GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62043
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Xdh
Name: xanthine dehydrogenase
Acc ID: CHEBI:37537
Term: phorbol 13-acetate 12-myristate
Definition: A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted to the corresponding acetate and myristate esters.
Definition Source(s): ChemIDplus:16561-29-8, ChemIDplus:2407201, CiteXplore:18541361, CiteXplore:22696070, CiteXplore:25649981, CiteXplore:25918710, CiteXplore:26826276, CiteXplore:26894087, CiteXplore:3593207, KEGG COMPOUND:16561-29-8, KEGG COMPOUND:C05151, KNApSAcK:C00003491, Wikipedia:12-O-Tetradecanoylphorbol-13-acetate
Chemical ID: MESH:D013755
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityISORGD:623356480464CTDTetradecanoylphorbol Acetate results in increased activity of XDH protein

PMID:22036979, PMID:3677084
multiple interactionsISORGD:623356480464CTDAllopurinol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of XDH protein]

Fluocinolone Acetonide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of XDH protein]

Tretinoin promotes the reaction [Tetradecanoylphorbol Acetate results in increased activity of XDH protein]

PMID:3677084
multiple interactionsISORGD:623356480464CTDcaffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of XDH protein]

caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [XDH protein results in increased chemical synthesis of Uric Acid]]

PMID:22036979
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