GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62043
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Xdh
Name: xanthine dehydrogenase
Acc ID: CHEBI:37537
Term: phorbol 13-acetate 12-myristate
Definition: A phorbol ester that has formula C36H56O8.
CasRN: 16561-29-8
Chemical ID: MESH:D013755
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:623356480464CTDAllopurinol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of XDH protein]

Fluocinolone Acetonide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of XDH protein]

Tretinoin promotes the reaction [Tetradecanoylphorbol Acetate results in increased activity of XDH protein]

PMID:3677084
increases activityISORGD:623356480464CTDTetradecanoylphorbol Acetate results in increased activity of XDH protein

PMID:22036979
PMID:3677084
multiple interactionsISORGD:623356480464CTDcaffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of XDH protein]

caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [XDH protein results in increased chemical synthesis of Uric Acid]]

PMID:22036979
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