GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62076
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptges
Name: prostaglandin E synthase
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary.
CasRN: 15663-27-1
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDCisplatin results in decreased expression of PTGES protein

PMID:21272267
increases expressionISORGD:690326480464CTDCisplatin results in increased expression of PTGES protein

PMID:20844471
multiple interactionsISORGD:623686480464CTDPTGES protein promotes the reaction [Cisplatin results in increased expression of IL1B protein]

PTGES protein promotes the reaction [Cisplatin results in increased expression of TNF protein]

PMID:20844471
multiple interactionsISORGD:690326480464CTD[Cisplatin co-treated with ciglitazone] results in decreased expression of PTGES

PMID:21681689
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