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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2866 Species: Rattus norvegicus RGD Object: Gene Symbol: Ifng Name: interferon gamma

Acc ID: CHEBI:9150 Term: simvastatin Definition: A fatty acid ester comprising a dihydroxyheptanoic acid unit condensed into a lactone; a partially reduced naphthalene structure; and a 2,2-dimethylbutyric acyl substituent at C17. It is used as a cholesterol-lowering and anti-cardiovascular disease drug. CasRN: 79902-63-9 Chemical ID: MESH:D019821

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:737487	6480464	CTD	IFNG affects the reaction [Simvastatin results in decreased expression of IL17A mRNA] IFNG affects the reaction [Simvastatin results in decreased expression of RORC mRNA] IFNG affects the reaction [Simvastatin results in decreased secretion of IL17A protein]	PMID:18453621
multiple interactions	ISO	RGD:737487	6480464	CTD	Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL3 mRNA]] Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL2 mRNA]] Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL4 mRNA]] Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR2 mRNA]] Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR1 mRNA]] Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR5 mRNA]] Simvastatin inhibits the reaction [IFNG results in increased expression of CCR4 mRNA] Simvastatin inhibits the reaction [IFNG results in increased secretion of CCL2 protein] Simvastatin inhibits the reaction [IFNG results in increased secretion of CCL4 mRNA] Simvastatin inhibits the reaction [IFNG results in increased secretion of CCL3 mRNA]	PMID:16321392
multiple interactions	ISO	RGD:737487	6480464	CTD	Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of HLA-DRA protein]] Simvastatin inhibits the reaction [IFNG results in increased expression of CIITA protein] Simvastatin inhibits the reaction [IFNG results in increased expression of HLA-DRA mRNA]	PMID:11219190
multiple interactions	ISO	RGD:737487	6480464	CTD	Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFRSF4 mRNA]] Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFRSF4 protein]] Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 protein]] Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 mRNA]]	PMID:19589242
multiple interactions	ISO	RGD:737487	6480464	CTD	Simvastatin inhibits the reaction [IFNG results in increased expression of CCL2 mRNA]	PMID:16321392 PMID:21268089
multiple interactions	ISO	RGD:737487	6480464	CTD	Simvastatin inhibits the reaction [IFNG results in increased expression of PTGS2]	PMID:19886038
multiple interactions	ISO	RGD:737487	6480464	CTD	Simvastatin inhibits the reaction [IFNG results in increased expression of STAT1 mRNA]	PMID:21268089
increases expression	ISO	RGD:737487	6480464	CTD	Simvastatin results in increased expression of IFNG mRNA	PMID:18453621
increases secretion	ISO	RGD:737487	6480464	CTD	Simvastatin results in increased secretion of IFNG protein	PMID:18453621
multiple interactions	ISO	RGD:737488	6480464	CTD	geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 protein]] Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA]] geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA]] Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 protein]] Simvastatin inhibits the reaction [IFNG promotes the reaction [STAT1 binds to CD40 promoter]] Simvastatin inhibits the reaction [IFNG results in increased expression of IRF1 mRNA] Simvastatin inhibits the reaction [IFNG results in increased phosphorylation of STAT1 protein] Simvastatin promotes the reaction [IFNG promotes the reaction [RELA binds to CD40 promoter]]	PMID:17507688
multiple interactions	ISO	RGD:737488	6480464	CTD	Simvastatin promotes the reaction [IFNG results in increased expression of PTGS2]	PMID:19886038
multiple interactions	ISO	RGD:737487	6480464	CTD	Simvastatin inhibits the reaction [IFNG results in increased expression of CCL2 mRNA]	PMID:21268089 PMID:16321392