Gene: CTSD (cathepsin D) Homo sapiens
Symbol: CTSD
Name: cathepsin D
Description: This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease. [provided by RefSeq, Nov 2015]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cathepsin d (lysosomal aspartyl protease); ceroid-lipofuscinosis, neuronal 10; CLN10; CPSD; epididymis secretory sperm binding protein Li 130P; HEL-S-130P; lysosomal aspartyl peptidase; lysosomal aspartyl protease; MGC2311; OTTHUMP00000042282; OTTHUMP00000196039; OTTHUMP00000198692
Mus musculus : Ctsd (cathepsin D)  MGI
Rattus norvegicus : Ctsd (cathepsin D)
more info ...
Latest Assembly: Human Genome Assembly GRCh37
Human Genome Assembly GRCh38111,752,752 - 1,763,992-NCBI
Human Alternate Assembly CHM1_1111,772,933 - 1,784,154-NCBI
Human Genome Assembly HuRef111,564,872 - 1,576,226-NCBI
Human Genome Assembly GRCh37111,773,982 - 1,785,222-NCBI
Human Celera Assembly111,812,103 - 1,823,339-NCBI
Human Genome Assembly Build 36111,730,561 - 1,741,798-NCBI
Human Cytogenetic Map11p15.5 NCBI
Human Genome Assembly111,730,560 - 1,741,798 NCBI

Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19)
Launch JBrowse : build 36 (hg18) build 37 (hg19)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Human Genome Assembly GRCh37)
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CTSD
Entrez Gene
Ensembl Gene
GBrowse: hg18 hg19
JBrowse: hg18 hg19
HGNC Report
NCBI Map Viewer
Vista + UCSC

RGD Object Information
RGD ID: 1351014
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2016-01-05
Status: ACTIVE