GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731046
Species: Homo sapiens
RGD Object: Gene
Symbol: CCL2
Name: chemokine (C-C motif) ligand 2
Acc ID: CHEBI:28097
Term: chlorobenzene
Definition: The simplest member of the class of chlorobenzenes, that is benzene in which a single hydrogen has been substituted by a chlorine.
CasRN: 108-90-7
Chemical ID: MESH:C031294
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDchlorobenzene results in increased expression of CCL2 protein

PMID:17993253
PMID:18514500
PMID:18645721
multiple interactionsEXP 6480464CTDCCL2 protein promotes the reaction [chlorobenzene results in increased expression of IL13 protein]

PMID:18514500
multiple interactionsEXP 6480464CTD4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [chlorobenzene results in increased expression of CCL2 protein]

SB 203580 inhibits the reaction [chlorobenzene results in increased expression of CCL2 protein]

PMID:18645721
multiple interactionsEXP 6480464CTDbucillamine inhibits the reaction [chlorobenzene results in increased secretion of CCL2 protein]

Tiopronin inhibits the reaction [chlorobenzene results in increased secretion of CCL2 protein]

PMID:19800902
increases secretionEXP 6480464CTDchlorobenzene results in increased secretion of CCL2 protein

PMID:19800902
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