Term:hexosamine biosynthetic pathway
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Accession:PW:0000559 term browser browse the term
Definition:The formation of nucleotide hexosamines, primarily UDP-N-acetylglucosamine, constitutes the final step in the hexosamine biosynthetic pathway which provides substrates for the O-linked glycosylation of proteins. Glycoproteins that are either secreted from the cell or inserted into the plasma membrane undergo N-linked glycosylation. The O-linked glycosylation of nuclear and/or cytosolic proteins confers a signaling dimension to the hexosamine biosynthetic pathway.

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hexosamine biosynthetic pathway term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Gfpt1 glutamine fructose-6-phosphate transaminase 1 GBrowse link 4 121,204,274 121,250,160 RGD:1625426
G Gnpnat1 glucosamine-phosphate N-acetyltransferase 1 GBrowse link 15 21,272,165 21,284,459 RGD:1625539
G Gpi glucose-6-phosphate isomerase GBrowse link 1 86,658,836 86,686,712 RGD:1625539
G Mgea5 meningioma expressed antigen 5 (hyaluronidase) GBrowse link 1 250,966,386 251,000,363 RGD:2311625
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase GBrowse link X 89,721,369 89,766,218 RGD:1625539
G Pgm3 phosphoglucomutase 3 GBrowse link 8 91,810,223 91,827,293 RGD:1625539
G Uap1 UDP-N-acteylglucosamine pyrophosphorylase 1 GBrowse link 13 85,953,072 85,987,137 RGD:1625539

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Path 1
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  pathway 51680
    classic metabolic pathway 10246
      carbohydrate metabolic pathway 3172
        amino sugar metabolic pathway 169
          hexosamine metabolic pathway 25
            hexosamine biosynthetic pathway 25
Path 2
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  pathway 51680
    regulatory pathway 19065
      homeostasis pathway 7435
        glucose homeostasis pathway 2006
          glucose utilization pathway 580
            glucose conversion pathway 25
              hexosamine biosynthetic pathway 25
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