RAB5A (RAB5A, member RAS oncogene family)

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General
Array IDs

Gene: RAB5A (RAB5A, member RAS oncogene family) Homo sapiens

Symbol:

RAB5A

Name:

RAB5A, member RAS oncogene family

Description:

ENCODES a protein that exhibits GDP binding; GTP binding; GTPase activity; INVOLVED IN endocytosis; GTP catabolic process; positive regulation of exocytosis; PARTICIPATES IN platelet-derived growth factor signaling pathway; amyotrophic lateral sclerosis disease pathway; autophagy pathway; FOUND IN early endosome; INTERACTS WITH all-trans-retinoic acid; cyclosporin A; Delta(9)-tetrahydrocannabinol

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

OTTHUMP00000160334; OTTHUMP00000207855; RAB5; RAS-associated protein RAB5A; ras-related protein Rab-5A

Orthologs:

Mus musculus : Rab5a (RAB5A, member RAS oncogene family) MGI
Rattus norvegicus : Rab5a (RAB5A, member RAS oncogene family)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	3	19,924,594 - 19,962,580	+	NCBI
Human Genome Assembly HuRef	3	19,928,511 - 19,966,511	+	NCBI
Human Genome Assembly GRCh37	3	19,988,572 - 20,026,667	+	NCBI
Human Genome Assembly Build 36	3	19,963,760 - 20,001,647	+	NCBI
Human Cytogenetic Map	3	p24-p22		NCBI
Human Genome Assembly	3	19,963,762 - 20,001,647		NCBI

Model

Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19)

Annotation (Toggle Detail/Summary View)

Gene-Chemical Interaction Annotations

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine	multiple interactions	ISO		6480464	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine promotes the reaction [SNCA protein mutant form binds to RAB5A protein]	CTD	PMID:15099020
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine	multiple interactions	ISO	RGD:1558367	6480464	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine promotes the reaction [SNCA protein mutant form binds to RAB5A protein]	CTD	PMID:15099020
2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	RGD:1558367	6480464	Tetrachlorodibenzodioxin affects the expression of RAB5A mRNA	CTD	PMID:21570461
2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO		6480464	Tetrachlorodibenzodioxin affects the expression of RAB5A mRNA	CTD	PMID:21570461
2-ethoxyethanol	increases expression	ISO	RGD:2319287	6480464	2-ethoxyethanol results in increased expression of RAB5A mRNA	CTD	PMID:19643169
2-ethoxyethanol	increases expression	ISO	RGD:620936	6480464	2-ethoxyethanol results in increased expression of RAB5A mRNA	CTD	PMID:19643169
2-methoxyethanol	increases expression	ISO	RGD:2319287	6480464	methyl cellosolve results in increased expression of RAB5A mRNA	CTD	PMID:19643169
2-methoxyethanol	increases expression	ISO	RGD:620936	6480464	methyl cellosolve results in increased expression of RAB5A mRNA	CTD	PMID:19643169
3H-1,2-dithiole-3-thione	decreases expression	ISO	RGD:2319287	6480464	1,2-dithiol-3-thione results in decreased expression of RAB5A mRNA	CTD	PMID:19162173
3H-1,2-dithiole-3-thione	decreases expression	ISO	RGD:620936	6480464	1,2-dithiol-3-thione results in decreased expression of RAB5A mRNA	CTD	PMID:19162173
all-trans-retinoic acid	decreases expression	EXP		6480464	Tretinoin results in decreased expression of RAB5A mRNA	CTD	PMID:15498508
ammonium chloride	affects expression	ISO	RGD:2319287	6480464	Ammonium Chloride affects the expression of RAB5A mRNA	CTD	PMID:16483693
ammonium chloride	affects expression	ISO	RGD:620936	6480464	Ammonium Chloride affects the expression of RAB5A mRNA	CTD	PMID:16483693
benzo[a]pyrene	multiple interactions	ISO	RGD:1558367	6480464	[Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of RAB5A mRNA	CTD	PMID:21715664
cyclosporin A	increases expression	EXP		6480464	Cyclosporine results in increased expression of RAB5A mRNA	CTD	PMID:20106945
Delta(9)-tetrahydrocannabinol	increases expression	EXP		6480464	Tetrahydrocannabinol results in increased expression of RAB5A mRNA	CTD	PMID:18454173
diarsenic trioxide	increases expression	EXP		6480464	arsenic trioxide results in increased expression of RAB5A mRNA	CTD	PMID:20458559
dibutyl phthalate	increases expression	ISO	RGD:1558367	6480464	Dibutyl Phthalate results in increased expression of RAB5A mRNA	CTD	PMID:21266533
dibutyl phthalate	increases expression	ISO		6480464	Dibutyl Phthalate results in increased expression of RAB5A mRNA	CTD	PMID:21266533
paracetamol	affects expression	ISO	RGD:1558367	6480464	Acetaminophen affects the expression of RAB5A mRNA	CTD	PMID:17562736
paracetamol	affects expression	ISO		6480464	Acetaminophen affects the expression of RAB5A mRNA	CTD	PMID:17562736
perfluorooctanoic acid	increases expression	ISO	RGD:2319287	6480464	perfluorooctanoic acid results in increased expression of RAB5A mRNA	CTD	PMID:19162173
perfluorooctanoic acid	increases expression	ISO	RGD:620936	6480464	perfluorooctanoic acid results in increased expression of RAB5A mRNA	CTD	PMID:19162173
phenobarbital	affects expression	EXP		6480464	Phenobarbital affects the expression of RAB5A mRNA	CTD	PMID:19159669
pirinixic acid	increases expression	ISO	RGD:2319287	6480464	pirinixic acid results in increased expression of RAB5A mRNA	CTD	PMID:19162173
pirinixic acid	increases expression	ISO	RGD:620936	6480464	pirinixic acid results in increased expression of RAB5A mRNA	CTD	PMID:19162173
propiconazole	increases expression	ISO	RGD:1558367	6480464	propiconazole results in increased expression of RAB5A mRNA	CTD	PMID:21278054
propiconazole	increases expression	ISO		6480464	propiconazole results in increased expression of RAB5A mRNA	CTD	PMID:21278054
rotenone	multiple interactions	ISO	RGD:1558367	6480464	Rotenone promotes the reaction [SNCA protein mutant form binds to RAB5A protein]	CTD	PMID:15099020
rotenone	multiple interactions	ISO		6480464	Rotenone promotes the reaction [SNCA protein mutant form binds to RAB5A protein]	CTD	PMID:15099020
tamibarotene	affects expression	EXP		6480464	Am 80 affects the expression of RAB5A mRNA; more ...	CTD	PMID:15498508
tamoxifen	affects expression	EXP		6480464	Tamoxifen affects the expression of RAB5A mRNA	CTD	PMID:14699072
taurine	decreases expression	EXP		6480464	Taurine results in decreased expression of RAB5A mRNA	CTD	PMID:16579726

Gene Ontology Annotations

Biological Process

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
blood coagulation		TAS		2290271	Reactome:REACT_604	Reactome	Reactome:REACT_604
cell differentiation		IEA	UniProtKB-KW:KW-0221	2290271	GO_REF:0000037	UniProtKB	GO_REF:0000037
endocytosis		IDA		2290271	PMID:15378032	UniProtKB	PMID:15378032
GTP catabolic process		TAS		2290271	PMID:2501306	GOC	PMID:2501306
GTP catabolic process		IDA		2290271	PMID:15378032	GOC	PMID:15378032
nervous system development		IEA	UniProtKB-KW:KW-0524	2290271	GO_REF:0000037	UniProtKB	GO_REF:0000037
positive regulation of exocytosis		IMP		2290271	PMID:19966785	UniProtKB	PMID:19966785
protein transport		IEA	UniProtKB-KW:KW-0653	2290271	GO_REF:0000037	UniProtKB	GO_REF:0000037
protein transport		IEA	InterPro:IPR003579	2290271	GO_REF:0000002	InterPro	GO_REF:0000002
receptor internalization involved in canonical Wnt receptor signaling pathway		IMP		2290271	PMID:16890161	BHF-UCL	PMID:16890161
regulation of filopodium assembly		IDA		2290271	PMID:14978216	UniProtKB	PMID:14978216
small GTPase mediated signal transduction		IEA	InterPro:IPR001806\|InterPro:IPR003579	2290271	GO_REF:0000002	InterPro	GO_REF:0000002
small GTPase mediated signal transduction		IEA	InterPro:IPR001806	2290271	GO_REF:0000002	InterPro	GO_REF:0000002

Cellular Component

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
actin cytoskeleton		IEA	Ensembl:ENSMUSP00000017975	2290271	GO_REF:0000019	ENSEMBL	GO_REF:0000019
early endosome		IDA		2290271	PMID:15078902	MGI	PMID:15078902
early endosome		IDA		2290271	PMID:15378032	UniProtKB	PMID:15378032
early endosome membrane		IEA	UniProtKB-SubCell:SL-0093	2290271	GO_REF:0000039	UniProtKB	GO_REF:0000039
endocytic vesicle		IEA	Ensembl:ENSMUSP00000017975	2290271	GO_REF:0000019	ENSEMBL	GO_REF:0000019
endosome membrane		TAS		2290271	Reactome:REACT_24949	Reactome	Reactome:REACT_24949
melanosome		IEA	UniProtKB-SubCell:SL-0161	2290271	GO_REF:0000039	UniProtKB	GO_REF:0000039
membrane raft		IEA	Ensembl:ENSMUSP00000017975	2290271	GO_REF:0000019	ENSEMBL	GO_REF:0000019
plasma membrane		IEA	UniProtKB-SubCell:SL-0039	2290271	GO_REF:0000039	UniProtKB	GO_REF:0000039
ruffle		IEA	UniProtKB-SubCell:SL-0300	2290271	GO_REF:0000039	UniProtKB	GO_REF:0000039

Molecular Function

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
GDP binding		IDA		2290271	PMID:15378032	UniProtKB	PMID:15378032
GTP binding		IDA		2290271	PMID:15378032	UniProtKB	PMID:15378032
GTP binding		IEA	UniProtKB-KW:KW-0342	2290271	GO_REF:0000038	UniProtKB	GO_REF:0000038
GTPase activity		IDA		2290271	PMID:15378032	UniProtKB	PMID:15378032
protein binding		IPI	UniProtKB:Q15075	2290271	PMID:10491193	IntAct	PMID:10491193
protein binding		IPI	UniProtKB:Q15075	2290271	PMID:11870209	IntAct	PMID:11870209
protein binding		IPI	UniProtKB:Q8NEU8	2290271	PMID:15016378	UniProtKB	PMID:15016378
protein binding		IPI	UniProtKB:Q9UKG1	2290271	PMID:15016378	UniProtKB	PMID:15016378
protein binding		IPI	UniProtKB:P23727	2290271	PMID:15377662	IntAct	PMID:15377662
protein binding		IPI	UniProtKB:Q15276	2290271	PMID:15378032	UniProtKB	PMID:15378032
protein binding		IPI	UniProtKB:Q9H1K0	2290271	PMID:16034420	UniProtKB	PMID:16034420
protein binding		IPI	UniProtKB:Q15075	2290271	PMID:9697774	IntAct	PMID:9697774

Molecular Pathway Annotations

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
amyotrophic lateral sclerosis disease pathway		IEA	RGD:1342715	6907045		KEGG	hsa:05014
autophagy pathway		TAS		4892310		RGD
endocytosis pathway		IEA	RGD:1342715	6907045		KEGG	hsa:04144
Entamoeba histolyca infection pathway		IEA	RGD:1342715	6907045		KEGG	hsa:05146
insulin responsive facilitative sugar transporter mediated glucose transport pathway		TAS		2302395		RGD
Mycobacterium tuberculosis infection pathway		IEA	RGD:1342715	6907045		KEGG	hsa:05152
platelet-derived growth factor signaling pathway		EXP		6484113		PID	PID:200149
Rab family mediated signaling pathway		TAS		2302395		RGD
Rab family mediated signaling pathway		TAS		2306494		RGD
vasopressin signaling pathway via receptor type 2		IEA	RGD:1342715	6907045		KEGG	hsa:04962

External Database Links
KEGG Pathway	Amoebiasis
	Amyotrophic lateral sclerosis (ALS)
	Endocytosis
	Phagosome
	Tuberculosis
	Vasopressin-regulated water reabsorption
Pathway Interaction Database	ErbB1 downstream signaling (PID:200133)
	IL8- and CXCR1-mediated signaling events (PID:200199)
	IL8- and CXCR2-mediated signaling events (PID:200167)
	Internalization of ErbB1 (PID:200171)
	PDGFR-beta signaling pathway (PID:200149)
	Posttranslational regulation of adherens junction stability and dissassembly (PID:200117)
	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) (PID:200041)
	Signaling mediated by p38-alpha and p38-beta (PID:200180)

Gene-Chemical Interaction Annotations

	1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (ISO)
	2,3,7,8-tetrachlorodibenzodioxine (ISO)
	2-ethoxyethanol (ISO)
	2-methoxyethanol (ISO)
	3H-1,2-dithiole-3-thione (ISO)
	all-trans-retinoic acid (EXP)
	ammonium chloride (ISO)
	benzo[a]pyrene (ISO)

	cyclosporin A (EXP)
	Delta(9)-tetrahydrocannabinol (EXP)
	diarsenic trioxide (EXP)
	dibutyl phthalate (ISO)
	paracetamol (ISO)
	perfluorooctanoic acid (ISO)
	phenobarbital (EXP)
	pirinixic acid (ISO)

	propiconazole (ISO)
	rotenone (ISO)
	tamibarotene (EXP)
	tamoxifen (EXP)
	taurine (EXP)

Gene Ontology Annotations

Biological Process

	blood coagulation (TAS)
	cell differentiation (IEA)
	endocytosis (IDA)
	GTP catabolic process (IDA,TAS)
	nervous system development (IEA)
	positive regulation of exocytosis (IMP)

	protein transport (IEA)
	receptor internalization involved in canonical Wnt receptor signaling pathway (IMP)
	regulation of filopodium assembly (IDA)
	small GTPase mediated signal transduction (IEA)

Cellular Component

	actin cytoskeleton (IEA)
	early endosome (IDA)
	early endosome membrane (IEA)
	endocytic vesicle (IEA)

	endosome membrane (TAS)
	melanosome (IEA)
	membrane raft (IEA)
	plasma membrane (IEA)

ruffle (IEA)

Molecular Function

	GDP binding (IDA)
	GTP binding (IDA,IEA)

	GTPase activity (IDA)
	protein binding (IPI)

Molecular Pathway Annotations

	amyotrophic lateral sclerosis disease pathway (IEA)
	autophagy pathway (TAS)
	endocytosis pathway (IEA)
	Entamoeba histolyca infection pathway (IEA)
	insulin responsive facilitative sugar transporter mediated glucose transport pathway (TAS)

	Mycobacterium tuberculosis infection pathway (IEA)
	platelet-derived growth factor signaling pathway (EXP)
	Rab family mediated signaling pathway (TAS)
	vasopressin signaling pathway via receptor type 2 (IEA)

External Database Links
KEGG Pathway	Amoebiasis
	Amyotrophic lateral sclerosis (ALS)
	Endocytosis
	Phagosome
	Tuberculosis
	Vasopressin-regulated water reabsorption
Pathway Interaction Database	ErbB1 downstream signaling (PID:200133)
	IL8- and CXCR1-mediated signaling events (PID:200199)
	IL8- and CXCR2-mediated signaling events (PID:200167)
	Internalization of ErbB1 (PID:200171)
	PDGFR-beta signaling pathway (PID:200149)
	Posttranslational regulation of adherens junction stability and dissassembly (PID:200117)
	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) (PID:200041)
	Signaling mediated by p38-alpha and p38-beta (PID:200180)

References - curated

1.	GOA_HUMAN data from the GO Consortium
2.	Kaddai V, etal., Acta Physiol (Oxf). 2008 Jan;192(1):75-88.
3.	Mehrpour M, etal., Cell Res. 2010 Jul;20(7):748-62. Epub 2010 Jun 15.
4.	Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology
5.	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
6.	RGD automated import pipeline for gene-chemical interactions
7.	Watson RT and Pessin JE, Cell Signal. 2007 Nov;19(11):2209-17. Epub 2007 Jun 21.

References - uncurated

PubMed	10329441
	10491193
	10512627
	10720461
	10722846
	10818110
	11062261
	11076863
	11099046
	11493665
	11536198
	11682489
	11703925
	11718716
	11733506
	11788822
	11792815
	11884531
	12034881
	12147258
	12359748
	12432064
	12433916
	12477932
	12612085
	12668728
	12761223
	12832475
	12972505
	14600265
	14613930
	14617813
	14644159
	14665628
	14669515
	14978216
	15014045
	15016378
	15023538
	15078902
	1516130
	15207266
	15328530
	15377662
	15378032
	15388334
	15489334
	15489336
	15782196
	16034420
	16354686
	16381901
	16554017
	16622416
	16754960
	16890161
	16902405
	16923123
	17081065
	17173037
	17301141
	17301152
	17353931
	17403676
	17473071
	17524504
	17581628
	17611268
	18005733
	18725540
	18755741
	18781797
	18957427
	18974049
	18982021
	19032933
	19118546
	19126785
	19322201
	19372461
	19398555
	19460345
	19620308
	19656886
	19723633
	19759177
	19819222
	19830447
	19913121
	19923319
	19966785
	1999336
	20376209
	20412119
	20457610
	20472552
	20558162
	20628086
	20847427
	20926780
	21104291
	21139048
	21203429
	21423773
	21500550
	21640764
	21655223
	21669283
	21835792
	21849022
	21895870
	21987812
	22178872
	22341461
	22505724
	22547071
	22558309
	22768177
	22833562
	22939629
	22942286
	23048039
	2501306
	7991565
	8294464
	8521472
	8831575
	9045618
	9524117
	9697774
	9730828

RGD Disease Portals

RAB5A has been annotated in the following RGD Disease Portals.

Cancer Pathways

Biological Process

Cardiovascular Pathways

Diabetes Pathways

Immune and Inflammatory Pathways

Neurological Pathways

Obesity Pathways

Respiratory Pathways

Genomics

Comparative Map Data

RAB5A (Homo sapiens)

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	3	19,924,594 - 19,962,580	+	NCBI
Human Genome Assembly HuRef	3	19,928,511 - 19,966,511	+	NCBI
Human Genome Assembly GRCh37	3	19,988,572 - 20,026,667	+	NCBI
Human Genome Assembly Build 36	3	19,963,760 - 20,001,647	+	NCBI
Human Cytogenetic Map	3	p24-p22		NCBI
Human Genome Assembly	3	19,963,762 - 20,001,647		NCBI

Rab5a (Mus musculus)

Map	Chr	Position	Strand	Source
Mouse Genome Assembly GRCm38	17	53,479,234 - 53,507,678	+	NCBI
Mouse cM Map	17	27.82		NCBI
Mouse Celera Assembly	17	56,925,059 - 56,953,192	+	NCBI
Mouse Genome Assembly Build 37	17	53,618,559 - 53,647,003	+	NCBI
Mouse Genome Assembly Build 36.1	17	53,618,559 - 53,647,003	+	NCBI
Mouse Cytogenetic Map	17	C		NCBI

Rab5a (Rattus norvegicus)

Map	Chr	Position	Strand	Source
Rat Cytogenetic Map	9	q11		NCBI
RGSC Genome Assembly v5.0	9	5,572 - 5,722	-	NCBI
RGSC Genome Assembly v3.4	9	1,492,864 - 1,516,405	-	NCBI
Genome Assembly 3.1	9	1,492,865 - 1,516,405	-	NCBI

Position Markers

RH91784

Map	Chr	Position	Source
Human GeneMap99-GB4 RH Map	3	73.61	UniSTS
Human Genome Assembly HuRef	3	19,966,277 - 19,966,459	UniSTS
Human Genome Assembly GRCh37	3	20,026,433 - 20,026,615	UniSTS
Human Celera Assembly	3	19,966,965 - 19,967,147	RGD
Human Genome Assembly Build 36	3	20,001,437 - 20,001,619	RGD
Human Cytogenetic Map	3	p24.3	UniSTS
Human Cytogenetic Map	3	p24-p22	UniSTS

D3S2948E

Map	Chr	Position	Source
Human Genome Assembly HuRef	3	19,965,374 - 19,965,493	UniSTS
Human Genome Assembly GRCh37	3	20,025,531 - 20,025,650	UniSTS
Human Celera Assembly	3	19,966,062 - 19,966,181	RGD
Human Genome Assembly Build 36	3	20,000,535 - 20,000,654	RGD
Human Cytogenetic Map	3	p24.3	UniSTS
Human Cytogenetic Map	3	p24-p22	UniSTS

D3S3483E

Map	Chr	Position	Source
Human Genome Assembly HuRef	3	19,965,590 - 19,965,709	UniSTS
Human Genome Assembly GRCh37	3	20,025,746 - 20,025,865	UniSTS
Human Celera Assembly	3	19,966,278 - 19,966,397	RGD
Human Genome Assembly Build 36	3	20,000,750 - 20,000,869	RGD
Human Cytogenetic Map	3	p24.3	UniSTS
Human Cytogenetic Map	3	p24-p22	UniSTS

RAB5A_779

Map	Chr	Position	Source
Human Genome Assembly HuRef	3	19,965,810 - 19,966,605	UniSTS
Human Genome Assembly GRCh37	3	20,025,966 - 20,026,761	UniSTS
Human Celera Assembly	3	19,966,498 - 19,967,293	RGD
Human Genome Assembly Build 36	3	20,000,970 - 20,001,765	RGD

HSC13E052

Map	Chr	Position	Source
Human Whitehead-YAC Contig Map	3		UniSTS
Human Genome Assembly HuRef	3	19,966,277 - 19,966,502	UniSTS
Human Genome Assembly GRCh37	3	20,026,433 - 20,026,658	UniSTS
Human Celera Assembly	3	19,966,965 - 19,967,190	RGD
Human Genome Assembly Build 36	3	20,001,437 - 20,001,662	RGD
Human Cytogenetic Map	3	p24.3	UniSTS
Human Cytogenetic Map	3	p24-p22	UniSTS

QTLs in Region (Human Genome Assembly GRCh37)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1559349	SCL88_H	Serum cholesterol level QTL 88 (human)	1.67	.003	Lipid level	total cholesterol	3	1	24517367	Human
1559363	SCL87_H	Serum cholesterol level QTL 87 (human)	2.47	.0004	Lipid level	LDL cholesterol	3	1	24517367	Human
1300011	BW24_H	Body weight QTL 24 (human)	2.03		Body weight	body mass index	3	1	25098826	Human
1298439	BP30_H	Blood pressure QTL 30 (human)	2.03		Blood pressure	systolic	3	1	32165375	Human
1643372	BW336_H	Body weight QTL 336 (human)	2.2		Body fat amount	percent body fat	3	172530	26172530	Human
2289256	BW95_H	Body weight QTL 95 (human)	1.61	.0032	Body fat amount	percent fat	3	704334	26704334	Human
1643090	BW152_H	Body weight QTL 152 (human)		.0112	Body fat amount	percent body fat	3	2819327	28819327	Human
1298511	RA3_H	Rheumatoid arthritis QTL 3 (human)		.0139	Joint/bone inflammation	rheumatoid arthritis	3	8949604	34949604	Human
1643540	GLUCO17_H	Glucose level QTL 17 (human)		.007	Glucose level	non-insulin-dependent	3	8949604	34949604	Human
1559370	BW78_H	Body weight QTL 78 (human)	1.77	.0065	Body weight	body mass index	3	10668524	32165375	Human
1357318	AASTH43_H	Allergic/atopic asthma related QTL 43 (human)		.001	Reversible airflow obstruction		3	19165307	45165307	Human
1643472	SLIPL8_H	Serum lipid level QTL 8 (human)	2.02	.001	Lipid level		3	19165307	45165307	Human
2289188	BW349_H	Body weight QTL 349 (human)		.0015	Body fat amount	percent fat	3	19165307	45165307	Human
2289205	BW370_H	Body weight QTL 370 (human)	1.9		Body fat amount	percent fat	3	19165307	45165307	Human
2292867	PRSTS92_H	Prostate tumor susceptibility QTL 92 (human)			Prostate tumor susceptibility		3	19165307	45165307	Human

Sequence

Nucleotide Sequences

Nucleotide RefSeqs	NM_004162	(Get FASTA)	Search GEO for Microarray Profiles
GenBank Nucleotide	ABBA01025093	(Get FASTA)	Search GEO for Microarray Profiles
	ABBA01025094	(Get FASTA)	Search GEO for Microarray Profiles
	AC097635	(Get FASTA)	Search GEO for Microarray Profiles
	AF464088	(Get FASTA)	Search GEO for Microarray Profiles
	AF498936	(Get FASTA)	Search GEO for Microarray Profiles
	AK295992	(Get FASTA)	Search GEO for Microarray Profiles
	AK309287	(Get FASTA)	Search GEO for Microarray Profiles
	AK312618	(Get FASTA)	Search GEO for Microarray Profiles
	AMYH01013012	(Get FASTA)	Search GEO for Microarray Profiles
	BC001267	(Get FASTA)	Search GEO for Microarray Profiles
	BC018288	(Get FASTA)	Search GEO for Microarray Profiles
	BJ991078	(Get FASTA)	Search GEO for Microarray Profiles
	CH471055	(Get FASTA)	Search GEO for Microarray Profiles
	CR536492	(Get FASTA)	Search GEO for Microarray Profiles
	DC330362	(Get FASTA)	Search GEO for Microarray Profiles
	M28215	(Get FASTA)	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

NM_004162

RefSeq Status:

VALIDATED

Type:

CODING

Protein Acc Id:

NP_004153

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	3	19,924,594 - 19,962,580	+	NCBI
Human Genome Assembly HuRef	3	19,928,511 - 19,966,511	+	ENTREZGENE
Human Genome Assembly GRCh37	3	19,988,572 - 20,026,667	+	ENTREZGENE
Human Genome Assembly Build 36	3	19,963,760 - 20,001,647	+	NCBI Archive

Protein Sequences

Protein RefSeqs	NP_004153	(Get FASTA)
GenBank Protein	AAA60245	(Get FASTA)
	AAH01267	(Get FASTA)
	AAH18288	(Get FASTA)
	AAM21084	(Get FASTA)
	AAO15677	(Get FASTA)
	ABM82716	(Get FASTA)
	ABM85898	(Get FASTA)
	BAG35504	(Get FASTA)
	BAG58767	(Get FASTA)
	CAG38731	(Get FASTA)
	CAL37675	(Get FASTA)
	CAL37879	(Get FASTA)
	EAW64301	(Get FASTA)
	EAW64302	(Get FASTA)
	EAW64303	(Get FASTA)
	P20339	(Get FASTA)

Promoters

RGD ID:

6801138

Promoter ID:

HG_KWN:44020

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

CD4+TCell, CD4+TCell_12Hour, CD4+TCell_2Hour, HeLa_S3, K562, Lymphoblastoid, NB4

Transcripts:

OTTHUMT00000252137, OTTHUMT00000339744, OTTHUMT00000339745, OTTHUMT00000339746, OTTHUMT00000339747, OTTHUMT00000339748, OTTHUMT00000339749, OTTHUMT00000339753, UC003CBM.1, UC010HEY.1

Position:

Map	Chr	Position	Strand	Source
Human Genome Assembly Build 36	3	19,962,701 - 19,964,537	+	MPROMDB

RGD ID:

6851550

Promoter ID:

EP73576

Type:

initiation region

Name:

HS_RAB5A

Description:

RAB5A, member RAS oncogene family.

SO ACC ID:

SO:0000170

Source:

EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

NEDO full length human cDNA sequencing project.; Oligo-capping

Position:

Map	Chr	Position	Strand	Source
Human Genome Assembly Build 36	3	19,963,868 - 19,963,928		EPD

RGD ID:

6863004

Promoter ID:

EPDNEW_H4667

Type:

initiation region

Name:

RAB5A_1

Description:

RAB5A, member RAS oncogene family

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Position:

Map	Chr	Position	Strand	Source
Human Genome Assembly Build 36	3	19,988,740 - 19,988,800		EPDNEW

RGD ID:

6863006

Promoter ID:

EPDNEW_H4668

Type:

initiation region

Name:

RAB5A_2

Description:

RAB5A, member RAS oncogene family

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Position:

Map	Chr	Position	Strand	Source
Human Genome Assembly Build 36	3	19,988,869 - 19,988,929		EPDNEW

RGD ID:

6863008

Promoter ID:

EPDNEW_H4669

Type:

initiation region

Name:

RAB5A_3

Description:

RAB5A, member RAS oncogene family

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Position:

Map	Chr	Position	Strand	Source
Human Genome Assembly Build 36	3	19,992,532 - 19,992,592		EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
COSMIC	RAB5A	COSMIC
Ensembl Genes	ENSG00000144566	ENTREZGENE
Ensembl Protein	ENSP00000273047	ENTREZGENE
Ensembl Transcript	ENST00000273047	ENTREZGENE
Entrez Gene	5868	ENTREZGENE
Germonline	ENSG00000144566
HGNC ID	9783	ENTREZGENE
HPRD ID	01542	ENTREZGENE
InterPro	Small_GTP-bd_dom	UniProtKB/Swiss-Prot
	Small_GTPase	UniProtKB/Swiss-Prot
	Small_GTPase_Rab_type	UniProtKB/Swiss-Prot
IPI	IPI00023510	UniProtKB/Swiss-Prot
	IPI00797838	UniProtKB/TrEMBL
	IPI00924632	UniProtKB/TrEMBL
	IPI00927292	UniProtKB/TrEMBL
	IPI00927674	UniProtKB/TrEMBL
	IPI00927919	UniProtKB/TrEMBL
KEGG Report	hsa:5868	ENTREZGENE, UniProtKB/Swiss-Prot
OMIM	179512	OMIM
Pfam	Ras	UniProtKB/Swiss-Prot
PharmGKB	PA34143	PharmGKB
PRINTS	RASTRNSFRMNG	UniProtKB/Swiss-Prot
PROSITE	RAB	UniProtKB/Swiss-Prot
SMART	RAB	UniProtKB/Swiss-Prot
TIGRFAMs	Small_GTP	UniProtKB/Swiss-Prot
UniGene	Hs.475663	ENTREZGENE
UniProt	B4DJA5_HUMAN	UniProtKB/TrEMBL
	C9J3X8_HUMAN	UniProtKB/TrEMBL
	F8WC93_HUMAN	UniProtKB/TrEMBL
	F8WCY6_HUMAN	UniProtKB/TrEMBL
	F8WD79_HUMAN	UniProtKB/TrEMBL
	RAB5A_HUMAN	UniProtKB/Swiss-Prot

More on RAB5A

Entrez Gene

Ensembl Gene

Genome Browser:

(hg18) (hg19)

RGD Object Information
RGD ID:	1342715
Created:	2005-03-08
Species:	Homo sapiens
Last Modified:	2013-03-06
Status:	ACTIVE