ONTOLOGY REPORT - ANNOTATIONS


Term:integrin mediated signaling pathway
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Accession:PW:0000286 term browser browse the term
Definition:Integrins signal bi-directionally across the plasma membrane and provide an example of mechanotransduction. Inside-out signaling modulates their interaction with ligands to regulate cell adhesion and ECM organization. Ligand binding initiates and shapes many signaling events and links to the cytoskeleton. Via protein clustering and ECM organization integrins synergize with and/or modulate various growth factor pathways. Integrin signaling regulates multiple processes including gene expression, cell proliferation, differentiation and survival.

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integrin mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apbb1ip amyloid beta precursor protein binding family B member 1 interacting protein JBrowse link 17 90,098,953 90,149,192 RGD:2300340
G Fabp3 fatty acid binding protein 3 JBrowse link 5 148,528,854 148,535,597 RGD:7364738
G Fblim1 filamin binding LIM protein 1 JBrowse link 5 160,122,466 160,158,522 RGD:7349373
G Fermt1 fermitin family member 1 JBrowse link 3 125,566,744 125,607,864 RGD:7349373
G Fermt2 fermitin family member 2 JBrowse link 15 19,807,806 19,876,537 RGD:7349373
G Fermt3 fermitin family member 3 JBrowse link 1 222,254,178 222,272,779 RGD:7349373
G Flna filamin A JBrowse link X 156,460,784 156,487,245 RGD:7364738
G Flnb filamin B JBrowse link 15 18,750,152 18,883,020 RGD:7364738
G Flnc filamin C JBrowse link 4 56,710,930 56,738,779 RGD:7364738
G Ilk integrin-linked kinase JBrowse link 1 170,578,941 170,585,192 RGD:633110
RGD:2300344
RGD:2302091
G Ilkap integrin-linked kinase-associated serine/threonine phosphatase JBrowse link 9 98,514,599 98,536,586 RGD:2300344
G Itga1 integrin subunit alpha 1 JBrowse link 2 47,120,340 47,281,387 RGD:729264
RGD:5135538
G Itga10 integrin subunit alpha 10 JBrowse link 2 198,772,937 198,792,253 RGD:1358329
RGD:5135538
G Itga11 integrin subunit alpha 11 JBrowse link 8 67,566,872 67,683,973 RGD:1358329
RGD:5135538
G Itga2 integrin alpha 2 JBrowse link 2 46,996,904 47,097,011 RGD:1302878
RGD:5135538
G Itga2b integrin subunit alpha 2b JBrowse link 10 90,397,960 90,416,544 RGD:5135538
G Itga3 integrin subunit alpha 3 JBrowse link 10 82,855,841 82,887,779 RGD:1358329
RGD:5135538
G Itga4 integrin subunit alpha 4 JBrowse link 3 66,192,977 66,264,344 RGD:1302879
RGD:5135538
G Itga5 integrin subunit alpha 5 JBrowse link 7 144,970,444 144,993,652 RGD:1300196
RGD:5135538
G Itga6 integrin subunit alpha 6 JBrowse link 3 58,442,904 58,515,124 RGD:1358329
RGD:5135538
G Itga7 integrin subunit alpha 7 JBrowse link 7 3,355,081 3,384,093 RGD:70774
RGD:5135538
G Itga8 integrin subunit alpha 8 JBrowse link 17 79,321,896 79,676,499 RGD:633055
RGD:5135538
G Itga9 integrin subunit alpha 9 JBrowse link 8 127,270,929 127,576,709 RGD:1358329
G Itgad integrin subunit alpha D JBrowse link 1 199,596,024 199,623,670 RGD:1358329
RGD:5135538
G Itgae integrin subunit alpha E JBrowse link 10 59,652,549 59,711,793 RGD:633077
RGD:5135538
G Itgal integrin subunit alpha L JBrowse link 1 198,744,051 198,781,745 RGD:1358329
RGD:5135538
G Itgam integrin subunit alpha M JBrowse link 1 199,495,307 199,545,738 RGD:1358329
RGD:5135538
G Itgav integrin subunit alpha V JBrowse link 3 71,113,267 71,205,958 RGD:1358329
RGD:1625134
RGD:5135538
G Itgax integrin subunit alpha X JBrowse link 1 199,555,563 199,576,948 RGD:5135538
G Itgb1 integrin subunit beta 1 JBrowse link 19 61,677,512 61,725,537 RGD:1302874
RGD:1625134
RGD:5135538
G Itgb1bp1 integrin subunit beta 1 binding protein 1 JBrowse link 6 43,348,927 43,363,630 RGD:7349373
RGD:7364738
G Itgb2 integrin subunit beta 2 JBrowse link 20 11,777,773 11,815,647 RGD:1358329
RGD:5135538
G Itgb3 integrin subunit beta 3 JBrowse link 10 92,667,869 92,783,413 RGD:633129
RGD:1625134
RGD:5135538
G Itgb4 integrin subunit beta 4 JBrowse link 10 104,524,000 104,560,180 RGD:729025
RGD:5135538
G Itgb5 integrin subunit beta 5 JBrowse link 11 70,056,500 70,172,164 RGD:724441
RGD:5135538
G Itgb6 integrin subunit beta 6 JBrowse link 3 46,652,624 46,775,363 RGD:1358329
RGD:5135538
G Itgb7 integrin subunit beta 7 JBrowse link 7 143,820,236 143,837,806 RGD:633040
RGD:5135538
G Itgb8 integrin subunit beta 8 JBrowse link 6 147,089,280 147,172,845 RGD:1358329
RGD:5135538
G Krit1 KRIT1, ankyrin repeat containing JBrowse link 4 27,438,609 27,473,150 RGD:7349373
RGD:7364738
G Lims1 LIM zinc finger domain containing 1 JBrowse link 20 27,895,983 28,004,767 RGD:2300344
G Lims2 LIM zinc finger domain containing 2 JBrowse link 18 24,707,940 24,746,159 RGD:2300344
G Nck2 NCK adaptor protein 2 JBrowse link 9 50,246,759 50,373,307 RGD:2300344
G Parva parvin, alpha JBrowse link 1 177,249,302 177,405,143 RGD:2300344
G Parvb parvin, beta JBrowse link 7 125,189,827 125,277,639 RGD:2300344
G Parvg parvin, gamma JBrowse link 7 125,288,081 125,307,587 RGD:2300344
G Ptk2 protein tyrosine kinase 2 JBrowse link 7 114,436,419 114,611,334 RGD:2300402
G Pxn paxillin JBrowse link 12 46,797,953 46,845,085 RGD:2300344
G Sharpin SHANK-associated RH domain interactor JBrowse link 7 117,413,151 117,417,363 RGD:7349373
RGD:7364738
G Tln1 talin 1 JBrowse link 5 59,033,635 59,063,592 RGD:2300340
RGD:7349373
G Tln2 talin 2 JBrowse link 8 73,009,980 73,257,145 RGD:7349373
altered integrin mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ilk integrin-linked kinase JBrowse link 1 170,578,941 170,585,192 RGD:5490966
G Itga1 integrin subunit alpha 1 JBrowse link 2 47,120,340 47,281,387 RGD:1302875
G Itga11 integrin subunit alpha 11 JBrowse link 8 67,566,872 67,683,973 RGD:5490966
G Itga4 integrin subunit alpha 4 JBrowse link 3 66,192,977 66,264,344 RGD:1302879
RGD:5490966
G Itga5 integrin subunit alpha 5 JBrowse link 7 144,970,444 144,993,652 RGD:1302875
G Itga7 integrin subunit alpha 7 JBrowse link 7 3,355,081 3,384,093 RGD:70774
G Itga8 integrin subunit alpha 8 JBrowse link 17 79,321,896 79,676,499 RGD:633055
G Itga9 integrin subunit alpha 9 JBrowse link 8 127,270,929 127,576,709 RGD:5490966
G Itgb1 integrin subunit beta 1 JBrowse link 19 61,677,512 61,725,537 RGD:1302874

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  pathway 88549
    signaling pathway 22742
      mechanotransduction pathway 313
        integrin mediated signaling pathway 236
          altered integrin mediated signaling pathway 22
          integrin mediated cell-cell signaling pathway 0
          integrin mediated cell-extracellular matrix signaling pathway 0
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