ONTOLOGY REPORT - ANNOTATIONS


Term:integrin mediated signaling pathway
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Accession:PW:0000286 term browser browse the term
Definition:Integrins signal bi-directionally across the plasma membrane and provide an example of mechanotransduction. Inside-out signaling modulates their interaction with ligands to regulate cell adhesion and ECM organization. Ligand binding initiates and shapes many signaling events and links to the cytoskeleton. Via protein clustering and ECM organization integrins synergize with and/or modulate various growth factor pathways. Integrin signaling regulates multiple processes including gene expression, cell proliferation, differentiation and survival.

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integrin mediated signaling pathway term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Apbb1ip amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein GBrowse link 17 96,476,962 96,527,635 RGD:2300340
G Fabp3 fatty acid binding protein 3, muscle and heart GBrowse link 5 149,340,525 149,347,268 RGD:7364738
G Fblim1 filamin binding LIM protein 1 GBrowse link 5 160,468,558 160,495,015 RGD:7349373
G Fermt1 fermitin family member 1 GBrowse link 3 120,699,769 120,744,016 RGD:7349373
G Fermt2 fermitin family member 2 GBrowse link 15 21,358,411 21,427,264 RGD:7349373
G Fermt3 fermitin family member 3 GBrowse link 1 209,672,810 209,691,579 RGD:7349373
G Flna filamin A, alpha GBrowse link X 160,362,334 160,385,626 RGD:7364738
G Flnb filamin B, beta GBrowse link 15 18,949,027 19,082,504 RGD:7364738
G Flnc filamin C, gamma GBrowse link 4 56,313,707 56,341,400 RGD:7364738
G Ilk integrin-linked kinase GBrowse link 1 163,481,299 163,487,550 RGD:633110
RGD:2300344
RGD:2302091
G Ilkap integrin-linked kinase-associated serine/threonine phosphatase GBrowse link 9 90,602,949 90,626,753 RGD:2300344
G Itga1 integrin, alpha 1 GBrowse link 2 47,107,849 47,206,261 RGD:729264
RGD:5135538
G Itga10 integrin, alpha 10 GBrowse link 2 191,448,684 191,467,941 RGD:1358329
RGD:5135538
G Itga11 integrin, alpha 11 GBrowse link 8 66,828,256 66,937,646 RGD:1358329
RGD:5135538
G Itga2 integrin, alpha 2 GBrowse link 2 46,967,681 47,080,909 RGD:1302878
RGD:5135538
G Itga2b integrin, alpha 2B GBrowse link 10 91,557,086 91,574,194 RGD:5135538
G Itga3 integrin, alpha 3 GBrowse link 10 83,728,710 83,759,576 RGD:1358329
RGD:5135538
G Itga4 integrin, alpha 4 GBrowse link 3 62,024,747 62,097,456 RGD:1302879
RGD:5135538
G Itga5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) GBrowse link 7 142,254,256 142,277,464 RGD:1300196
RGD:5135538
G Itga6 integrin, alpha 6 GBrowse link 3 54,202,931 54,272,803 RGD:1358329
RGD:5135538
G Itga7 integrin, alpha 7 GBrowse link 7 2,230,747 2,269,403 RGD:70774
RGD:5135538
G Itga8 integrin, alpha 8 GBrowse link 17 86,427,191 86,649,268 RGD:633055
RGD:5135538
G Itga9 integrin, alpha 9 GBrowse link 8 123,526,904 123,838,241 RGD:1358329
G Itgad integrin, alpha D GBrowse link 1 187,436,291 187,464,212 RGD:1358329
RGD:5135538
G Itgae integrin, alpha E RGD:633077
RGD:5135538
G Itgal integrin, alpha L GBrowse link 1 186,561,795 186,598,908 RGD:1358329
RGD:5135538
G Itgam integrin, alpha M GBrowse link 1 187,334,413 187,385,583 RGD:1358329
RGD:5135538
G Itgav integrin, alpha V GBrowse link 3 66,953,403 67,029,774 RGD:1358329
RGD:1625134
RGD:5135538
G Itgax integrin, alpha X GBrowse link 1 187,396,184 187,416,273 RGD:5135538
G Itgb1 integrin, beta 1 GBrowse link 19 58,600,095 58,647,531 RGD:1302874
RGD:1625134
RGD:5135538
G Itgb1bp1 integrin beta 1 binding protein 1 GBrowse link 6 41,830,110 41,844,514 RGD:7349373
RGD:7364738
G Itgb2 integrin, beta 2 GBrowse link 20 11,446,521 11,485,009 RGD:1358329
RGD:5135538
G Itgb3 integrin, beta 3 RGD:633129
RGD:1625134
RGD:5135538
G Itgb4 integrin, beta 4 GBrowse link 10 106,080,452 106,116,632 RGD:729025
RGD:5135538
G Itgb5 integrin, beta 5 RGD:724441
RGD:5135538
G Itgb6 integrin, beta 6 GBrowse link 3 42,286,140 42,360,793 RGD:1358329
RGD:5135538
G Itgb7 integrin, beta 7 GBrowse link 7 140,971,310 140,984,091 RGD:633040
RGD:5135538
G Itgb8 integrin, beta 8 GBrowse link 6 146,494,978 146,573,064 RGD:1358329
RGD:5135538
G Krit1 KRIT1, ankyrin repeat containing GBrowse link 4 27,014,488 27,048,636 RGD:7349373
RGD:7364738
G Lims1 LIM and senescent cell antigen-like domains 1 GBrowse link 20 37,349,188 37,397,427 RGD:2300344
G Lims2 LIM and senescent cell antigen like domains 2 GBrowse link 18 24,347,374 24,386,082 RGD:2300344
G Nck2 NCK adaptor protein 2 GBrowse link 9 42,650,261 42,776,967 RGD:2300344
G Parva parvin, alpha GBrowse link 1 170,232,441 170,387,843 RGD:2300344
G Parvb parvin, beta GBrowse link 7 122,223,325 122,310,356 RGD:2300344
G Parvg parvin, gamma GBrowse link 7 122,322,460 122,341,398 RGD:2300344
G Ptk2 protein tyrosine kinase 2 GBrowse link 7 110,933,298 111,084,554 RGD:2300402
G Pxn paxillin GBrowse link 12 42,322,193 42,370,507 RGD:2300344
G Sharpin SHANK-associated RH domain interactor GBrowse link 7 114,397,762 114,401,974 RGD:7349373
RGD:7364738
G Tln1 talin 1 GBrowse link 5 60,010,952 60,040,908 RGD:2300340
RGD:7349373
G Tln2 talin 2 GBrowse link 8 71,532,270 71,964,142 RGD:7349373
altered integrin mediated signaling pathway term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Ilk integrin-linked kinase GBrowse link 1 163,481,299 163,487,550 RGD:5490966
G Itga1 integrin, alpha 1 GBrowse link 2 47,107,849 47,206,261 RGD:1302875
G Itga11 integrin, alpha 11 GBrowse link 8 66,828,256 66,937,646 RGD:5490966
G Itga4 integrin, alpha 4 GBrowse link 3 62,024,747 62,097,456 RGD:1302879
RGD:5490966
G Itga5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) GBrowse link 7 142,254,256 142,277,464 RGD:1302875
G Itga7 integrin, alpha 7 GBrowse link 7 2,230,747 2,269,403 RGD:70774
G Itga8 integrin, alpha 8 GBrowse link 17 86,427,191 86,649,268 RGD:633055
G Itga9 integrin, alpha 9 GBrowse link 8 123,526,904 123,838,241 RGD:5490966
G Itgb1 integrin, beta 1 GBrowse link 19 58,600,095 58,647,531 RGD:1302874

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  pathway 18013
    signaling pathway 7751
      mechanotransduction pathway 117
        integrin mediated signaling pathway 92
          altered integrin mediated signaling pathway 10
          integrin mediated cell-cell signaling pathway 0
          integrin mediated cell-extracellular matrix signaling pathway 0
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