Gene: XIAP (X-linked inhibitor of apoptosis) Homo sapiens
Symbol: XIAP
Name: X-linked inhibitor of apoptosis
Description: This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: API3; apoptosis inhibitor 3; baculoviral IAP repeat-containing protein 4; BIRC4; E3 ubiquitin-protein ligase XIAP; FLJ26913; hIAP-3; hIAP3; IAP-3; IAP-like protein; ILP1; inhibitor of apoptosis protein 3; MIHA; OTTHUMP00000023975; OTTHUMP00000196392; X-linked IAP; X-linked inhibitor of apoptosis protein; X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase; XLP2
Orthologs:
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X123,859,812 - 123,913,979 (+)NCBIGRCh38hg38GRCh38
GRCh37X122,993,662 - 123,047,829 (+)NCBIGRCh37hg19GRCh37
Build 36X122,821,729 - 122,875,503 (+)NCBINCBI36hg18NCBI36
Build 34X122,719,582 - 122,773,357NCBI
CeleraX123,378,893 - 123,432,624 (+)NCBI
Cytogenetic MapXq25NCBImapview
HuRefX112,377,835 - 112,430,903 (+)NCBI
CHM1_1X122,904,824 - 122,959,188 (+)NCBI
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences