GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2866
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ifng
Name: interferon gamma
Acc ID: CHEBI:9150
Term: simvastatin
Definition: A carbobicyclic compound that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
Definition Source(s): Beilstein:4768037, ChemIDplus:79902-63-9, CiteXplore:11336576, CiteXplore:12827636, CiteXplore:14561068, CiteXplore:14691614, CiteXplore:14973129, CiteXplore:16116309, CiteXplore:16144183, CiteXplore:16433891, CiteXplore:16442367, CiteXplore:16634254, CiteXplore:16651050, CiteXplore:16864763, CiteXplore:17640385, CiteXplore:18199328, CiteXplore:18688862, CiteXplore:18936176, DrugBank:DB00641, HMDB:HMDB05007, KEGG DRUG:79902-63-9, KEGG DRUG:D00434, Patent:EP33538, Patent:US4444784, PDBeChem:SIM, Wikipedia:Simvastatin
Chemical ID: MESH:D019821
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:7374876480464CTDSimvastatin results in increased expression of IFNG mRNA

PMID:18453621
increases secretionISORGD:7374876480464CTDSimvastatin results in increased secretion of IFNG protein

PMID:18453621
multiple interactionsISORGD:7374876480464CTDIFNG affects the reaction [Simvastatin results in decreased expression of IL17A mRNA]

IFNG affects the reaction [Simvastatin results in decreased expression of RORC mRNA]

IFNG affects the reaction [Simvastatin results in decreased secretion of IL17A protein]

PMID:18453621
multiple interactionsISORGD:7374876480464CTDMevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL3 mRNA]]

Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL2 mRNA]]

Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL4 mRNA]]

Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR2 mRNA]]

Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR1 mRNA]]

Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR5 mRNA]]

Simvastatin inhibits the reaction [IFNG results in increased expression of CCR4 mRNA]

Simvastatin inhibits the reaction [IFNG results in increased secretion of CCL2 protein]

Simvastatin inhibits the reaction [IFNG results in increased secretion of CCL4 mRNA]

Simvastatin inhibits the reaction [IFNG results in increased secretion of CCL3 mRNA]

PMID:16321392
multiple interactionsISORGD:7374876480464CTDMevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of HLA-DRA protein]]

Simvastatin inhibits the reaction [IFNG results in increased expression of CIITA protein]

Simvastatin inhibits the reaction [IFNG results in increased expression of HLA-DRA mRNA]

PMID:11219190
multiple interactionsISORGD:7374876480464CTDMevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFRSF4 mRNA]]

Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFRSF4 protein]]

Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 protein]]

Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 mRNA]]

PMID:19589242
multiple interactionsISORGD:7374876480464CTDSimvastatin inhibits the reaction [IFNG results in increased expression of CCL2 mRNA]

PMID:16321392, PMID:21268089
multiple interactionsISORGD:7374876480464CTDSimvastatin inhibits the reaction [IFNG results in increased expression of PTGS2]

PMID:19886038
multiple interactionsISORGD:7374876480464CTDSimvastatin inhibits the reaction [IFNG results in increased expression of STAT1 mRNA]

PMID:21268089
multiple interactionsISORGD:7374886480464CTDgeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 protein]]

Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA]]

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA]]

Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 protein]]

Simvastatin inhibits the reaction [IFNG promotes the reaction [STAT1 binds to CD40 promoter]]

Simvastatin inhibits the reaction [IFNG results in increased expression of IRF1 mRNA]

Simvastatin inhibits the reaction [IFNG results in increased phosphorylation of STAT1 protein]

Simvastatin promotes the reaction [IFNG promotes the reaction [RELA binds to CD40 promoter]]

PMID:17507688
multiple interactionsISORGD:7374886480464CTDSimvastatin promotes the reaction [IFNG results in increased expression of PTGS2]

PMID:19886038
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