LIMS1 (LIM and senescent cell antigen-like domains 1)

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Keyword

Gene: LIMS1 (LIM and senescent cell antigen-like domains 1) Homo sapiens

Symbol:

LIMS1

Name:

LIM and senescent cell antigen-like domains 1

Description:

The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

LIM and senescent cell antigen-like-containing domain protein 1; OTTHUMP00000161608; OTTHUMP00000203425; OTTHUMP00000203426; OTTHUMP00000203429; OTTHUMP00000203448; particularly interesting new Cys-His protein 1; PINCH; PINCH-1; PINCH-1; PINCH1; renal carcinoma antigen NY-REN-48

Orthologs:

Mus musculus : Lims1 (LIM and senescent cell antigen-like domains 1) MGI
Rattus norvegicus : Lims1 (LIM and senescent cell antigen-like domains 1)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	2	108,854,785 - 108,953,676	+	NCBI
Human Genome Assembly HuRef	2	102,803,913 - 102,903,724	+	NCBI
Human Genome Assembly GRCh37	2	109,150,811 - 109,303,702	+	NCBI
Human Genome Assembly Build 36	2	108,571,199 - 108,667,321	+	NCBI
Human Cytogenetic Map	2	q12.3		NCBI
Human Genome Assembly	2	108,663,284 - 108,759,405		NCBI