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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731046 Species: Homo sapiens RGD Object: Gene Symbol: CCL2 Name: chemokine (C-C motif) ligand 2

Acc ID: CHEBI:28097 Term: chlorobenzene Definition: The simplest member of the class of chlorobenzenes, that is benzene in which a single hydrogen has been substituted by a chlorine. CasRN: 108-90-7 Chemical ID: MESH:C031294

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	EXP		6480464	CTD	chlorobenzene results in increased expression of CCL2 protein	PMID:17993253 PMID:18514500 PMID:18645721
increases expression	EXP		6480464	CTD	chlorobenzene results in increased expression of CCL2 protein	PMID:18645721 PMID:18514500 PMID:17993253
multiple interactions	EXP		6480464	CTD	CCL2 protein promotes the reaction [chlorobenzene results in increased expression of IL13 protein]	PMID:18514500
multiple interactions	EXP		6480464	CTD	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [chlorobenzene results in increased expression of CCL2 protein] SB 203580 inhibits the reaction [chlorobenzene results in increased expression of CCL2 protein]	PMID:18645721
increases expression	EXP		6480464	CTD	chlorobenzene results in increased expression of CCL2 protein	PMID:18514500 PMID:18645721 PMID:17993253
increases expression	EXP		6480464	CTD	chlorobenzene results in increased expression of CCL2 protein	PMID:18514500 PMID:17993253 PMID:18645721
multiple interactions	EXP		6480464	CTD	bucillamine inhibits the reaction [chlorobenzene results in increased secretion of CCL2 protein] Tiopronin inhibits the reaction [chlorobenzene results in increased secretion of CCL2 protein]	PMID:19800902
increases secretion	EXP		6480464	CTD	chlorobenzene results in increased secretion of CCL2 protein	PMID:19800902