Gene: CTSD (cathepsin D) Homo sapiens
Symbol: CTSD
Name: cathepsin D
Description: This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cathepsin d (lysosomal aspartyl protease); ceroid-lipofuscinosis, neuronal 10; CLN10; CPSD; epididymis secretory sperm binding protein Li 130P; HEL-S-130P; lysosomal aspartyl peptidase; lysosomal aspartyl protease; MGC2311; OTTHUMP00000042282; OTTHUMP00000196039; OTTHUMP00000198692
Mus musculus : Ctsd (cathepsin D)  MGI
Rattus norvegicus : Ctsd (cathepsin D)
more info ...
Latest Assembly: Human Genome Assembly GRCh37
Human Genome Assembly GRCh38111,752,752 - 1,763,992-NCBI
Human Alternate Assembly CHM1_1111,772,933 - 1,784,154-NCBI
Human Genome Assembly HuRef111,564,872 - 1,576,226-NCBI
Human Genome Assembly GRCh37111,773,982 - 1,785,222-NCBI
Human Celera Assembly111,812,103 - 1,823,339-NCBI
Human Genome Assembly Build 36111,730,561 - 1,741,798-NCBI
Human Cytogenetic Map11p15.5 NCBI
Human Genome Assembly111,730,560 - 1,741,798 NCBI

Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19)
Launch JBrowse : build 36 (hg18) build 37 (hg19)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Human Genome Assembly GRCh37)
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CTSD
Entrez Gene
Ensembl Gene
GBrowse: hg18 hg19
JBrowse: hg18 hg19
HGNC Report
NCBI Map Viewer
Vista + UCSC

RGD Object Information
RGD ID: 1351014
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2015-11-10
Status: ACTIVE