GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62043
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Xdh
Name: xanthine dehydrogenase
Acc ID: CHEBI:15379
Term: dioxygen
Definition: An elemental molecule that has formula O2.
CasRN: 7782-44-7
Chemical ID: MESH:D010100
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[Xanthine co-treated with XDH protein] inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]

PMID:12595275
increases activityISORGD:13484526480464CTDOxygen deficiency results in increased activity of XDH protein

PMID:16226770
multiple interactionsISORGD:13484526480464CTD[[Oxygen deficiency results in increased abundance of Hypoxanthine] affects the reaction [XDH protein affects the metabolism of Hypoxanthine]] which affects the abundance of Hydroxyl Radical

PMID:7929072
multiple interactionsISORGD:13484526480464CTD[Oxygen deficiency co-treated with Mitomycin] results in decreased activity of XDH protein

[Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in decreased activity of XDH protein

[Tetrachlorodibenzodioxin co-treated with Mitomycin co-treated with Oxygen deficiency] affects the activity of XDH protein

PMID:16226770
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