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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619951 Species: Rattus norvegicus RGD Object: Gene Symbol: Abcb1a Name: ATP-binding cassette, sub-family B (MDR/TAP), member 1A

Acc ID: CHEBI:6367 Term: lamotrigine Definition: Lamotrigine is a member of the class of 1,2,4-triazines in which the triazene skeleton is substituted by amino groups at positions 3 and 5, and by a 2,3-dichlorophenyl group at position 6. CasRN: 84057-84-1 Chemical ID: MESH:C047781

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases activity	ISO	RGD:730823	6480464	CTD	lamotrigine results in decreased activity of ABCB1 protein	PMID:18408562