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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62043 Species: Rattus norvegicus RGD Object: Gene Symbol: Xdh Name: xanthine dehydrogenase

Acc ID: CHEBI:15379 Term: dioxygen Definition: An elemental molecule that has formula O2. CasRN: 7782-44-7 Chemical ID: MESH:D010100

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases activity	ISO	RGD:1348452	6480464	CTD	Oxygen deficiency results in increased activity of XDH protein	PMID:16226770
multiple interactions	ISO	RGD:1348452	6480464	CTD	[Oxygen deficiency co-treated with Mitomycin] results in decreased activity of XDH protein [Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in decreased activity of XDH protein [Tetrachlorodibenzodioxin co-treated with Mitomycin co-treated with Oxygen deficiency] affects the activity of XDH protein	PMID:16226770
multiple interactions	ISO	RGD:1348452	6480464	CTD	[[Oxygen deficiency results in increased abundance of Hypoxanthine] affects the reaction [XDH protein affects the metabolism of Hypoxanthine]] which affects the abundance of Hydroxyl Radical	PMID:7929072
multiple interactions	EXP		6480464	CTD	[Xanthine co-treated with XDH protein] inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]	PMID:12595275