GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3645
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Definition Source(s): ChemIDplus:458-37-7, CiteXplore:10923784, CiteXplore:12083767, CiteXplore:12450549, CiteXplore:12826232, CiteXplore:14561543, CiteXplore:14634121, CiteXplore:15129424, CiteXplore:15659840, CiteXplore:15753945, CiteXplore:15809436, CiteXplore:15842781, CiteXplore:15879598, CiteXplore:16276182, CiteXplore:16292655, CiteXplore:16413584, CiteXplore:16712454, CiteXplore:16972983, CiteXplore:17182546, CiteXplore:18815282, CiteXplore:19038979, CiteXplore:19204190, CiteXplore:19234767, CiteXplore:20057137, CiteXplore:21466422, CiteXplore:21642934, CiteXplore:22044005, CiteXplore:22051121, CiteXplore:22118895, CiteXplore:22122768, CiteXplore:22211691, CiteXplore:22318308, CiteXplore:22753715, CiteXplore:23386263, CiteXplore:23574161, CiteXplore:9698073, HMDB:HMDB02269, KEGG COMPOUND:458-37-7, KEGG COMPOUND:C10443, KNApSAcK:C00002731, LINCS:LSM-4521, MetaCyc:CPD-6602, Patent:DE859145, Patent:KR20130050834, Reaxys:2306965, Wikipedia:Curcumin
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDCurcumin results in decreased expression of CCL2 mRNA

PMID:10925121, PMID:11053056
multiple interactionsEXP 6480464CTDCurcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of CCL2 mRNA]

PMID:22683883
decreases expressionISORGD:112756480464CTDCurcumin results in decreased expression of CCL2 mRNA

Curcumin results in decreased expression of CCL2 protein

PMID:18403477
increases expressionISORGD:7310466480464CTDCurcumin results in increased expression of CCL2 mRNA

PMID:17198877
multiple interactionsISORGD:112756480464CTDCurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]

PMID:20712904
multiple interactionsISORGD:7310466480464CTDCurcumin inhibits the reaction [Oxygen deficiency results in increased expression of CCL2 mRNA]

PMID:23452621
multiple interactionsISORGD:7310466480464CTDCurcumin inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]

PMID:17666914, PMID:19152916
multiple interactionsISORGD:7310466480464CTDCurcumin inhibits the reaction [TNF protein results in increased expression of CCL2 protein]

Curcumin inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]

PMID:17666914
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