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Term:integrin mediated signaling pathway
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Accession:PW:0000286 term browser browse the term
Definition:Integrins signal bi-directionally across the plasma membrane. Inside-out signaling modulates their interaction with ligands to regulate cell adhesion and ECM organization. Ligand binding initiates and shapes many signaling events and links to the cytoskeleton. Via protein clustering and ECM organization integrins synergize with and/or modulate various growth factor pathways. Integrin signaling regulates multiple processes including gene expression, cell proliferation, differentiation and survival.

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integrin mediated signaling pathway term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Apbb1ip amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein GBrowse link ISS 17 96,476,962 96,527,635 RGD:2300340 RGD
G Fabp3 fatty acid binding protein 3, muscle and heart GBrowse link ISS 5 149,340,525 149,347,268 RGD:7364738 RGD
G Fblim1 filamin binding LIM protein 1 GBrowse link ISS 5 160,468,558 160,495,015 RGD:7349373 RGD
G Fermt1 fermitin family member 1 GBrowse link ISS 3 120,699,769 120,744,016 RGD:7349373 RGD
G Fermt2 fermitin family member 2 GBrowse link ISS 15 21,358,411 21,427,264 RGD:7349373 RGD
G Fermt3 fermitin family member 3 GBrowse link ISS 1 209,672,810 209,691,579 RGD:7349373 RGD
G Flna filamin A, alpha GBrowse link ISS X 160,362,334 160,385,626 RGD:7364738 RGD
G Flnb filamin B, beta GBrowse link ISS 15 18,949,027 19,082,504 RGD:7364738 RGD
G Flnc filamin C, gamma GBrowse link ISS 4 56,313,707 56,341,400 RGD:7364738 RGD
G Ilk integrin-linked kinase GBrowse link ISS 1 163,481,299 163,487,550 RGD:633110 RGD
G Ilk integrin-linked kinase GBrowse link IMP 1 163,481,299 163,487,550 RGD:2302091 RGD
G Ilk integrin-linked kinase GBrowse link ISS 1 163,481,299 163,487,550 RGD:2300344 RGD
G Ilkap integrin-linked kinase-associated serine/threonine phosphatase GBrowse link ISS 9 90,602,949 90,626,753 RGD:2300344 RGD
G Itga1 integrin, alpha 1 GBrowse link ISS 2 47,107,849 47,206,261 RGD:729264 RGD
G Itga1 integrin, alpha 1 GBrowse link ISS 2 47,107,849 47,206,261 RGD:5135538 RGD
G Itga10 integrin, alpha 10 GBrowse link ISS 2 191,448,684 191,467,941 RGD:1358329 RGD
G Itga10 integrin, alpha 10 GBrowse link ISS 2 191,448,684 191,467,941 RGD:5135538 RGD
G Itga11 integrin, alpha 11 GBrowse link ISS 8 66,828,256 66,937,646 RGD:1358329 RGD
G Itga11 integrin, alpha 11 GBrowse link ISS 8 66,828,256 66,937,646 RGD:5135538 RGD
G Itga2 integrin, alpha 2 GBrowse link TAS 2 46,967,681 47,080,909 RGD:1302878 RGD
G Itga2 integrin, alpha 2 GBrowse link ISS 2 46,967,681 47,080,909 RGD:5135538 RGD
G Itga2b integrin, alpha 2B GBrowse link ISS 10 91,557,086 91,574,194 RGD:5135538 RGD
G Itga3 integrin, alpha 3 GBrowse link ISS 10 83,728,710 83,759,576 RGD:1358329 RGD
G Itga3 integrin, alpha 3 GBrowse link ISS 10 83,728,710 83,759,576 RGD:5135538 RGD
G Itga4 integrin, alpha 4 GBrowse link TAS 3 62,024,747 62,097,456 RGD:1302879 RGD
G Itga4 integrin, alpha 4 GBrowse link ISS 3 62,024,747 62,097,456 RGD:5135538 RGD
G Itga5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) GBrowse link IDA 7 142,254,256 142,277,464 RGD:1300196 RGD
G Itga5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) GBrowse link ISS 7 142,254,256 142,277,464 RGD:5135538 RGD
G Itga6 integrin, alpha 6 GBrowse link ISS 3 54,202,931 54,272,803 RGD:1358329 RGD
G Itga6 integrin, alpha 6 GBrowse link ISS 3 54,202,931 54,272,803 RGD:5135538 RGD
G Itga7 integrin, alpha 7 GBrowse link IDA 7 2,230,747 2,269,403 RGD:70774 RGD
G Itga7 integrin, alpha 7 GBrowse link ISS 7 2,230,747 2,269,403 RGD:5135538 RGD
G Itga8 integrin, alpha 8 GBrowse link TAS 17 86,427,191 86,649,268 RGD:633055 RGD
G Itga8 integrin, alpha 8 GBrowse link ISS 17 86,427,191 86,649,268 RGD:5135538 RGD
G Itga9 integrin, alpha 9 GBrowse link ISS 8 123,526,904 123,838,241 RGD:1358329 RGD
G Itgad integrin, alpha D GBrowse link ISS 1 187,436,291 187,464,212 RGD:1358329 RGD
G Itgad integrin, alpha D GBrowse link ISS 1 187,436,291 187,464,212 RGD:5135538 RGD
G Itgae integrin, alpha E TAS RGD:633077 RGD
G Itgae integrin, alpha E ISS RGD:5135538 RGD
G Itgal integrin, alpha L GBrowse link ISS 1 186,561,795 186,598,908 RGD:1358329 RGD
G Itgal integrin, alpha L GBrowse link ISS 1 186,561,795 186,598,908 RGD:5135538 RGD
G Itgam integrin, alpha M GBrowse link ISS 1 187,334,413 187,385,583 RGD:1358329 RGD
G Itgam integrin, alpha M GBrowse link ISS 1 187,334,413 187,385,583 RGD:5135538 RGD
G Itgav integrin, alpha V GBrowse link ISS 3 66,953,403 67,029,774 RGD:1358329 RGD
G Itgav integrin, alpha V GBrowse link IDA 3 66,953,403 67,029,774 RGD:1625134 RGD
G Itgav integrin, alpha V GBrowse link ISS 3 66,953,403 67,029,774 RGD:5135538 RGD
G Itgax integrin, alpha X GBrowse link ISS 1 187,396,184 187,416,273 RGD:5135538 RGD
G Itgb1 integrin, beta 1 GBrowse link ISS 19 58,600,095 58,647,531 RGD:1302874 RGD
G Itgb1 integrin, beta 1 GBrowse link IDA 19 58,600,095 58,647,531 RGD:1625134 RGD
G Itgb1 integrin, beta 1 GBrowse link ISS 19 58,600,095 58,647,531 RGD:5135538 RGD
G Itgb1bp1 integrin beta 1 binding protein 1 GBrowse link ISS 6 41,830,110 41,844,514 RGD:7364738 RGD
G Itgb1bp1 integrin beta 1 binding protein 1 GBrowse link ISS 6 41,830,110 41,844,514 RGD:7349373 RGD
G Itgb2 integrin, beta 2 GBrowse link ISS 20 11,446,521 11,485,009 RGD:1358329 RGD
G Itgb2 integrin, beta 2 GBrowse link ISS 20 11,446,521 11,485,009 RGD:5135538 RGD
G Itgb3 integrin, beta 3 ISS RGD:633129 RGD
G Itgb3 integrin, beta 3 IDA RGD:1625134 RGD
G Itgb3 integrin, beta 3 ISS RGD:5135538 RGD
G Itgb4 integrin, beta 4 GBrowse link TAS 10 106,080,452 106,116,632 RGD:729025 RGD
G Itgb4 integrin, beta 4 GBrowse link ISS 10 106,080,452 106,116,632 RGD:5135538 RGD
G Itgb5 integrin, beta 5 ISS RGD:724441 RGD
G Itgb5 integrin, beta 5 ISS RGD:5135538 RGD
G Itgb6 integrin, beta 6 GBrowse link ISS 3 42,286,140 42,360,793 RGD:1358329 RGD
G Itgb6 integrin, beta 6 GBrowse link ISS 3 42,286,140 42,360,793 RGD:5135538 RGD
G Itgb7 integrin, beta 7 GBrowse link TAS 7 140,971,310 140,984,091 RGD:633040 RGD
G Itgb7 integrin, beta 7 GBrowse link ISS 7 140,971,310 140,984,091 RGD:5135538 RGD
G Itgb8 integrin, beta 8 GBrowse link ISS 6 146,494,978 146,573,064 RGD:1358329 RGD
G Itgb8 integrin, beta 8 GBrowse link ISS 6 146,494,978 146,573,064 RGD:5135538 RGD
G Krit1 KRIT1, ankyrin repeat containing GBrowse link ISS 4 27,014,488 27,048,636 RGD:7364738 RGD
G Krit1 KRIT1, ankyrin repeat containing GBrowse link ISS 4 27,014,488 27,048,636 RGD:7349373 RGD
G Lims1 LIM and senescent cell antigen-like domains 1 GBrowse link ISS 20 37,349,188 37,397,427 RGD:2300344 RGD
G Lims2 LIM and senescent cell antigen like domains 2 GBrowse link ISS 18 24,347,374 24,386,082 RGD:2300344 RGD
G Nck2 NCK adaptor protein 2 GBrowse link ISS 9 42,650,261 42,776,967 RGD:2300344 RGD
G Parva parvin, alpha GBrowse link ISS 1 170,232,441 170,387,843 RGD:2300344 RGD
G Parvb parvin, beta GBrowse link ISS 7 122,223,325 122,310,356 RGD:2300344 RGD
G Parvg parvin, gamma GBrowse link ISS 7 122,322,460 122,341,398 RGD:2300344 RGD
G Ptk2 protein tyrosine kinase 2 GBrowse link ISS 7 110,933,298 111,084,554 RGD:2300402 RGD
G Pxn paxillin GBrowse link ISS 12 42,322,193 42,370,507 RGD:2300344 RGD
G Sharpin SHANK-associated RH domain interactor GBrowse link ISS 7 114,397,762 114,401,974 RGD:7349373 RGD
G Sharpin SHANK-associated RH domain interactor GBrowse link ISS 7 114,397,762 114,401,974 RGD:7364738 RGD
G Tln1 talin 1 GBrowse link ISS 5 60,010,952 60,040,908 RGD:7349373 RGD
G Tln1 talin 1 GBrowse link ISS 5 60,010,952 60,040,908 RGD:2300340 RGD
G Tln2 talin 2 GBrowse link ISS 8 71,532,270 71,964,142 RGD:7349373 RGD
altered integrin mediated signaling pathway term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Itga1 integrin, alpha 1 GBrowse link IMP 2 47,107,849 47,206,261 RGD:1302875 RGD
G Itga4 integrin, alpha 4 GBrowse link IMP 3 62,024,747 62,097,456 RGD:1302879 RGD
G Itga5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) GBrowse link ISS 7 142,254,256 142,277,464 RGD:1302875 RGD
G Itga7 integrin, alpha 7 GBrowse link ISS 7 2,230,747 2,269,403 RGD:70774 RGD
G Itga8 integrin, alpha 8 GBrowse link IMP 17 86,427,191 86,649,268 RGD:633055 RGD
G Itgb1 integrin, beta 1 GBrowse link ISS 19 58,600,095 58,647,531 RGD:1302874 RGD

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  pathway 17508
    signaling pathway 7856
      cell adhesion signaling pathway 728
        integrin mediated signaling pathway 88
          altered integrin mediated signaling pathway 6
          integrin mediated cell-cell signaling pathway 0
          integrin mediated cell-extracellular matrix signaling pathway 0
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