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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11275 Species: Mus musculus RGD Object: Gene Symbol: Ccl2 Name: chemokine (C-C motif) ligand 2

Acc ID: CHEBI:3750 Term: clofibrate Definition: A propanoate ester that has formula C12H15ClO3. CasRN: 637-07-0 Chemical ID: MESH:D002994

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:731046	6480464	CTD	Clofibrate inhibits the reaction [Glucose results in increased expression of CCL2 mRNA] Clofibrate inhibits the reaction [Glucose results in increased expression of CCL2 protein] Clofibrate inhibits the reaction [Glucose results in increased secretion of CCL2 protein]	PMID:16600694
multiple interactions	ISO	RGD:731046	6480464	CTD	Clofibrate inhibits the reaction [Glucose results in increased expression of CCL2 mRNA] Clofibrate inhibits the reaction [Glucose results in increased expression of CCL2 protein]	PMID:19132243 PMID:16600694
multiple interactions	ISO	RGD:731046	6480464	CTD	Clofibrate inhibits the reaction [Glucose results in increased expression of CCL2 protein] Clofibrate inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]	PMID:16600694 PMID:19132243