GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11275
Species: Mus musculus
RGD Object: Gene
Symbol: Ccl2
Name: chemokine (C-C motif) ligand 2
Acc ID: CHEBI:5855
Term: ibuprofen
Definition: A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(2-methylpropyl)phenyl group.
CasRN: 15687-27-1
Chemical ID: MESH:D007052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:7310466480464CTDIbuprofen results in increased expression of CCL2 mRNA

PMID:17070997
multiple interactionsISORGD:7310466480464CTDIbuprofen inhibits the reaction [IL1A protein results in increased secretion of CCL2 protein]

PMID:11230753
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