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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62076 Species: Rattus norvegicus RGD Object: Gene Symbol: Ptges Name: prostaglandin E synthase

Acc ID: CHEBI:27881 Term: resveratrol Definition: A stilbenol that has formula C14H12O3. CasRN: 501-36-0 Chemical ID: MESH:C059514

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGES protein] resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGES mRNA]	PMID:17927823
multiple interactions	EXP		6480464	CTD	resveratrol inhibits the reaction [Dextran Sulfate results in increased expression of PTGES protein]	PMID:19228061
multiple interactions	ISO	RGD:69032	6480464	CTD	[Coumestrol co-treated with resveratrol] results in increased expression of PTGES mRNA	PMID:19167446
multiple interactions	ISO	RGD:62368	6480464	CTD	resveratrol inhibits the reaction [Dextran Sulfate results in increased expression of PTGES protein]	PMID:20132809