ONTOLOGY REPORT - ANNOTATIONS


Term:folate metabolic pathway
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Accession:PW:0000140 term browser browse the term
Definition:Folate metabolism represents the various aspects of folate cycle and the folate mediate transfer reactions essential for several biosynthetic pathways. The folate cycle and the folate mediated one-carbon pathways are part of folate metabolism. Folate compounds are water-soluble forms of vitamin B9.
Synonyms:related_synonym: KEGG:00790;   vitamin B9 metabolic pathway


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folate metabolic pathway term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Akp3 alkaline phosphatase 3, intestine, not Mn requiring GBrowse link IEA 9 85,924,232 85,927,327 RGD:6907045 KEGG
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 TAS RGD:1547843 RGD
G Alpi alkaline phosphatase, intestinal GBrowse link IEA 9 85,892,887 85,896,353 RGD:6907045 KEGG
G Alpl alkaline phosphatase, liver/bone/kidney GBrowse link IEA 5 156,501,739 156,558,727 RGD:6907045 KEGG
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase GBrowse link IDA 9 70,676,744 70,696,865 RGD:70804 RGD
G Dhfr dihydrofolate reductase GBrowse link IDA 2 22,607,093 22,828,487 RGD:1298877 RGD
G Dhfr dihydrofolate reductase GBrowse link IEA 2 22,607,093 22,828,487 RGD:6907045 KEGG
G Dmgdh dimethylglycine dehydrogenase GBrowse link TAS 2 23,976,563 24,052,766 RGD:1547831 RGD
G Folh1 folate hydrolase 1 GBrowse link TAS 1 142,936,379 143,010,358 RGD:728645 RGD
G Folr2 folate receptor 2 (fetal) GBrowse link ISS 1 159,295,773 159,314,107 RGD:1540379 RGD
G Fpgs folylpolyglutamate synthase IEA RGD:6907045 KEGG
G Gart phosphoribosylglycinamide formyltransferase GBrowse link ISS 11 31,594,859 31,620,110 RGD:1547842 RGD
G Gch1 GTP cyclohydrolase 1 GBrowse link IEA 15 23,023,996 23,139,794 RGD:6907045 KEGG
G Ggh gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) GBrowse link IEA 5 34,670,883 34,693,791 RGD:6907045 KEGG
G Ggh gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) GBrowse link TAS 5 34,670,883 34,693,791 RGD:69845 RGD
G Gnmt glycine N-methyltransferase GBrowse link TAS 9 10,127,092 10,130,444 RGD:1359070 RGD
G Mocs1 molybdenum cofactor synthesis 1 GBrowse link IEA 9 6,759,531 6,779,930 RGD:6907045 KEGG
G Mocs2 molybdenum cofactor synthesis 2 GBrowse link IEA 2 46,948,321 46,960,060 RGD:6907045 KEGG
G Mthfd1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase GBrowse link TAS 6 98,849,446 98,916,936 RGD:1299513 RGD
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase GBrowse link ISS 4 117,517,611 117,529,128 RGD:1540378 RGD
G Mthfr methylenetetrahydrofolate reductase (NAD(P)H) GBrowse link ISS 5 165,112,850 165,126,885 RGD:1535021 RGD
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase GBrowse link IDA 17 68,782,708 68,867,101 RGD:1359026 RGD
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase GBrowse link ISS 17 5,086,219 5,118,086 RGD:1359037 RGD
G Pts 6-pyruvoyl-tetrahydropterin synthase GBrowse link IEA 8 53,880,701 53,887,711 RGD:6907045 KEGG
G Qdpr quinoid dihydropteridine reductase GBrowse link IEA 14 70,741,998 70,755,600 RGD:6907045 KEGG
G Sardh sarcosine dehydrogenase GBrowse link TAS 3 6,076,166 6,142,565 RGD:634034 RGD
G Shmt1 serine hydroxymethyltransferase 1 (soluble) GBrowse link TAS 10 46,936,605 46,964,779 RGD:1359815 RGD
G Shmt2 serine hydroxymethyltransferase 2 (mitochondrial) GBrowse link TAS 7 67,494,470 67,499,540 RGD:1359815 RGD
G Slc19a1 solute carrier family 19 (folate transporter), member 1 GBrowse link TAS 20 11,984,283 12,001,865 RGD:735239 RGD
G Spr sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) GBrowse link IEA 4 119,365,578 119,369,308 RGD:6907045 KEGG
G Tyms thymidylate synthetase GBrowse link IDA 9 112,604,912 112,617,706 RGD:1545055 RGD
altered folate cycle metabolic pathway term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 ISS RGD:7242562 RGD
G Dhfr dihydrofolate reductase GBrowse link ISS 2 22,607,093 22,828,487 RGD:7242557 RGD
G Folr1 folate receptor 1 (adult) GBrowse link ISS 1 159,315,191 159,324,141 RGD:7242557 RGD
G Mthfd1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase GBrowse link ISS 6 98,849,446 98,916,936 RGD:7242557 RGD
G Mthfr methylenetetrahydrofolate reductase (NAD(P)H) GBrowse link ISS 5 165,112,850 165,126,885 RGD:7242557 RGD
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase GBrowse link ISS 17 68,782,708 68,867,101 RGD:7242557 RGD
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase GBrowse link ISS 17 68,782,708 68,867,101 RGD:7242557 RGD
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase GBrowse link ISS 17 5,086,219 5,118,086 RGD:7242557 RGD
G Slc46a1 solute carrier family 46 (folate transporter), member 1 GBrowse link ISS 10 64,576,068 64,582,504 RGD:7242557 RGD
altered folate mediated one-carbon metabolic pathway term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Mthfd1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase GBrowse link ISS 6 98,849,446 98,916,936 RGD:7242562 RGD
G Mthfr methylenetetrahydrofolate reductase (NAD(P)H) GBrowse link ISS 5 165,112,850 165,126,885 RGD:7242562 RGD
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase GBrowse link ISS 17 68,782,708 68,867,101 RGD:7242562 RGD
folate cycle metabolic pathway term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 ISS RGD:7242562 RGD
G Amt aminomethyltransferase ISS RGD:7242560 RGD
G Dhfr dihydrofolate reductase GBrowse link ISS 2 22,607,093 22,828,487 RGD:7242557 RGD
G Dld dihydrolipoamide dehydrogenase GBrowse link ISS 6 49,185,188 49,205,894 RGD:7242560 RGD
G Dmgdh dimethylglycine dehydrogenase GBrowse link ISS 2 23,976,563 24,052,766 RGD:7242560 RGD
G Folh1 folate hydrolase 1 GBrowse link ISS 1 142,936,379 143,010,358 RGD:7242559 RGD
G Folh1 folate hydrolase 1 GBrowse link ISS 1 142,936,379 143,010,358 RGD:7242426 RGD
G Folr1 folate receptor 1 (adult) GBrowse link ISS 1 159,315,191 159,324,141 RGD:7242557 RGD
G Folr2 folate receptor 2 (fetal) GBrowse link ISS 1 159,295,773 159,314,107 RGD:7242557 RGD
G Fpgs folylpolyglutamate synthase ISS RGD:7242559 RGD
G Gcsh glycine cleavage system protein H (aminomethyl carrier) GBrowse link ISS 19 47,091,226 47,101,983 RGD:7242560 RGD
G Ggh gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) GBrowse link TAS 5 34,670,883 34,693,791 RGD:7242559 RGD
G Gldc glycine dehydrogenase (decarboxylating) GBrowse link ISS 1 233,846,690 233,925,736 RGD:7242560 RGD
G Mthfd1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase GBrowse link ISS 6 98,849,446 98,916,936 RGD:7242557 RGD
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like GBrowse link ISS 1 34,759,445 34,800,865 RGD:7242557 RGD
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase GBrowse link ISS 4 117,517,611 117,529,128 RGD:7242557 RGD
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase GBrowse link ISS 4 117,517,611 117,529,128 RGD:7242560 RGD
G Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like GBrowse link ISS 14 18,585,147 18,665,534 RGD:7242557 RGD
G Mthfr methylenetetrahydrofolate reductase (NAD(P)H) GBrowse link ISS 5 165,112,850 165,126,885 RGD:7242557 RGD
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase GBrowse link ISS 17 68,782,708 68,867,101 RGD:7242557 RGD
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase GBrowse link ISS 17 5,086,219 5,118,086 RGD:7242557 RGD
G Sardh sarcosine dehydrogenase GBrowse link ISS 3 6,076,166 6,142,565 RGD:7242560 RGD
G Shmt1 serine hydroxymethyltransferase 1 (soluble) GBrowse link ISS 10 46,936,605 46,964,779 RGD:7242557 RGD
G Shmt2 serine hydroxymethyltransferase 2 (mitochondrial) GBrowse link ISS 7 67,494,470 67,499,540 RGD:7242557 RGD
G Shmt2 serine hydroxymethyltransferase 2 (mitochondrial) GBrowse link ISS 7 67,494,470 67,499,540 RGD:7242560 RGD
G Slc19a1 solute carrier family 19 (folate transporter), member 1 GBrowse link ISS 20 11,984,283 12,001,865 RGD:7242557 RGD
G Slc19a1 solute carrier family 19 (folate transporter), member 1 GBrowse link ISS 20 11,984,283 12,001,865 RGD:7242426 RGD
G Slc25a32 solute carrier family 25 (mitochondrial folate carrier) , member 32 GBrowse link ISS 7 74,650,541 74,668,358 RGD:7242561 RGD
G Slc46a1 solute carrier family 46 (folate transporter), member 1 GBrowse link ISS 10 64,576,068 64,582,504 RGD:7242426 RGD
G Slc46a1 solute carrier family 46 (folate transporter), member 1 GBrowse link ISS 10 64,576,068 64,582,504 RGD:7242557 RGD
folate mediated one-carbon metabolic pathway term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 TAS RGD:1547843 RGD
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 IEA RGD:6907045 KEGG
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 GBrowse link IEA 7 22,398,067 22,450,381 RGD:6907045 KEGG
G Amt aminomethyltransferase IEA RGD:6907045 KEGG
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase GBrowse link IEA 9 70,676,744 70,696,865 RGD:6907045 KEGG
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase GBrowse link IDA 9 70,676,744 70,696,865 RGD:70804 RGD
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase GBrowse link ISS 9 70,676,744 70,696,865 RGD:7242561 RGD
G Dhfr dihydrofolate reductase GBrowse link IDA 2 22,607,093 22,828,487 RGD:1298877 RGD
G Dhfr dihydrofolate reductase GBrowse link IEA 2 22,607,093 22,828,487 RGD:6907045 KEGG
G Dhfr dihydrofolate reductase GBrowse link ISS 2 22,607,093 22,828,487 RGD:7242561 RGD
G Dmgdh dimethylglycine dehydrogenase GBrowse link TAS 2 23,976,563 24,052,766 RGD:1547831 RGD
G Folh1 folate hydrolase 1 GBrowse link TAS 1 142,936,379 143,010,358 RGD:728645 RGD
G Ftcd formimidoyltransferase cyclodeaminase GBrowse link IEA 20 12,470,291 12,483,807 RGD:6907045 KEGG
G Gart phosphoribosylglycinamide formyltransferase GBrowse link ISS 11 31,594,859 31,620,110 RGD:1547842 RGD
G Gart phosphoribosylglycinamide formyltransferase GBrowse link IEA 11 31,594,859 31,620,110 RGD:6907045 KEGG
G Gart phosphoribosylglycinamide formyltransferase GBrowse link ISS 11 31,594,859 31,620,110 RGD:7242561 RGD
G Ggh gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) GBrowse link TAS 5 34,670,883 34,693,791 RGD:69845 RGD
G Gnmt glycine N-methyltransferase GBrowse link TAS 9 10,127,092 10,130,444 RGD:1545057 RGD
G Mtfmt mitochondrial methionyl-tRNA formyltransferase GBrowse link IEA 8 69,683,737 69,701,721 RGD:6907045 KEGG
G Mthfd1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase GBrowse link IEA 6 98,849,446 98,916,936 RGD:6907045 KEGG
G Mthfd1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase GBrowse link TAS 6 98,849,446 98,916,936 RGD:1299513 RGD
G Mthfd1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase GBrowse link ISS 6 98,849,446 98,916,936 RGD:7242561 RGD
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like GBrowse link IEA 1 34,759,445 34,800,865 RGD:6907045 KEGG
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase GBrowse link ISS 4 117,517,611 117,529,128 RGD:1540378 RGD
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase GBrowse link IEA 4 117,517,611 117,529,128 RGD:6907045 KEGG
G Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like GBrowse link IEA 14 18,585,147 18,665,534 RGD:6907045 KEGG
G Mthfr methylenetetrahydrofolate reductase (NAD(P)H) GBrowse link ISS 5 165,112,850 165,126,885 RGD:7242561 RGD
G Mthfr methylenetetrahydrofolate reductase (NAD(P)H) GBrowse link ISS 5 165,112,850 165,126,885 RGD:1535021 RGD
G Mthfr methylenetetrahydrofolate reductase (NAD(P)H) GBrowse link IEA 5 165,112,850 165,126,885 RGD:6907045 KEGG
G Mthfs 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) GBrowse link IEA 8 94,058,605 94,108,277 RGD:6907045 KEGG
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase GBrowse link IEA 17 68,782,708 68,867,101 RGD:6907045 KEGG
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase GBrowse link IDA 17 68,782,708 68,867,101 RGD:1359026 RGD
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase GBrowse link ISS 17 68,782,708 68,867,101 RGD:7242426 RGD
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase GBrowse link ISS 17 5,086,219 5,118,086 RGD:7242426 RGD
G RGD1564040 similar to methylenetetrahydrofolate dehydrogenase (NAD) (EC 1.5.1.15)/methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) precursor GBrowse link IEA 5 122,694,391 122,695,440 RGD:6907045 KEGG
G Sardh sarcosine dehydrogenase GBrowse link TAS 3 6,076,166 6,142,565 RGD:634034 RGD
G Shmt1 serine hydroxymethyltransferase 1 (soluble) GBrowse link TAS 10 46,936,605 46,964,779 RGD:1359815 RGD
G Shmt1 serine hydroxymethyltransferase 1 (soluble) GBrowse link IEA 10 46,936,605 46,964,779 RGD:6907045 KEGG
G Shmt1 serine hydroxymethyltransferase 1 (soluble) GBrowse link IDA 10 46,936,605 46,964,779 RGD:2300383 RGD
G Shmt1 serine hydroxymethyltransferase 1 (soluble) GBrowse link ISS 10 46,936,605 46,964,779 RGD:7242561 RGD
G Shmt2 serine hydroxymethyltransferase 2 (mitochondrial) GBrowse link TAS 7 67,494,470 67,499,540 RGD:1359815 RGD
G Shmt2 serine hydroxymethyltransferase 2 (mitochondrial) GBrowse link ISS 7 67,494,470 67,499,540 RGD:7242561 RGD
G Shmt2 serine hydroxymethyltransferase 2 (mitochondrial) GBrowse link IEA 7 67,494,470 67,499,540 RGD:6907045 KEGG
G Shmt2 serine hydroxymethyltransferase 2 (mitochondrial) GBrowse link IDA 7 67,494,470 67,499,540 RGD:2300383 RGD
G Tyms thymidylate synthetase GBrowse link IDA 9 112,604,912 112,617,706 RGD:1545055 RGD
G Tyms thymidylate synthetase GBrowse link IEA 9 112,604,912 112,617,706 RGD:6907045 KEGG
G Tyms thymidylate synthetase GBrowse link ISS 9 112,604,912 112,617,706 RGD:7242561 RGD

Term paths to the root
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  pathway 17508
    classic metabolic pathway 3631
      metabolic pathway of cofactors, vitamins, nutrients 442
        folate metabolic pathway 120
          altered folate metabolic pathway + 12
          folate cycle metabolic pathway + 39
          folate mediated one-carbon metabolic pathway + 50
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