Gene: Ctsb (cathepsin B) Mus musculus
Symbol: Ctsb
Name: cathepsin B
Description: This gene encodes a member of the peptidase C1 family and preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to generate the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. Homozygous knockout mice for this gene exhibit reduced pancreatic damage following induced pancreatitis and reduced hepatocyte apoptosis in a model of liver injury. Pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Aug 2015]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cathepsin B1; CB
Homo sapiens : CTSB (cathepsin B)  HGNC
Rattus norvegicus : Ctsb (cathepsin B)
more info ...
Related Pseudogenes: Gm14032  
Latest Assembly: Mouse Genome Assembly Build 37
Mouse Genome Assembly GRCm381463,122,462 - 63,145,923+NCBI
Mouse cM Map1433.24 NCBI
Mouse Celera Assembly1460,885,227 - 60,908,695+NCBI
Mouse Genome Assembly Build 371463,741,302 - 63,764,758+NCBI
Mouse Genome Assembly Build 36.11462,076,575 - 62,100,031+NCBI
Mouse Cytogenetic Map14 D1 NCBI

Launch Genome Browser (GBrowse)     Launch JBrowse

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Mouse Genome Assembly Build 37)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Ctsb
Entrez Gene
Ensembl Gene
Genome Browser
MGI Report
NCBI Map Viewer
Vista + UCSC

RGD Object Information
RGD ID: 1558619
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2015-11-10
Status: ACTIVE