GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3645
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Definition Source(s): CAS:458-37-7, CAS:458-37-7, HMDB:HMDB02269, KEGG:C10443, KNApSAcK:C00002731, MetaCyc:CPD-6602, Patent:DE859145, Patent:KR20130050834, PMID:10923784, PMID:12083767, PMID:12826232, PMID:14561543, PMID:14634121, PMID:15129424, PMID:15659840, PMID:15753945, PMID:15809436, PMID:15842781, PMID:15879598, PMID:16276182, PMID:16292655, PMID:16972983, PMID:17182546, PMID:18815282, PMID:19038979, PMID:19204190, PMID:19234767, PMID:20057137, PMID:21466422, PMID:21642934, PMID:22044005, PMID:22051121, PMID:22118895, PMID:22122768, PMID:22211691, PMID:22318308, PMID:22753715, PMID:23386263, PMID:23574161, PMID:9698073, Reaxys:2306965, Wikipedia:Curcumin
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDCurcumin results in decreased expression of CCL2 mRNA

PMID:10925121, PMID:11053056
multiple interactionsEXP 6480464CTDCurcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of CCL2 mRNA]

PMID:22683883
decreases expressionISORGD:112756480464CTDCurcumin results in decreased expression of CCL2 mRNA

Curcumin results in decreased expression of CCL2 protein

PMID:18403477
increases expressionISORGD:7310466480464CTDCurcumin results in increased expression of CCL2 mRNA

PMID:17198877
multiple interactionsISORGD:112756480464CTDCurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]

PMID:20712904
multiple interactionsISORGD:7310466480464CTDCurcumin inhibits the reaction [Oxygen deficiency results in increased expression of CCL2 mRNA]

PMID:23452621
multiple interactionsISORGD:7310466480464CTDCurcumin inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]

PMID:17666914, PMID:19152916
multiple interactionsISORGD:7310466480464CTDCurcumin inhibits the reaction [TNF protein results in increased expression of CCL2 protein]

Curcumin inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]

PMID:17666914
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