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Term:G protein mediated signaling pathway via Galphaq family
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Accession:PW:0000229 term browser browse the term
Definition:Based on sequence similarity, the Galpha genes have been grouped into four classes. Exchange of GDP to GTP promoted through binding to receptors dissociates the heterotrimeric Galpha/beta/gamma complex. GTP-bound Galpha can then interact with downstream effectors. Lipid modification of Galpha regulates membrane localization and interactions with specific effectors.


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G protein mediated signaling pathway via Galphaq family term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Adra1a adrenoceptor alpha 1A GBrowse link ISS 15 46,173,429 46,263,198 RGD:1559318 RGD
G Adra1b adrenoceptor alpha 1B GBrowse link ISS 10 28,889,092 28,946,889 RGD:1559318 RGD
G Adra1d adrenoceptor alpha 1D GBrowse link ISS 3 119,279,974 119,295,985 RGD:1559318 RGD
G Agtr1a angiotensin II receptor, type 1a GBrowse link IMP 17 40,629,318 40,684,982 RGD:70819 RGD
G Agtr1a angiotensin II receptor, type 1a GBrowse link TAS 17 40,629,318 40,684,982 RGD:629553 RGD
G Agtr1b angiotensin II receptor, type 1b GBrowse link TAS 2 105,503,269 105,602,591 RGD:629553 RGD
G Avpr1a arginine vasopressin receptor 1A GBrowse link ISS 7 62,225,537 62,229,461 RGD:1579891 RGD
G Avpr1b arginine vasopressin receptor 1B GBrowse link ISS 13 44,537,103 44,547,318 RGD:1579891 RGD
G Avpr1b arginine vasopressin receptor 1B GBrowse link IDA 13 44,537,103 44,547,318 RGD:2312649 RGD
G Bdkrb1 bradykinin receptor B1 GBrowse link ISS 6 129,760,129 129,762,545 RGD:7401223 RGD
G Bdkrb2 bradykinin receptor B2 GBrowse link ISS 6 129,744,781 129,748,851 RGD:7401223 RGD
G Casr calcium-sensing receptor GBrowse link IMP 11 66,084,169 66,153,292 RGD:7207227 RGD
G Casr calcium-sensing receptor GBrowse link IMP 11 66,084,169 66,153,292 RGD:7207059 RGD
G Chrm1 cholinergic receptor, muscarinic 1 GBrowse link ISS 1 211,351,738 211,353,120 RGD:8549585 RGD
G Chrm3 cholinergic receptor, muscarinic 3 GBrowse link ISS 17 71,214,906 71,218,463 RGD:8549585 RGD
G Chrm5 cholinergic receptor, muscarinic 5 GBrowse link ISS 3 98,326,809 98,378,531 RGD:8549585 RGD
G Ghsr growth hormone secretagogue receptor GBrowse link TAS 2 113,269,623 113,272,999 RGD:1642818 RGD
G Gna11 guanine nucleotide binding protein, alpha 11 GBrowse link ISS 7 9,636,748 9,662,492 RGD:8549590 RGD
G Gna11 guanine nucleotide binding protein, alpha 11 GBrowse link ISS 7 9,636,748 9,662,492 RGD:1579891 RGD
G Gna11 guanine nucleotide binding protein, alpha 11 GBrowse link ISS 7 9,636,748 9,662,492 RGD:5131495 RGD
G Gna14 guanine nucleotide binding protein, alpha 14 GBrowse link ISS 1 219,906,120 219,983,252 RGD:8549590 RGD
G Gna14 guanine nucleotide binding protein, alpha 14 GBrowse link ISS 1 219,906,120 219,983,252 RGD:5131495 RGD
G Gna15 guanine nucleotide binding protein, alpha 15 GBrowse link IMP 7 9,669,956 9,689,442 RGD:728647 RGD
G Gna15 guanine nucleotide binding protein, alpha 15 GBrowse link ISS 7 9,669,956 9,689,442 RGD:5131495 RGD
G Gnaq guanine nucleotide binding protein (G protein), q polypeptide GBrowse link ISS 1 219,520,998 219,764,401 RGD:8549590 RGD
G Gnaq guanine nucleotide binding protein (G protein), q polypeptide GBrowse link ISS 1 219,520,998 219,764,401 RGD:5131495 RGD
G Gnaq guanine nucleotide binding protein (G protein), q polypeptide GBrowse link IMP 1 219,520,998 219,764,401 RGD:1642020 RGD
G Gnaq guanine nucleotide binding protein (G protein), q polypeptide GBrowse link ISS 1 219,520,998 219,764,401 RGD:1579891 RGD
G Hcrtr1 hypocretin (orexin) receptor 1 GBrowse link IDA 5 149,160,739 149,170,736 RGD:1642020 RGD
G Hcrtr2 hypocretin (orexin) receptor 2 GBrowse link IDA 8 81,068,303 81,196,608 RGD:1642020 RGD
G Lpar1 lysophosphatidic acid receptor 1 GBrowse link IMP 5 76,449,470 76,571,458 RGD:1626471 RGD
G Lpar3 lysophosphatidic acid receptor 3 GBrowse link IMP 2 244,431,789 244,510,815 RGD:1626471 RGD
G Oxtr oxytocin receptor GBrowse link ISS 4 148,314,089 148,326,797 RGD:1579891 RGD
G Oxtr oxytocin receptor GBrowse link IMP 4 148,314,089 148,326,797 RGD:2304227 RGD
G Plcb1 phospholipase C, beta 1 (phosphoinositide-specific) GBrowse link ISS 3 122,797,718 123,523,675 RGD:5131495 RGD
G Plcb2 phospholipase C, beta 2 GBrowse link ISS 3 105,203,524 105,223,342 RGD:5131495 RGD
G Plcb3 phospholipase C, beta 3 (phosphatidylinositol-specific) GBrowse link ISS 1 209,628,425 209,643,694 RGD:5131495 RGD
G Plcb4 phospholipase C, beta 4 GBrowse link ISS 3 123,706,313 124,077,381 RGD:5131495 RGD
G Pth1r parathyroid hormone 1 receptor GBrowse link IDA 8 115,099,763 115,119,362 RGD:7207455 RGD
G Pth1r parathyroid hormone 1 receptor GBrowse link ISS 8 115,099,763 115,119,362 RGD:7207465 RGD
G Pth1r parathyroid hormone 1 receptor GBrowse link ISS 8 115,099,763 115,119,362 RGD:7207470 RGD
G Rgs2 regulator of G-protein signaling 2 GBrowse link ISS 13 57,891,849 57,894,452 RGD:7207227 RGD
G Rgs2 regulator of G-protein signaling 2 GBrowse link ISS 13 57,891,849 57,894,452 RGD:5133418 RGD
G Rgs4 regulator of G-protein signaling 4 GBrowse link ISS 13 85,533,882 85,540,173 RGD:7207227 RGD
G Rgs5 regulator of G-protein signaling 5 GBrowse link ISS 13 85,445,325 85,482,294 RGD:7207228 RGD

Term paths to the root
Path 1
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  pathway 17508
    signaling pathway 7856
      G protein mediated signaling pathway 116
        G protein mediated signaling pathway via Galphaq family 45
Path 2
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  pathway 17508
    signaling pathway 7856
      signaling pathway pertinent to the brain 659
        neuron-to-neuron signaling pathways 478
          neuron-to-neuron signaling pathway via the chemical synapse 476
            excitatory synaptic transmission pathway 359
              glutamate signaling pathway 193
                glutamate signaling pathway via metabotropic glutamate receptor 67
                  glutamate signaling pathway via group I metabotropic glutamate receptor 45
                    G protein mediated signaling pathway via Galphaq family 45
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