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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11275 Species: Mus musculus RGD Object: Gene Symbol: Ccl2 Name: chemokine (C-C motif) ligand 2

Acc ID: CHEBI:41774 Term: tamoxifen Definition: A stilbenoid that has formula C26H29NO. CasRN: 10540-29-1 Chemical ID: MESH:D013629

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:731046	6480464	CTD	[Tamoxifen co-treated with ESR2 protein] results in increased expression of CCL2 mRNA	PMID:19059307
multiple interactions	EXP		6480464	CTD	Tamoxifen inhibits the reaction [Dietary Fats results in increased expression of CCL2 mRNA] Tamoxifen inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of CCL2 mRNA]	PMID:23038002