ONTOLOGY REPORT - ANNOTATIONS


Term:folate metabolic pathway
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Accession:PW:0000140 term browser browse the term
Definition:Folate metabolism represents the various aspects of folate cycle and the folate mediate transfer reactions essential for several biosynthetic pathways. The folate cycle and the folate mediated one-carbon pathways are part of folate metabolism. Folate compounds are water-soluble forms of vitamin B9.
Synonyms:related_synonym: KEGG:00790;   vitamin B9 metabolic pathway


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folate metabolic pathway term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Akp3 alkaline phosphatase 3, intestine, not Mn requiring GBrowse link 9 93,954,155 93,957,145 RGD:6907045
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 GBrowse link 4 186,990,816 187,030,955 RGD:1547843
G Alpi alkaline phosphatase, intestinal GBrowse link 9 93,922,817 93,926,531 RGD:6907045
G Alpl alkaline phosphatase, liver/bone/kidney GBrowse link 5 159,841,916 159,897,391 RGD:6907045
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase GBrowse link 9 78,636,339 78,656,387 RGD:70804
G Dhfr dihydrofolate reductase GBrowse link 2
2
41,137,784
41,162,308
41,149,417
41,162,496
RGD:1298877
RGD:6907045
G Dmgdh dimethylglycine dehydrogenase GBrowse link 2 42,469,950 42,545,633 RGD:1547831
G Folh1 folate hydrolase 1 GBrowse link 1 156,631,301 156,702,948 RGD:728645
G Folr2 folate receptor 2 (fetal) GBrowse link 1 173,104,830 173,123,162 RGD:1540379
G Fpgs folylpolyglutamate synthase GBrowse link 3 17,058,730 17,068,957 RGD:6907045
G Gart phosphoribosylglycinamide formyltransferase GBrowse link 11 35,389,216 35,414,461 RGD:1547842
G Gch1 GTP cyclohydrolase 1 GBrowse link 15 27,876,253 27,910,213 RGD:6907045
G Ggh gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) GBrowse link 5 38,693,591 38,716,702 RGD:69845
RGD:6907045
G Gnmt glycine N-methyltransferase GBrowse link 9 15,471,889 15,475,241 RGD:1359070
G Mocs1 molybdenum cofactor synthesis 1 GBrowse link 9 12,426,594 12,452,999 RGD:6907045
G Mocs2 molybdenum cofactor synthesis 2 GBrowse link 2 71,520,174 71,532,084 RGD:6907045
G Mthfd1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase GBrowse link 6 108,694,405 108,761,922 RGD:1299513
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase GBrowse link 4 179,592,799 179,604,331 RGD:1540378
G Mthfr methylenetetrahydrofolate reductase (NAD(P)H) GBrowse link 5 168,502,556 168,522,350 RGD:1535021
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase GBrowse link 17 67,954,893 68,041,488 RGD:1359026
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase GBrowse link 1 39,124,730 39,156,109 RGD:1359037
G Pts 6-pyruvoyl-tetrahydropterin synthase GBrowse link 8 53,551,584 53,558,594 RGD:6907045
G Qdpr quinoid dihydropteridine reductase GBrowse link 14 70,207,866 70,221,468 RGD:6907045
G Sardh sarcosine dehydrogenase GBrowse link 3 11,100,670 11,164,367 RGD:634034
G Shmt1 serine hydroxymethyltransferase 1 (soluble) GBrowse link 10 46,802,986 46,831,051 RGD:1359815
G Shmt2 serine hydroxymethyltransferase 2 (mitochondrial) GBrowse link 7 70,998,103 71,003,197 RGD:1359815
G Slc19a1 solute carrier family 19 (folate transporter), member 1 GBrowse link 20 14,497,058 14,515,221 RGD:735239
G Spr sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) GBrowse link 4 181,492,882 181,496,612 RGD:6907045
G Tyms thymidylate synthetase GBrowse link 9 121,368,418 121,381,493 RGD:1545055
altered folate cycle metabolic pathway term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 GBrowse link 4 186,990,816 187,030,955 RGD:7242562
G Dhfr dihydrofolate reductase GBrowse link 2
2
41,137,784
41,162,308
41,149,417
41,162,496
RGD:7242557
G Folr1 folate receptor 1 (adult) GBrowse link 1 173,124,242 173,135,651 RGD:7242557
G Mthfd1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase GBrowse link 6 108,694,405 108,761,922 RGD:7242557
G Mthfr methylenetetrahydrofolate reductase (NAD(P)H) GBrowse link 5 168,502,556 168,522,350 RGD:7242557
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase GBrowse link 17 67,954,893 68,041,488 RGD:7242557
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase GBrowse link 1 39,124,730 39,156,109 RGD:7242557
G Slc46a1 solute carrier family 46 (folate transporter), member 1 GBrowse link 10 65,902,790 65,915,107 RGD:7242557
altered folate mediated one-carbon metabolic pathway term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Mthfd1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase GBrowse link 6 108,694,405 108,761,922 RGD:7242562
G Mthfr methylenetetrahydrofolate reductase (NAD(P)H) GBrowse link 5 168,502,556 168,522,350 RGD:7242562
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase GBrowse link 17 67,954,893 68,041,488 RGD:7242562
folate cycle metabolic pathway term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 GBrowse link 4 186,990,816 187,030,955 RGD:7242562
G Amt aminomethyltransferase GBrowse link 8 116,421,237 116,427,437 RGD:7242560
G Dhfr dihydrofolate reductase GBrowse link 2
2
41,137,784
41,162,308
41,149,417
41,162,496
RGD:7242557
G Dld dihydrolipoamide dehydrogenase GBrowse link 6 59,273,427 59,293,925 RGD:7242560
G Dmgdh dimethylglycine dehydrogenase GBrowse link 2 42,469,950 42,545,633 RGD:7242560
G Folh1 folate hydrolase 1 GBrowse link 1 156,631,301 156,702,948 RGD:7242426
RGD:7242559
G Folr1 folate receptor 1 (adult) GBrowse link 1 173,124,242 173,135,651 RGD:7242557
G Folr2 folate receptor 2 (fetal) GBrowse link 1 173,104,830 173,123,162 RGD:7242557
G Fpgs folylpolyglutamate synthase GBrowse link 3 17,058,730 17,068,957 RGD:7242559
G Gcsh glycine cleavage system protein H (aminomethyl carrier) GBrowse link 19 60,313,300 60,324,057 RGD:7242560
G Ggh gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) GBrowse link 5 38,693,591 38,716,702 RGD:7242559
G Gldc glycine dehydrogenase (decarboxylating) GBrowse link 1 255,544,863 255,624,599 RGD:7242560
G Mthfd1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase GBrowse link 6 108,694,405 108,761,922 RGD:7242557
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like GBrowse link 1 41,876,363 42,065,394 RGD:7242557
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase GBrowse link 4 179,592,799 179,604,331 RGD:7242557
RGD:7242560
G Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like GBrowse link 14 18,548,222 18,629,209 RGD:7242557
G Mthfr methylenetetrahydrofolate reductase (NAD(P)H) GBrowse link 5 168,502,556 168,522,350 RGD:7242557
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase GBrowse link 17 67,954,893 68,041,488 RGD:7242557
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase GBrowse link 1 39,124,730 39,156,109 RGD:7242557
G Sardh sarcosine dehydrogenase GBrowse link 3 11,100,670 11,164,367 RGD:7242560
G Shmt1 serine hydroxymethyltransferase 1 (soluble) GBrowse link 10 46,802,986 46,831,051 RGD:7242557
G Shmt2 serine hydroxymethyltransferase 2 (mitochondrial) GBrowse link 7 70,998,103 71,003,197 RGD:7242557
RGD:7242560
G Slc19a1 solute carrier family 19 (folate transporter), member 1 GBrowse link 20 14,497,058 14,515,221 RGD:7242426
RGD:7242557
G Slc25a32 solute carrier family 25 (mitochondrial folate carrier) , member 32 GBrowse link 7 78,244,446 78,265,340 RGD:7242561
G Slc46a1 solute carrier family 46 (folate transporter), member 1 GBrowse link 10 65,902,790 65,915,107 RGD:7242426
RGD:7242557
folate mediated one-carbon metabolic pathway term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 GBrowse link 4 186,990,816 187,030,955 RGD:1547843
RGD:6907045
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 GBrowse link 7 26,506,321 26,555,206 RGD:6907045
G Amt aminomethyltransferase GBrowse link 8 116,421,237 116,427,437 RGD:6907045
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase GBrowse link 9 78,636,339 78,656,387 RGD:70804
RGD:6907045
RGD:7242561
G Dhfr dihydrofolate reductase GBrowse link 2
2
41,137,784
41,162,308
41,149,417
41,162,496
RGD:1298877
RGD:6907045
RGD:7242561
G Dmgdh dimethylglycine dehydrogenase GBrowse link 2 42,469,950 42,545,633 RGD:1547831
G Folh1 folate hydrolase 1 GBrowse link 1 156,631,301 156,702,948 RGD:728645
G Ftcd formimidoyltransferase cyclodeaminase GBrowse link 20 14,965,126 14,978,635 RGD:6907045
G Gart phosphoribosylglycinamide formyltransferase GBrowse link 11 35,389,216 35,414,461 RGD:1547842
RGD:6907045
RGD:7242561
G Ggh gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) GBrowse link 5 38,693,591 38,716,702 RGD:69845
G Gnmt glycine N-methyltransferase GBrowse link 9 15,471,889 15,475,241 RGD:1545057
G Mtfmt mitochondrial methionyl-tRNA formyltransferase GBrowse link 8 70,644,131 70,674,636 RGD:6907045
G Mthfd1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase GBrowse link 6 108,694,405 108,761,922 RGD:1299513
RGD:6907045
RGD:7242561
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like GBrowse link 1 41,876,363 42,065,394 RGD:6907045
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase GBrowse link 4 179,592,799 179,604,331 RGD:1540378
RGD:6907045
G Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like GBrowse link 14 18,548,222 18,629,209 RGD:6907045
G Mthfr methylenetetrahydrofolate reductase (NAD(P)H) GBrowse link 5 168,502,556 168,522,350 RGD:1535021
RGD:6907045
RGD:7242561
G Mthfs 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) GBrowse link 8 96,071,796 96,121,086 RGD:6907045
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase GBrowse link 17 67,954,893 68,041,488 RGD:1359026
RGD:6907045
RGD:7242426
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase GBrowse link 1 39,124,730 39,156,109 RGD:7242426
G RGD1564040 similar to methylenetetrahydrofolate dehydrogenase (NAD) (EC 1.5.1.15)/methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) precursor GBrowse link 5 124,738,251 124,739,298 RGD:6907045
G Sardh sarcosine dehydrogenase GBrowse link 3 11,100,670 11,164,367 RGD:634034
G Shmt1 serine hydroxymethyltransferase 1 (soluble) GBrowse link 10 46,802,986 46,831,051 RGD:1359815
RGD:2300383
RGD:6907045
RGD:7242561
G Shmt2 serine hydroxymethyltransferase 2 (mitochondrial) GBrowse link 7 70,998,103 71,003,197 RGD:1359815
RGD:2300383
RGD:6907045
RGD:7242561
G Tyms thymidylate synthetase GBrowse link 9 121,368,418 121,381,493 RGD:1545055
RGD:6907045
RGD:7242561

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  pathway 52399
    classic metabolic pathway 10246
      metabolic pathway of cofactors, vitamins, nutrients 1319
        folate metabolic pathway 321
          altered folate metabolic pathway + 35
          folate cycle metabolic pathway + 116
          folate mediated one-carbon metabolic pathway + 131
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