GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620218
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Creb1
Name: cAMP responsive element binding protein 1
Acc ID: CHEBI:4495
Term: diazoxide
Definition: A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
CasRN: 7683-59-2
Chemical ID: MESH:D003981
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7308876480464CTDoxophenylarsine inhibits the reaction [Isoproterenol results in increased phosphorylation of CREB1 protein]

PMID:17141199
multiple interactionsEXP 6480464CTDCREM protein inhibits the reaction [Isoproterenol results in increased activity of CREB1 protein]

PMID:12791704
increases phosphorylationEXP 6480464CTDIsoproterenol results in increased phosphorylation of CREB1 protein

PMID:12791704
increases phosphorylationISORGD:7308876480464CTDIsoproterenol results in increased phosphorylation of CREB1 protein

PMID:17141199
PMID:21745194
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