Gene: CTSD (cathepsin D)  Homo sapiens Symbol: CTSD Name: cathepsin D Description: This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease. [provided by RefSeq, Jul 2008] Type: protein-coding RefSeq Status: REVIEWED Also known as: cathepsin D; cathepsin d (lysosomal aspartyl protease); ceroid-lipofuscinosis, neuronal 10; CLN10; CPSD; lysosomal aspartyl peptidase; lysosomal aspartyl protease; MGC2311; OTTHUMP00000042282; OTTHUMP00000196039; OTTHUMP00000198692 Orthologs: Mus musculus : Ctsd (cathepsin D)  MGI Rattus norvegicus : Ctsd (cathepsin D) Latest Assembly: Human Genome Assembly GRCh37 Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 11 1,708,731 - 1,719,969 - NCBI Human Genome Assembly HuRef 11 1,564,872 - 1,576,226 - NCBI Human Genome Assembly GRCh37 11 1,773,982 - 1,785,222 - NCBI Human Genome Assembly Build 36 11 1,730,561 - 1,741,798 - NCBI Human Cytogenetic Map 11 p15.5   NCBI Human Genome Assembly 11 1,730,560 - 1,741,798   NCBI Model Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19) Annotation    (Toggle Detail/Summary View) Disease Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) Alzheimer Disease   IAGP   1358532   RGD   Alzheimer Disease   IED   1358533   RGD   Atherosclerosis   ISS RGD:732637 5687152   RGD   Ceroid Lipofuscinosis, Neuronal, 10   IEA   7240710   OMIM   Gene-Chemical Interaction Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) (+)-alpha-tocopherol increases expression ISO RGD:621511 6480464 alpha-Tocopherol results in increased expression of CTSD protein CTD PMID:18942769 (+)-pilocarpine increases expression ISO RGD:621511 6480464 Pilocarpine results in increased expression of CTSD mRNA CTD PMID:17971868 (-)-epigallocatechin 3-gallate multiple interactions ISO RGD:621511 6480464 epigallocatechin gallate inhibits the reaction [Isoproterenol affects the activity of CTSD protein] CTD PMID:18294627 (R)-lipoic acid multiple interactions ISO RGD:621511 6480464 Thioctic Acid inhibits the reaction [Doxorubicin results in decreased activity of CTSD protein] CTD PMID:12841641 (S)-amphetamine decreases expression ISO RGD:732637 6480464 Dextroamphetamine results in decreased expression of CTSD mRNA CTD PMID:12558987 1,2,4-trimethylbenzene decreases expression ISO RGD:621511 6480464 pseudocumene results in decreased expression of CTSD protein CTD PMID:17337753 17beta-estradiol multiple interactions EXP   6480464 Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CTSD mRNA] CTD PMID:11165043 more ... 17beta-estradiol increases expression EXP   6480464 Estradiol results in increased expression of CTSD mRNA CTD PMID:10411295 more ... 17beta-estradiol increases expression EXP   6480464 Estradiol results in increased expression of CTSD protein CTD PMID:22235307 more ... 17beta-estradiol increases secretion EXP   6480464 Estradiol results in increased secretion of CTSD protein CTD PMID:2278856 more ... 17beta-estradiol increases expression EXP   6480464 Estradiol results in increased expression of CTSD mRNA CTD PMID:10411295 more ... 17beta-estradiol multiple interactions EXP   6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased secretion of CTSD protein CTD PMID:7909315 17beta-estradiol increases secretion EXP   6480464 Estradiol results in increased secretion of CTSD protein CTD PMID:2278856 more ... 17beta-estradiol multiple interactions EXP   6480464 [Estradiol results in increased activity of ESR1 protein] which results in increased expression of CTSD mRNA CTD PMID:22403704 17beta-estradiol increases expression EXP   6480464 Estradiol results in increased expression of CTSD mRNA CTD PMID:10411295 more ... 17beta-estradiol multiple interactions EXP   6480464 Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CTSD mRNA] CTD PMID:11165043 more ... 17beta-estradiol increases expression EXP   6480464 Estradiol results in increased expression of CTSD protein CTD PMID:22235307 17beta-estradiol multiple interactions EXP   6480464 3',4'-dimethoxy-alpha-naphthoflavone inhibits the reaction [Estradiol results in increased expression of CTSD mRNA]; more ... CTD PMID:22235307 17beta-estradiol multiple interactions EXP   6480464 fulvestrant inhibits the reaction [Estradiol results in increased expression of CTSD mRNA] CTD PMID:19365803 PMID:19654927 17beta-estradiol increases expression EXP   6480464 Estradiol results in increased expression of CTSD mRNA CTD PMID:10411295 more ... 17beta-estradiol increases expression EXP   6480464 Estradiol results in increased expression of CTSD mRNA CTD PMID:10411295 more ... 17beta-estradiol increases expression EXP   6480464 Estradiol results in increased expression of CTSD mRNA CTD PMID:19654927 more ... 17beta-estradiol increases expression EXP   6480464 Estradiol results in increased expression of CTSD mRNA CTD PMID:15090535 more ... 17beta-estradiol multiple interactions EXP   6480464 Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CTSD mRNA] CTD PMID:11179685 PMID:11165043 17beta-estradiol increases secretion EXP   6480464 Estradiol results in increased secretion of CTSD protein CTD PMID:8384872 PMID:2278856 17beta-estradiol increases expression EXP   6480464 Estradiol results in increased expression of CTSD mRNA CTD PMID:11179685 more ... 17beta-estradiol multiple interactions EXP   6480464 Estradiol promotes the reaction [[ESR1 protein binds to CTSD promoter] which results in increased expression of CTSD mRNA] CTD PMID:11165043 PMID:11165043 17beta-estradiol multiple interactions EXP   6480464 fulvestrant inhibits the reaction [Estradiol results in increased expression of CTSD mRNA] CTD PMID:19654927 17beta-estradiol increases expression EXP   6480464 Estradiol results in increased expression of CTSD mRNA CTD PMID:19619570 more ... 17beta-estradiol multiple interactions EXP   6480464 Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased secretion of CTSD protein] CTD PMID:2278856 PMID:8384872 17beta-estradiol increases expression EXP   6480464 Estradiol results in increased expression of CTSD mRNA CTD PMID:11165043 more ... 17beta-estradiol multiple interactions EXP   6480464 Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased secretion of CTSD protein modified form] CTD PMID:2278856 17beta-estradiol multiple interactions EXP   6480464 Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased secretion of CTSD protein] CTD PMID:8384872 PMID:2278856 17beta-estradiol multiple interactions EXP   6480464 Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CTSD mRNA] CTD PMID:11165043 PMID:11179685 17beta-estradiol increases secretion EXP   6480464 Estradiol results in increased secretion of CTSD protein modified form CTD PMID:2278856 17beta-estradiol increases expression EXP   6480464 Estradiol results in increased expression of CTSD mRNA CTD PMID:19619570 more ... 17beta-estradiol increases secretion EXP   6480464 Estradiol results in increased secretion of CTSD protein CTD PMID:2278856 PMID:8384872 17beta-estradiol multiple interactions EXP   6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CTSD mRNA CTD PMID:19619570 17beta-estradiol multiple interactions EXP   6480464 Estradiol promotes the reaction [ESR1 protein binds to CTSD promoter] CTD PMID:19698761 17beta-estradiol multiple interactions EXP   6480464 alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CTSD mRNA]]; more ... CTD PMID:11165043 17beta-estradiol increases expression EXP   6480464 Estradiol results in increased expression of CTSD protein CTD PMID:22235307 PMID:8524236 17beta-estradiol increases expression EXP   6480464 Estradiol results in increased expression of CTSD mRNA CTD PMID:10411295 more ... 17beta-estradiol multiple interactions EXP   6480464 Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased secretion of CTSD protein] CTD PMID:2278856 more ... 17beta-estradiol multiple interactions EXP   6480464 Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CTSD protein] CTD PMID:22235307 PMID:8524236 17beta-estradiol increases secretion EXP   6480464 Estradiol results in increased secretion of CTSD protein CTD PMID:2278856 more ... 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one decreases expression EXP   6480464 Metribolone results in decreased expression of CTSD protein CTD PMID:17152098 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP   6480464 Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased secretion of CTSD protein modified form] CTD PMID:2278856 2,3,7,8-tetrachlorodibenzodioxine increases secretion EXP   6480464 Tetrachlorodibenzodioxin results in increased secretion of CTSD protein CTD PMID:7909315 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP   6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased secretion of CTSD protein CTD PMID:7909315 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP   6480464 Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CTSD mRNA] CTD PMID:11165043 more ... 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP   6480464 Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CTSD protein] CTD PMID:22235307 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP   6480464 Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased secretion of CTSD protein] CTD PMID:2278856 more ... 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:732637 6480464 Tetrachlorodibenzodioxin affects the expression of CTSD mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP   6480464 Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CTSD protein] CTD PMID:22235307 PMID:8524236 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP   6480464 Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CTSD mRNA] CTD PMID:11165043 more ... 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP   6480464 Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased secretion of CTSD protein] CTD PMID:2278856 PMID:8384872 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP   6480464 Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CTSD mRNA] CTD PMID:11165043 PMID:11179685 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP   6480464 Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased secretion of CTSD protein] CTD PMID:8384872 PMID:2278856 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP   6480464 Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CTSD mRNA] CTD PMID:11179685 PMID:11165043 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP   6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CTSD mRNA CTD PMID:19619570 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP   6480464 alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CTSD mRNA]]; more ... CTD PMID:11165043 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:732637 6480464 Tetrachlorodibenzodioxin results in increased expression of CTSD mRNA CTD PMID:11879969 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP   6480464 Tetrachlorodibenzodioxin results in decreased expression of CTSD mRNA CTD PMID:19619570 2-amino-2-deoxy-D-glucopyranose affects localization EXP   6480464 Glucosamine affects the localization of CTSD protein CTD PMID:15972124 2-amino-2-deoxy-D-glucopyranose increases activity EXP   6480464 Glucosamine results in increased activity of CTSD protein CTD PMID:16850161 2-amino-2-deoxy-D-glucopyranose decreases expression EXP   6480464 Glucosamine results in decreased expression of CTSD protein alternative form CTD PMID:16850161 2-amino-2-deoxy-D-glucopyranose multiple interactions EXP   6480464 pepstatin inhibits the reaction [Glucosamine results in decreased expression of CTSD protein alternative form] CTD PMID:16850161 2-butoxyethanol increases expression ISO RGD:732637 6480464 n-butoxyethanol results in increased expression of CTSD mRNA CTD PMID:19812364 2-nitrofluorene increases expression ISO RGD:621511 6480464 2-nitrofluorene results in increased expression of CTSD mRNA CTD PMID:15890375 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine increases activity ISO RGD:621511 6480464 Puromycin Aminonucleoside results in increased activity of CTSD protein CTD PMID:6497855 3,4-methylenedioxymethamphetamine increases expression ISO RGD:732637 6480464 N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CTSD mRNA CTD PMID:20188158 3-methylcholanthrene increases expression EXP   6480464 Methylcholanthrene results in increased expression of CTSD mRNA CTD PMID:16257430 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases expression ISO RGD:621511 6480464 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CTSD mRNA CTD PMID:15890375 6alpha-methylprednisolone multiple interactions ISO RGD:621511 6480464 Methylprednisolone inhibits the reaction [Isoproterenol results in increased expression of CTSD mRNA] CTD PMID:894732 7,12-dimethyltetraphene increases expression ISO RGD:621511 6480464 9,10-Dimethyl-1,2-benzanthracene results in increased expression of CTSD mRNA CTD PMID:12097258 aflatoxin B1 increases expression ISO RGD:621511 6480464 Aflatoxin B1 results in increased expression of CTSD mRNA CTD PMID:15890375 aldehydo-D-glucosamine affects localization EXP   6480464 Glucosamine affects the localization of CTSD protein CTD PMID:15972124 aldehydo-D-glucosamine increases activity EXP   6480464 Glucosamine results in increased activity of CTSD protein CTD PMID:16850161 aldehydo-D-glucosamine decreases expression EXP   6480464 Glucosamine results in decreased expression of CTSD protein alternative form CTD PMID:16850161 aldehydo-D-glucosamine multiple interactions EXP   6480464 pepstatin inhibits the reaction [Glucosamine results in decreased expression of CTSD protein alternative form] CTD PMID:16850161 all-trans-retinoic acid increases expression EXP   6480464 Tretinoin results in increased expression of CTSD mRNA CTD PMID:17218384 PMID:16054129 all-trans-retinoic acid increases expression EXP   6480464 Tretinoin results in increased expression of CTSD mRNA CTD PMID:15498508 more ... all-trans-retinoic acid increases expression EXP   6480464 Tretinoin results in increased expression of CTSD mRNA CTD PMID:15498508 more ... all-trans-retinoic acid increases expression EXP   6480464 Tretinoin results in increased expression of CTSD mRNA CTD PMID:17218384 more ... all-trans-retinoic acid increases expression EXP   6480464 Tretinoin results in increased expression of CTSD mRNA CTD PMID:16054129 more ... amlodipine multiple interactions ISO RGD:621511 6480464 [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:11829124 PMID:14499179 amlodipine multiple interactions ISO RGD:621511 6480464 [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:14499179 PMID:11829124 amlodipine multiple interactions ISO RGD:621511 6480464 [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein] CTD PMID:14499179 ammonium chloride increases expression ISO RGD:621511 6480464 Ammonium Chloride results in increased expression of CTSD protein CTD PMID:16483693 ammonium chloride affects expression ISO RGD:621511 6480464 Ammonium Chloride affects the expression of CTSD mRNA CTD PMID:16483693 benzo[a]pyrene decreases expression EXP   6480464 Benzo(a)pyrene results in decreased expression of CTSD mRNA CTD PMID:17879257 benzo[a]pyrene multiple interactions EXP   6480464 fulvestrant inhibits the reaction [Benzo(a)pyrene results in increased expression of CTSD mRNA]; more ... CTD PMID:19365803 benzo[a]pyrene increases expression EXP   6480464 Benzo(a)pyrene analog results in increased expression of CTSD mRNA; more ... CTD PMID:19365803 benzo[a]pyrene increases expression ISO RGD:732637 6480464 Benzo(a)pyrene results in increased expression of CTSD mRNA CTD PMID:21715664 PMID:22228805 benzo[a]pyrene increases expression ISO RGD:732637 6480464 Benzo(a)pyrene results in increased expression of CTSD mRNA CTD PMID:21715664 beta-D-glucosamine affects localization EXP   6480464 Glucosamine affects the localization of CTSD protein CTD PMID:15972124 beta-D-glucosamine decreases expression EXP   6480464 Glucosamine results in decreased expression of CTSD protein alternative form CTD PMID:16850161 beta-D-glucosamine multiple interactions EXP   6480464 pepstatin inhibits the reaction [Glucosamine results in decreased expression of CTSD protein alternative form] CTD PMID:16850161 beta-D-glucosamine increases activity EXP   6480464 Glucosamine results in increased activity of CTSD protein CTD PMID:16850161 bisphenol A multiple interactions EXP   6480464 [bisphenol A results in increased activity of ESR1 protein] which results in increased expression of CTSD mRNA CTD PMID:14754635 bisphenol A multiple interactions EXP   6480464 [bisphenol A results in increased activity of ESR1 protein] which results in increased expression of CTSD mRNA CTD PMID:14754635 PMID:22403704 cadmium dichloride increases expression EXP   6480464 Cadmium Chloride results in increased expression of CTSD CTD PMID:22041583 cadmium dichloride decreases expression ISO RGD:621511 6480464 Cadmium Chloride results in decreased expression of CTSD mRNA CTD PMID:21297351 cadmium dichloride multiple interactions EXP   6480464 Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of CTSD] CTD PMID:22041583 chloroquine affects localization ISO RGD:621511 6480464 Chloroquine affects the localization of CTSD protein CTD PMID:7715800 chloroquine increases expression ISO RGD:621511 6480464 Chloroquine results in increased expression of CTSD protein CTD PMID:2759144 choline multiple interactions ISO RGD:732637 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CTSD mRNA CTD PMID:20938992 cimetidine decreases activity ISO RGD:621511 6480464 Cimetidine results in decreased activity of CTSD protein CTD PMID:12903910 cis-caffeic acid multiple interactions ISO RGD:621511 6480464 caffeic acid inhibits the reaction [Isoproterenol affects the activity of CTSD protein] CTD PMID:20391626 cisplatin increases expression ISO RGD:732637 6480464 Cisplatin results in increased expression of CTSD mRNA CTD PMID:21151649 clofibrate decreases expression ISO RGD:732637 6480464 Clofibrate results in decreased expression of CTSD mRNA CTD PMID:17585979 cobalt dichloride increases expression EXP   6480464 cobaltous chloride results in increased expression of CTSD mRNA CTD PMID:19320972 PMID:19376846 cocaine affects expression ISO RGD:732637 6480464 Cocaine affects the expression of CTSD mRNA CTD PMID:15681117 copper atom multiple interactions EXP   6480464 [NSC 689534 binds to Copper] which results in increased expression of CTSD mRNA CTD PMID:20971185 copper(0) multiple interactions EXP   6480464 [NSC 689534 binds to Copper] which results in increased expression of CTSD mRNA CTD PMID:20971185 curcumin multiple interactions ISO RGD:621511 6480464 Curcumin inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein]; more ... CTD PMID:8534267 cyclophosphamide multiple interactions ISO RGD:732637 6480464 [Cyclophosphamide co-treated with Mecamylamine] results in increased expression of CTSD mRNA CTD PMID:18433785 cyclosporin A increases expression EXP   6480464 Cyclosporine results in increased expression of CTSD mRNA CTD PMID:20106945 cysteamine increases expression ISO RGD:621511 6480464 Cysteamine results in increased expression of CTSD protein CTD PMID:20165931 cysteamine multiple interactions ISO RGD:621511 6480464 thamira parpam inhibits the reaction [Cysteamine results in increased expression of CTSD protein]; more ... CTD PMID:20165931 DDT multiple interactions EXP   6480464 [DDT results in increased activity of ESR1 protein] which results in increased expression of CTSD mRNA CTD PMID:22403704 Delta(9)-tetrahydrocannabinol increases expression EXP   6480464 Tetrahydrocannabinol results in increased expression of CTSD protein; more ... CTD PMID:18163980 dexamethasone increases expression ISO RGD:732637 6480464 Dexamethasone results in increased expression of CTSD mRNA CTD PMID:21041162 diazoxide multiple interactions ISO RGD:621511 6480464 alliin affects the reaction [Isoproterenol affects the activity of CTSD protein] CTD PMID:17623887 diazoxide affects activity ISO RGD:621511 6480464 Isoproterenol affects the activity of CTSD protein CTD PMID:17623887 more ... diazoxide multiple interactions ISO RGD:621511 6480464 epigallocatechin gallate inhibits the reaction [Isoproterenol affects the activity of CTSD protein] CTD PMID:18294627 diazoxide affects activity ISO RGD:621511 6480464 Isoproterenol affects the activity of CTSD protein CTD PMID:17623887 PMID:20391626 diazoxide multiple interactions ISO RGD:621511 6480464 caffeic acid inhibits the reaction [Isoproterenol affects the activity of CTSD protein] CTD PMID:20391626 diazoxide increases activity ISO RGD:621511 6480464 Isoproterenol results in increased activity of CTSD protein CTD PMID:11829124 more ... diazoxide increases activity ISO RGD:621511 6480464 Isoproterenol results in increased activity of CTSD protein CTD PMID:17188415 more ... diazoxide decreases activity ISO RGD:621511 6480464 Isoproterenol results in decreased activity of CTSD protein CTD PMID:14499179 more ... diazoxide increases activity ISO RGD:621511 6480464 Isoproterenol results in increased activity of CTSD protein CTD PMID:14499179 more ... diazoxide increases activity ISO RGD:621511 6480464 Isoproterenol results in increased activity of CTSD protein CTD PMID:17188415 more ... diazoxide decreases activity ISO RGD:621511 6480464 Isoproterenol results in decreased activity of CTSD protein CTD PMID:14499179 more ... diazoxide increases activity ISO RGD:621511 6480464 Isoproterenol results in increased activity of CTSD protein CTD PMID:21762681 more ... diazoxide decreases activity ISO RGD:621511 6480464 Isoproterenol results in decreased activity of CTSD protein CTD PMID:19172585 more ... diazoxide multiple interactions ISO RGD:621511 6480464 [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:11829124 PMID:14499179 diazoxide increases activity ISO RGD:621511 6480464 Isoproterenol results in increased activity of CTSD protein CTD PMID:19641666 more ... diazoxide increases expression ISO RGD:621511 6480464 Isoproterenol results in increased expression of CTSD mRNA CTD PMID:17182065 PMID:894732 diazoxide decreases activity ISO RGD:621511 6480464 Isoproterenol results in decreased activity of CTSD protein CTD PMID:8534267 more ... diazoxide multiple interactions ISO RGD:621511 6480464 Ellagic Acid inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:21762681 diazoxide multiple interactions ISO RGD:621511 6480464 S-allylcysteine inhibits the reaction [Isoproterenol results in increased expression of CTSD mRNA] CTD PMID:17182065 diazoxide multiple interactions ISO RGD:621511 6480464 Plant Extracts inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:19641666 diazoxide multiple interactions ISO RGD:621511 6480464 [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:14499179 PMID:11829124 diazoxide multiple interactions ISO RGD:621511 6480464 [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein] CTD PMID:14499179 diazoxide multiple interactions ISO RGD:621511 6480464 naringin inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:17188415 diazoxide multiple interactions ISO RGD:621511 6480464 Methylprednisolone inhibits the reaction [Isoproterenol results in increased expression of CTSD mRNA] CTD PMID:894732 diazoxide multiple interactions ISO RGD:621511 6480464 mangiferin inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein] CTD PMID:19172585 diazoxide increases expression ISO RGD:621511 6480464 Isoproterenol results in increased expression of CTSD protein CTD PMID:18424012 diazoxide increases expression ISO RGD:621511 6480464 Isoproterenol results in increased expression of CTSD mRNA CTD PMID:894732 PMID:17182065 diazoxide increases activity ISO RGD:621511 6480464 Isoproterenol results in increased activity of CTSD protein CTD PMID:8534267 more ... diazoxide decreases activity ISO RGD:621511 6480464 Isoproterenol results in decreased activity of CTSD protein CTD PMID:8534267 more ... diazoxide affects activity ISO RGD:621511 6480464 Isoproterenol affects the activity of CTSD protein CTD PMID:17623887 diazoxide multiple interactions ISO RGD:621511 6480464 [ferulic acid co-treated with Ascorbic Acid] inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:17045618 diazoxide multiple interactions ISO RGD:621511 6480464 Curcumin inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein]; more ... CTD PMID:8534267 dibutyl phthalate decreases expression ISO RGD:621511 6480464 Dibutyl Phthalate results in decreased expression of CTSD mRNA CTD PMID:17379624 diethylstilbestrol increases expression ISO RGD:621511 6480464 Diethylstilbestrol results in increased expression of CTSD mRNA CTD PMID:15890375 disodium cromoglycate multiple interactions ISO RGD:732637 6480464 [pristane co-treated with Cromolyn Sodium] results in increased expression of CTSD protein CTD PMID:8812242 diuron decreases expression ISO RGD:621511 6480464 Diuron results in decreased expression of CTSD mRNA CTD PMID:21551480 doxorubicin decreases response to substance EXP   6480464 CTSD protein results in decreased susceptibility to Doxorubicin CTD PMID:18566016 doxorubicin decreases activity ISO RGD:621511 6480464 Doxorubicin results in decreased activity of CTSD protein CTD PMID:12841641 doxorubicin multiple interactions ISO RGD:621511 6480464 Thioctic Acid inhibits the reaction [Doxorubicin results in decreased activity of CTSD protein] CTD PMID:12841641 doxorubicin decreases expression ISO RGD:621511 6480464 Doxorubicin results in decreased expression of CTSD mRNA CTD PMID:19915844 doxorubicin increases expression EXP   6480464 Doxorubicin results in increased expression of CTSD protein CTD PMID:18566016 ellagic acid multiple interactions ISO RGD:621511 6480464 Ellagic Acid inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:21762681 emodin decreases expression EXP   6480464 Emodin results in decreased expression of CTSD mRNA CTD PMID:16045814 ethambutol multiple interactions ISO RGD:621511 6480464 Ethambutol results in increased expression of and affects the localization of CTSD protein; more ... CTD PMID:19063910 ferulic acid multiple interactions ISO RGD:621511 6480464 [ferulic acid co-treated with Ascorbic Acid] inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:17045618 folic acid multiple interactions ISO RGD:732637 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CTSD mRNA CTD PMID:20938992 fulvestrant increases expression EXP   6480464 fulvestrant results in increased expression of CTSD mRNA CTD PMID:15072547 fulvestrant multiple interactions EXP   6480464 fulvestrant inhibits the reaction [4-tert-octylphenol results in increased expression of CTSD mRNA] CTD PMID:23219593 fulvestrant decreases expression EXP   6480464 fulvestrant results in decreased expression of CTSD mRNA CTD PMID:14750165 fulvestrant multiple interactions EXP   6480464 fulvestrant inhibits the reaction [Estradiol results in increased expression of CTSD mRNA] CTD PMID:19365803 PMID:19654927 fulvestrant multiple interactions EXP   6480464 fulvestrant inhibits the reaction [Benzo(a)pyrene analog results in increased expression of CTSD mRNA]; more ... CTD PMID:19365803 fulvestrant multiple interactions EXP   6480464 fulvestrant inhibits the reaction [1,7-diphenyl-5-heptene-3-one results in increased expression of CTSD mRNA]; more ... CTD PMID:19654927 fumonisin B1 increases expression ISO RGD:732637 6480464 fumonisin B1 results in increased expression of CTSD mRNA CTD PMID:16221962 genistein increases expression EXP   6480464 Genistein results in increased expression of CTSD mRNA CTD PMID:15090535 genistein decreases expression ISO RGD:732637 6480464 Genistein results in decreased expression of CTSD mRNA CTD PMID:21048042 hydrogen peroxide affects expression EXP   6480464 Hydrogen Peroxide affects the expression of CTSD protein CTD PMID:21179406 indole-3-methanol decreases expression EXP   6480464 indole-3-carbinol results in decreased expression of CTSD protein CTD PMID:11110848 isoprenaline multiple interactions ISO RGD:621511 6480464 alliin affects the reaction [Isoproterenol affects the activity of CTSD protein] CTD PMID:17623887 isoprenaline affects activity ISO RGD:621511 6480464 Isoproterenol affects the activity of CTSD protein CTD PMID:17623887 more ... isoprenaline multiple interactions ISO RGD:621511 6480464 epigallocatechin gallate inhibits the reaction [Isoproterenol affects the activity of CTSD protein] CTD PMID:18294627 isoprenaline affects activity ISO RGD:621511 6480464 Isoproterenol affects the activity of CTSD protein CTD PMID:17623887 PMID:20391626 isoprenaline multiple interactions ISO RGD:621511 6480464 caffeic acid inhibits the reaction [Isoproterenol affects the activity of CTSD protein] CTD PMID:20391626 isoprenaline increases activity ISO RGD:621511 6480464 Isoproterenol results in increased activity of CTSD protein CTD PMID:11829124 more ... isoprenaline increases activity ISO RGD:621511 6480464 Isoproterenol results in increased activity of CTSD protein CTD PMID:17188415 more ... isoprenaline decreases activity ISO RGD:621511 6480464 Isoproterenol results in decreased activity of CTSD protein CTD PMID:14499179 more ... isoprenaline increases activity ISO RGD:621511 6480464 Isoproterenol results in increased activity of CTSD protein CTD PMID:14499179 more ... isoprenaline multiple interactions ISO RGD:621511 6480464 [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:11829124 PMID:14499179 isoprenaline increases expression ISO RGD:621511 6480464 Isoproterenol results in increased expression of CTSD mRNA CTD PMID:17182065 PMID:894732 isoprenaline increases activity ISO RGD:621511 6480464 Isoproterenol results in increased activity of CTSD protein CTD PMID:17188415 more ... isoprenaline decreases activity ISO RGD:621511 6480464 Isoproterenol results in decreased activity of CTSD protein CTD PMID:14499179 more ... isoprenaline multiple interactions ISO RGD:621511 6480464 S-allylcysteine inhibits the reaction [Isoproterenol results in increased expression of CTSD mRNA] CTD PMID:17182065 isoprenaline multiple interactions ISO RGD:621511 6480464 [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:14499179 PMID:11829124 isoprenaline multiple interactions ISO RGD:621511 6480464 Plant Extracts inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:19641666 isoprenaline multiple interactions ISO RGD:621511 6480464 naringin inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:17188415 isoprenaline multiple interactions ISO RGD:621511 6480464 [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein] CTD PMID:14499179 isoprenaline multiple interactions ISO RGD:621511 6480464 Methylprednisolone inhibits the reaction [Isoproterenol results in increased expression of CTSD mRNA] CTD PMID:894732 isoprenaline increases expression ISO RGD:621511 6480464 Isoproterenol results in increased expression of CTSD protein CTD PMID:18424012 isoprenaline multiple interactions ISO RGD:621511 6480464 mangiferin inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein] CTD PMID:19172585 isoprenaline increases expression ISO RGD:621511 6480464 Isoproterenol results in increased expression of CTSD mRNA CTD PMID:894732 PMID:17182065 isoprenaline increases activity ISO RGD:621511 6480464 Isoproterenol results in increased activity of CTSD protein CTD PMID:21762681 more ... isoprenaline decreases activity ISO RGD:621511 6480464 Isoproterenol results in decreased activity of CTSD protein CTD PMID:19172585 more ... isoprenaline affects activity ISO RGD:621511 6480464 Isoproterenol affects the activity of CTSD protein CTD PMID:17623887 isoprenaline multiple interactions ISO RGD:621511 6480464 [ferulic acid co-treated with Ascorbic Acid] inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:17045618 isoprenaline multiple interactions ISO RGD:621511 6480464 Ellagic Acid inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:21762681 isoprenaline multiple interactions ISO RGD:621511 6480464 Curcumin inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein]; more ... CTD PMID:8534267 L-ascorbic acid multiple interactions ISO RGD:621511 6480464 [ferulic acid co-treated with Ascorbic Acid] inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:17045618 L-methionine multiple interactions ISO RGD:732637 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CTSD mRNA CTD PMID:20938992 linalool increases expression EXP   6480464 linalool results in increased expression of CTSD mRNA CTD PMID:19922762 lipoic acid multiple interactions ISO RGD:621511 6480464 Thioctic Acid inhibits the reaction [Doxorubicin results in decreased activity of CTSD protein] CTD PMID:12841641 lithium atom increases expression ISO RGD:621511 6480464 Lithium results in increased expression of CTSD protein CTD PMID:18296634 lucanthone increases expression EXP   6480464 Lucanthone results in increased expression of CTSD protein; more ... CTD PMID:21148553 malathion increases expression ISO RGD:732637 6480464 Malathion results in increased expression of CTSD protein CTD PMID:8812242 mangiferin multiple interactions ISO RGD:621511 6480464 mangiferin inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein] CTD PMID:19172585 melatonin multiple interactions EXP   6480464 Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of CTSD] CTD PMID:22041583 methamphetamine affects localization ISO RGD:621511 6480464 Methamphetamine affects the localization of CTSD protein CTD PMID:17105920 methapyrilene increases expression ISO RGD:621511 6480464 Methapyrilene results in increased expression of CTSD mRNA CTD PMID:15890375 N-nitrosodimethylamine increases expression ISO RGD:621511 6480464 Dimethylnitrosamine results in increased expression of CTSD mRNA CTD PMID:15890375 N-tosyl-L-phenylalanyl chloromethyl ketone increases expression EXP   6480464 Tosylphenylalanyl Chloromethyl Ketone results in increased expression of CTSD protein CTD PMID:10772776 naringin multiple interactions ISO RGD:621511 6480464 naringin inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:17188415 nitric oxide increases secretion ISO RGD:621511 6480464 Nitric Oxide results in increased secretion of CTSD protein CTD PMID:15040013 nitroglycerin decreases expression ISO RGD:621511 6480464 Nitroglycerin results in decreased expression of CTSD mRNA CTD PMID:12102619 omeprazole multiple interactions ISO RGD:621511 6480464 Omeprazole inhibits the reaction [Cysteamine results in increased expression of CTSD protein] CTD PMID:20165931 paracetamol increases expression ISO RGD:732637 6480464 Acetaminophen results in increased expression of CTSD protein CTD PMID:8794998 paracetamol affects expression ISO RGD:732637 6480464 Acetaminophen affects the expression of CTSD mRNA CTD PMID:17562736 paraquat decreases expression ISO RGD:732637 6480464 Paraquat results in decreased expression of CTSD mRNA CTD PMID:16797015 phenacetin increases expression ISO RGD:621511 6480464 Phenacetin results in increased expression of CTSD mRNA CTD PMID:17698508 phenobarbital increases expression ISO RGD:621511 6480464 Phenobarbital results in increased expression of CTSD mRNA CTD PMID:19162173 phenylhydrazine increases expression ISO RGD:621511 6480464 phenylhydrazine results in increased expression of CTSD mRNA CTD PMID:17698508 piperonyl butoxide increases expression ISO RGD:621511 6480464 Piperonyl Butoxide results in increased expression of CTSD mRNA CTD PMID:15890375 piperonyl butoxide increases expression ISO RGD:621511 6480464 Piperonyl Butoxide results in increased expression of CTSD mRNA CTD PMID:15890375 PMID:22484513 pirimiphos-methyl decreases activity ISO RGD:621511 6480464 pirimiphos methyl results in decreased activity of CTSD protein CTD PMID:9204212 pirimiphos-methyl increases activity ISO RGD:621511 6480464 pirimiphos methyl results in increased activity of CTSD protein CTD PMID:9204212 pirinixic acid increases expression ISO RGD:732637 6480464 pirinixic acid results in increased expression of CTSD mRNA CTD PMID:18301758 PMID:20813756 pirinixic acid increases expression ISO RGD:621511 6480464 pirinixic acid results in increased expression of CTSD mRNA CTD PMID:19162173 PMID:15890375 pirinixic acid increases expression ISO RGD:732637 6480464 pirinixic acid results in increased expression of CTSD mRNA CTD PMID:20813756 PMID:18301758 pirinixic acid increases expression ISO RGD:621511 6480464 pirinixic acid results in increased expression of CTSD mRNA CTD PMID:15890375 PMID:19162173 pregnenolone 16alpha-carbonitrile increases expression ISO RGD:621511 6480464 Pregnenolone Carbonitrile results in increased expression of CTSD mRNA CTD PMID:19162173 pristane increases expression ISO RGD:732637 6480464 pristane results in increased expression of CTSD protein CTD PMID:8812242 pristane multiple interactions ISO RGD:732637 6480464 [pristane co-treated with Cromolyn Sodium] results in increased expression of CTSD protein CTD PMID:8812242 propiconazole increases expression ISO RGD:732637 6480464 propiconazole results in increased expression of CTSD mRNA CTD PMID:22334560 quercetin increases expression EXP   6480464 Quercetin results in increased expression of CTSD mRNA CTD PMID:15090535 quercetin increases expression EXP   6480464 Quercetin results in increased expression of CTSD mRNA CTD PMID:15090535 PMID:21632981 resveratrol increases expression EXP   6480464 resveratrol metabolite results in increased expression of CTSD mRNA CTD PMID:19496085 resveratrol increases expression EXP   6480464 resveratrol results in increased expression of CTSD mRNA CTD PMID:20878097 resveratrol increases expression EXP   6480464 resveratrol results in increased expression of CTSD protein CTD PMID:18089832 resveratrol increases expression EXP   6480464 resveratrol results in increased expression of CTSD CTD PMID:10402233 resveratrol decreases expression EXP   6480464 resveratrol results in decreased expression of CTSD mRNA CTD PMID:14750165 resveratrol increases expression ISO RGD:732637 6480464 resveratrol results in increased expression of CTSD mRNA CTD PMID:16081268 resveratrol increases secretion EXP   6480464 resveratrol results in increased secretion of CTSD protein CTD PMID:16393696 resveratrol affects expression EXP   6480464 resveratrol affects the expression of CTSD mRNA CTD PMID:16393696 resveratrol affects response to substance EXP   6480464 CTSD protein affects the susceptibility to resveratrol CTD PMID:17116725 resveratrol multiple interactions EXP   6480464 ESR1 protein affects the reaction [resveratrol affects the secretion of CTSD protein]; more ... CTD PMID:16393696 resveratrol multiple interactions EXP   6480464 CTSD protein affects the reaction [resveratrol affects the localization of CYCS protein]; more ... CTD PMID:17116725 retinyl acetate increases expression ISO RGD:732637 6480464 retinol acetate results in increased expression of CTSD mRNA CTD PMID:16772331 stilben-4-ol increases expression EXP   6480464 4-hydroxystilbene results in increased expression of CTSD mRNA CTD PMID:19496085 stilbene-4,4'-diol increases expression EXP   6480464 4,4'-dihydroxystilbene results in increased expression of CTSD mRNA CTD PMID:19496085 tamibarotene increases expression EXP   6480464 Am 80 results in increased expression of CTSD mRNA; more ... CTD PMID:15498508 trans-resveratrol increases expression EXP   6480464 resveratrol metabolite results in increased expression of CTSD mRNA CTD PMID:19496085 trans-resveratrol increases expression EXP   6480464 resveratrol results in increased expression of CTSD mRNA CTD PMID:20878097 trans-resveratrol increases expression EXP   6480464 resveratrol results in increased expression of CTSD protein CTD PMID:18089832 trans-resveratrol increases expression EXP   6480464 resveratrol results in increased expression of CTSD CTD PMID:10402233 trans-resveratrol decreases expression EXP   6480464 resveratrol results in decreased expression of CTSD mRNA CTD PMID:14750165 trans-resveratrol multiple interactions EXP   6480464 CTSD protein affects the reaction [resveratrol affects the localization of CYCS protein]; more ... CTD PMID:17116725 trans-resveratrol multiple interactions EXP   6480464 ESR1 protein affects the reaction [resveratrol affects the secretion of CTSD protein]; more ... CTD PMID:16393696 trans-resveratrol affects response to substance EXP   6480464 CTSD protein affects the susceptibility to resveratrol CTD PMID:17116725 trans-resveratrol affects expression EXP   6480464 resveratrol affects the expression of CTSD mRNA CTD PMID:16393696 trans-resveratrol increases secretion EXP   6480464 resveratrol results in increased secretion of CTSD protein CTD PMID:16393696 trans-resveratrol increases expression ISO RGD:732637 6480464 resveratrol results in increased expression of CTSD mRNA CTD PMID:16081268 vancomycin decreases expression ISO RGD:732637 6480464 Vancomycin results in decreased expression of CTSD mRNA CTD PMID:18930951 Gene Ontology Annotations Biological Process Term Qualifier Evidence With Reference Notes Source Original Reference(s) antigen processing and presentation of exogenous peptide antigen via MHC class II   TAS   2290271 Reactome:REACT_121399 Reactome Reactome:REACT_121399 autophagic vacuole assembly   IEA Ensembl:ENSMUSP00000121203 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 cell death   IEA UniProtKB-KW:KW-0523 2290271 GO_REF:0000037 UniProtKB GO_REF:0000037 collagen catabolic process   TAS   2290271 Reactome:REACT_150401 Reactome Reactome:REACT_150401 extracellular matrix disassembly   TAS   2290271 Reactome:REACT_118572 Reactome Reactome:REACT_118572 extracellular matrix organization   TAS   2290271 Reactome:REACT_118779 Reactome Reactome:REACT_118779 proteolysis   IEA UniProtKB-KW:KW-0645 2290271 GO_REF:0000038 UniProtKB GO_REF:0000038 proteolysis   IEA UniProtKB-KW:KW-0645 2290271 GO_REF:0000037 UniProtKB GO_REF:0000037 Cellular Component Term Qualifier Evidence With Reference Notes Source Original Reference(s) extracellular matrix colocalizes_with IDA   2290271 PMID:20551380 BHF-UCL PMID:20551380 extracellular region   NAS   2290271 PMID:14718574 UniProtKB PMID:14718574 extracellular region   TAS   2290271 Reactome:REACT_150386 Reactome Reactome:REACT_150386 extracellular space   IDA   2290271 PMID:20551380 BHF-UCL PMID:20551380 extracellular space   ISS UniProtKB:P00795 2290271 PMID:22261194 BHF-UCL PMID:22261194 lysosomal lumen   TAS   2290271 Reactome:REACT_120767 Reactome Reactome:REACT_120767 lysosomal lumen   TAS   2290271 Reactome:REACT_121107 Reactome Reactome:REACT_121107 lysosome   IDA   2290271 PMID:1837142 UniProtKB PMID:1837142 lysosome   IEA Ensembl:ENSMUSP00000121203 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 lysosome   IDA   2290271 PMID:19723497 MGI PMID:19723497 melanosome   IEA UniProtKB-SubCell:SL-0161 2290271 GO_REF:0000039 UniProtKB GO_REF:0000039 mitochondrion   IEA Ensembl:ENSMUSP00000121203 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 Molecular Function Term Qualifier Evidence With Reference Notes Source Original Reference(s) aspartic-type endopeptidase activity   IEA UniProtKB-KW:KW-0064 2290271 GO_REF:0000038 UniProtKB GO_REF:0000038 aspartic-type endopeptidase activity   IEA Ensembl:ENSMUSP00000121203 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 Molecular Pathway Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) autophagy pathway   ISS RGD:621511 1643198   RGD   ceramide signaling pathway   EXP   6484113   PID PID:200119 Mycobacterium tuberculosis infection pathway   IEA RGD:1351014 6907045   KEGG hsa:05152 External Database Links KEGG Pathway Lysosome Tuberculosis Pathway Interaction Database Ceramide signaling pathway (PID:200119) Direct p53 effectors (PID:200120) LKB1 signaling events (PID:200074) Validated nuclear estrogen receptor alpha network (PID:200158) Phenotype Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) behavior/neurological phenotype   IAGP   1358532   RGD   Disease Annotations Alzheimer Disease  (IAGP,IED) Atherosclerosis  (ISS) Ceroid Lipofuscinosis, Neuronal, 10  (IEA) Gene-Chemical Interaction Annotations (+)-alpha-tocopherol  (ISO) (+)-pilocarpine  (ISO) (-)-epigallocatechin 3-gallate  (ISO) (R)-lipoic acid  (ISO) (S)-amphetamine  (ISO) 1,2,4-trimethylbenzene  (ISO) 17beta-estradiol  (EXP) 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP) 2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO) 2-amino-2-deoxy-D-glucopyranose  (EXP) 2-butoxyethanol  (ISO) 2-nitrofluorene  (ISO) 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO) 3,4-methylenedioxymethamphetamine  (ISO) 3-methylcholanthrene  (EXP) 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO) 6alpha-methylprednisolone  (ISO) 7,12-dimethyltetraphene  (ISO) aflatoxin B1  (ISO) aldehydo-D-glucosamine  (EXP) all-trans-retinoic acid  (EXP) amlodipine  (ISO) ammonium chloride  (ISO) benzo[a]pyrene  (EXP,ISO) beta-D-glucosamine  (EXP) bisphenol A  (EXP) cadmium dichloride  (EXP,ISO) chloroquine  (ISO) choline  (ISO) cimetidine  (ISO) cis-caffeic acid  (ISO) cisplatin  (ISO) clofibrate  (ISO) cobalt dichloride  (EXP) cocaine  (ISO) copper atom  (EXP) copper(0)  (EXP) curcumin  (ISO) cyclophosphamide  (ISO) cyclosporin A  (EXP) cysteamine  (ISO) DDT  (EXP) Delta(9)-tetrahydrocannabinol  (EXP) dexamethasone  (ISO) diazoxide  (ISO) dibutyl phthalate  (ISO) diethylstilbestrol  (ISO) disodium cromoglycate  (ISO) diuron  (ISO) doxorubicin  (EXP,ISO) ellagic acid  (ISO) emodin  (EXP) ethambutol  (ISO) ferulic acid  (ISO) folic acid  (ISO) fulvestrant  (EXP) fumonisin B1  (ISO) genistein  (EXP,ISO) hydrogen peroxide  (EXP) indole-3-methanol  (EXP) isoprenaline  (ISO) L-ascorbic acid  (ISO) L-methionine  (ISO) linalool  (EXP) lipoic acid  (ISO) lithium atom  (ISO) lucanthone  (EXP) malathion  (ISO) mangiferin  (ISO) melatonin  (EXP) methamphetamine  (ISO) methapyrilene  (ISO) N-nitrosodimethylamine  (ISO) N-tosyl-L-phenylalanyl chloromethyl ketone  (EXP) naringin  (ISO) nitric oxide  (ISO) nitroglycerin  (ISO) omeprazole  (ISO) paracetamol  (ISO) paraquat  (ISO) phenacetin  (ISO) phenobarbital  (ISO) phenylhydrazine  (ISO) piperonyl butoxide  (ISO) pirimiphos-methyl  (ISO) pirinixic acid  (ISO) pregnenolone 16alpha-carbonitrile  (ISO) pristane  (ISO) propiconazole  (ISO) quercetin  (EXP) resveratrol  (EXP,ISO) retinyl acetate  (ISO) stilben-4-ol  (EXP) stilbene-4,4'-diol  (EXP) tamibarotene  (EXP) trans-resveratrol  (EXP,ISO) vancomycin  (ISO) Gene Ontology Annotations Biological Process antigen processing and presentation of exogenous peptide antigen via MHC class II  (TAS) autophagic vacuole assembly  (IEA) cell death  (IEA) collagen catabolic process  (TAS) extracellular matrix disassembly  (TAS) extracellular matrix organization  (TAS) proteolysis  (IEA) Cellular Component extracellular matrix  (IDA) extracellular region  (NAS,TAS) extracellular space  (IDA,ISS) lysosomal lumen  (TAS) lysosome  (IDA,IEA) melanosome  (IEA) mitochondrion  (IEA) Molecular Function aspartic-type endopeptidase activity  (IEA) Molecular Pathway Annotations autophagy pathway  (ISS) ceramide signaling pathway  (EXP) Mycobacterium tuberculosis infection pathway  (IEA) External Database Links KEGG Pathway Lysosome Tuberculosis Pathway Interaction Database Ceramide signaling pathway (PID:200119) Direct p53 effectors (PID:200120) LKB1 signaling events (PID:200074) Validated nuclear estrogen receptor alpha network (PID:200158) Phenotype Annotations behavior/neurological phenotype  (IAGP) References - curated 1. GOA_HUMAN data from the GO Consortium 2. Jormsjo S, etal., Am J Pathol. 2002 Sep;161(3):939-45. 3. Menzer G, etal., Am J Med Genet 2001 Mar 8;105(2):179-82. 4. Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology 5. Pipeline to import Pathway Interaction Database annotations from NCI into RGD 6. RGD automated import pipeline for gene-chemical interactions 7. RGD Automated Pipelines 8. Straface E, etal., FEBS Lett 2005 May 23;579(13):2759-66. Epub 2005 Apr 19. 9. Wohlgemuth SE, etal., Rejuvenation Res. 2007 Sep;10(3):281-92. 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Cancer Pathways Cardiovascular Diseases Cardiovascular Pathways Diabetes Diseases Diabetes Pathways Biological Process Immune and Inflammatory Pathways Neurological Diseases Neurological Pathways Obesity Diseases Obesity Pathways Biological Process Respiratory Pathways Genomics Comparative Map Data CTSD   (Homo sapiens) Map Chr Position Strand Source Human Alternate Assembly CHM1_1 11 1,708,731 - 1,719,969 - NCBI Human Genome Assembly HuRef 11 1,564,872 - 1,576,226 - NCBI Human Genome Assembly GRCh37 11 1,773,982 - 1,785,222 - NCBI Human Genome Assembly Build 36 11 1,730,561 - 1,741,798 - NCBI Human Cytogenetic Map 11 p15.5   NCBI Human Genome Assembly 11 1,730,560 - 1,741,798   NCBI Ctsd   (Mus musculus) Map Chr Position Strand Source Mouse Genome Assembly GRCm38 7 142,375,916 - 142,387,870 - NCBI Mouse cM Map 7   - NCBI Mouse Celera Assembly 7 142,131,673 - 142,143,627 - NCBI Mouse Genome Assembly Build 37 7 149,561,821 - 149,573,775 - NCBI Mouse Genome Assembly Build 36.1 7 149,561,821 - 149,573,775 - NCBI Mouse Cytogenetic Map 7 F5   NCBI Ctsd   (Rattus norvegicus) Map Chr Position Strand Source Rat Cytogenetic Map 1 q41   NCBI RGSC Genome Assembly v5.0 1 222,436,922 - 222,448,798 - NCBI RGSC Genome Assembly v3.4 1 202,619,669 - 202,631,545 - NCBI Rat Celera Assembly 1 195,146,345 - 195,158,236 - NCBI Genome Assembly 3.1 1 202,779,384 - 202,791,261 - NCBI Position Markers ECD00297   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,571,848 - 1,572,764   UniSTS Human Genome Assembly GRCh37 11 1,780,844 - 1,781,760   UniSTS Human Celera Assembly 11 1,818,961 - 1,819,877   RGD Human Genome Assembly Build 36 11 1,737,420 - 1,738,336   RGD Human Cytogenetic Map 11 p15.5   UniSTS ECD00346   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,567,981 - 1,568,893   UniSTS Human Genome Assembly GRCh37 11 1,776,977 - 1,777,889   UniSTS Human Celera Assembly 11 1,815,094 - 1,816,006   RGD Human Genome Assembly Build 36 11 1,733,553 - 1,734,465   RGD Human Cytogenetic Map 11 p15.5   UniSTS ECD00599   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,569,927 - 1,570,825   UniSTS Human Genome Assembly GRCh37 11 1,778,923 - 1,779,821   UniSTS Human Celera Assembly 11 1,817,040 - 1,817,938   RGD Human Genome Assembly Build 36 11 1,735,499 - 1,736,397   RGD Human Cytogenetic Map 11 p15.5   UniSTS ECD00904   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,572,833 - 1,573,718   UniSTS Human Genome Assembly GRCh37 11 1,781,829 - 1,782,714   UniSTS Human Celera Assembly 11 1,819,946 - 1,820,831   RGD Human Genome Assembly Build 36 11 1,738,405 - 1,739,290   RGD Human Cytogenetic Map 11 p15.5   UniSTS ECD00954   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,569,000 - 1,569,883   UniSTS Human Genome Assembly GRCh37 11 1,777,996 - 1,778,879   UniSTS Human Celera Assembly 11 1,816,113 - 1,816,996   RGD Human Genome Assembly Build 36 11 1,734,572 - 1,735,455   RGD Human Cytogenetic Map 11 p15.5   UniSTS ECD01139   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,565,143 - 1,566,019   UniSTS Human Genome Assembly GRCh37 11 1,774,253 - 1,775,129   UniSTS Human Celera Assembly 11 1,812,371 - 1,813,247   RGD Human Genome Assembly Build 36 11 1,730,829 - 1,731,705   RGD Human Cytogenetic Map 11 p15.5   UniSTS ECD01325   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,567,032 - 1,567,901   UniSTS Human Genome Assembly GRCh37 11 1,776,028 - 1,776,897   UniSTS Human Celera Assembly 11 1,814,145 - 1,815,014   RGD Human Genome Assembly Build 36 11 1,732,604 - 1,733,473   RGD Human Cytogenetic Map 11 p15.5   UniSTS ECD01352   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,570,909 - 1,571,777   UniSTS Human Genome Assembly GRCh37 11 1,779,905 - 1,780,773   UniSTS Human Celera Assembly 11 1,818,022 - 1,818,890   RGD Human Genome Assembly Build 36 11 1,736,481 - 1,737,349   RGD Human Cytogenetic Map 11 p15.5   UniSTS ECD06238   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,573,990 - 1,574,704   UniSTS Human Genome Assembly GRCh37 11 1,782,986 - 1,783,700   UniSTS Human Celera Assembly 11 1,821,103 - 1,821,817   RGD Human Genome Assembly Build 36 11 1,739,562 - 1,740,276   RGD Human Cytogenetic Map 11 p15.5   UniSTS ECD07271   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,574,759 - 1,575,445   UniSTS Human Genome Assembly GRCh37 11 1,783,755 - 1,784,441   UniSTS Human Celera Assembly 11 1,821,872 - 1,822,558   RGD Human Genome Assembly Build 36 11 1,740,331 - 1,741,017   RGD Human Cytogenetic Map 11 p15.5   UniSTS ECD07571   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,575,476 - 1,576,154   UniSTS Human Genome Assembly GRCh37 11 1,784,472 - 1,785,150   UniSTS Human Celera Assembly 11 1,822,589 - 1,823,267   RGD Human Genome Assembly Build 36 11 1,741,048 - 1,741,726   RGD Human Cytogenetic Map 11 p15.5   UniSTS ECD22944   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,576,368 - 1,576,571   UniSTS Human Genome Assembly GRCh37 11 1,785,364 - 1,785,567   UniSTS Human Celera Assembly 11 1,823,481 - 1,823,684   RGD Human Genome Assembly Build 36 11 1,741,940 - 1,742,143   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61163   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,577,982 - 1,578,220   UniSTS Human Genome Assembly GRCh37 11 1,786,977 - 1,787,215   UniSTS Human Celera Assembly 11 1,825,094 - 1,825,332   RGD Human Genome Assembly Build 36 11 1,743,553 - 1,743,791   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61164   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,577,775 - 1,578,006   UniSTS Human Genome Assembly GRCh37 11 1,786,770 - 1,787,001   UniSTS Human Celera Assembly 11 1,824,887 - 1,825,118   RGD Human Genome Assembly Build 36 11 1,743,346 - 1,743,577   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61165   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,577,568 - 1,577,798   UniSTS Human Genome Assembly GRCh37 11 1,786,563 - 1,786,793   UniSTS Human Celera Assembly 11 1,824,680 - 1,824,910   RGD Human Genome Assembly Build 36 11 1,743,139 - 1,743,369   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61166   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,576,570 - 1,576,797   UniSTS Human Genome Assembly GRCh37 11 1,785,566 - 1,785,793   UniSTS Human Celera Assembly 11 1,823,683 - 1,823,910   RGD Human Genome Assembly Build 36 11 1,742,142 - 1,742,369   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61167   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,576,368 - 1,576,592   UniSTS Human Genome Assembly GRCh37 11 1,785,364 - 1,785,588   UniSTS Human Celera Assembly 11 1,823,481 - 1,823,705   RGD Human Genome Assembly Build 36 11 1,741,940 - 1,742,164   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61168   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,575,421 - 1,575,655   UniSTS Human Genome Assembly GRCh37 11 1,784,417 - 1,784,651   UniSTS Human Celera Assembly 11 1,822,534 - 1,822,768   RGD Human Genome Assembly Build 36 11 1,740,993 - 1,741,227   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61169   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,575,185 - 1,575,445   UniSTS Human Genome Assembly GRCh37 11 1,784,181 - 1,784,441   UniSTS Human Celera Assembly 11 1,822,298 - 1,822,558   RGD Human Genome Assembly Build 36 11 1,740,757 - 1,741,017   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61170   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,574,958 - 1,575,198   UniSTS Human Genome Assembly GRCh37 11 1,783,954 - 1,784,194   UniSTS Human Celera Assembly 11 1,822,071 - 1,822,311   RGD Human Genome Assembly Build 36 11 1,740,530 - 1,740,770   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61171   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,574,719 - 1,574,978   UniSTS Human Genome Assembly GRCh37 11 1,783,715 - 1,783,974   UniSTS Human Celera Assembly 11 1,821,832 - 1,822,091   RGD Human Genome Assembly Build 36 11 1,740,291 - 1,740,550   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61172   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,574,486 - 1,574,738   UniSTS Human Genome Assembly GRCh37 11 1,783,482 - 1,783,734   UniSTS Human Celera Assembly 11 1,821,599 - 1,821,851   RGD Human Genome Assembly Build 36 11 1,740,058 - 1,740,310   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61173   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,574,273 - 1,574,507   UniSTS Human Genome Assembly GRCh37 11 1,783,269 - 1,783,503   UniSTS Human Celera Assembly 11 1,821,386 - 1,821,620   RGD Human Genome Assembly Build 36 11 1,739,845 - 1,740,079   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61174   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,574,055 - 1,574,281   UniSTS Human Genome Assembly GRCh37 11 1,783,051 - 1,783,277   UniSTS Human Celera Assembly 11 1,821,168 - 1,821,394   RGD Human Genome Assembly Build 36 11 1,739,627 - 1,739,853   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61175   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,573,762 - 1,574,009   UniSTS Human Genome Assembly GRCh37 11 1,782,758 - 1,783,005   UniSTS Human Celera Assembly 11 1,820,875 - 1,821,122   RGD Human Genome Assembly Build 36 11 1,739,334 - 1,739,581   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61176   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,573,543 - 1,573,781   UniSTS Human Genome Assembly GRCh37 11 1,782,539 - 1,782,777   UniSTS Human Celera Assembly 11 1,820,656 - 1,820,894   RGD Human Genome Assembly Build 36 11 1,739,115 - 1,739,353   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61177   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,573,334 - 1,573,566   UniSTS Human Genome Assembly GRCh37 11 1,782,330 - 1,782,562   UniSTS Human Celera Assembly 11 1,820,447 - 1,820,679   RGD Human Genome Assembly Build 36 11 1,738,906 - 1,739,138   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61178   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,573,123 - 1,573,347   UniSTS Human Genome Assembly GRCh37 11 1,782,119 - 1,782,343   UniSTS Human Celera Assembly 11 1,820,236 - 1,820,460   RGD Human Genome Assembly Build 36 11 1,738,695 - 1,738,919   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61179   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,572,733 - 1,572,978   UniSTS Human Genome Assembly GRCh37 11 1,781,729 - 1,781,974   UniSTS Human Celera Assembly 11 1,819,846 - 1,820,091   RGD Human Genome Assembly Build 36 11 1,738,305 - 1,738,550   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61180   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,572,526 - 1,572,753   UniSTS Human Genome Assembly GRCh37 11 1,781,522 - 1,781,749   UniSTS Human Celera Assembly 11 1,819,639 - 1,819,866   RGD Human Genome Assembly Build 36 11 1,738,098 - 1,738,325   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61181   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,572,160 - 1,572,426   UniSTS Human Genome Assembly GRCh37 11 1,781,156 - 1,781,422   UniSTS Human Celera Assembly 11 1,819,273 - 1,819,539   RGD Human Genome Assembly Build 36 11 1,737,732 - 1,737,998   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61182   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,571,956 - 1,572,182   UniSTS Human Genome Assembly GRCh37 11 1,780,952 - 1,781,178   UniSTS Human Celera Assembly 11 1,819,069 - 1,819,295   RGD Human Genome Assembly Build 36 11 1,737,528 - 1,737,754   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61183   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,571,741 - 1,571,972   UniSTS Human Genome Assembly GRCh37 11 1,780,737 - 1,780,968   UniSTS Human Celera Assembly 11 1,818,854 - 1,819,085   RGD Human Genome Assembly Build 36 11 1,737,313 - 1,737,544   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61184   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,571,442 - 1,571,674   UniSTS Human Genome Assembly GRCh37 11 1,780,438 - 1,780,670   UniSTS Human Celera Assembly 11 1,818,555 - 1,818,787   RGD Human Genome Assembly Build 36 11 1,737,014 - 1,737,246   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61185   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,571,044 - 1,571,273   UniSTS Human Genome Assembly GRCh37 11 1,780,040 - 1,780,269   UniSTS Human Celera Assembly 11 1,818,157 - 1,818,386   RGD Human Genome Assembly Build 36 11 1,736,616 - 1,736,845   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61186   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,570,799 - 1,571,024   UniSTS Human Genome Assembly GRCh37 11 1,779,795 - 1,780,020   UniSTS Human Celera Assembly 11 1,817,912 - 1,818,137   RGD Human Genome Assembly Build 36 11 1,736,371 - 1,736,596   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61187   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,570,563 - 1,570,823   UniSTS Human Genome Assembly GRCh37 11 1,779,559 - 1,779,819   UniSTS Human Celera Assembly 11 1,817,676 - 1,817,936   RGD Human Genome Assembly Build 36 11 1,736,135 - 1,736,395   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61188   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,570,246 - 1,570,471   UniSTS Human Genome Assembly GRCh37 11 1,779,242 - 1,779,467   UniSTS Human Celera Assembly 11 1,817,359 - 1,817,584   RGD Human Genome Assembly Build 36 11 1,735,818 - 1,736,043   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61189   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,570,025 - 1,570,267   UniSTS Human Genome Assembly GRCh37 11 1,779,021 - 1,779,263   UniSTS Human Celera Assembly 11 1,817,138 - 1,817,380   RGD Human Genome Assembly Build 36 11 1,735,597 - 1,735,839   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61190   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,569,818 - 1,570,043   UniSTS Human Genome Assembly GRCh37 11 1,778,814 - 1,779,039   UniSTS Human Celera Assembly 11 1,816,931 - 1,817,156   RGD Human Genome Assembly Build 36 11 1,735,390 - 1,735,615   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61191   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,569,569 - 1,569,824   UniSTS Human Genome Assembly GRCh37 11 1,778,565 - 1,778,820   UniSTS Human Celera Assembly 11 1,816,682 - 1,816,937   RGD Human Genome Assembly Build 36 11 1,735,141 - 1,735,396   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61192   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,569,352 - 1,569,584   UniSTS Human Genome Assembly GRCh37 11 1,778,348 - 1,778,580   UniSTS Human Celera Assembly 11 1,816,465 - 1,816,697   RGD Human Genome Assembly Build 36 11 1,734,924 - 1,735,156   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61193   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,568,998 - 1,569,250   UniSTS Human Genome Assembly GRCh37 11 1,777,994 - 1,778,246   UniSTS Human Celera Assembly 11 1,816,111 - 1,816,363   RGD Human Genome Assembly Build 36 11 1,734,570 - 1,734,822   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61194   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,568,685 - 1,568,922   UniSTS Human Genome Assembly GRCh37 11 1,777,681 - 1,777,918   UniSTS Human Celera Assembly 11 1,815,798 - 1,816,035   RGD Human Genome Assembly Build 36 11 1,734,257 - 1,734,494   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61195   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,568,328 - 1,568,577   UniSTS Human Genome Assembly GRCh37 11 1,777,324 - 1,777,573   UniSTS Human Celera Assembly 11 1,815,441 - 1,815,690   RGD Human Genome Assembly Build 36 11 1,733,900 - 1,734,149   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61196   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,567,877 - 1,568,121   UniSTS Human Genome Assembly GRCh37 11 1,776,873 - 1,777,117   UniSTS Human Celera Assembly 11 1,814,990 - 1,815,234   RGD Human Genome Assembly Build 36 11 1,733,449 - 1,733,693   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61197   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,567,654 - 1,567,893   UniSTS Human Genome Assembly GRCh37 11 1,776,650 - 1,776,889   UniSTS Human Celera Assembly 11 1,814,767 - 1,815,006   RGD Human Genome Assembly Build 36 11 1,733,226 - 1,733,465   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61198   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,567,418 - 1,567,672   UniSTS Human Genome Assembly GRCh37 11 1,776,414 - 1,776,668   UniSTS Human Celera Assembly 11 1,814,531 - 1,814,785   RGD Human Genome Assembly Build 36 11 1,732,990 - 1,733,244   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61199   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,567,213 - 1,567,441   UniSTS Human Genome Assembly GRCh37 11 1,776,209 - 1,776,437   UniSTS Human Celera Assembly 11 1,814,326 - 1,814,554   RGD Human Genome Assembly Build 36 11 1,732,785 - 1,733,013   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61200   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,566,998 - 1,567,223   UniSTS Human Genome Assembly GRCh37 11 1,775,993 - 1,776,219   UniSTS Human Celera Assembly 11 1,814,111 - 1,814,336   RGD Human Genome Assembly Build 36 11 1,732,569 - 1,732,795   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61203   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,566,190 - 1,566,414   UniSTS Human Genome Assembly GRCh37 11 1,775,300 - 1,775,524   UniSTS Human Celera Assembly 11 1,813,418 - 1,813,642   RGD Human Genome Assembly Build 36 11 1,731,876 - 1,732,100   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61204   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,565,811 - 1,566,044   UniSTS Human Genome Assembly GRCh37 11 1,774,921 - 1,775,154   UniSTS Human Celera Assembly 11 1,813,039 - 1,813,272   RGD Human Genome Assembly Build 36 11 1,731,497 - 1,731,730   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61205   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,565,574 - 1,565,821   UniSTS Human Genome Assembly GRCh37 11 1,774,684 - 1,774,931   UniSTS Human Celera Assembly 11 1,812,802 - 1,813,049   RGD Human Genome Assembly Build 36 11 1,731,260 - 1,731,507   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61206   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,565,301 - 1,565,544   UniSTS Human Genome Assembly GRCh37 11 1,774,411 - 1,774,654   UniSTS Human Celera Assembly 11 1,812,529 - 1,812,772   RGD Human Genome Assembly Build 36 11 1,730,987 - 1,731,230   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61207   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,565,068 - 1,565,310   UniSTS Human Genome Assembly GRCh37 11 1,774,178 - 1,774,420   UniSTS Human Celera Assembly 11 1,812,296 - 1,812,538   RGD Human Genome Assembly Build 36 11 1,730,754 - 1,730,996   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61208   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,564,856 - 1,565,090   UniSTS Human Genome Assembly GRCh37 11 1,773,966 - 1,774,200   UniSTS Human Celera Assembly 11 1,812,084 - 1,812,318   RGD Human Genome Assembly Build 36 11 1,730,542 - 1,730,776   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61209   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,564,607 - 1,564,877   UniSTS Human Genome Assembly GRCh37 11 1,773,717 - 1,773,987   UniSTS Human Celera Assembly 11 1,811,835 - 1,812,105   RGD Human Genome Assembly Build 36 11 1,730,293 - 1,730,563   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN61210   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,564,391 - 1,564,628   UniSTS Human Genome Assembly GRCh37 11 1,773,501 - 1,773,738   UniSTS Human Celera Assembly 11 1,811,619 - 1,811,856   RGD Human Genome Assembly Build 36 11 1,730,077 - 1,730,314   RGD Human Cytogenetic Map 11 p15.5   UniSTS STS-M63138   Map Chr Position Strand Source Human NCBI RH Map 11 10.0   UniSTS Human GeneMap99-GB4 RH Map 11 22.72   UniSTS Human Genome Assembly HuRef 11 1,564,537 - 1,564,692   UniSTS Human Genome Assembly GRCh37 11 1,773,647 - 1,773,802   UniSTS Human Celera Assembly 11 1,811,765 - 1,811,920   RGD Human Genome Assembly Build 36 11 1,730,223 - 1,730,378   RGD Human Cytogenetic Map 11 p15.5   UniSTS CTSD   Map Chr Position Strand Source Human NCBI RH Map 11 10.0   UniSTS Human GeneMap99-GB4 RH Map 11 22.82   UniSTS Human Genome Assembly HuRef 11 1,569,557 - 1,569,790   UniSTS Human Genome Assembly GRCh37 11 1,778,553 - 1,778,786   UniSTS Human Celera Assembly 11 1,816,670 - 1,816,903   RGD Human Genome Assembly Build 36 11 1,735,129 - 1,735,362   RGD Human Cytogenetic Map 11 p15.5   UniSTS MARC_10183-10184:1004371792:5   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,571,221 - 1,571,832   UniSTS Human Genome Assembly GRCh37 11 1,780,217 - 1,780,828   UniSTS Human Celera Assembly 11 1,818,334 - 1,818,945   RGD Human Genome Assembly Build 36 11 1,736,793 - 1,737,404   RGD stSG548467   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,569,843 - 1,571,585   UniSTS Human Genome Assembly GRCh37 11 1,778,839 - 1,780,581   UniSTS Human Celera Assembly 11 1,816,956 - 1,818,698   RGD Human Genome Assembly Build 36 11 1,735,415 - 1,737,157   RGD stSG548468   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,571,758 - 1,573,098   UniSTS Human Genome Assembly GRCh37 11 1,780,754 - 1,782,094   UniSTS Human Celera Assembly 11 1,818,871 - 1,820,211   RGD Human Genome Assembly Build 36 11 1,737,330 - 1,738,670   RGD stSG548469   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,573,079 - 1,574,646   UniSTS Human Genome Assembly GRCh37 11 1,782,075 - 1,783,642   UniSTS Human Celera Assembly 11 1,820,192 - 1,821,759   RGD Human Genome Assembly Build 36 11 1,738,651 - 1,740,218   RGD stSG548470   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,574,625 - 1,574,804   UniSTS Human Genome Assembly GRCh37 11 1,783,621 - 1,783,800   UniSTS Human Celera Assembly 11 1,821,738 - 1,821,917   RGD Human Genome Assembly Build 36 11 1,740,197 - 1,740,376   RGD QTLs in Region (Human Genome Assembly GRCh37) The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer RGD ID Symbol Name LOD P Value Trait Sub Trait Chr Start Stop Species 2289212 BW357_H Body weight QTL 357 (human) .0365 Body fat amount percent fat 11 1 17539910 Human 2316722 GLUCO278_H Glucose level QTL 278 (human) 1.25 .01371 Glucose level 11 1 18988104 Human 2314986 INSUL33_H Insulin level QTL 33 (human) 1.9 Insulin level 11 1566810 4539970 Human Sequence Nucleotide Sequences Nucleotide RefSeqs NG_008655 (Get FASTA) Search GEO for Microarray Profiles   NM_001909 (Get FASTA) Search GEO for Microarray Profiles GenBank Nucleotide ABBA01012158 (Get FASTA) Search GEO for Microarray Profiles   AC068580 (Get FASTA) Search GEO for Microarray Profiles   AK130178 (Get FASTA) Search GEO for Microarray Profiles   AMYH01003315 (Get FASTA) Search GEO for Microarray Profiles   BC001574 (Get FASTA) Search GEO for Microarray Profiles   BC016320 (Get FASTA) Search GEO for Microarray Profiles   BM762986 (Get FASTA) Search GEO for Microarray Profiles   BM976200 (Get FASTA) Search GEO for Microarray Profiles   BT006910 (Get FASTA) Search GEO for Microarray Profiles   BT020155 (Get FASTA) Search GEO for Microarray Profiles   CH471158 (Get FASTA) Search GEO for Microarray Profiles   CR456947 (Get FASTA) Search GEO for Microarray Profiles   L12980 (Get FASTA) Search GEO for Microarray Profiles   M11233 (Get FASTA) Search GEO for Microarray Profiles   M63138 (Get FASTA) Search GEO for Microarray Profiles   S52557 (Get FASTA) Search GEO for Microarray Profiles   S74689 (Get FASTA) Search GEO for Microarray Profiles   X05344 (Get FASTA) Search GEO for Microarray Profiles Reference Sequences RefSeq Acc Id: NM_001909 RefSeq Status: REVIEWED Type: CODING Protein Acc Id: NP_001900 Peptide Label: preproprotein Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 11 1,708,731 - 1,719,969 - NCBI Human Genome Assembly HuRef 11 1,564,872 - 1,576,226 - ENTREZGENE Human Genome Assembly GRCh37 11 1,773,982 - 1,785,222 - ENTREZGENE Human Genome Assembly Build 36 11 1,730,561 - 1,741,798 - NCBI Archive Protein Sequences Protein RefSeqs NP_001900 (Get FASTA) GenBank Protein AAA16314 (Get FASTA)   AAA51922 (Get FASTA)   AAB59529 (Get FASTA)   AAD13868 (Get FASTA)   AAD14156 (Get FASTA)   AAH16320 (Get FASTA)   AAP35556 (Get FASTA)   AAV38957 (Get FASTA)   ABM84473 (Get FASTA)   ABM84804 (Get FASTA)   CAA28955 (Get FASTA)   CAG33228 (Get FASTA)   EAX02461 (Get FASTA)   EAX02462 (Get FASTA)   EAX02463 (Get FASTA)   P07339 (Get FASTA) Promoters RGD ID: 6788658 Promoter ID: HG_KWN:11928 Type: Non-CpG SO ACC ID: SO:0000170 Source: MPROMDB Tissues & Cell Lines: CD4+TCell Transcripts: OTTHUMT00000105335,   OTTHUMT00000105336 Position: Map Chr Position Strand Source Human Genome Assembly Build 36 11 1,733,556 - 1,734,056 - MPROMDB RGD ID: 6788659 Promoter ID: HG_KWN:11931 Type: CpG-Island SO ACC ID: SO:0000170 Source: MPROMDB Tissues & Cell Lines: HeLa_S3 Transcripts: OTTHUMT00000105337 Position: Map Chr Position Strand Source Human Genome Assembly Build 36 11 1,739,651 - 1,740,151 - MPROMDB RGD ID: 6788657 Promoter ID: HG_KWN:11932 Type: CpG-Island SO ACC ID: SO:0000170 Source: MPROMDB Tissues & Cell Lines: CD4+TCell_12Hour,   HeLa_S3,   K562 Transcripts: OTTHUMT00000105334 Position: Map Chr Position Strand Source Human Genome Assembly Build 36 11 1,740,371 - 1,740,871 - MPROMDB RGD ID: 6788421 Promoter ID: HG_KWN:11933 Type: CpG-Island SO ACC ID: SO:0000170 Source: MPROMDB Tissues & Cell Lines: CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4 Transcripts: ENST00000407742,   NM_053005,   OTTHUMT00000104272,   OTTHUMT00000105340,   UC001LTQ.1,   UC009YDA.1 Position: Map Chr Position Strand Source Human Genome Assembly Build 36 11 1,741,644 - 1,742,144 - MPROMDB RGD ID: 6863976 Promoter ID: EPDNEW_H5153 Type: initiation region Name: ABHD6_1 Description: abhydrolase domain containing 6 SO ACC ID: SO:0000170 Source: EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) Position: Map Chr Position Strand Source Human Genome Assembly Build 36 3 58,223,263 - 58,223,323   EPDNEW Additional Information External Database Links Database Acc Id Source(s) COSMIC CTSD COSMIC Ensembl Genes ENSG00000117984 ENTREZGENE Ensembl Protein ENSP00000236671 ENTREZGENE Ensembl Transcript ENST00000236671 ENTREZGENE Entrez Gene 1509 ENTREZGENE Gene3D-CATH Pept_Aspartc_cat UniProtKB/Swiss-Prot Germonline ENSG00000117984 HGNC ID 2529 ENTREZGENE HomoloGene Group ID 55616 ENTREZGENE HPRD ID 00291 ENTREZGENE InterPro Peptidase_A1 UniProtKB/Swiss-Prot   Peptidase_aspartic UniProtKB/Swiss-Prot   Peptidase_aspartic_AS UniProtKB/Swiss-Prot   Propep_A1 UniProtKB/Swiss-Prot KEGG Report hsa:1509 ENTREZGENE, UniProtKB/Swiss-Prot OMIM 116840 OMIM   610127 OMIM PANTHER Peptidase_A1 UniProtKB/Swiss-Prot Pfam A1_Propeptide UniProtKB/Swiss-Prot   Asp UniProtKB/Swiss-Prot PharmGKB PA27029 PharmGKB PRINTS PEPSIN UniProtKB/Swiss-Prot PROSITE ASP_PROTEASE UniProtKB/Swiss-Prot Superfamily-SCOP Pept_Aspartic UniProtKB/Swiss-Prot UniGene Hs.654447 ENTREZGENE UniProt C9JH19_HUMAN UniProtKB/TrEMBL   CATD_HUMAN UniProtKB/Swiss-Prot   F8W787_HUMAN UniProtKB/TrEMBL   F8WD96_HUMAN UniProtKB/TrEMBL   H7C1V0_HUMAN UniProtKB/TrEMBL Nomenclature History Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status 2011-08-16 CTSD  cathepsin D  CTSD  cathepsin D  Symbol and/or name change 39860 APPROVED

More on CTSD Entrez Gene Ensembl Gene Genome Browser: (hg18) (hg19) HGNC Report NCBI Map Viewer Vista Vista + UCSC RGD Object Information RGD ID: 1351014 Created: 2005-03-08 Species: Homo sapiens Last Modified: 2013-06-11 Status: ACTIVE