RGD ID: 11275
Species: Mus musculus
RGD Object: Gene
Symbol: Ccl2
Name: chemokine (C-C motif) ligand 2
Acc ID: CHEBI:5855
Term: ibuprofen
Definition: A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(2-methylpropyl)phenyl group.
Definition Source(s): ChemIDplus:15687-27-1, ChemIDplus:2049713, CiteXplore:11433218, CiteXplore:11832356, CiteXplore:12207314, CiteXplore:12723739, CiteXplore:14562167, CiteXplore:15342182, CiteXplore:15506544, CiteXplore:15544868, CiteXplore:15567010, CiteXplore:15746067, CiteXplore:15809462, CiteXplore:16176022, CiteXplore:1672904, CiteXplore:18335846, CiteXplore:18697608, CiteXplore:21368281, CiteXplore:24168233, CiteXplore:25708941, CiteXplore:25915907, CiteXplore:3079594, CiteXplore:3365913, CiteXplore:6465162, CiteXplore:6720796, CiteXplore:7471614, CiteXplore:7587932, CiteXplore:7893261, CiteXplore:8496270, CiteXplore:8527289, CiteXplore:8759674, CiteXplore:9296242, DrugBank:DB01050, HMDB:HMDB01925, KEGG COMPOUND:15687-27-1, KEGG COMPOUND:C01588, KEGG DRUG:D00126, MetaCyc:CARBOXYPHENYLAMINO-DEOXYRIBULOSE-P, NIST Chemistry WebBook:15687-27-1, Patent:GB971700, Patent:US3228831, Patent:US3385886, Patent:US5215755, Patent:US6727286, Reaxys:2049713, Wikipedia:Ibuprofen
Chemical ID: MESH:D007052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDIbuprofen inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]

Ibuprofen inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]

increases expressionISORGD:7310466480464CTDIbuprofen results in increased expression of CCL2 mRNA

multiple interactionsISORGD:7310466480464CTDIbuprofen inhibits the reaction [IL1A protein results in increased secretion of CCL2 protein]

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