GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619951
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 1A
Acc ID: CHEBI:6367
Term: lamotrigine
Definition: Lamotrigine is a member of the class of 1,2,4-triazines in which the triazene skeleton is substituted by amino groups at positions 3 and 5, and by a 2,3-dichlorophenyl group at position 6.
CasRN: 84057-84-1
Chemical ID: MESH:C047781
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityISORGD:7308236480464CTDlamotrigine results in decreased activity of ABCB1 protein

PMID:18408562
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