ONTOLOGY REPORT - ANNOTATIONS


Term:folate metabolic pathway
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Accession:PW:0000140 term browser browse the term
Definition:Folate metabolism represents the various aspects of folate cycle and the folate mediate transfer reactions essential for several biosynthetic pathways. The folate cycle and the folate mediated one-carbon pathways are part of folate metabolism. Folate compounds are water-soluble forms of vitamin B9.
Synonyms:related_synonym: KEGG:00790;   vitamin B9 metabolic pathway


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folate metabolic pathway term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Akp3 alkaline phosphatase 3, intestine, not Mn requiring GBrowse link 9 85,924,232 85,927,327 RGD:6907045
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 RGD:1547843
G Alpi alkaline phosphatase, intestinal GBrowse link 9 85,892,887 85,896,353 RGD:6907045
G Alpl alkaline phosphatase, liver/bone/kidney GBrowse link 5 156,501,739 156,558,727 RGD:6907045
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase GBrowse link 9 70,676,744 70,696,865 RGD:70804
G Dhfr dihydrofolate reductase GBrowse link 2 22,607,093 22,828,487 RGD:1298877
RGD:6907045
G Dmgdh dimethylglycine dehydrogenase GBrowse link 2 23,976,563 24,052,766 RGD:1547831
G Folh1 folate hydrolase 1 GBrowse link 1 142,936,379 143,010,358 RGD:728645
G Folr2 folate receptor 2 (fetal) GBrowse link 1 159,295,773 159,314,107 RGD:1540379
G Fpgs folylpolyglutamate synthase RGD:6907045
G Gart phosphoribosylglycinamide formyltransferase GBrowse link 11 31,594,859 31,620,110 RGD:1547842
G Gch1 GTP cyclohydrolase 1 GBrowse link 15 23,023,996 23,139,794 RGD:6907045
G Ggh gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) GBrowse link 5 34,670,883 34,693,791 RGD:69845
RGD:6907045
G Gnmt glycine N-methyltransferase GBrowse link 9 10,127,092 10,130,444 RGD:1359070
G Mocs1 molybdenum cofactor synthesis 1 GBrowse link 9 6,759,531 6,779,930 RGD:6907045
G Mocs2 molybdenum cofactor synthesis 2 GBrowse link 2 46,948,321 46,960,060 RGD:6907045
G Mthfd1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase GBrowse link 6 98,849,446 98,916,936 RGD:1299513
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase GBrowse link 4 117,517,611 117,529,128 RGD:1540378
G Mthfr methylenetetrahydrofolate reductase (NAD(P)H) GBrowse link 5 165,112,850 165,126,885 RGD:1535021
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase GBrowse link 17 68,782,708 68,867,101 RGD:1359026
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase GBrowse link 17 5,086,219 5,118,086 RGD:1359037
G Pts 6-pyruvoyl-tetrahydropterin synthase GBrowse link 8 53,880,701 53,887,711 RGD:6907045
G Qdpr quinoid dihydropteridine reductase GBrowse link 14 70,741,998 70,755,600 RGD:6907045
G Sardh sarcosine dehydrogenase GBrowse link 3 6,076,166 6,142,565 RGD:634034
G Shmt1 serine hydroxymethyltransferase 1 (soluble) GBrowse link 10 46,936,605 46,964,779 RGD:1359815
G Shmt2 serine hydroxymethyltransferase 2 (mitochondrial) GBrowse link 7 67,494,470 67,499,540 RGD:1359815
G Slc19a1 solute carrier family 19 (folate transporter), member 1 GBrowse link 20 11,984,283 12,001,865 RGD:735239
G Spr sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) GBrowse link 4 119,365,578 119,369,308 RGD:6907045
G Tyms thymidylate synthetase GBrowse link 9 112,604,912 112,617,706 RGD:1545055
altered folate cycle metabolic pathway term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 RGD:7242562
G Dhfr dihydrofolate reductase GBrowse link 2 22,607,093 22,828,487 RGD:7242557
G Folr1 folate receptor 1 (adult) GBrowse link 1 159,315,191 159,324,141 RGD:7242557
G Mthfd1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase GBrowse link 6 98,849,446 98,916,936 RGD:7242557
G Mthfr methylenetetrahydrofolate reductase (NAD(P)H) GBrowse link 5 165,112,850 165,126,885 RGD:7242557
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase GBrowse link 17 68,782,708 68,867,101 RGD:7242557
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase GBrowse link 17 5,086,219 5,118,086 RGD:7242557
G Slc46a1 solute carrier family 46 (folate transporter), member 1 GBrowse link 10 64,576,068 64,582,504 RGD:7242557
altered folate mediated one-carbon metabolic pathway term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Mthfd1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase GBrowse link 6 98,849,446 98,916,936 RGD:7242562
G Mthfr methylenetetrahydrofolate reductase (NAD(P)H) GBrowse link 5 165,112,850 165,126,885 RGD:7242562
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase GBrowse link 17 68,782,708 68,867,101 RGD:7242562
folate cycle metabolic pathway term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 RGD:7242562
G Amt aminomethyltransferase RGD:7242560
G Dhfr dihydrofolate reductase GBrowse link 2 22,607,093 22,828,487 RGD:7242557
G Dld dihydrolipoamide dehydrogenase GBrowse link 6 49,185,188 49,205,894 RGD:7242560
G Dmgdh dimethylglycine dehydrogenase GBrowse link 2 23,976,563 24,052,766 RGD:7242560
G Folh1 folate hydrolase 1 GBrowse link 1 142,936,379 143,010,358 RGD:7242426
RGD:7242559
G Folr1 folate receptor 1 (adult) GBrowse link 1 159,315,191 159,324,141 RGD:7242557
G Folr2 folate receptor 2 (fetal) GBrowse link 1 159,295,773 159,314,107 RGD:7242557
G Fpgs folylpolyglutamate synthase RGD:7242559
G Gcsh glycine cleavage system protein H (aminomethyl carrier) GBrowse link 19 47,091,226 47,101,983 RGD:7242560
G Ggh gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) GBrowse link 5 34,670,883 34,693,791 RGD:7242559
G Gldc glycine dehydrogenase (decarboxylating) GBrowse link 1 233,846,690 233,925,736 RGD:7242560
G Mthfd1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase GBrowse link 6 98,849,446 98,916,936 RGD:7242557
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like GBrowse link 1 34,759,445 34,800,865 RGD:7242557
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase GBrowse link 4 117,517,611 117,529,128 RGD:7242557
RGD:7242560
G Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like GBrowse link 14 18,585,147 18,665,534 RGD:7242557
G Mthfr methylenetetrahydrofolate reductase (NAD(P)H) GBrowse link 5 165,112,850 165,126,885 RGD:7242557
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase GBrowse link 17 68,782,708 68,867,101 RGD:7242557
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase GBrowse link 17 5,086,219 5,118,086 RGD:7242557
G Sardh sarcosine dehydrogenase GBrowse link 3 6,076,166 6,142,565 RGD:7242560
G Shmt1 serine hydroxymethyltransferase 1 (soluble) GBrowse link 10 46,936,605 46,964,779 RGD:7242557
G Shmt2 serine hydroxymethyltransferase 2 (mitochondrial) GBrowse link 7 67,494,470 67,499,540 RGD:7242557
RGD:7242560
G Slc19a1 solute carrier family 19 (folate transporter), member 1 GBrowse link 20 11,984,283 12,001,865 RGD:7242426
RGD:7242557
G Slc25a32 solute carrier family 25 (mitochondrial folate carrier) , member 32 GBrowse link 7 74,650,541 74,668,358 RGD:7242561
G Slc46a1 solute carrier family 46 (folate transporter), member 1 GBrowse link 10 64,576,068 64,582,504 RGD:7242426
RGD:7242557
folate mediated one-carbon metabolic pathway term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 RGD:1547843
RGD:6907045
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 GBrowse link 7 22,398,067 22,450,381 RGD:6907045
G Amt aminomethyltransferase RGD:6907045
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase GBrowse link 9 70,676,744 70,696,865 RGD:70804
RGD:6907045
RGD:7242561
G Dhfr dihydrofolate reductase GBrowse link 2 22,607,093 22,828,487 RGD:1298877
RGD:6907045
RGD:7242561
G Dmgdh dimethylglycine dehydrogenase GBrowse link 2 23,976,563 24,052,766 RGD:1547831
G Folh1 folate hydrolase 1 GBrowse link 1 142,936,379 143,010,358 RGD:728645
G Ftcd formimidoyltransferase cyclodeaminase GBrowse link 20 12,470,291 12,483,807 RGD:6907045
G Gart phosphoribosylglycinamide formyltransferase GBrowse link 11 31,594,859 31,620,110 RGD:1547842
RGD:6907045
RGD:7242561
G Ggh gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) GBrowse link 5 34,670,883 34,693,791 RGD:69845
G Gnmt glycine N-methyltransferase GBrowse link 9 10,127,092 10,130,444 RGD:1545057
G Mtfmt mitochondrial methionyl-tRNA formyltransferase GBrowse link 8 69,683,737 69,701,721 RGD:6907045
G Mthfd1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase GBrowse link 6 98,849,446 98,916,936 RGD:1299513
RGD:6907045
RGD:7242561
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like GBrowse link 1 34,759,445 34,800,865 RGD:6907045
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase GBrowse link 4 117,517,611 117,529,128 RGD:1540378
RGD:6907045
G Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like GBrowse link 14 18,585,147 18,665,534 RGD:6907045
G Mthfr methylenetetrahydrofolate reductase (NAD(P)H) GBrowse link 5 165,112,850 165,126,885 RGD:1535021
RGD:6907045
RGD:7242561
G Mthfs 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) GBrowse link 8 94,058,605 94,108,277 RGD:6907045
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase GBrowse link 17 68,782,708 68,867,101 RGD:1359026
RGD:6907045
RGD:7242426
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase GBrowse link 17 5,086,219 5,118,086 RGD:7242426
G RGD1564040 similar to methylenetetrahydrofolate dehydrogenase (NAD) (EC 1.5.1.15)/methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) precursor GBrowse link 5 122,694,391 122,695,440 RGD:6907045
G Sardh sarcosine dehydrogenase GBrowse link 3 6,076,166 6,142,565 RGD:634034
G Shmt1 serine hydroxymethyltransferase 1 (soluble) GBrowse link 10 46,936,605 46,964,779 RGD:1359815
RGD:2300383
RGD:6907045
RGD:7242561
G Shmt2 serine hydroxymethyltransferase 2 (mitochondrial) GBrowse link 7 67,494,470 67,499,540 RGD:1359815
RGD:2300383
RGD:6907045
RGD:7242561
G Tyms thymidylate synthetase GBrowse link 9 112,604,912 112,617,706 RGD:1545055
RGD:6907045
RGD:7242561

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  pathway 18089
    classic metabolic pathway 3661
      metabolic pathway of cofactors, vitamins, nutrients 442
        folate metabolic pathway 120
          altered folate metabolic pathway + 12
          folate cycle metabolic pathway + 39
          folate mediated one-carbon metabolic pathway + 50
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