ONTOLOGY REPORT - ANNOTATIONS


Term:hexosamine biosynthetic pathway
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Accession:PW:0000559 term browser browse the term
Definition:The formation of nucleotide hexosamines, primarily UDP-N-acetylglucosamine, constitutes the final step in the hexosamine biosynthetic pathway which provides substrates for the O-linked glycosylation of proteins. Glycoproteins that are either secreted from the cell or inserted into the plasma membrane undergo N-linked glycosylation. The O-linked glycosylation of nuclear and/or cytosolic proteins confers a signaling dimension to the hexosamine biosynthetic pathway.

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hexosamine biosynthetic pathway term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Gfpt1 glutamine fructose-6-phosphate transaminase 1 GBrowse link IMP 4 121,204,274 121,250,160 RGD:1625426 RGD
G Gfpt1 glutamine fructose-6-phosphate transaminase 1 GBrowse link ISS 4 121,204,274 121,250,160 RGD:1625539 RGD
G Gnpnat1 glucosamine-phosphate N-acetyltransferase 1 GBrowse link ISS 15 21,272,165 21,284,459 RGD:1625539 RGD
G Gpi glucose-6-phosphate isomerase GBrowse link ISS 1 86,658,836 86,686,712 RGD:1625539 RGD
G Mgea5 meningioma expressed antigen 5 (hyaluronidase) GBrowse link TAS 1 250,966,386 251,000,363 RGD:2311625 RGD
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase GBrowse link ISS X 89,721,369 89,766,218 RGD:1625539 RGD
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase GBrowse link TAS X 89,721,369 89,766,218 RGD:2311625 RGD
G Pgm3 phosphoglucomutase 3 GBrowse link ISS 8 91,810,223 91,827,293 RGD:1625539 RGD
G Uap1 UDP-N-acteylglucosamine pyrophosphorylase 1 GBrowse link ISS 13 85,953,072 85,987,137 RGD:1625539 RGD

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Path 1
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  pathway 17508
    classic metabolic pathway 3631
      carbohydrate metabolic pathway 1045
        amino sugar metabolic pathway 56
          hexosamine metabolic pathway 9
            hexosamine biosynthetic pathway 9
Path 2
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  pathway 17508
    regulatory pathway 5888
      homeostasis pathway 2123
        glucose homeostasis pathway 708
          glucose utilization pathway 197
            glucose conversion pathway 9
              hexosamine biosynthetic pathway 9
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