GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3963
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vldlr
Name: very low density lipoprotein receptor
Acc ID: CHEBI:32509
Term: pirinixic acid
Definition: An aryl sulfide that has formula C14H14ClN3O2S.
CasRN: 50892-23-4
Chemical ID: MESH:C006253
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:7339276480464CTDpirinixic acid affects the expression of VLDLR mRNA

PMID:19136022
decreases expressionISORGD:7355946480464CTDpirinixic acid results in decreased expression of LDLR mRNA

PMID:23150725
increases expressionISORGD:7339276480464CTDpirinixic acid results in increased expression of VLDLR mRNA

PMID:17426115, PMID:17950772, PMID:18301758, PMID:20813756, PMID:23811191
multiple interactionsISORGD:7339266480464CTD[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of VLDLR mRNA

PMID:19710929
multiple interactionsISORGD:7339276480464CTD[pirinixic acid co-treated with PPARA] results in increased expression of VLDLR mRNA

PMID:20813756
multiple interactionsISORGD:7339276480464CTDPPARA protein promotes the reaction [pirinixic acid results in increased expression of VLDLR mRNA]

PMID:17950772
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