14(8):1112-7. |
| 21. |
Mazzolla R, etal., FEMS Immunol Med Microbiol. 2002 Jan 14;32(2):149-58. |
| 22. |
Meisner SJ, etal., Am J Trop Med Hyg. 2001 Dec;65(6):733-5. |
| 23. |
Monack DM, etal., J Exp Med. 2004 Jan 19;199(2):231-41. |
| 24. |
Nishino M, etal., Metabolism. 2005 May;54(5):628-33. |
| 25. |
Paccagnini D, etal., PLoS One. 2009 Sep 21;4(9):e7109. |
| 26. |
Pedroza LS, etal., Lupus. 2011 Mar;20(3):265-73. Epub 2011 Jan 13. |
| 27. |
Peters LC, etal., Genes Immun. 2007 Jan;8(1):51-6. Epub 2006 Nov 23. |
| 28. |
RGD automated import pipeline for gene-chemical interactions |
| 29. |
RGD Automated Pipelines |
| 30. |
RGD comprehensive gene curation |
| 31. |
Rodriguez MR, etal., Tissue Antigens. 2002 Apr;59(4):311-5. |
| 32. |
Romero-Gomez M, etal., Gut. 2004 Mar;53(3):446-50. |
| 33. |
Sanjeevi CB, etal., Arthritis Rheum. 2000 Jun;43(6):1397-404. |
| 34. |
Sechi LA, etal., World J Gastroenterol. 2006 Nov 28;12(44):7161-4. |
| 35. |
Smit JJ, etal., J Immunol. 2003 Jul 15;171(2):754-60. |
| 36. |
Stagas MK, etal., Med Sci Monit. 2011 Jan;17(1):PH1-6. |
| 37. |
Stewart LC, etal., World J Gastroenterol. 2010 Dec 7;16(45):5727-31. |
| 38. |
Valdez Y, etal., Cell Microbiol. 2009 Feb;11(2):351-62. Epub 2008 Nov 3. |
| 39. |
van Crevel R, etal., J Infect Dis. 2009 Dec 1;200(11):1671-4. |
| 40. |
Yang JH, etal., BMC Med Genet. 2011 Apr 27;12:59. |
| 41. |
Yang YS, etal., J Korean Med Sci. 2000 Feb;15(1):83-7. |
| 42. |
Zaahl MG, etal., Int J Colorectal Dis. 2006 Jul;21(5):402-8. Epub 2005 Jul 30. |
References - uncuratedRGD Disease Portals| Slc11a1 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Slc11a1 (Rattus norvegicus) |
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| SLC11A1 (Homo sapiens) |
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| Slc11a1 (Mus musculus) |
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Position Markers| D9Got99 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001031658 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06061095 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06061096 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01060855 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01060856 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC100653 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH474004 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U53822 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_001031658 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001026828 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001026828 | (Get FASTA) |
| GenBank Protein | AAB49833 | (Get FASTA) |
| AAI00654 | (Get FASTA) | |
| EDL75352 | (Get FASTA) | |
| EDL75353 | (Get FASTA) | |
| P70553 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000014956 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000054282 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000057472 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 316519 | ENTREZGENE |
| HomoloGene Group ID | 73884 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:7932285 | IMAGE-MGC_LOAD |
| InterPro | Nat-R-assoc-macro_Nramp | UniProtKB/Swiss-Prot |
| IPI | IPI00362939 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:316519 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:124692 | IMAGE-MGC_LOAD |
| PANTHER | Nramp | UniProtKB/Swiss-Prot |
| Pfam | Nramp | UniProtKB/Swiss-Prot |
| PRINTS | NATRESASSCMP | UniProtKB/Swiss-Prot |
| TIGRFAMs | nramp | UniProtKB/Swiss-Prot |
| UniGene | Rn.105919 | ENTREZGENE |
| UniProt | F1LSN8_RAT | UniProtKB/TrEMBL |
| NRAM1_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2007-04-21 | Slc11a1 | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
| More on Slc11a1 | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 1601463 |
| Created: | 2007-04-21 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.