GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731046
Species: Homo sapiens
RGD Object: Gene
Symbol: CCL2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:28097
Term: chlorobenzene
Definition: The simplest member of the class of monochlorobenzenes, that is benzene in which a single hydrogen has been substituted by a chlorine.
Definition Source(s): Beilstein:605632, CAS:108-90-7, CAS:108-90-7, CAS:108-90-7, Gmelin:26704, HMDB:HMDB41855, KEGG:C06990, MetaCyc:CHLOROBENZENE, PDBeChem:8CL, PMID:23360185, PMID:23957149, PMID:24341791, Reaxys:605632, UM-BBD_compID:c0105, Wikipedia:Chlorobenzene
Chemical ID: MESH:C031294
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDchlorobenzene results in increased expression of CCL2 protein

PMID:17993253, PMID:18514500, PMID:18645721
increases secretionEXP 6480464CTDchlorobenzene results in increased secretion of CCL2 protein

PMID:19800902
multiple interactionsEXP 6480464CTD4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [chlorobenzene results in increased expression of CCL2 protein]

SB 203580 inhibits the reaction [chlorobenzene results in increased expression of CCL2 protein]

PMID:18645721
multiple interactionsEXP 6480464CTDbucillamine inhibits the reaction [chlorobenzene results in increased secretion of CCL2 protein]

Tiopronin inhibits the reaction [chlorobenzene results in increased secretion of CCL2 protein]

PMID:19800902
multiple interactionsEXP 6480464CTDCCL2 protein promotes the reaction [chlorobenzene results in increased expression of IL13 protein]

PMID:18514500
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