Annotation (Toggle Detail/Summary View) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (S)-nicotine | decreases expression | ISO | RGD:733088 | 6480464 | Nicotine results in decreased expression of CAP1 mRNA | CTD | PMID:21955143 | 17beta-estradiol | increases expression | EXP | | 6480464 | Estradiol results in increased expression of CAP1 mRNA | CTD | PMID:21632981 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of CAP1 mRNA | CTD | PMID:21632981 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:733088 | 6480464 | Tetrachlorodibenzodioxin affects the expression of CAP1 mRNA | CTD | PMID:21570461 | 4,4'-diaminodiphenylmethane | increases expression | ISO | RGD:733088 | 6480464 | 4,4'-diaminodiphenylmethane results in increased expression of CAP1 mRNA | CTD | PMID:18648102 | 4-hydroxynon-2-enal | affects binding | EXP | | 6480464 | CAP1 protein binds to 4-hydroxy-2-nonenal | CTD | PMID:20043646 | ammonium chloride | affects expression | ISO | RGD:620309 | 6480464 | Ammonium Chloride affects the expression of CAP1 mRNA | CTD | PMID:16483693 | cobalt dichloride | decreases expression | EXP | | 6480464 | cobaltous chloride results in decreased expression of CAP1 mRNA | CTD | PMID:19320972 | copper(2+) sulfate | increases expression | EXP | | 6480464 | Copper Sulfate results in increased expression of CAP1 mRNA | CTD | PMID:19549813 | Delta(9)-tetrahydrocannabinol | increases expression | ISO | RGD:733088 | 6480464 | Tetrahydrocannabinol results in increased expression of CAP1 mRNA | CTD | PMID:21955143 | dibutyl phthalate | increases expression | ISO | RGD:620309 | 6480464 | Dibutyl Phthalate results in increased expression of CAP1 mRNA | CTD | PMID:21266533 | dimethylarsinic acid | increases expression | ISO | RGD:620309 | 6480464 | Cacodylic Acid results in increased expression of CAP1 mRNA | CTD | PMID:16122865 | ethanol | decreases expression | ISO | RGD:733088 | 6480464 | Ethanol results in decreased expression of CAP1 mRNA | CTD | PMID:21955143 | lead(0) | decreases expression | EXP | | 6480464 | Lead results in decreased expression of CAP1 mRNA | CTD | PMID:19921347 | morphine | decreases expression | ISO | RGD:733088 | 6480464 | Morphine results in decreased expression of CAP1 mRNA | CTD | PMID:21955143 | naphthalene | multiple interactions | ISO | RGD:733088 | 6480464 | [naphthalene co-treated with CFTR gene mutant form] results in decreased expression of CAP1 protein | CTD | PMID:19438287 | paracetamol | affects expression | ISO | RGD:733088 | 6480464 | Acetaminophen affects the expression of CAP1 mRNA | CTD | PMID:17562736 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of CAP1 mRNA | CTD | PMID:22230336 | trimellitic anhydride | increases expression | ISO | RGD:733088 | 6480464 | trimellitic anhydride results in increased expression of CAP1 mRNA | CTD | PMID:19042947 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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References - curated| 1. |
GOA_HUMAN data from the GO Consortium |
| 2. |
RGD automated import pipeline for gene-chemical interactions |
| 3. |
Yamazaki K, etal., Lab Invest. 2009 Apr;89(4):425-32. Epub 2009 Feb 2. |
References - uncurated| PubMed | 11557983 |
| 11950878 | |
| 12477932 | |
| 12665801 | |
| 1406678 | |
| 14702039 | |
| 15311924 | |
| 15489334 | |
| 16289162 | |
| 16341674 | |
| 16710414 | |
| 16807684 | |
| 17900295 | |
| 18671965 | |
| 18716285 | |
| 20416077 | |
| 20471030 | |
| 21139048 | |
| 21800051 | |
| 21890473 | |
| 22586326 | |
| 22863883 | |
| 22939629 | |
| 22990118 | |
| 23182705 | |
| 7962207 | |
| 8125298 | |
| 8761950 |
RGD Disease Portals| CAP1 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| CAP1 (Homo sapiens) |
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| Cap1 (Mus musculus) |
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| Cap1 (Rattus norvegicus) |
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Position Markers| D1S2572 |
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| RH118585 |
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| G16306 |
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| WI-12268 |
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| SHGC-74659 |
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| D1S1857E |
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| RH69007 |
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QTLs in Region (Human Genome Assembly GRCh37)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001105530 | (Get FASTA) | Search GEO for Microarray Profiles |
| NM_006367 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | ABBA01023190 | (Get FASTA) | Search GEO for Microarray Profiles |
| AK096193 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK222513 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK295396 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK297829 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK298094 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK298110 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK300861 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK315731 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AL512599 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AMYH01000531 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC013963 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC020367 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC095440 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BI460362 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BM772471 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BP391532 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BT007152 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH471059 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CR457409 | (Get FASTA) | Search GEO for Microarray Profiles | |
| L12168 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M98474 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_006367 | |||||||||||||||||||||||||
| RefSeq Status: | REVIEWED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_006358 | |||||||||||||||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_001105530 | |||||||||||||||||||||||||
| RefSeq Status: | REVIEWED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_001099000 | |||||||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001099000 | (Get FASTA) |
| NP_006358 | (Get FASTA) | |
| GenBank Protein | AAA35507 | (Get FASTA) |
| AAA35648 | (Get FASTA) | |
| AAH13963 | (Get FASTA) | |
| AAH95440 | (Get FASTA) | |
| AAP35816 | (Get FASTA) | |
| ABM81586 | (Get FASTA) | |
| ABM84766 | (Get FASTA) | |
| BAD96233 | (Get FASTA) | |
| BAG38086 | (Get FASTA) | |
| BAG58350 | (Get FASTA) | |
| BAG60165 | (Get FASTA) | |
| BAG60379 | (Get FASTA) | |
| BAG60395 | (Get FASTA) | |
| BAG62510 | (Get FASTA) | |
| CAG33690 | (Get FASTA) | |
| EAX07239 | (Get FASTA) | |
| EAX07240 | (Get FASTA) | |
| EAX07241 | (Get FASTA) | |
| EAX07242 | (Get FASTA) | |
| EAX07243 | (Get FASTA) | |
| EAX07244 | (Get FASTA) | |
| EAX07245 | (Get FASTA) | |
| Q01518 | (Get FASTA) |
Promoters| RGD ID: | 6854260 | ||||||||||
| Promoter ID: | EPDNEW_H295 | ||||||||||
| Type: | initiation region | ||||||||||
| Name: | ATP13A2_1 | ||||||||||
| Description: | ATPase type 13A2 | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||||
| Position: |
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| RGD ID: | 6785225 | ||||||||||
| Promoter ID: | HG_KWN:2185 | ||||||||||
| Type: | CpG-Island | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | CD4+TCell, CD4+TCell_12Hour, CD4+TCell_2Hour, HeLa_S3, Jurkat, K562, Lymphoblastoid, NB4 | ||||||||||
| Transcripts: | ENST00000372794, ENST00000372797, ENST00000372798, ENST00000372802, ENST00000372805, ENST00000401065, NM_006367, OTTHUMT00000013115, OTTHUMT00000013116, OTTHUMT00000013117, OTTHUMT00000013118, OTTHUMT00000013119, OTTHUMT00000013120, OTTHUMT00000013121, OTTHUMT00000013122, OTTHUMT00000013123, OTTHUMT00000013124, UC001CEZ.2, UC009VVZ.1 | ||||||||||
| Position: |
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| RGD ID: | 6809521 | ||||||||||
| Promoter ID: | HG_ACW:1688 | ||||||||||
| Type: | Non-CpG | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | CD4+TCell_12Hour, Lymphoblastoid | ||||||||||
| Transcripts: | CAP1.JAPR07, CAP1.RAPR07 | ||||||||||
| Position: |
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| RGD ID: | 6814449 | ||||||||||
| Promoter ID: | HG_XEF:182 | ||||||||||
| Type: | Non-CpG | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | Lymphoblastoid | ||||||||||
| Transcripts: | NM_001001239, NM_001085907, NM_001089170 | ||||||||||
| Position: |
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| RGD ID: | 6784840 | ||||||||||
| Promoter ID: | HG_KWN:2186 | ||||||||||
| Type: | Non-CpG | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | K562, Lymphoblastoid | ||||||||||
| Transcripts: | OTTHUMT00000013106 | ||||||||||
| Position: |
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| RGD ID: | 6784841 | ||||||||||
| Promoter ID: | HG_KWN:2188 | ||||||||||
| Type: | Non-CpG | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | Lymphoblastoid | ||||||||||
| Transcripts: | OTTHUMT00000013108 | ||||||||||
| Position: |
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External Database Links| Database | Acc Id | Source(s) |
| COSMIC | CAP1 | COSMIC |
| Ensembl Genes | ENSG00000131236 | ENTREZGENE |
| Ensembl Protein | ENSP00000344832 | ENTREZGENE |
| ENSP00000361883 | ENTREZGENE | |
| Ensembl Transcript | ENST00000340450 | ENTREZGENE |
| ENST00000372797 | ENTREZGENE | |
| Entrez Gene | 10487 | ENTREZGENE |
| Gene3D-CATH | CAP/MinC_C | UniProtKB/Swiss-Prot |
| Germonline | ENSG00000131236 | |
| HGNC ID | 20040 | ENTREZGENE |
| HomoloGene Group ID | 74572 | ENTREZGENE |
| HPRD ID | 09869 | ENTREZGENE |
| InterPro | Adenylate_cyclase-assoc_CAP | UniProtKB/Swiss-Prot |
| Adenylate_cyclase-assoc_CAP_C | UniProtKB/Swiss-Prot | |
| Adenylate_cyclase-assoc_CAP_N | UniProtKB/Swiss-Prot | |
| C-CAP_CF_C-like | UniProtKB/Swiss-Prot | |
| CAP/MinC_C | UniProtKB/Swiss-Prot | |
| CAP_CS | UniProtKB/Swiss-Prot | |
| CARP_motif | UniProtKB/Swiss-Prot | |
| IPI | IPI00008274 | UniProtKB/Swiss-Prot |
| IPI00514858 | UniProtKB/TrEMBL | |
| IPI00639931 | UniProtKB/Swiss-Prot | |
| IPI00641881 | UniProtKB/TrEMBL | |
| IPI00642414 | UniProtKB/TrEMBL | |
| IPI00644109 | UniProtKB/TrEMBL | |
| IPI00644589 | UniProtKB/TrEMBL | |
| IPI00645789 | UniProtKB/TrEMBL | |
| IPI00646269 | UniProtKB/TrEMBL | |
| IPI00646869 | UniProtKB/TrEMBL | |
| IPI00647351 | UniProtKB/TrEMBL | |
| IPI00939159 | UniProtKB/TrEMBL | |
| KEGG Report | hsa:10487 | ENTREZGENE, UniProtKB/Swiss-Prot |
| OMIM | 614849 | OMIM |
| PANTHER | CAP | UniProtKB/Swiss-Prot |
| Pfam | CAP_C | UniProtKB/Swiss-Prot |
| CAP_N | UniProtKB/Swiss-Prot | |
| PharmGKB | PA399 | PharmGKB |
| PROSITE | C_CAP_COFACTOR_C | UniProtKB/Swiss-Prot |
| CAP_1 | UniProtKB/Swiss-Prot | |
| CAP_2 | UniProtKB/Swiss-Prot | |
| SMART | CARP | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | Adenylate_cyclase-assoc_CAP_N | UniProtKB/Swiss-Prot |
| CARP | UniProtKB/Swiss-Prot | |
| UniGene | Hs.370581 | ENTREZGENE |
| Hs.713078 | ENTREZGENE | |
| UniProt | CAP1_HUMAN | UniProtKB/Swiss-Prot |
| D3DPU2_HUMAN | UniProtKB/TrEMBL | |
| Q5T0R1_HUMAN | UniProtKB/TrEMBL | |
| Q5T0R2_HUMAN | UniProtKB/TrEMBL | |
| Q5T0R3_HUMAN | UniProtKB/TrEMBL | |
| Q5T0R4_HUMAN | UniProtKB/TrEMBL | |
| Q5T0R5_HUMAN | UniProtKB/TrEMBL | |
| Q5T0R6_HUMAN | UniProtKB/TrEMBL | |
| Q5T0R7_HUMAN | UniProtKB/TrEMBL | |
| Q5T0R8_HUMAN | UniProtKB/TrEMBL | |
| Q5T0R9_HUMAN | UniProtKB/TrEMBL | |
| Q5T0S3_HUMAN | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2011-08-23 | CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | Symbol and/or name change | 39860 | APPROVED |
| More on CAP1 | |||
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Entrez Gene | ||
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Ensembl Gene | ||
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HGNC Report | ||
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NCBI Map Viewer | ||
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Vista | ||
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Vista + UCSC | ||
| RGD Object Information | |
| RGD ID: | 1349457 |
| Created: | 2005-03-08 |
| Species: | Homo sapiens |
| Last Modified: | 2013-03-05 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




