Term:hexosamine biosynthetic pathway
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Accession:PW:0000559 term browser browse the term
Definition:The formation of nucleotide hexosamines, primarily UDP-N-acetylglucosamine, constitutes the final step in the hexosamine biosynthetic pathway which provides substrates for the O-linked glycosylation of proteins. Glycoproteins that are either secreted from the cell or inserted into the plasma membrane undergo N-linked glycosylation. The O-linked glycosylation of nuclear and/or cytosolic proteins confers a signaling dimension to the hexosamine biosynthetic pathway.

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hexosamine biosynthetic pathway term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Gfpt1 glutamine fructose-6-phosphate transaminase 1 GBrowse link 4 183,421,338 183,470,867 RGD:1625426
G Gnpnat1 glucosamine-phosphate N-acetyltransferase 1 GBrowse link 15 23,685,448 23,698,244 RGD:1625539
G Gpi glucose-6-phosphate isomerase GBrowse link 1 91,207,014 91,234,890 RGD:1625539
G Mgea5 meningioma expressed antigen 5 (hyaluronidase) GBrowse link 1 272,936,992 272,972,453 RGD:2311625
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase GBrowse link X 72,390,218 72,435,241 RGD:1625539
G Pgm3 phosphoglucomutase 3 GBrowse link 8 93,738,656 93,756,367 RGD:1625539
G Uap1 UDP-N-acetylglucosamine pyrophosphorylase 1 GBrowse link 13 93,089,458 93,123,827 RGD:1625539

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Path 1
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  pathway 54461
    classic metabolic pathway 10656
      carbohydrate metabolic pathway 3157
        amino sugar metabolic pathway 169
          hexosamine metabolic pathway 25
            hexosamine biosynthetic pathway 25
Path 2
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  pathway 54461
    regulatory pathway 22362
      homeostasis pathway 9014
        glucose homeostasis pathway 2108
          glucose utilization pathway 575
            glucose conversion pathway 25
              hexosamine biosynthetic pathway 25
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