ONTOLOGY REPORT - ANNOTATIONS


Term:integrin mediated signaling pathway
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Accession:PW:0000286 term browser browse the term
Definition:Integrins signal bi-directionally across the plasma membrane and provide an example of mechanotransduction. Inside-out signaling modulates their interaction with ligands to regulate cell adhesion and ECM organization. Ligand binding initiates and shapes many signaling events and links to the cytoskeleton. Via protein clustering and ECM organization integrins synergize with and/or modulate various growth factor pathways. Integrin signaling regulates multiple processes including gene expression, cell proliferation, differentiation and survival.

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integrin mediated signaling pathway term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Apbb1ip amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein GBrowse link 17 91,762,064 91,812,342 RGD:2300340
G Fabp3 fatty acid binding protein 3, muscle and heart GBrowse link 5 152,246,250 152,252,993 RGD:7364738
G Fblim1 filamin binding LIM protein 1 GBrowse link 5 163,841,377 163,867,441 RGD:7349373
G Fermt1 fermitin family member 1 GBrowse link 3 132,049,511 132,090,550 RGD:7349373
G Fermt2 fermitin family member 2 GBrowse link 15 23,771,816 23,840,554 RGD:7349373
G Fermt3 fermitin family member 3 GBrowse link 1 229,244,957 229,263,151 RGD:7349373
G Flna filamin A, alpha GBrowse link 1 152,200,936 152,227,391 RGD:7364738
G Flnb filamin B, beta GBrowse link 15 22,716,606 22,849,401 RGD:7364738
G Flnc filamin C, gamma GBrowse link 4 56,478,171 56,505,940 RGD:7364738
G Ilk integrin-linked kinase GBrowse link 1 177,584,793 177,591,044 RGD:633110
RGD:2300344
RGD:2302091
G Ilkap integrin-linked kinase-associated serine/threonine phosphatase GBrowse link 9 98,190,668 98,212,634 RGD:2300344
G Itga1 integrin, alpha 1 GBrowse link 2 71,666,601 71,823,120 RGD:729264
RGD:5135538
G Itga10 integrin, alpha 10 GBrowse link 2 218,259,871 218,279,187 RGD:1358329
RGD:5135538
G Itga11 integrin, alpha 11 GBrowse link 8 67,298,905 67,412,933 RGD:1358329
RGD:5135538
G Itga2 integrin, alpha 2 GBrowse link 2 71,536,102 71,636,203 RGD:1302878
RGD:5135538
G Itga2b integrin, alpha 2B GBrowse link 10 90,186,491 90,205,094 RGD:5135538
G Itga3 integrin, alpha 3 GBrowse link 10 82,666,856 82,698,319 RGD:1358329
RGD:5135538
G Itga4 integrin, alpha 4 GBrowse link 3 72,754,339 72,825,872 RGD:1302879
RGD:5135538
G Itga5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) GBrowse link 7 142,749,459 142,773,323 RGD:1300196
RGD:5135538
G Itga6 integrin, alpha 6 GBrowse link 3 64,931,497 65,003,370 RGD:1358329
RGD:5135538
G Itga7 integrin, alpha 7 GBrowse link 7 3,325,268 3,354,361 RGD:70774
RGD:5135538
G Itga8 integrin, alpha 8 GBrowse link 17
17
81,190,818
80,956,109
81,304,978
81,030,622
RGD:633055
RGD:5135538
G Itga9 integrin, alpha 9 GBrowse link 8 126,493,359 126,795,566 RGD:1358329
G Itgad integrin, alpha D GBrowse link 1 206,632,107 206,669,878 RGD:1358329
RGD:5135538
G Itgae integrin, alpha E GBrowse link 10 59,391,989 59,450,857 RGD:633077
RGD:5135538
G Itgal integrin, alpha L GBrowse link 1 205,742,280 205,780,282 RGD:1358329
RGD:5135538
G Itgam integrin, alpha M GBrowse link 1 206,522,794 206,573,619 RGD:1358329
RGD:5135538
G Itgav integrin, alpha V GBrowse link 3 77,643,270 77,731,358 RGD:1358329
RGD:1625134
RGD:5135538
G Itgax integrin, alpha X GBrowse link 1 206,583,608 206,604,971 RGD:5135538
G Itgb1 integrin, beta 1 GBrowse link 19 72,324,582 72,372,325 RGD:1302874
RGD:1625134
RGD:5135538
G Itgb1bp1 integrin beta 1 binding protein 1 GBrowse link 6 60,216,633 60,231,381 RGD:7349373
RGD:7364738
G Itgb2 integrin, beta 2 GBrowse link 20 13,944,190 13,981,048 RGD:1358329
RGD:5135538
G Itgb3 integrin, beta 3 GBrowse link 10 92,424,545 92,538,859 RGD:633129
RGD:1625134
RGD:5135538
G Itgb4 integrin, beta 4 GBrowse link 10 103,725,179 103,761,358 RGD:729025
RGD:5135538
G Itgb5 integrin, beta 5 GBrowse link 11 73,146,146 73,261,215 RGD:724441
RGD:5135538
G Itgb6 integrin, beta 6 GBrowse link 3 51,760,871 51,883,770 RGD:1358329
RGD:5135538
G Itgb7 integrin, beta 7 GBrowse link 7 141,617,387 141,634,902 RGD:633040
RGD:5135538
G Itgb8 integrin, beta 8 GBrowse link 6 156,002,320 156,082,312 RGD:1358329
RGD:5135538
G Krit1 KRIT1, ankyrin repeat containing GBrowse link 4 27,341,835 27,376,376 RGD:7349373
RGD:7364738
G Lims1 LIM and senescent cell antigen-like domains 1 GBrowse link 20 29,715,580 29,824,252 RGD:2300344
G Lims2 LIM and senescent cell antigen like domains 2 GBrowse link 18 24,422,274 24,460,482 RGD:2300344
G Nck2 NCK adaptor protein 2 GBrowse link 9 49,914,483 50,040,945 RGD:2300344
G Parva parvin, alpha GBrowse link 1 184,227,712 184,383,031 RGD:2300344
G Parvb parvin, beta GBrowse link 7 63,181,011 63,268,380 RGD:2300344
G Parvg parvin, gamma GBrowse link 7 63,279,792 63,299,076 RGD:2300344
G Ptk2 protein tyrosine kinase 2 GBrowse link 7 114,371,979 114,525,553 RGD:2300402
G Pxn paxillin GBrowse link 12 48,595,399 48,642,177 RGD:2300344
G Sharpin SHANK-associated RH domain interactor GBrowse link 7 117,400,781 117,404,993 RGD:7349373
RGD:7364738
G Tln1 talin 1 GBrowse link 5 63,558,230 63,588,186 RGD:2300340
RGD:7349373
G Tln2 talin 2 GBrowse link 8 77,342,736 77,771,053 RGD:7349373
altered integrin mediated signaling pathway term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Ilk integrin-linked kinase GBrowse link 1 177,584,793 177,591,044 RGD:5490966
G Itga1 integrin, alpha 1 GBrowse link 2 71,666,601 71,823,120 RGD:1302875
G Itga11 integrin, alpha 11 GBrowse link 8 67,298,905 67,412,933 RGD:5490966
G Itga4 integrin, alpha 4 GBrowse link 3 72,754,339 72,825,872 RGD:1302879
RGD:5490966
G Itga5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) GBrowse link 7 142,749,459 142,773,323 RGD:1302875
G Itga7 integrin, alpha 7 GBrowse link 7 3,325,268 3,354,361 RGD:70774
G Itga8 integrin, alpha 8 GBrowse link 17
17
81,190,818
80,956,109
81,304,978
81,030,622
RGD:633055
G Itga9 integrin, alpha 9 GBrowse link 8 126,493,359 126,795,566 RGD:5490966
G Itgb1 integrin, beta 1 GBrowse link 19 72,324,582 72,372,325 RGD:1302874

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  pathway 52399
    signaling pathway 21699
      mechanotransduction pathway 312
        integrin mediated signaling pathway 235
          altered integrin mediated signaling pathway 22
          integrin mediated cell-cell signaling pathway 0
          integrin mediated cell-extracellular matrix signaling pathway 0
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