Gene: LIMS1 (LIM and senescent cell antigen-like domains 1) Homo sapiens
Symbol: LIMS1
Name: LIM and senescent cell antigen-like domains 1
Description: The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: LIM and senescent cell antigen-like-containing domain protein 1; OTTHUMP00000161608; OTTHUMP00000203425; OTTHUMP00000203426; OTTHUMP00000203429; OTTHUMP00000203448; particularly interesting new Cys-His protein 1; PINCH; PINCH-1; PINCH1; renal carcinoma antigen NY-REN-48
Latest Assembly: Human Genome Assembly GRCh37
Human Genome Assembly GRCh382108,534,355 - 108,687,246+NCBI
Human Alternate Assembly CHM1_12109,154,977 - 109,307,968+NCBI
Human Genome Assembly HuRef2102,803,913 - 102,903,724+NCBI
Human Genome Assembly GRCh372109,150,811 - 109,303,702+NCBI
Human Celera Assembly2103,464,751 - 103,615,238+NCBI
Human Genome Assembly Build 362108,571,199 - 108,667,321+NCBI
Human Cytogenetic Map2q12.3 NCBI
Human Genome Assembly2108,663,284 - 108,759,405 NCBI

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Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Human Genome Assembly GRCh37)
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on LIMS1
Entrez Gene
Ensembl Gene
GBrowse: hg18 hg19
JBrowse: hg18 hg19
HGNC Report
NCBI Map Viewer
Vista + UCSC

RGD Object Information
RGD ID: 1313937
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2015-11-10
Status: ACTIVE