Gene: PTPN12 (protein tyrosine phosphatase, non-receptor type 12) Homo sapiens
Symbol: PTPN12
Name: protein tyrosine phosphatase, non-receptor type 12
Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: OTTHUMP00000161275; OTTHUMP00000208615; OTTHUMP00000208616; protein-tyrosine phosphatase G1; PTP-PEST; PTPG1; tyrosine-protein phosphatase non-receptor type 12
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38777,537,160 - 77,640,071 (+)NCBIGRCh38hg38GRCh38
GRCh37777,166,773 - 77,269,388 (+)NCBIGRCh37hg19GRCh37
Build 36777,004,771 - 77,107,322 (+)NCBINCBI36hg18NCBI36
Build 34776,811,485 - 76,914,037NCBI
Celera771,867,421 - 71,970,039 (+)NCBI
Cytogenetic Map7q11.23NCBImapview
HuRef771,768,818 - 71,871,494 (+)NCBI
CHM1_1777,097,083 - 77,199,758 (+)NCBI
CRA_TCAGchr7v2776,499,836 - 76,602,451 (+)NCBI

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PTPN12
Entrez Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Map Viewer
Vista + UCSC

RGD Object Information
RGD ID: 1346224
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2016-10-11
Status: ACTIVE