GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62043
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Xdh
Name: xanthine dehydrogenase
Acc ID: CHEBI:15379
Term: dioxygen
Definition: An elemental molecule that has formula O2.
Definition Source(s): ChemIDplus:7782-44-7, CiteXplore:10036348, CiteXplore:10458334, CiteXplore:10713010, CiteXplore:10906528, CiteXplore:1090895, CiteXplore:11099687, CiteXplore:12091281, CiteXplore:12147646, CiteXplore:12471082, CiteXplore:12471084, CiteXplore:12598492, CiteXplore:12611573, CiteXplore:12628892, CiteXplore:12628893, CiteXplore:12695252, CiteXplore:12768124, CiteXplore:12946829, CiteXplore:1442597, CiteXplore:1446842, CiteXplore:15241774, CiteXplore:15474135, CiteXplore:15635604, CiteXplore:15677487, CiteXplore:15765131, CiteXplore:15820462, CiteXplore:15902792, CiteXplore:15990736, CiteXplore:15990737, CiteXplore:16243980, CiteXplore:16259656, CiteXplore:16306052, CiteXplore:16306053, CiteXplore:16690641, CiteXplore:16757831, CiteXplore:16798186, CiteXplore:16799386, CiteXplore:16821755, CiteXplore:16945553, CiteXplore:16977326, CiteXplore:16996009, CiteXplore:17027622, CiteXplore:17156225, CiteXplore:17218587, CiteXplore:17337663, CiteXplore:17403851, CiteXplore:17488158, CiteXplore:18048895, CiteXplore:18048896, CiteXplore:18048899, CiteXplore:18210929, CiteXplore:1845919, CiteXplore:18638417, CiteXplore:1924583, CiteXplore:19840863, CiteXplore:2026022, CiteXplore:2026027, CiteXplore:2026028, CiteXplore:2026029, CiteXplore:2035771, CiteXplore:2036843, CiteXplore:208444, CiteXplore:2203620, CiteXplore:2403513, CiteXplore:2553296, CiteXplore:3276245, CiteXplore:3307585, CiteXplore:3315479, CiteXplore:3905287, CiteXplore:6115579, CiteXplore:6254418, CiteXplore:6414343, CiteXplore:6419199, CiteXplore:6986411, CiteXplore:7039970, CiteXplore:7648095, CiteXplore:7710549, CiteXplore:8037390, CiteXplore:8085584, CiteXplore:8141076, CiteXplore:8160966, CiteXplore:8328508, CiteXplore:8451675, CiteXplore:8451680, CiteXplore:8596792, CiteXplore:8625644, CiteXplore:8635921, CiteXplore:8637306, CiteXplore:8782482, CiteXplore:8795322, CiteXplore:9037219, CiteXplore:9463773, CiteXplore:9715819, CiteXplore:9753223, CiteXplore:9917705, Gmelin:485, HMDB:HMDB01377, KEGG COMPOUND:7782-44-7, KEGG COMPOUND:C00007, KEGG DRUG:D00003, MetaCyc:CPD-6641, MetaCyc:OXYGEN-MOLECULE, MolBase:750, NIST Chemistry WebBook:7782-44-7, PDBeChem:OXY, Wikipedia:Oxygen
Chemical ID: MESH:D010100
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[Xanthine co-treated with XDH protein] inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]

PMID:12595275
multiple interactionsEXP 6480464CTDDichlororibofuranosylbenzimidazole inhibits the reaction [Oxygen deficiency results in increased phosphorylation of and results in increased activity of XDH protein]

SB 203580 inhibits the reaction [Oxygen deficiency results in increased phosphorylation of and results in increased activity of XDH protein]

PMID:11278616
increases activityISORGD:13484526480464CTDOxygen deficiency results in increased activity of XDH protein

PMID:16226770
multiple interactionsISORGD:13484526480464CTD[[Oxygen deficiency results in increased abundance of Hypoxanthine] affects the reaction [XDH protein affects the metabolism of Hypoxanthine]] which affects the abundance of Hydroxyl Radical

PMID:7929072
multiple interactionsISORGD:13484526480464CTD[Oxygen deficiency co-treated with Mitomycin] results in decreased activity of XDH protein

[Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in decreased activity of XDH protein

[Tetrachlorodibenzodioxin co-treated with Mitomycin co-treated with Oxygen deficiency] affects the activity of XDH protein

PMID:16226770
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