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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3645 Species: Rattus norvegicus RGD Object: Gene Symbol: Ccl2 Name: chemokine (C-C motif) ligand 2

Acc ID: CHEBI:3962 Term: curcumin Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa. CasRN: 458-37-7 Chemical ID: MESH:D003474

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:731046	6480464	CTD	Curcumin inhibits the reaction [TNF protein results in increased expression of CCL2 protein] Curcumin inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]	PMID:17666914
increases expression	ISO	RGD:731046	6480464	CTD	Curcumin results in increased expression of CCL2 mRNA	PMID:17198877
decreases expression	ISO	RGD:11275	6480464	CTD	Curcumin results in decreased expression of CCL2 mRNA Curcumin results in decreased expression of CCL2 protein	PMID:18403477
decreases expression	EXP		6480464	CTD	Curcumin results in decreased expression of CCL2 mRNA	PMID:11053056 PMID:10925121
decreases expression	EXP		6480464	CTD	Curcumin results in decreased expression of CCL2 mRNA	PMID:10925121 PMID:11053056
multiple interactions	ISO	RGD:11275	6480464	CTD	Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]	PMID:20712904
multiple interactions	EXP		6480464	CTD	Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of CCL2 mRNA]	PMID:22683883