Gene: UPP1 (uridine phosphorylase 1) Homo sapiens
Symbol: UPP1
Name: uridine phosphorylase 1
Description: The 2 known types of pyrimidine nucleoside phosphorylases, uridine phosphorylase (UP; EC and thymidine phosphorylase (TP; EC, in the presence of orthophosphate, catalyze the reversible phosphorolysis of uridine and thymidine or deoxyuridine, respectively, to free bases and ribose-1-phosphate or deoxyribose-1-phosphate. Pyrimidine nucleoside phosphorylases can add ribose or deoxyribose to pyrimidine bases to form nucleosides that can be incorporated into RNA or DNA (Watanabe and Uchida, 1995 [PubMed 7488099]).[supplied by OMIM, Aug 2009]
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: OTTHUMP00000159566; OTTHUMP00000208692; UDRPASE; UP; UPASE; UPase 1; UPP; urdPase 1
Latest Assembly: Human Genome Assembly GRCh37
Human Genome Assembly GRCh38748,088,603 - 48,108,733+NCBI
Human Alternate Assembly CHM1_1748,131,900 - 48,152,030+NCBI
Human Alternate Assembly CRA_TCAGchr7v2748,168,224 - 48,188,201+NCBI
Human Genome Assembly HuRef748,013,793 - 48,033,924+NCBI
Human Genome Assembly GRCh37748,128,355 - 48,148,330+NCBI
Human Celera Assembly748,227,538 - 48,247,515+NCBI
Human Genome Assembly Build 36748,094,880 - 48,114,855+NCBI
Human Cytogenetic Map7p12.3 NCBI

Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19)
Launch JBrowse : build 36 (hg18) build 37 (hg19)

Disease Annotations
Gene-Chemical Interaction Annotations
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References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Human Genome Assembly GRCh37)
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on UPP1
Entrez Gene
Ensembl Gene
GBrowse: hg18 hg19
JBrowse: hg18 hg19
HGNC Report
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Vista + UCSC

RGD Object Information
RGD ID: 1313669
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2015-07-21
Status: ACTIVE