Gene: PTPN12 (protein tyrosine phosphatase, non-receptor type 12) Homo sapiens
Symbol: PTPN12
Name: protein tyrosine phosphatase, non-receptor type 12
Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: OTTHUMP00000161275; OTTHUMP00000208615; OTTHUMP00000208616; protein-tyrosine phosphatase G1; PTP-PEST; PTPG1; tyrosine-protein phosphatase non-receptor type 12
Orthologs:
Latest Assembly: Human Genome Assembly GRCh37
Position:
MapChrPositionStrandSource
Human Genome Assembly GRCh38777,537,456 - 77,640,071+NCBI
Human Alternate Assembly CHM1_1777,097,083 - 77,199,758+NCBI
Human Alternate Assembly CRA_TCAGchr7v2776,499,836 - 76,602,451+NCBI
Human Genome Assembly HuRef771,768,818 - 71,871,494+NCBI
Human Genome Assembly GRCh37777,166,773 - 77,269,388+NCBI
Human Celera Assembly771,867,421 - 71,970,039+NCBI
Human Genome Assembly Build 36777,004,771 - 77,107,322+NCBI
Human Cytogenetic Map7q11.23 NCBI
Human Genome Assembly776,811,485 - 76,914,037 NCBI
Model

Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19)


References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Human Genome Assembly GRCh37)

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on PTPN12
Entrez Gene
Ensembl Gene
Genome Browser: (hg18) (hg19)
HGNC Report
NCBI Map Viewer
Vista
Vista + UCSC

RGD Object Information
RGD ID: 1346224
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2014-10-15
Status: ACTIVE