Gene: LIMS1 (LIM zinc finger domain containing 1) Homo sapiens
Symbol: LIMS1
Name: LIM zinc finger domain containing 1
Description: The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: LIM and senescent cell antigen-like domains 1; LIM and senescent cell antigen-like-containing domain protein 1; LIM-type zinc finger domains 1; OTTHUMP00000161608; OTTHUMP00000203425; OTTHUMP00000203426; OTTHUMP00000203429; OTTHUMP00000203448; particularly interesting new Cys-His protein 1; PINCH; PINCH-1; PINCH1; renal carcinoma antigen NY-REN-48; senescent cell antigen
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382108,534,355 - 108,687,246 (+)NCBIGRCh38hg38GRCh38
GRCh372109,150,811 - 109,303,702 (+)NCBIGRCh37hg19GRCh37
Build 362108,571,199 - 108,667,321 (+)NCBINCBI36hg18NCBI36
Build 342108,663,284 - 108,759,405NCBI
Celera2103,464,751 - 103,615,238 (+)NCBI
Cytogenetic Map2q12.3NCBImapview
HuRef2102,803,913 - 102,903,724 (+)NCBI
CHM1_12109,154,977 - 109,307,968 (+)NCBI

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on LIMS1
Entrez Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Map Viewer
Vista + UCSC

RGD Object Information
RGD ID: 1313937
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2016-05-10
Status: ACTIVE