Term:hexosamine biosynthetic pathway
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Accession:PW:0000559 term browser browse the term
Definition:The formation of nucleotide hexosamines, primarily UDP-N-acetylglucosamine, constitutes the final step in the hexosamine biosynthetic pathway which provides substrates for the O-linked glycosylation of proteins. Glycoproteins that are either secreted from the cell or inserted into the plasma membrane undergo N-linked glycosylation. The O-linked glycosylation of nuclear and/or cytosolic proteins confers a signaling dimension to the hexosamine biosynthetic pathway.

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hexosamine biosynthetic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gfpt1 glutamine fructose-6-phosphate transaminase 1 JBrowse link 4 118,852,046 118,901,583 RGD:1625426
G Gnpnat1 glucosamine-phosphate N-acetyltransferase 1 JBrowse link 15 19,721,292 19,734,032 RGD:1625539
G Gpi glucose-6-phosphate isomerase JBrowse link 1 90,063,411 90,091,287 RGD:1625539
G Mgea5 meningioma expressed antigen 5 (hyaluronidase) JBrowse link 1 265,506,752 265,542,452 RGD:2311625
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase JBrowse link X 71,540,870 71,585,906 RGD:1625539
G Pgm3 phosphoglucomutase 3 JBrowse link 8 94,225,513 94,243,230 RGD:1625539
G Uap1 UDP-N-acetylglucosamine pyrophosphorylase 1 JBrowse link 13 88,463,532 88,497,901 RGD:1625539

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Path 1
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  pathway 89232
    classic metabolic pathway 14060
      carbohydrate metabolic pathway 3874
        amino sugar metabolic pathway 220
          hexosamine metabolic pathway 25
            hexosamine biosynthetic pathway 25
Path 2
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  pathway 89232
    regulatory pathway 24501
      homeostasis pathway 10687
        glucose homeostasis pathway 2332
          glucose utilization pathway 684
            glucose conversion pathway 25
              hexosamine biosynthetic pathway 25
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