GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620218
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Creb1
Name: cAMP responsive element binding protein 1
Acc ID: CHEBI:2972
Term: baclofen
Definition: A monocarboxylic acid that is butanoic acid substituted by an amino group at position 4 and a 4-chlorophenyl group at position 3. It acts as a central nervous system depressant, GABA agonist and muscle relaxant.
Definition Source(s): Beilstein:2104494, CAS:1134-47-0, CAS:1134-47-0, DrugBank:DB00181, HMDB:HMDB14327, KEGG:D00241, LINCS:LSM-5169, Patent:NL6407755, Patent:US3471548, PMID:11772961, PMID:18682277, PMID:18824012, Reaxys:2104494, Wikipedia:Baclofen
Chemical ID: MESH:D001418
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7308876480464CTDBaclofen inhibits the reaction [Amphetamine affects the phosphorylation of CREB1 protein]

PMID:16983645
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