Gene: CTSD (cathepsin D) Homo sapiens
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Symbol: CTSD
Name: cathepsin D
Description: This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease. [provided by RefSeq, Nov 2015]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cathepsin d (lysosomal aspartyl protease); ceroid-lipofuscinosis, neuronal 10; CLN10; CPSD; epididymis secretory sperm binding protein Li 130P; HEL-S-130P; lysosomal aspartyl peptidase; lysosomal aspartyl protease; MGC2311; OTTHUMP00000042282; OTTHUMP00000196039; OTTHUMP00000198692
Orthologs:
Mus musculus : Ctsd (cathepsin D)  MGI
Rattus norvegicus : Ctsd (cathepsin D)
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Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38111,752,752 - 1,763,992 (-)NCBIGRCh38hg38GRCh38
GRCh37111,773,982 - 1,785,222 (-)NCBIGRCh37hg19GRCh37
Build 36111,730,561 - 1,741,798 (-)NCBINCBI36hg18NCBI36
Build 34111,730,560 - 1,741,798NCBI
Celera111,812,103 - 1,823,339 (-)NCBI
Cytogenetic Map11p15.5NCBImapview
HuRef111,564,872 - 1,576,226 (-)NCBI
CHM1_1111,772,933 - 1,784,154 (-)NCBI
Model


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Comparative Map Data
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miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
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Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on CTSD
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Map Viewer
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Vista + UCSC

RGD Object Information
RGD ID: 1351014
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2016-11-22
Status: ACTIVE