Gene: Ctnnal1 (catenin (cadherin associated protein), alpha-like 1)
Rattus norvegicus
Symbol:
Ctnnal1
Name:
catenin (cadherin associated protein), alpha-like 1
Description:
ENCODES a protein that exhibits cadherin binding (inferred); structural molecule activity (inferred); INVOLVED IN Rho protein signal transduction (ortholog); FOUND IN cytosol (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
alpha-catulin; catenin (cadherin associated protein), alpha-like 1; catenin (cadherin associated protein), alpha-like 1 (predicted); catenin alpha-like 1; catenin alpha-like 1 (predicted); Catnal1; Catnal1_predicted; Ctnnal1_predicted; LOC298019
Orthologs:
Homo sapiens : CTNNAL1
(catenin (cadherin-associated protein), alpha-like 1)
HGNC
Ctnnal1
(catenin (cadherin associated protein), alpha-like 1)
MGI
Latest Assembly:
RGSC Genome Assembly v3.4
Position:
Map Chr Position Strand Source Rat Cytogenetic Map 5 q24 NCBI RGSC Genome Assembly v5.0 5 77,719,359 - 77,778,979 - NCBI RGSC Genome Assembly v3.4 5 74,716,087 - 74,771,424 - NCBI Rat Celera Assembly 5 70,368,361 - 70,423,528 - NCBI Genome Assembly 3.1 5 74,722,450 - 74,776,428 - NCBI
Model
Gene-Chemical Interaction Annotations
2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1553734 6480464 Tetrachlorodibenzodioxin results in increased expression of CTNNAL1 mRNA CTD PMID:21354282 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1553734 6480464 Tetrachlorodibenzodioxin affects the expression of CTNNAL1 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of CTNNAL1 mRNA CTD PMID:22298810 2,4-dinitrotoluene affects expression EXP 6480464 2,4-dinitrotoluene affects the expression of CTNNAL1 mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression EXP 6480464 2,6-dinitrotoluene affects the expression of CTNNAL1 mRNA CTD PMID:21346803 2-methoxyethanol increases expression EXP 6480464 methyl cellosolve results in increased expression of CTNNAL1 mRNA CTD PMID:21061450 aflatoxin B1 increases expression ISO RGD:1553734 6480464 Aflatoxin B1 results in increased expression of CTNNAL1 mRNA CTD PMID:19770486 aflatoxin B1 increases expression ISO RGD:1322895 6480464 Aflatoxin B1 results in increased expression of CTNNAL1 mRNA CTD PMID:22100608 all-trans-retinoic acid decreases expression ISO RGD:1322895 6480464 Tretinoin results in decreased expression of CTNNAL1 mRNA CTD PMID:15498508 carmustine increases expression ISO RGD:1322895 6480464 Carmustine results in increased expression of CTNNAL1 mRNA CTD PMID:15980968 cisplatin affects response to substance ISO RGD:1322895 6480464 CTNNAL1 protein affects the susceptibility to Cisplatin CTD PMID:16217747 copper(2+) sulfate increases expression ISO RGD:1322895 6480464 Copper Sulfate results in increased expression of CTNNAL1 mRNA CTD PMID:19549813 coumestrol multiple interactions ISO RGD:1322895 6480464 [Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of CTNNAL1 mRNA; more ... CTD PMID:19167446 coumestrol multiple interactions ISO RGD:1322895 6480464 [Coumestrol co-treated with ESR1 protein] results in increased expression of CTNNAL1 mRNA; more ... CTD PMID:18310284 coumestrol increases expression ISO RGD:1322895 6480464 Coumestrol results in increased expression of CTNNAL1 mRNA CTD PMID:19167446 cyclosporin A increases expression ISO RGD:1322895 6480464 Cyclosporine results in increased expression of CTNNAL1 mRNA CTD PMID:20106945 diarsenic trioxide increases expression ISO RGD:1322895 6480464 arsenic trioxide results in increased expression of CTNNAL1 mRNA CTD PMID:22521957 diazoxide increases expression ISO RGD:1553734 6480464 Isoproterenol results in increased expression of CTNNAL1 mRNA CTD PMID:20003209 dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of CTNNAL1 mRNA CTD PMID:21266533 dibutyl phthalate increases expression ISO RGD:1553734 6480464 Dibutyl Phthalate results in increased expression of CTNNAL1 mRNA CTD PMID:17361019 diuron decreases expression EXP 6480464 Diuron results in decreased expression of CTNNAL1 mRNA CTD PMID:21551480 isoprenaline increases expression ISO RGD:1553734 6480464 Isoproterenol results in increased expression of CTNNAL1 mRNA CTD PMID:20003209 kojic acid decreases expression ISO RGD:1322895 6480464 kojic acid results in decreased expression of CTNNAL1 mRNA CTD PMID:16595896 mifepristone increases expression ISO RGD:1322895 6480464 Mifepristone results in increased expression of CTNNAL1 mRNA CTD PMID:17584828 morphine increases expression ISO RGD:1553734 6480464 Morphine results in increased expression of CTNNAL1 mRNA CTD PMID:21178816 phenobarbital affects expression ISO RGD:1322895 6480464 Phenobarbital affects the expression of CTNNAL1 mRNA CTD PMID:19159669 pirinixic acid increases expression ISO RGD:1553734 6480464 pirinixic acid results in increased expression of CTNNAL1 mRNA CTD PMID:18301758 piroxicam decreases expression ISO RGD:1322895 6480464 Piroxicam results in decreased expression of CTNNAL1 mRNA CTD PMID:21858171 pyrogallol decreases expression ISO RGD:1553734 6480464 Pyrogallol results in decreased expression of CTNNAL1 mRNA CTD PMID:20362636 resveratrol multiple interactions ISO RGD:1322895 6480464 [Coumestrol co-treated with resveratrol] results in increased expression of CTNNAL1 mRNA CTD PMID:19167446 simvastatin decreases expression ISO RGD:1322895 6480464 Simvastatin results in decreased expression of CTNNAL1 mRNA CTD PMID:17428261 tamibarotene decreases expression ISO RGD:1322895 6480464 Am 80 results in decreased expression of CTNNAL1 mRNA; more ... CTD PMID:15498508 trans-resveratrol multiple interactions ISO RGD:1322895 6480464 [Coumestrol co-treated with resveratrol] results in increased expression of CTNNAL1 mRNA CTD PMID:19167446
Gene Ontology Annotations
Biological Process cell adhesion IEA InterPro:IPR001033|InterPro:IPR006077 1600115 GO_REF:0000002 InterPro GO_REF:0000002 Rho protein signal transduction IEA Ensembl:ENSP00000320434 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 Rho protein signal transduction ISO RGD:1322895 1624291 PMID:12270917 RGD PMID:12270917
1331756 Rf34 Renal function QTL 34 4.16275 Renal function renal blood flow 5 1 94516069 Rat 70212 Niddm25 Non-insulin dependent diabetes mellitus QTL 25 3.54 Glucose level fasting 5 1 138272129 Rat 1331771 Rf35 Renal function QTL 35 4.36965 Renal function renal blood flow 5 378448 90620456 Rat 1576314 Eutr1 Estrogen induced uterine response QTL 1 Uterine inflammation estrogen-induced 5 1220773 79863911 Rat 634305 Mamtr1 Mammary tumor resistance QTL 1 .0001 Mammary tumor resistance 7,12-dimethylbenzanthracene induced 5 12880403 119333229 Rat 2316959 Gluco59 Glucose level QTL 59 4.7 Glucose level postprandial 5 17517235 119332868 Rat 1578766 Tcas11 Tongue tumor susceptibility QTL 11 4.12 Tongue tumor susceptibility tongue tumor number 5 17517235 168005953 Rat 1358353 Srcrtb2 Stress Responsive Cort Basal QTL 2 3.48 .003 Hypothalamic-pituitary-adrenal axis corticosterone 5 19206257 77484299 Rat 1578776 Stresp18 Stress response QTL 18 2.9 Stress response thymus weight 5 30030683 75030683 Rat 6903292 Stl28 Serum triglyceride level QTL 28 2.6 .0073 Lipid level triglyceride level 5 30606308 75606308 Rat 6903306 Scl35 Serum cholesterol QTL 35 2.6 .0073 Lipid level cholesterol level 5 30606308 75606308 Rat 2290448 Scl54 Serum cholesterol level QTL 54 2.93 Lipid level cholesterol level 5 32701659 138272129 Rat 1331782 Rf36 Renal function QTL 36 3.296 Renal function renal blood flow 5 35390492 101506667 Rat 1298067 Scl15 Serum cholesterol level QTL 15 4.8 .001 Lipid level cholesterol 5 35474610 80474610 Rat 1302786 Kidm8 Kidney mass QTL 8 28.15 Kidney mass 5 35474610 80474610 Rat 1598807 Glom12 Glomerulus QTL 12 2.7 Renal pathology glomerular injury score 5 35474610 80474610 Rat 1576317 Eutr2 Estrogen induced uterine response QTL 2 .01 Uterine inflammation estrogen-induced 5 35911094 109163425 Rat 1641912 Alcrsp18 Alcohol response QTL 18 Alcohol response loss of righting reflex 5 36386126 148460381 Rat 1549845 Scl44 Serum cholesterol level QTL 44 6 Lipid level serum cholesterol, post dietary 5 41498818 155121024 Rat 1331773 Scl26 Serum cholesterol QTL 26 3.065 Lipid level cholesterol 5 45499364 90620456 Rat 1331801 Rf33 Renal function QTL 33 4.149 Renal function renal vascular resistance 5 45499364 135916908 Rat 1300115 Hrtrt7 Heart rate QTL 7 2.76 Heart rate salt-loaded 5 49767270 89261520 Rat 1576312 Emca8 Estrogen-induced mammary cancer QTL 8 4.1 Mammary tumor susceptibility estradiol-induced 5 52434178 148460381 Rat 2303615 Vencon7 Ventilatory control QTL 7 .001 Ventilatory control re-oxygenation after hypoxia 5 54207464 99207464 Rat 2303574 Gluco42 Glucose level QTL 42 2 Glucose level fasting 5 57040762 102040762 Rat 61359 Eaex Experimental allergic encephalomyelitis QTL x 3 Brain/spinal cord inflammation onset of disease 5 57974567 102974567 Rat 70189 Mcs5 Mammary carcinoma susceptibility QTL 5 10.51 Mammary tumor susceptibility 5 58063971 139156771 Rat 1358895 Bp254 Blood pressure QTL 254 3.6 .0003 Blood pressure mean arterial 5 61080077 134872385 Rat 61426 Scl2 Serum cholesterol level QTL 2 7.3 .001 Lipid level cholesterol 5 62098646 149757440 Rat 2316954 Rf57 Renal function QTL 57 0 Renal function structural damage of the kidney 5 62098775 94515803 Rat 2316957 Pur21 Proteinuria QTL 21 6.2 Renal function urine protein level 5 62098775 119332868 Rat 61386 Bp49 Blood pressure QTL 49 16.6 Blood pressure 5 62555131 103059258 Rat 61393 Bp7 Blood pressure QTL 7 4.5 .0001 Blood pressure salt-loaded systolic 5 62555131 168174140 Rat 2306971 Anxrr21 Anxiety related response QTL 21 9.47 Anxiety response 5 68843563 130756605 Rat 2290005 Mcs24 Mammary carcinoma susceptibility QTL 24 Mammary tumor susceptibility 5 70181758 115181758 Rat 61380 Edpm5 Estrogen-dependent pituitary mass QTL 5 4.5 .92 Gland mass pituitary 5 71814715 109163425 Rat 1357396 Bw44 Body weight QTL 44 4.19 Body weight 5 71814715 109163425 Rat 1357402 Bw46 Body weight QTL 46 4.47 Body weight body mass index 5 71814715 109163425 Rat 2312671 Scl64 Serum cholesterol level QTL 64 .001 Lipid level serum cholesterol 5 71814715 109163425 Rat 2302381 Bw84 Body weight QTL 84 4.47 Body weight BMI 5 71814715 109163425 Rat 1354598 Srn6 Serum renin concentration QTL 6 3.8 Renin concentration serum 5 71971592 157597184 Rat
Gene Ontology Annotations
