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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of MSH6 mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MSH6 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MSH6 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of MSH6 mRNA | CTD | PMID:21570461 | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of MSH6 mRNA | CTD | PMID:19770486 | aflatoxin B1 | decreases expression | ISO | RGD:1321738 | 6480464 | Aflatoxin B1 results in decreased expression of MSH6 mRNA | CTD | PMID:21641981 | all-trans-retinoic acid | decreases expression | ISO | RGD:1321738 | 6480464 | Tretinoin results in decreased expression of MSH6 mRNA | CTD | PMID:21934132 | all-trans-retinoic acid | decreases expression | ISO | RGD:1321738 | 6480464 | Tretinoin results in decreased expression of MSH6 mRNA | CTD | PMID:21934132 PMID:15498508 | all-trans-retinoic acid | decreases expression | ISO | RGD:1321738 | 6480464 | Tretinoin results in decreased expression of MSH6 mRNA | CTD | PMID:15498508 PMID:21934132 | benzo[a]pyrene | multiple interactions | EXP | | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in increased expression of MSH6 mRNA | CTD | PMID:21715664 | benzo[a]pyrene | decreases expression | ISO | RGD:1321738 | 6480464 | Benzo(a)pyrene results in decreased expression of MSH6 protein | CTD | PMID:23313663 | benzo[a]pyrene | decreases expression | ISO | RGD:1321738 | 6480464 | Benzo(a)pyrene results in decreased expression of MSH6 mRNA | CTD | PMID:21632981 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of MSH6 mRNA | CTD | PMID:19770486 | celastrol | decreases expression | ISO | RGD:1321738 | 6480464 | tripterine results in decreased expression of MSH6 mRNA | CTD | PMID:17010675 | copper atom | multiple interactions | ISO | RGD:1321738 | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of MSH6 mRNA | CTD | PMID:20971185 | copper(0) | multiple interactions | ISO | RGD:1321738 | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of MSH6 mRNA | CTD | PMID:20971185 | copper(2+) sulfate | decreases expression | ISO | RGD:1321738 | 6480464 | Copper Sulfate results in decreased expression of MSH6 mRNA | CTD | PMID:19549813 | coumestrol | multiple interactions | ISO | RGD:1321738 | 6480464 | [Coumestrol co-treated with resveratrol] results in increased expression of MSH6 mRNA; more ... | CTD | PMID:19167446 | coumestrol | increases expression | ISO | RGD:1321738 | 6480464 | Coumestrol results in increased expression of MSH6 mRNA | CTD | PMID:19167446 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of MSH6 mRNA | CTD | PMID:21266533 | doxorubicin | decreases expression | ISO | RGD:1321738 | 6480464 | Doxorubicin results in decreased expression of MSH6 mRNA | CTD | PMID:16404146 | gedunin | decreases expression | ISO | RGD:1321738 | 6480464 | gedunin results in decreased expression of MSH6 mRNA | CTD | PMID:17010675 | hydrogen peroxide | affects expression | ISO | RGD:1321738 | 6480464 | Hydrogen Peroxide affects the expression of MSH6 mRNA | CTD | PMID:20044591 | lycopene | increases expression | ISO | RGD:1321738 | 6480464 | lycopene results in increased expression of MSH6 mRNA | CTD | PMID:16886892 | manganese atom | decreases expression | ISO | RGD:1321738 | 6480464 | Manganese results in decreased expression of MSH6 mRNA | CTD | PMID:17175027 | manganese(0) | decreases expression | ISO | RGD:1321738 | 6480464 | Manganese results in decreased expression of MSH6 mRNA | CTD | PMID:17175027 | manganese(II) chloride | decreases expression | ISO | RGD:1321738 | 6480464 | manganese chloride results in decreased expression of MSH6 mRNA | CTD | PMID:17175027 | menadione | affects expression | ISO | RGD:1321738 | 6480464 | Vitamin K 3 affects the expression of MSH6 mRNA | CTD | PMID:20044591 | mercury atom | increases expression | ISO | RGD:1321738 | 6480464 | Mercury results in increased expression of MSH6 mRNA | CTD | PMID:19937285 | mercury(0) | increases expression | ISO | RGD:1321738 | 6480464 | Mercury results in increased expression of MSH6 mRNA | CTD | PMID:19937285 | N-ethyl-N-nitrosourea | increases mutagenesis | ISO | RGD:2322311 | 6480464 | Ethylnitrosourea results in increased mutagenesis of MSH6 gene | CTD | PMID:16495775 PMID:18417481 | N-ethyl-N-nitrosourea | increases mutagenesis | ISO | RGD:2322311 | 6480464 | Ethylnitrosourea results in increased mutagenesis of MSH6 gene | CTD | PMID:18417481 PMID:16495775 | N-ethyl-N-nitrosourea | increases mutagenesis | ISO | | 6480464 | Ethylnitrosourea results in increased mutagenesis of MSH6 gene | CTD | PMID:16495775 PMID:18417481 | N-ethyl-N-nitrosourea | increases mutagenesis | ISO | | 6480464 | Ethylnitrosourea results in increased mutagenesis of MSH6 gene | CTD | PMID:18417481 PMID:16495775 | N-methyl-N-nitrosurea | multiple interactions | ISO | RGD:1321738 | 6480464 | Methylnitrosourea promotes the reaction [MSH2 protein binds to PCNA protein binds to MSH6 protein] | CTD | PMID:16204460 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of MSH6 mRNA | CTD | PMID:17585979 | paracetamol | increases expression | ISO | RGD:1321738 | 6480464 | Acetaminophen results in increased expression of MSH6 mRNA | CTD | PMID:22230336 | phenobarbital | increases expression | EXP | | 6480464 | Phenobarbital results in increased expression of MSH6 mRNA | CTD | PMID:19270015 | phenobarbital | affects expression | ISO | RGD:1321738 | 6480464 | Phenobarbital affects the expression of MSH6 mRNA | CTD | PMID:19159669 | pirinixic acid | decreases expression | EXP | | 6480464 | pirinixic acid results in decreased expression of MSH6 mRNA | CTD | PMID:18445702 | piroxicam | decreases expression | ISO | RGD:1321738 | 6480464 | Piroxicam results in decreased expression of MSH6 mRNA | CTD | PMID:21858171 | quercetin | decreases expression | ISO | RGD:1321738 | 6480464 | Quercetin results in decreased expression of MSH6 mRNA | CTD | PMID:21632981 | resveratrol | multiple interactions | ISO | RGD:1321738 | 6480464 | [Coumestrol co-treated with resveratrol] results in increased expression of MSH6 mRNA | CTD | PMID:19167446 | resveratrol | decreases expression | ISO | RGD:1321738 | 6480464 | resveratrol results in decreased expression of MSH6 protein; more ... | CTD | PMID:18089832 | sodium dichromate | increases expression | EXP | | 6480464 | sodium bichromate results in increased expression of MSH6 mRNA | CTD | PMID:22155349 | tamibarotene | decreases expression | ISO | RGD:1321738 | 6480464 | Am 80 results in decreased expression of MSH6 mRNA; more ... | CTD | PMID:15498508 | tert-butyl hydroperoxide | decreases expression | ISO | RGD:1321738 | 6480464 | tert-Butylhydroperoxide results in decreased expression of MSH6 mRNA | CTD | PMID:15336504 | trans-resveratrol | multiple interactions | ISO | RGD:1321738 | 6480464 | [Coumestrol co-treated with resveratrol] results in increased expression of MSH6 mRNA | CTD | PMID:19167446 | trans-resveratrol | decreases expression | ISO | RGD:1321738 | 6480464 | resveratrol results in decreased expression of MSH6 protein; more ... | CTD | PMID:18089832 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Colorectal cancer |
| Mismatch repair | |
| Pathways in cancer | |
Phenotype Annotations
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Colorectal cancer |
| Mismatch repair | |
| Pathways in cancer | |
Phenotype Annotations
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References - curated| 1. |
Bansal N, etal., Cancer Control. 2009 Jan;16(1):8-13. |
| 2. |
Chintamani, etal., Int Semin Surg Oncol. 2007 Feb 14;4:5. |
| 3. |
Jacob S and Praz F, Biochimie. 2002 Jan;84(1):27-47. |
| 4. |
Karihtala P, etal., Eur J Cancer. 2006 Oct;42(15):2653-9. Epub 2006 Sep 22. |
| 5. |
Kawai J, etal., Nature 2001 Feb 8;409(6821):685-90. |
| 6. |
Ko MS, etal., Development 2000 Apr;127(8):1737-49. |
| 7. |
Li GM Cell Res. 2008 Jan;18(1):85-98. |
| 8. |
MGD data from the GO Consortium |
| 9. |
MGD IEA |
| 10. |
Mongiat-Artus P, etal., Oncogene. 2006 Mar 30;25(14):2113-8. |
| 11. |
Mylona E, etal., APMIS. 2008 Jan;116(1):59-65. |
| 12. |
Okazaki Y, etal., Nature 2002 Dec 5;420(6915):563-73. |
| 13. |
Papadopoulos N, etal., Science. 1995 Jun 30;268(5219):1915-7. |
| 14. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 15. |
Rey JM, etal., Cancer Genet Cytogenet. 2004 Dec;155(2):149-51. |
| 16. |
RGD automated import pipeline |
| 17. |
RGD automated import pipeline for gene-chemical interactions |
| 18. |
RGD Automated Pipelines |
| 19. |
Yin J, etal., Hum Mutat. 1997;10(6):474-8. |
References - uncurated| PubMed | 10349636 |
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| 10662804 | |
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| 10922068 | |
| 11042159 | |
| 11076861 | |
| 11223406 | |
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| 11809728 | |
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| 12612914 | |
| 12904583 | |
| 14610273 | |
| 14632208 | |
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| 15805259 | |
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| 16618598 | |
| 16713580 | |
| 16728433 | |
| 17015724 | |
| 17142234 | |
| 17615258 | |
| 18413732 | |
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| 18799693 | |
| 19029948 | |
| 19124772 | |
| 20362541 | |
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| 21804017 | |
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| 22289650 | |
| 22922362 | |
| 23071719 | |
| 8812455 | |
| 8870641 | |
| 9354786 | |
| 9390556 | |
| 9823302 |
RGD Disease Portals| Msh6 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Msh6 (Mus musculus) |
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| MSH6 (Homo sapiens) |
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| Msh6 (Rattus norvegicus) |
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Position Markers| AW550279 |
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| AU044881 |
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| UniSTS:237725 |
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| RH140511 |
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| RH126790 |
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| Gtmbp-rs |
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| RH127753 |
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QTLs in Region (Mouse Genome Assembly Build 37)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_010830 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AAHY01135673 | (Get FASTA) | Search GEO for Microarray Profiles |
| AC087233 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF031085 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF031086 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF031087 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK010643 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK088259 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC035274 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC051160 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC051634 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CN458717 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U41283 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U42190 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U61388 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U61389 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_010830 | |||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_034960 | |||||||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_034960 | (Get FASTA) |
| GenBank Protein | AAA83775 | (Get FASTA) |
| AAB39930 | (Get FASTA) | |
| AAB39931 | (Get FASTA) | |
| AAB88445 | (Get FASTA) | |
| AAC53034 | (Get FASTA) | |
| AAH51160 | (Get FASTA) | |
| AAH51634 | (Get FASTA) | |
| BAB27085 | (Get FASTA) | |
| BAC40242 | (Get FASTA) | |
| P54276 | (Get FASTA) |
Promoters| RGD ID: | 6828389 | ||||||||||
| Promoter ID: | MM_KWN:24410 | ||||||||||
| Type: | CpG-Island | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | 3T3L1_Day0, 3T3L1_Day2, 3T3L1_Day3, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, ES_Cell, Kidney, Liver, Lung, MEF_B4, MEF_B6, Spleen | ||||||||||
| Transcripts: | ENSMUST00000005503, XM_917266_GM6720 | ||||||||||
| Position: |
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSMUSG00000005370 | ENTREZGENE |
| Ensembl Protein | ENSMUSP00000005503 | ENTREZGENE |
| Ensembl Transcript | ENSMUST00000005503 | ENTREZGENE |
| Entrez Gene | 17688 | ENTREZGENE |
| Gene3D-CATH | DNA_mismatch_repair_MutS_N | UniProtKB/Swiss-Prot |
| Germonline | ENSMUSG00000005370 | |
| HomoloGene Group ID | 149 | ENTREZGENE |
| InterPro | DNA_mismatch_repair_Msh6 | UniProtKB/Swiss-Prot |
| DNA_mismatch_repair_MSH6_C | UniProtKB/Swiss-Prot | |
| DNA_mismatch_repair_MutS-lik_N | UniProtKB/Swiss-Prot | |
| DNA_mismatch_repair_MutS_C | UniProtKB/Swiss-Prot | |
| DNA_mismatch_repair_MutS_clamp | UniProtKB/Swiss-Prot | |
| DNA_mismatch_repair_MutS_connt | UniProtKB/Swiss-Prot | |
| DNA_mismatch_repair_MutS_core | UniProtKB/Swiss-Prot | |
| DNA_mismatch_repair_MutS_N | UniProtKB/Swiss-Prot | |
| PWWP | UniProtKB/Swiss-Prot | |
| IPI | IPI00323790 | UniProtKB/Swiss-Prot |
| KEGG Report | mmu:17688 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGD | MGI:1343961 | ENTREZGENE |
| PANTHER | MutS_Hmlg_MSH6 | UniProtKB/Swiss-Prot |
| Pfam | MutS_I | UniProtKB/Swiss-Prot |
| MutS_II | UniProtKB/Swiss-Prot | |
| MutS_III | UniProtKB/Swiss-Prot | |
| MutS_IV | UniProtKB/Swiss-Prot | |
| MutS_V | UniProtKB/Swiss-Prot | |
| PWWP | UniProtKB/Swiss-Prot | |
| PharmGKB | MSH6 | RGD |
| PIRSF | DNA_mis_repair_Msh6 | UniProtKB/Swiss-Prot |
| PROSITE | DNA_MISMATCH_REPAIR_2 | UniProtKB/Swiss-Prot |
| PWWP | UniProtKB/Swiss-Prot | |
| SMART | MUTSac | UniProtKB/Swiss-Prot |
| MUTSd | UniProtKB/Swiss-Prot | |
| PWWP | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | DNA_mismatch_repair_MutS_N | UniProtKB/Swiss-Prot |
| DNA_repair_MutS_domIII | UniProtKB/Swiss-Prot | |
| UniGene | Mm.18210 | ENTREZGENE |
| UniProt | MSH6_MOUSE | UniProtKB/Swiss-Prot |
| Q61061_MOUSE | UniProtKB/TrEMBL | |
| Q8C2N9_MOUSE | UniProtKB/TrEMBL | |
| Q9CRH0_MOUSE | UniProtKB/TrEMBL |
| More on Msh6 | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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MGI Report |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 1321739 |
| Created: | 2005-01-12 |
| Species: | Mus musculus |
| Last Modified: | 2013-02-27 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




