GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3645
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl2
Name: chemokine (C-C motif) ligand 2
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
CasRN: 458-37-7
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDCurcumin results in decreased expression of CCL2 mRNA

PMID:10925121, PMID:11053056
multiple interactionsEXP 6480464CTDCurcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of CCL2 mRNA]

PMID:22683883
decreases expressionISORGD:112756480464CTDCurcumin results in decreased expression of CCL2 mRNA

Curcumin results in decreased expression of CCL2 protein

PMID:18403477
increases expressionISORGD:7310466480464CTDCurcumin results in increased expression of CCL2 mRNA

PMID:17198877
multiple interactionsISORGD:112756480464CTDCurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]

PMID:20712904
multiple interactionsISORGD:7310466480464CTDCurcumin inhibits the reaction [TNF protein results in increased expression of CCL2 protein]

Curcumin inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]

PMID:17666914
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