ONTOLOGY REPORT - ANNOTATIONS


Term:folate metabolic pathway
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Accession:PW:0000140 term browser browse the term
Definition:Folate metabolism represents the various aspects of folate cycle and the folate mediate transfer reactions essential for several biosynthetic pathways. The folate cycle and the folate mediated one-carbon pathways are part of folate metabolism. Folate compounds are water-soluble forms of vitamin B9.
Synonyms:related_synonym: KEGG:00790;   SMP:00053;   vitamin B9 metabolic pathway


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folate metabolic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akp3 alkaline phosphatase 3, intestine, not Mn requiring JBrowse link 9 94,228,960 94,232,001 RGD:6907045
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 JBrowse link 4 123,516,553 123,564,067 RGD:1547843
RGD:10402751
G Alpi alkaline phosphatase, intestinal JBrowse link 9 94,197,616 94,201,910 RGD:6907045
G Alpl alkaline phosphatase, liver/bone/kidney JBrowse link 5 156,086,496 156,141,513 RGD:6907045
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase JBrowse link 9 78,862,013 78,882,061 RGD:70804
G Dhfr dihydrofolate reductase JBrowse link 2 21,931,887 21,958,927 RGD:1298877
RGD:6907045
RGD:10402751
G Dmgdh dimethylglycine dehydrogenase JBrowse link 2 23,289,376 23,370,360 RGD:1547831
G Folh1 folate hydrolase 1 JBrowse link 1 150,323,768 150,395,415 RGD:728645
G Folr2 folate receptor beta JBrowse link 1 166,915,045 166,933,377 RGD:1540379
G Fpgs folylpolyglutamate synthase JBrowse link 3 11,717,667 11,729,694 RGD:6907045
RGD:10402751
G Ftcd formimidoyltransferase cyclodeaminase JBrowse link 20 12,806,957 12,820,466 RGD:10402751
G Gart phosphoribosylglycinamide formyltransferase JBrowse link 11 31,780,477 31,805,728 RGD:1547842
G Gch1 GTP cyclohydrolase 1 JBrowse link 15 23,935,011 23,968,971 RGD:6907045
G Ggh gamma-glutamyl hydrolase JBrowse link 5 34,040,258 34,063,369 RGD:69845
RGD:6907045
RGD:10402751
G Gnmt glycine N-methyltransferase JBrowse link 9 16,565,274 16,568,626 RGD:1359070
G Mocs1 molybdenum cofactor synthesis 1 JBrowse link 9 13,493,705 13,520,113 RGD:6907045
G Mocs2 molybdenum cofactor synthesis 2 JBrowse link 2 46,980,976 46,992,886 RGD:6907045
G Mtfmt mitochondrial methionyl-tRNA formyltransferase JBrowse link 8 70,952,173 70,986,393 RGD:10402751
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 JBrowse link 6 99,282,850 99,350,367 RGD:1299513
RGD:10402751
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like JBrowse link 1 40,529,092 40,719,232 RGD:10402751
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase JBrowse link 4 115,004,448 115,015,965 RGD:1540378
RGD:10402751
G Mthfr methylenetetrahydrofolate reductase (NAD(P)H) JBrowse link 5 164,844,653 164,864,360 RGD:1535021
RGD:10402751
G Mthfs 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) JBrowse link 8 96,564,877 96,614,384 RGD:10402751
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase JBrowse link 17 66,210,444 66,295,014 RGD:1359026
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase JBrowse link 1 37,743,100 37,774,485 RGD:1359037
G Pts 6-pyruvoyl-tetrahydropterin synthase JBrowse link 8 54,954,261 54,961,271 RGD:6907045
G Qdpr quinoid dihydropteridine reductase JBrowse link 14 70,164,682 70,178,284 RGD:6907045
G Sardh sarcosine dehydrogenase JBrowse link 3 5,737,202 5,802,146 RGD:634034
G Shmt1 serine hydroxymethyltransferase 1 JBrowse link 10 47,030,812 47,059,216 RGD:1359815
G Shmt2 serine hydroxymethyltransferase 2 JBrowse link 7 70,824,719 70,829,824 RGD:1359815
G Slc19a1 solute carrier family 19 member 1 JBrowse link 20 12,334,675 12,353,853 RGD:735239
G Slc46a1 solute carrier family 46 member 1 JBrowse link 10 65,728,484 65,741,708 RGD:10402751
G Spr sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) JBrowse link 4 116,912,343 116,916,073 RGD:6907045
G Tyms thymidylate synthetase JBrowse link 9 121,918,875 121,931,564 RGD:1545055
altered folate cycle metabolic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 JBrowse link 4 123,516,553 123,564,067 RGD:7242562
G Dhfr dihydrofolate reductase JBrowse link 2 21,931,887 21,958,927 RGD:7242557
G Folr1 folate receptor 1 (adult) JBrowse link 1 166,934,457 166,943,592 RGD:7242557
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 JBrowse link 6 99,282,850 99,350,367 RGD:7242557
G Mthfr methylenetetrahydrofolate reductase (NAD(P)H) JBrowse link 5 164,844,653 164,864,360 RGD:7242557
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase JBrowse link 17 66,210,444 66,295,014 RGD:7242557
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase JBrowse link 1 37,743,100 37,774,485 RGD:7242557
G Slc46a1 solute carrier family 46 member 1 JBrowse link 10 65,728,484 65,741,708 RGD:7242557
altered folate mediated one-carbon metabolic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 JBrowse link 6 99,282,850 99,350,367 RGD:7242562
G Mthfr methylenetetrahydrofolate reductase (NAD(P)H) JBrowse link 5 164,844,653 164,864,360 RGD:7242562
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase JBrowse link 17 66,210,444 66,295,014 RGD:7242562
folate cycle metabolic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 JBrowse link 4 123,516,553 123,564,067 RGD:7242562
G Amt aminomethyltransferase JBrowse link 8 117,068,388 117,078,633 RGD:7242560
G Dhfr dihydrofolate reductase JBrowse link 2 21,931,887 21,958,927 RGD:7242557
G Dld dihydrolipoamide dehydrogenase JBrowse link 6 50,597,677 50,618,694 RGD:7242560
G Dmgdh dimethylglycine dehydrogenase JBrowse link 2 23,289,376 23,370,360 RGD:7242560
G Folh1 folate hydrolase 1 JBrowse link 1 150,323,768 150,395,415 RGD:7242426
RGD:7242559
G Folr1 folate receptor 1 (adult) JBrowse link 1 166,934,457 166,943,592 RGD:7242557
G Folr2 folate receptor beta JBrowse link 1 166,915,045 166,933,377 RGD:7242557
G Fpgs folylpolyglutamate synthase JBrowse link 3 11,717,667 11,729,694 RGD:7242559
G Gcsh glycine cleavage system protein H JBrowse link 19 49,522,054 49,532,811 RGD:7242560
G Ggh gamma-glutamyl hydrolase JBrowse link 5 34,040,258 34,063,369 RGD:7242559
G Gldc glycine decarboxylase JBrowse link 1 248,295,140 248,377,120 RGD:7242560
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 JBrowse link 6 99,282,850 99,350,367 RGD:7242557
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like JBrowse link 1 40,529,092 40,719,232 RGD:7242557
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase JBrowse link 4 115,004,448 115,015,965 RGD:7242557
RGD:7242560
G Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like JBrowse link 14 18,640,279 18,720,357 RGD:7242557
G Mthfr methylenetetrahydrofolate reductase (NAD(P)H) JBrowse link 5 164,844,653 164,864,360 RGD:7242557
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase JBrowse link 17 66,210,444 66,295,014 RGD:7242557
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase JBrowse link 1 37,743,100 37,774,485 RGD:7242557
G Sardh sarcosine dehydrogenase JBrowse link 3 5,737,202 5,802,146 RGD:7242560
G Shmt1 serine hydroxymethyltransferase 1 JBrowse link 10 47,030,812 47,059,216 RGD:7242557
G Shmt2 serine hydroxymethyltransferase 2 JBrowse link 7 70,824,719 70,829,824 RGD:7242557
RGD:7242560
G Slc19a1 solute carrier family 19 member 1 JBrowse link 20 12,334,675 12,353,853 RGD:7242426
RGD:7242557
G Slc25a32 solute carrier family 25 member 32 JBrowse link 7 77,983,885 78,005,054 RGD:7242561
G Slc46a1 solute carrier family 46 member 1 JBrowse link 10 65,728,484 65,741,708 RGD:7242426
RGD:7242557
folate mediated one-carbon metabolic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 JBrowse link 4 123,516,553 123,564,067 RGD:1547843
RGD:6907045
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 JBrowse link 7 26,375,866 26,425,838 RGD:6907045
G Amt aminomethyltransferase JBrowse link 8 117,068,388 117,078,633 RGD:6907045
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase JBrowse link 9 78,862,013 78,882,061 RGD:70804
RGD:6907045
RGD:7242561
G Dhfr dihydrofolate reductase JBrowse link 2 21,931,887 21,958,927 RGD:1298877
RGD:6907045
RGD:7242561
G Dmgdh dimethylglycine dehydrogenase JBrowse link 2 23,289,376 23,370,360 RGD:1547831
G Folh1 folate hydrolase 1 JBrowse link 1 150,323,768 150,395,415 RGD:728645
G Ftcd formimidoyltransferase cyclodeaminase JBrowse link 20 12,806,957 12,820,466 RGD:6907045
G Gart phosphoribosylglycinamide formyltransferase JBrowse link 11 31,780,477 31,805,728 RGD:1547842
RGD:6907045
RGD:7242561
G Ggh gamma-glutamyl hydrolase JBrowse link 5 34,040,258 34,063,369 RGD:69845
G Gnmt glycine N-methyltransferase JBrowse link 9 16,565,274 16,568,626 RGD:1545057
G Mtfmt mitochondrial methionyl-tRNA formyltransferase JBrowse link 8 70,952,173 70,986,393 RGD:6907045
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 JBrowse link 6 99,282,850 99,350,367 RGD:1299513
RGD:6907045
RGD:7242561
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like JBrowse link 1 40,529,092 40,719,232 RGD:6907045
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase JBrowse link 4 115,004,448 115,015,965 RGD:1540378
RGD:6907045
G Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like JBrowse link 14 18,640,279 18,720,357 RGD:6907045
G Mthfr methylenetetrahydrofolate reductase (NAD(P)H) JBrowse link 5 164,844,653 164,864,360 RGD:1535021
RGD:6907045
RGD:7242561
G Mthfs 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) JBrowse link 8 96,564,877 96,614,384 RGD:6907045
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase JBrowse link 17 66,210,444 66,295,014 RGD:1359026
RGD:6907045
RGD:7242426
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase JBrowse link 1 37,743,100 37,774,485 RGD:7242426
G RGD1564040 similar to methylenetetrahydrofolate dehydrogenase (NAD) (EC 1.5.1.15)/methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) precursor JBrowse link 5 120,869,141 120,870,188 RGD:6907045
G Sardh sarcosine dehydrogenase JBrowse link 3 5,737,202 5,802,146 RGD:634034
G Shmt1 serine hydroxymethyltransferase 1 JBrowse link 10 47,030,812 47,059,216 RGD:1359815
RGD:2300383
RGD:6907045
RGD:7242561
G Shmt2 serine hydroxymethyltransferase 2 JBrowse link 7 70,824,719 70,829,824 RGD:1359815
RGD:2300383
RGD:6907045
RGD:7242561
G Tyms thymidylate synthetase JBrowse link 9 121,918,875 121,931,564 RGD:1545055
RGD:6907045
RGD:7242561

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 88399
    classic metabolic pathway 13789
      metabolic pathway of cofactors, vitamins, nutrients 1879
        folate metabolic pathway 357
          altered folate metabolic pathway + 35
          folate cycle metabolic pathway + 116
          folate mediated one-carbon metabolic pathway + 131
Path 2
Term Annotations click to browse term
  pathway 88399
    regulatory pathway 23819
      homeostasis pathway 10084
        organic chemical homeostasis pathway 2368
          S-adenosylmethionine homeostasis pathway 1576
            folate metabolic pathway 357
              altered folate metabolic pathway + 35
              folate cycle metabolic pathway + 116
              folate mediated one-carbon metabolic pathway + 131
paths to the root