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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62043 Species: Rattus norvegicus RGD Object: Gene Symbol: Xdh Name: xanthine dehydrogenase

Acc ID: CHEBI:37537 Term: phorbol 13-acetate 12-myristate Definition: A phorbol ester that has formula C36H56O8. CasRN: 16561-29-8 Chemical ID: MESH:D013755

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases activity	ISO	RGD:62335	6480464	CTD	Tetradecanoylphorbol Acetate results in increased activity of XDH protein	PMID:3677084
multiple interactions	ISO	RGD:62335	6480464	CTD	Allopurinol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of XDH protein] Fluocinolone Acetonide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of XDH protein] Tretinoin promotes the reaction [Tetradecanoylphorbol Acetate results in increased activity of XDH protein]	PMID:3677084
increases activity	ISO	RGD:62335	6480464	CTD	Tetradecanoylphorbol Acetate results in increased activity of XDH protein	PMID:22036979 PMID:3677084
multiple interactions	ISO	RGD:62335	6480464	CTD	caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of XDH protein] caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [XDH protein results in increased chemical synthesis of Uric Acid]]	PMID:22036979