| The following 129 regions match your request. |
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Matches on Chr1
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| RGD1603953 | DOCK8 is a member of the DOCK180-related (DOCK1; MIM 601403) protein family (Ruusala and Aspenstrom‚ 2004 [PubMed 15304341]).[supplied by OMIM] | Chr1:228..228.2 Mbp (192.2 kbp) | score=10.42 |
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| RGD1316352 | ELOVL3 plays a role in fatty acid chain elongation and formation of neutral lipids required for skin barrier function (Westerberg et al.‚ 2004 [PubMed 14581464]).[supplied by OMIM] | Chr1:251.3..251.3 Mbp (3.204 kbp) | score=9.94 |
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| RGD1606081 | SPRED3 is a member of the Sprouty (see SPRY1; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1; MIM 176948) (Nonami et al.‚ 2004 [PubMed 15465815]).[supplied by OMIM] | Chr1:82.07..82.07 Mbp (5.933 kbp) | score=9.67 |
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| RGD1315779 | Basic helix-loop-helix transcription factors‚ such as ASCL3‚ are essential for the determination of cell fate and the development and differentiation of numerous tissues (Jonsson et al.‚ 2004 [PubMed 15475265]).[supplied by OMIM] | Chr1:167.1..167.1 Mbp (5.462 kbp) | score=9.60 |
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| RGD1317247 | The SLC25 gene family encodes mitochondrial carriers that transport a variety of metabolites across the inner mitochondrial membrane (Palmieri‚ 2004 [PubMed 14598172]). SLC25A22‚ also known as GC1‚ is 1 of the 2 mitochondrial glutamate/H symporters‚ the other being SLC25A18 (MIM 609303).[supplied by OMIM] | Chr1:201.6..201.6 Mbp (5.747 kbp) | score=9.35 |
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| RGD734007 | NXF is a member of the basic helix-loop-helix-PER (MIM 602260)-ARNT (MIM 126110)-SIM (see SIM2; MIM 600892) (bHLH-PAS) class of transcriptional regulators‚ which are involved in a wide range of physiologic and developmental events (Ooe et al.‚ 2004 [PubMed 14701734]).[supplied by OMIM] | Chr1:208.6..208.6 Mbp (5.703 kbp) | score=9.31 |
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| RGD1315231 | BLOC1S2 is a component of the ubiquitously expressed BLOC1 multisubunit protein complex. BLOC1 is required for normal biogenesis of specialized organelles of the endosomal-lysosomal system‚ such as melanosomes and platelet dense granules (Starcevic and Dell'Angelica‚ 2004 [PubMed 15102850]).[supplied by OMIM] | Chr1:249.1..249.1 Mbp (12.73 kbp) | score=9.09 |
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| RGD1350428 | G proteins are heterotrimers of alpha‚ beta‚ and gamma subunits. Gamma subunits‚ such as GNG3‚ contribute to the specificity of the hundreds of receptor signaling pathways involving G proteins (Schwindinger et al.‚ 2004 [PubMed 15314181]).[supplied by OMIM] | Chr1:213.7..213.7 Mbp (1.544 kbp) | score=9.00 |
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| RGD1348893 | tRNA splicing is a fundamental process required for cell growth and division. SEN34 is a subunit of the tRNA splicing endonuclease‚ which catalyzes the removal of introns‚ the first step in tRNA splicing (Paushkin et al.‚ 2004 [PubMed 15109492]).[supplied by OMIM] | Chr1:63.6..63.6 Mbp (3.33 kbp) | score=8.91 |
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| RGD1343469 | Nicotinamide adenine dinucleotide (NAD ) is essential for life in all organisms‚ both as a coenzyme for oxidoreductases and as a source of ADP-ribosyl groups used in various reactions. Nicotinic acid and nicotinamide‚ collectively known as niacin‚ are the vitamin precursors of NAD . Nicotinamide riboside kinases‚ such as NRK1‚ function to synthesize NAD through nicotinamide mononucleotide using nicotinamide riboside as the precursor (Bieganowski and Brenner‚ 2004 [PubMed 15137942]).[supplied by OMIM] | Chr1:239.6..239.6 Mbp (26.98 kbp) | score=8.33 |
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| RGD1322203 | Members of the F-box protein family‚ such as FBXL19‚ are characterized by an approximately 40-amino acid F-box motif. SCF complexes‚ formed by SKP1 (MIM 601434)‚ cullin (see CUL1; MIM 603134)‚ and F-box proteins‚ act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box‚ and they interact with ubiquitination targets through other protein interaction domains (Jin et al.‚ 2004 [PubMed 15520277]).[supplied by OMIM] | Chr1:180.2..180.2 Mbp (24.21 kbp) | score=8.26 |
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| RGD734342 | Members of the ZAS family‚ such as ZAS2 (HIVEP2)‚ are large proteins that contain a ZAS domain‚ a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine-rich sequence. These proteins bind specific DNA sequences‚ including the kappa-B motif (GGGACTTTCC)‚ in the promoters and enhancer regions of several genes and viruses‚ including human immunodeficiency virus (HIV). ZAS genes span more than 150 kb and contain at least 10 exons‚ one of which is longer than 5.5 kb (Allen and Wu‚ 2004).[supplied by OMIM] | Chr1:13.01..13.2 Mbp (193.7 kbp) | score=7.68 |
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| RGD1348964 | The TAAR6 (TRAR4) gene belongs to the trace amine receptor family. Trace amines are endogenous amine compounds that are chemically similar to classic biogenic amines like dopamine‚ norepinephrine‚ serotonin‚ and histamine. Trace amines were thought to be 'false transmitters' that displace classic biogenic amines from their storage and act on transporters in a fashion similar to the amphetamines‚ but the identification of brain receptors specific to trace amines indicates that they also have effects of their own (Duan et al.‚ 2004 [PubMed 15329799]).[supplied by OMIM] | Chr1:21.84..21.84 Mbp (1.038 kbp) | score=7.38 |
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Matches on Chr10
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| RGD1603897 | CD300LF is an inhibitory receptor of the Ig superfamily expressed on myeloid cells. It mediates negative regulatory signals by recruiting SHP1 (PTPN6; MIM 176883) or SHIP (INPP5D; MIM 601582) (Sui et al.‚ 2004 [PubMed 15184070]; Alvarez-Errico et al.‚ 2004 [PubMed 15549731]).[supplied by OMIM] | Chr10:104.4..104.4 Mbp (18.66 kbp) | score=15.12 |
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| RGD1353878 | Meteorin regulates glial cell differentiation and promotes the formation of axonal networks during neurogenesis (Nishino et al.‚ 2004 [PubMed 15085178]).[supplied by OMIM] | Chr10:15.22..15.22 Mbp (2.308 kbp) | score=10.32 |
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| RGD731934 | TBKBP1 is an adaptor protein that binds to TBK1 (MIM 604834) and is part of the interaction network in the TNF (MIM 191160)/NFKB (see MIM 164011) pathway (Bouwmeester et al.‚ 2004 [PubMed 14743216]).[supplied by OMIM] | Chr10:76.47..76.48 Mbp (16.79 kbp) | score=10.03 |
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| RGD1605230 | CD300LE is an activating receptor of the immunoglobulin (Ig) superfamily expressed on myeloid cells. It mediates activating signals by interacting with DAP12 (TYROBP; MIM 604142) (Aguilar et al.‚ 2004 [PubMed 15557162]).[supplied by OMIM] | Chr10:104.3..104.4 Mbp (11.09 kbp) | score=9.60 |
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| RGD1604366 | PELP1 is a coactivator of estrogen receptor (see ESR1; MIM 133430)-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors (Choi et al.‚ 2004 [PubMed 15456770]).[supplied by OMIM] | Chr10:57.16..57.19 Mbp (32.95 kbp) | score=9.53 |
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| RGD1606224 | FN3KRP and FN3K (MIM 608425) protect proteins from nonenzymatic glycation by phosphorylating the modified amino acid. This phosphorylation destabilizes the sugar-amine linkage and leads to spontaneous decomposition (Conner et al.‚ 2004 [PubMed 15381090]).[supplied by OMIM] | Chr10:110.7..110.7 Mbp (11.26 kbp) | score=9.49 |
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| RGD1342772 | RNF43 is a HAP95 (AKAP8L; MIM 609475) binding ubiquitin ligase that promotes cell growth and is upregulated in colon cancer (Yagyu et al.‚ 2004 [PubMed 15492824]; Sugiura et al.‚ 2008 [PubMed 18313049]).[supplied by OMIM] | Chr10:75.29..75.35 Mbp (63.86 kbp) | score=9.46 |
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| RGD1351326 | Coronins‚ such as CORO7‚ constitute an evolutionarily conserved family of WD-repeat actin-binding proteins. CORO7 plays a role in Golgi complex morphology and function (Rybakin et al.‚ 2004‚ 2006 [PubMed 15327992] [PubMed 16905771]).[supplied by OMIM] | Chr10:2.956..3.018 Mbp (62.03 kbp) | score=9.06 |
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| RGD1602635 | tRNA splicing is a fundamental process required for cell growth and division. SEN54 is a subunit of the tRNA splicing endonuclease‚ which catalyzes the removal of introns‚ the first step in tRNA splicing (Paushkin et al.‚ 2004 [PubMed 15109492]).[supplied by OMIM] | Chr10:105.3..105.3 Mbp (8.212 kbp) | score=8.91 |
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| RGD1320548 | Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP36 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al.‚ 2004 [PubMed 14715245]).[supplied by OMIM] | Chr10:108.5..108.6 Mbp (44.01 kbp) | score=8.66 |
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| RGD1352320 | Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH1 is 1 of several enzymes involved in synthesis of diphthamide in EEF2 (Liu et al.‚ 2004 [PubMed 15485916]).[supplied by OMIM] | Chr10:60.23..60.24 Mbp (13.31 kbp) | score=8.46 |
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| RGD1346833 | Rho (see ARHA; MIM 165390)-like small GTPases are involved in many cellular processes‚ and they are inactive in the GDP-bound state and active in the GTP-bound state. GTPase-activating proteins‚ such as ARHGAP27‚ inhibit Rho-like proteins by stimulating their intrinsic GTPase activity (Katoh and Katoh‚ 2004 [PubMed 15492870]).[supplied by OMIM] | Chr10:92.77..92.81 Mbp (31.72 kbp) | score=8.34 |
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| RGD1320244 | The RHO (see ARHA; MIM 165390) family of small GTPases are involved in signal transduction through transmembrane receptors‚ and they are inactive in the GDP-bound form and active in the GTP-bound form. GTPase-activating proteins‚ such as ARHGAP23‚ inactivate RHO family proteins by stimulating their hydrolysis of GTP (Katoh and Katoh‚ 2004 [PubMed 15254754]).[supplied by OMIM] | Chr10:86.05..86.11 Mbp (54.47 kbp) | score=8.27 |
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| RGD1345687 | Members of the F-box protein family‚ such as FBXL20‚ are characterized by an approximately 40-amino acid F-box motif. SCF complexes‚ formed by SKP1 (MIM 601434)‚ cullin (see CUL1; MIM 603134)‚ and F-box proteins‚ act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box‚ and they interact with ubiquitination targets through other protein interaction domains (Jin et al.‚ 2004 [PubMed 15520277]).[supplied by OMIM] | Chr10:86.86..87 Mbp (141 kbp) | score=8.26 |
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| RGD731309 | Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases associate with microtubules during chromosome movement and segregation. Aurora kinase B localizes to microtubules near kinetochores‚ specifically to the specialized microtubules called K-fibers‚ and Aurora kinase A (MIM 603072) localizes to centrosomes (Lampson et al.‚ 2004 [PubMed 14767480]).[supplied by OMIM] | Chr10:54.64..54.65 Mbp (5.835 kbp) | score=7.88 |
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| RGD1605986 | WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins‚ such as WIPI1‚ have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al.‚ 2004 [PubMed 15602573]).[supplied by OMIM] | Chr10:98.91..98.95 Mbp (36.23 kbp) | score=7.88 |
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Matches on Chr11
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| RGD1605025 | TSSK1 belongs to a family of serine/threonine kinases highly expressed in testis (Hao et al.‚ 2004 [PubMed 15044604]).[supplied by OMIM] | Chr11:38.89..38.9 Mbp (1.996 kbp) | score=10.53 |
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| RGD1606567 | TSSK2 belongs to a family of serine/threonine kinases highly expressed in testis (Hao et al.‚ 2004 [PubMed 15044604]).[supplied by OMIM] | Chr11:85.03..85.03 Mbp (1.347 kbp) | score=10.53 |
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| RGD1312081 | LEPREL1 belongs to a family of collagen prolyl hydroxylases required for proper collagen biosynthesis‚ folding‚ and assembly (Vranka et al.‚ 2004 [PubMed 15044469]).[supplied by OMIM] | Chr11:78.34..78.5 Mbp (164.1 kbp) | score=9.82 |
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| RGD1344897 | Poly(ADP-ribosyl)ation is an immediate DNA damage-dependent posttranslational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. PARP14 belongs to the superfamily of enzymes that perform this modification (Ame et al.‚ 2004 [PubMed 15273990]).[supplied by OMIM] | Chr11:66.56..66.61 Mbp (50.02 kbp) | score=9.24 |
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| RGD1318427 | Claudins‚ such as CLDN8‚ are components of epithelial cell tight junctions. Tight junctions regulate movement of solutes and ions through the paracellular space and prevent mixing of proteins and lipids in the outer leaflet of the apical and basolateral plasma membrane domains (Acharya et al.‚ 2004).[supplied by OMIM] | Chr11:28.51..28.51 Mbp (1.989 kbp) | score=8.81 |
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| RGD1320304 | Members of the F-box protein family‚ such as FBXO40‚ are characterized by an approximately 40-amino acid F-box motif. SCF complexes‚ formed by SKP1 (MIM 601434)‚ cullin (see CUL1; MIM 603134)‚ and F-box proteins‚ act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box‚ and they interact with ubiquitination targets through other protein interaction domains (Jin et al.‚ 2004 [PubMed 15520277]).[supplied by OMIM] | Chr11:64.87..64.9 Mbp (36.97 kbp) | score=8.26 |
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Matches on Chr12
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| RGD1349643 | SLC24A6 belongs to a family of potassium-dependent sodium/calcium exchangers that maintain cellular calcium homeostasis through the electrogenic countertransport of 4 sodium ions for 1 calcium ion and 1 potassium ion (Cai and Lytton‚ 2004 [PubMed 14625281]).[supplied by OMIM] | Chr12:36.35..36.39 Mbp (36.35 kbp) | score=8.84 |
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| RGD1352891 | Members of the F-box protein family‚ such as FBXL18‚ are characterized by an approximately 40-amino acid F-box motif. SCF complexes‚ formed by SKP1 (MIM 601434)‚ cullin (see CUL1; MIM 603134)‚ and F-box proteins‚ act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box‚ and they interact with ubiquitination targets through other protein interaction domains (Jin et al.‚ 2004 [PubMed 15520277]).[supplied by OMIM] | Chr12:12.09..12.13 Mbp (37.97 kbp) | score=8.26 |
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| RGD1314977 | Members of the winged-helix/forkhead family of transcription factors‚ such as FOXN4‚ are characterized by a 110-amino acid DNA-binding domain that can fold into a variant of the helix-turn-helix motif consisting of 3 alpha helices flanked by 2 large loops or wings. These transcription factors are involved in a variety of biologic processes as key regulators in development and metabolism (Li et al.‚ 2004 [PubMed 15363391]).[supplied by OMIM] | Chr12:43.85..43.88 Mbp (31.24 kbp) | score=8.09 |
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| RGD1606810 | WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins‚ such as WIPI2‚ have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al.‚ 2004 [PubMed 15602573]).[supplied by OMIM] | Chr12:11.8..11.85 Mbp (43.65 kbp) | score=7.88 |
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Matches on Chr13
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| RGD1604819 | UFC1 is an E2-like conjugating enzyme for ubiquitin-fold modifier-1 (UFM1; MIM 610553) (Komatsu et al.‚ 2004 [PubMed 15071506]).[supplied by OMIM] | Chr13:87.99..87.99 Mbp (5.113 kbp) | score=10.53 |
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| RGD733496 | Neurofascin is an L1 family immunoglobulin cell adhesion molecule (see L1CAM; MIM 308840) involved in axon subcellular targeting and synapse formation during neural development (Ango et al.‚ 2004 [PubMed 15479642]).[supplied by OMIM] | Chr13:72.75..72.95 Mbp (194.1 kbp) | score=9.75 |
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| RGD1604615 | Zinc functions as a cofactor for numerous enzymes‚ nuclear factors‚ and hormones and as an intra- and intercellular signal ion. Members of the zinc transporter (ZNT)/SLC30 subfamily of the cation diffusion facilitator family‚ such as SLC30A10‚ permit cellular efflux of zinc (Seve et al.‚ 2004 [PubMed 15154973]).[supplied by OMIM] | Chr13:106.6..106.6 Mbp (14.39 kbp) | score=8.83 |
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| RGD1312107 | Members of the F-box protein family‚ such as FBXO28‚ are characterized by an approximately 40-amino acid F-box motif. SCF complexes‚ formed by SKP1 (MIM 601434)‚ cullin (see CUL1; MIM 603134)‚ and F-box proteins‚ act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box‚ and they interact with ubiquitination targets through other protein interaction domains (Jin et al.‚ 2004 [PubMed 15520277]).[supplied by OMIM] | Chr13:99.06..99.1 Mbp (45.43 kbp) | score=8.26 |
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Matches on Chr14
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| RGD1346979 | In the pancreas‚ NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) [PubMed 15056733].[supplied by OMIM] | Chr14:6.565..6.57 Mbp (4.952 kbp) | score=9.67 |
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| RGD1319580 | SPRED2 is a member of the Sprouty (see SPRY1; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1; MIM 176948) (Nonami et al.‚ 2004 [PubMed 15465815]).[supplied by OMIM] | Chr14:104.3..104.4 Mbp (121.3 kbp) | score=9.67 |
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| RGD1604816 | MTP18 is a mitochondrial protein and downstream target of the phosphatidylinositol 3-kinase (see PIK3CA‚ MIM 171834) signaling pathway that plays a role in cell viability and mitochondrial dynamics (Tondera et al.‚ 2004 [PubMed 15155745]).[supplied by OMIM] | Chr14:84.76..84.77 Mbp (3.322 kbp) | score=9.46 |
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| RGD1603662 | CoQ (ubiquinone) serves as a redox carrier in the mitochondrial respiratory chain and is a lipid-soluble antioxidant. COQ2‚ or parahydroxybenzoate-polyprenyltransferase (EC 2.5.1.39)‚ catalyzes one of the final reactions in the biosynthesis of CoQ‚ the prenylation of parahydroxybenzoate with an all-trans polyprenyl group (Forsgren et al.‚ 2004 [PubMed 15153069]).[supplied by OMIM] | Chr14:18.99..19.01 Mbp (20.99 kbp) | score=9.09 |
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Matches on Chr15
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| RGD1320823 | Members of the F-box protein family‚ such as FBXO34‚ are characterized by an approximately 40-amino acid F-box motif. SCF complexes‚ formed by SKP1 (MIM 601434)‚ cullin (see CUL1; MIM 603134)‚ and F-box proteins‚ act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box‚ and they interact with ubiquitination targets through other protein interaction domains (Jin et al.‚ 2004 [PubMed 15520277]).[supplied by OMIM] | Chr15:23.7..23.78 Mbp (82.25 kbp) | score=8.26 |
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Matches on Chr16
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| RGD1316310 | ARHGAPs‚ such as ARHGAP22‚ encode negative regulators of Rho GTPases (see ARHA; MIM 165390)‚ which are implicated in actin remodeling‚ cell polarity‚ and cell migration (Katoh and Katoh‚ 2004 [PubMed 15254788]).[supplied by OMIM] | Chr16:8.305..8.464 Mbp (159.1 kbp) | score=9.29 |
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| RGD1345956 | Proteins of the UNC13 family‚ such as UNC13A‚ are diacylglycerol and phorbol ester receptors with ligand affinities similar to those of protein kinase C (see PRKCA; MIM 176960). Rodent Unc13a is a presynaptic protein with an essential role in synaptic vesicle priming (Rossner et al.‚ 2004 [PubMed 15123597]).[supplied by OMIM] | Chr16:18.94..19.03 Mbp (87.27 kbp) | score=8.81 |
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| RGD1605077 | Myoinositol‚ the most common naturally occurring form of inositol‚ is a component of plasma membrane phospholipids and functions as a cell signaling molecule. ISYNA1 (EC 5.5.1.4)‚ or IPS‚ is a rate-limiting enzyme that catalyzes the de novo synthesis of myoinositol 1-phosphate from glucose 6-phosphate (Seelan et al.‚ 2004 [PubMed 15464731]).[supplied by OMIM] | Chr16:17.64..17.64 Mbp (3.319 kbp) | score=8.75 |
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Matches on Chr17
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| RGD1319952 | NOL8 binds Ras-related GTP-binding proteins (see MIM 608267) and plays a role in cell growth (Sekiguchi et al.‚ 2004 [PubMed 14660641]).[supplied by OMIM] | Chr17:20.33..20.36 Mbp (28.2 kbp) | score=10.32 |
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| RGD1347331 | ZNF322A is a member of the zinc-finger transcription factor family and may regulate transcriptional activation in MAPK (see MAPK1; MIM 176948) signaling pathways (Li et al.‚ 2004 [PubMed 15555580]).[supplied by OMIM] | Chr17:49.08..49.11 Mbp (25.35 kbp) | score=9.94 |
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| RGD1350652 | ISCA1 is a mitochondrial protein involved in the biogenesis and assembly of iron-sulfur clusters‚ which play a role in electron-transfer reactions (Cozar-Castellano et al.‚ 2004 [PubMed 15262227]).[supplied by OMIM] | Chr17:11.49..11.51 Mbp (18.03 kbp) | score=9.84 |
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| RGD1320397 | Enkurin interacts with transient receptor potential canonical (TRPC) cation channels (see TRPC1; MIM 602343) and functions as an adapter protein‚ tethering signal transduction proteins to TRPC channels (Sutton et al.‚ 2004 [PubMed 15385169]).[supplied by OMIM] | Chr17:95.08..95.11 Mbp (34.11 kbp) | score=9.06 |
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| RGD1319900 | Nucleotide sugars‚ which are synthesized in the cytosol or the nucleus‚ are high-energy donor substrates for glycosyltransferases located in the lumen of the endoplasmic reticulum and Golgi apparatus. Translocation of nucleotide sugars from the cytosol into the lumen compartment is mediated by specific nucleotide sugar transporters‚ such as SLC35D2 (Suda et al.‚ 2004 [PubMed 15082721]).[supplied by OMIM] | Chr17:7.55..7.613 Mbp (62.95 kbp) | score=8.26 |
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| RGD736425 | Members of the ZAS family‚ such as ZAS1 (HIVEP1)‚ are large proteins that contain a ZAS domain‚ a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine-rich sequence. These proteins bind specific DNA sequences‚ including the kappa-B motif (GGGACTTTCC)‚ in the promoters and enhancer regions of several genes and viruses‚ including human immunodeficiency virus (HIV). ZAS genes span more than 150 kb and contain at least 10 exons‚ one of which is longer than 5.5 kb (Allen and Wu‚ 2004).[supplied by OMIM] | Chr17:33.27..33.42 Mbp (152.5 kbp) | score=7.68 |
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Matches on Chr18
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| RGD1313589 | CABLES1 is a cyclin-dependent kinase (CDK)-binding protein that plays a role in proliferation and/or differentiation (Zukerberg et al.‚ 2004 [PubMed 14729625]).[supplied by OMIM] | Chr18:3.223..3.345 Mbp (122.9 kbp) | score=10.32 |
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| RGD1346452 | DOK6 is a member of the DOK (see DOK1; MIM 602919) family of intracellular adaptors that play a role in the RET (MIM 164761) signaling cascade (Crowder et al.‚ 2004 [PubMed 15286081]).[supplied by OMIM] | Chr18:78.31..78.75 Mbp (441.1 kbp) | score=10.13 |
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| RGD1321642 | Members of the F-box protein family‚ such as FBXO15‚ are characterized by an approximately 40-amino acid F-box motif. SCF complexes‚ formed by SKP1 (MIM 601434)‚ cullin (see CUL1; MIM 603134)‚ and F-box proteins‚ act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box‚ and they interact with ubiquitination targets through other protein interaction domains (Jin et al.‚ 2004 [PubMed 15520277]).[supplied by OMIM] | Chr18:82.98..83.06 Mbp (74.34 kbp) | score=8.26 |
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Matches on Chr19
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| RGD1315433 | ANKRD11 is a member of a family of ankyrin repeat-containing cofactors that interacts with p160 nuclear receptor coactivators (see NCOA1; MIM 602691) and inhibits ligand-dependent transcriptional activation (Zhang et al.‚ 2004 [PubMed 15184363]).[supplied by OMIM] | Chr19:53.41..53.63 Mbp (222.9 kbp) | score=9.58 |
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| RGD1346049 | CIAPIN1 is a cytokine-induced inhibitor of apoptosis with no relation to apoptosis regulatory molecules of the BCL2 (MIM 151430) or CASP (see MIM 147678) families. Expression of CIAPIN1 is dependent on growth factor stimulation (Shibayama et al.‚ 2004 [PubMed 14970183]).[supplied by OMIM] | Chr19:2.412..2.431 Mbp (19.28 kbp) | score=9.06 |
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| RGD1601867 | Arginine methylation is an apparently irreversible protein modification catalyzed by arginine methyltransferases‚ such as PMT7‚ using S-adenosylmethionine (AdoMet) as the methyl donor. Arginine methylation is implicated in signal transduction‚ RNA transport‚ and RNA splicing (Miranda et al.‚ 2004 [PubMed 15044439]).[supplied by OMIM] | Chr19:36.13..36.17 Mbp (46.22 kbp) | score=8.91 |
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| RGD1315938 | Members of the F-box protein family‚ such as FBXW9‚ are characterized by an approximately 40-amino acid F-box motif. SCF complexes‚ formed by SKP1 (MIM 601434)‚ cullin (see CUL1; MIM 603034)‚ and F-box proteins‚ act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box‚ and they interact with ubiquitination targets through other protein interaction domains (Jin et al.‚ 2004 [PubMed 15520277]).[supplied by OMIM] | Chr19:24.22..24.23 Mbp (7.726 kbp) | score=8.26 |
|---|
| RGD1318772 | Sphingolipids are a large class of lipids found in all eukaryotic cells and are involved in numerous cellular processes. The structural diversity of sphingolipids stems from more than 300 distinct head groups‚ as well as from modifications of the hydrophobic ceramide moiety. FA2H catalyzes a common modification of the ceramide moiety: hydroxylation at the 2 position of the N-acyl chain. Sphingolipids containing 2-hydroxy fatty acid are common in nervous and epidermal tissue. Glycosphingolipids containing a high proportion of 2-hydroxy fatty acid are critical components of myelin‚ and several very long chain ceramides with 2-hydroxy fatty acids are important for the permeability barrier function of epidermis (Alderson et al.‚ 2004 [PubMed 15337768]).[supplied by OMIM] | Chr19:41.11..41.17 Mbp (61.87 kbp) | score=6.67 |
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Matches on Chr2
|
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| RGD1350142 | The AGGF1 gene encodes a potent angiogenic factor that contains a forkhead-associated domain and a G-patch domain (Tian et al.‚ 2004 [PubMed 14961121]).[supplied by OMIM] | Chr2:23.93..23.96 Mbp (34.81 kbp) | score=9.96 |
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| RGD1604194 | RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al.‚ 2004 [PubMed 15268862]).[supplied by OMIM] | Chr2:69..69.14 Mbp (136.5 kbp) | score=9.53 |
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| RGD1348980 | The ZFYVE16 gene encodes endofin‚ an endosomal protein implicated in regulating membrane trafficking. It is characterized by the presence of a phosphatidylinositol 3-phosphate-binding FYVE domain positioned in the middle of the molecule (Seet et al.‚ 2004 [PubMed 14613930]).[supplied by OMIM] | Chr2:27.31..27.38 Mbp (71.66 kbp) | score=9.41 |
|---|
| RGD1319359 | TRIM45 belongs to a family of tripartite motif (TRIM) proteins that play important roles in a variety of cellular functions‚ including cell proliferation‚ differentiation‚ development‚ oncogenesis‚ and apoptosis (Wang et al.‚ 2004 [PubMed 15351693]).[supplied by OMIM] | Chr2:199.9..199.9 Mbp (10.72 kbp) | score=9.41 |
|---|
| RGD1344837 | UFM1 is a ubiquitin-like protein that is conjugated to target proteins by E1-like activating enzyme UBA5 (UBE1DC1; MIM 610552) and E2-like conjugating enzyme UFC1 (MIM 610554) in a manner analogous to ubiquitylation (see UBE2M; MIM 603173) (Komatsu et al.‚ 2004 [PubMed 15071506]).[supplied by OMIM] | Chr2:146.4..146.4 Mbp (13.12 kbp) | score=9.24 |
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| RGD1317319 | Zinc functions as a cofactor for numerous enzymes‚ nuclear factors‚ and hormones and as an intra- and intercellular signal ion. Members of the zinc transporter (ZNT)/SLC30 subfamily of the cation diffusion facilitator family‚ such as SLC30A7‚ permit cellular efflux of zinc (Seve et al.‚ 2004 [PubMed 15154973]).[supplied by OMIM] | Chr2:216.8..216.9 Mbp (83.33 kbp) | score=8.83 |
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| RGD1313118 | PPM1L‚ or PP2CE‚ belongs to the PP2C group of serine/threonine phosphatases‚ which are distinguished from other phosphatases by their structure‚ absolute requirement for Mg(2 ) or Mn(2 )‚ and insensitivity to okadaic acid. PP2Cs regulate stress-activated protein kinase (SAPK; see MIM 601158) signaling cascades that respond to extracellular stimuli (Jin et al.‚ 2004 [PubMed 15560375]).[supplied by OMIM] | Chr2:158.7..159 Mbp (314.8 kbp) | score=8.68 |
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| RGD1344882 | IL31RA is related to gp130 (IL6ST; MIM 600694)‚ the common receptor subunit for IL6 (MIM 147620)-type cytokines. Oncostatin M receptor (OSMR; MIM 601743) and IL31RA form the heterodimeric receptor through which IL31 (MIM 609509) signals. Expression of IL31RA and OSMR mRNA is induced in activated monocytes‚ and both mRNAs are constitutively expressed in epithelial cells (Dillon et al.‚ 2004 [PubMed 15184896]).[supplied by OMIM] | Chr2:42.06..42.12 Mbp (65.65 kbp) | score=8.05 |
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Matches on Chr3
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| RGD1603043 | APIP is an APAF1 (MIM 602233)-interacting protein that acts as a negative regulator of ischemic/hypoxic injury (Cho et al.‚ 2004 [PubMed 15262985]).[supplied by OMIM] | Chr3:83.39..83.42 Mbp (34.06 kbp) | score=10.32 |
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| RGD1343012 | LRSAM1 is a multifunctional RING finger protein that selectively regulates cell adhesion molecules‚ has ubiquitin ligase activity‚ and plays a role in receptor endocytosis and viral budding (Li et al.‚ 2003 [PubMed 14635195]; Amit et al.‚ 2004 [PubMed 15256501]).[supplied by OMIM] | Chr3:13.29..13.35 Mbp (51.99 kbp) | score=9.09 |
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| RGD1350551 | Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH4 is 1 of several enzymes involved in synthesis of diphthamide in EEF2 (Liu et al.‚ 2004 [PubMed 15485916]).[supplied by OMIM] | Chr3:93.05..93.11 Mbp (63.01 kbp) | score=8.46 |
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| RGD1317118 | Eukaryotic initiation factor-3 (EIF3) has a molecular mass of about 600 kD and contains 13 nonidentical protein subunits‚ including EIF3J. EIF3 plays a central role in binding of initiator methionyl-tRNA and mRNA to the 40S ribosomal subunit to form the 40S initiation complex (Fraser et al.‚ 2004 [PubMed 14688252]; Fraser et al.‚ 2007 [PubMed 17588516]).[supplied by OMIM] | Chr3:109.2..109.2 Mbp (25.74 kbp) | score=8.27 |
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| RGD1607029 | INOC1 is the human homolog of S. cerevisiae Ino80‚ the catalytic ATPase subunit of the INO80 chromatin remodeling complex (Shen et al.‚ 2000 [PubMed 10952318]; Bakshi et al.‚ 2004 [PubMed 15207721]). INOC1 defines a subfamily of SWI2/SNF2 chromatin remodeling proteins; see SMARCA (MIM 600014) for background information.[supplied by OMIM] | Chr3:105.6..105.7 Mbp (137.3 kbp) | score=8.19 |
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Matches on Chr4
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| A2m.t01 | RGD:2004 | Chr4:158.1..158.2 Mbp (49.73 kbp) | score=12.08 |
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| RGD2004 | RGD:2004 | Chr4:158.1..158.2 Mbp (49.73 kbp) | score=12.08 |
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| A2m.t01 | RGD:2004 | Chr4:158.1..158.2 Mbp (49.73 kbp) | score=12.08 |
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| RGD2004 | RGD:2004 | Chr4:158.1..158.2 Mbp (49.73 kbp) | score=12.08 |
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| A2m | RGD:2004 | Chr4:158.1..158.2 Mbp (49.73 kbp) | score=12.08 |
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| RGD2004 | RGD:2004 | Chr4:158.1..158.2 Mbp (49.73 kbp) | score=12.08 |
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| A2m | RGD:2004 | Chr4:158.1..158.2 Mbp (49.73 kbp) | score=12.08 |
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| RGD1348462 | Receptor protein tyrosine kinases‚ like STYK1‚ play important roles in diverse cellular and developmental processes‚ such as cell proliferation‚ differentiation‚ and survival (Liu et al.‚ 2004 [PubMed 15150103]).[supplied by OMIM] | Chr4:168.1..168.2 Mbp (55.1 kbp) | score=9.84 |
|---|
| RGD1313881 | LEPREL2 belongs to a family of collagen prolyl hydroxylases required for proper collagen biosynthesis‚ folding‚ and assembly (Vranka et al.‚ 2004 [PubMed 15044469]).[supplied by OMIM] | Chr4:161.1..161.1 Mbp (11.45 kbp) | score=9.82 |
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| RGD1603533 | NAPEPLD is a phospholipase D type enzyme that catalyzes the release of N-acylethanolamine (NAE) from N-acyl-phosphatidylethanolamine (NAPE) in the second step of the biosynthesis of N-acylethanolamine (Okamoto et al.‚ 2004 [PubMed 14634025]).[supplied by OMIM] | Chr4:6.832..6.881 Mbp (49.28 kbp) | score=9.75 |
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| RGD1348241 | EIF4E3 belongs to the EIF4E family of translational initiation factors that interact with the 5-prime cap structure of mRNA and recruit mRNA to the ribosome (Joshi et al.‚ 2004 [PubMed 15153109]).[supplied by OMIM] | Chr4:135.4..135.5 Mbp (70.9 kbp) | score=9.68 |
|---|
| RGD1318797 | Mitochondrial carriers‚ including SLC25A26‚ are a family of transport proteins found mostly in the inner membranes of mitochondria. They shuttle metabolites and cofactors through the mitochondrial membrane (Agrimi et al.‚ 2004 [PubMed 14674884]).[supplied by OMIM] | Chr4:129..129.1 Mbp (135.7 kbp) | score=9.60 |
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| RGD1604585 | APOLD1 is an endothelial cell early response protein that may play a role in regulation of endothelial cell signaling and vascular function (Regard et al.‚ 2004 [PubMed 15102925]).[supplied by OMIM] | Chr4:171.8..171.8 Mbp (5.783 kbp) | score=9.40 |
|---|
| RGD1351716 | ARHGAPs‚ such as ARHGAP25‚ encode negative regulators of Rho GTPases (see ARHA; MIM 165390)‚ which are implicated in actin remodeling‚ cell polarity‚ and cell migration (Katoh and Katoh‚ 2004 [PubMed 15254788]).[supplied by OMIM] | Chr4:120.1..120.2 Mbp (92 kbp) | score=9.29 |
|---|
| RGD1603298 | tRNA splicing is a fundamental process required for cell growth and division. SEN2 is a subunit of the tRNA splicing endonuclease‚ which catalyzes the removal of introns‚ the first step in tRNA splicing (Paushkin et al.‚ 2004 [PubMed 15109492]).[supplied by OMIM] | Chr4:151.8..151.8 Mbp (48.78 kbp) | score=8.91 |
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| RGD1314174 | Claudins‚ such as CLDN12‚ are components of epithelial cell tight junctions. Tight junctions regulate movement of solutes and ions through the paracellular space and prevent mixing of proteins and lipids in the outer leaflet of the apical and basolateral plasma membrane domains (Acharya et al.‚ 2004).[supplied by OMIM] | Chr4:24.99..25 Mbp (12.47 kbp) | score=8.81 |
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| RGD1313599 | Members of the F-box protein family‚ such as FBXL14‚ are characterized by an approximately 40-amino acid F-box motif. SCF complexes‚ formed by SKP1 (MIM 601434)‚ cullin (see CUL1; MIM 603134)‚ and F-box proteins‚ act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box‚ and they interact with ubiquitination targets through other protein interaction domains (Jin et al.‚ 2004 [PubMed 15520277]).[supplied by OMIM] | Chr4:155.9..155.9 Mbp (28.17 kbp) | score=8.26 |
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| RGD1312373 | The LRP6 gene encodes a member of the low density lipoprotein receptor (LDLR) gene family‚ which consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LDLR proteins are comprised of the same basic structural motifs: an extracellular domain that contains LDLR binding repeats and EGF repeats with associated spacer domains containing the YWTD motif; a single transmembrane-spanning domain; and a C-terminal cytoplasmic domain that generally contains at least 1 copy of the NPXY motif (Brown et al.‚ 1998 [PubMed 9704021]). LRP6 and LRP5 (MIM 603506) function as coreceptors for WNT (MIM 164820) ligands and thus play a role in WNT signaling‚ which is important in a wide variety of biologic processes during pre- and postnatal life in invertebrates and vertebrates (Kokubu et al.‚ 2004 [PubMed 15469977]).[supplied by OMIM] | Chr4:171.2..171.3 Mbp (150.9 kbp) | score=6.28 |
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Matches on Chr5
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| RGD1352624 | NIPSNAP3A belongs to a family of proteins with putative roles in vesicular transport (Buechler et al.‚ 2004 [PubMed 15177564]).[supplied by OMIM] | Chr5:70.3..70.32 Mbp (12.44 kbp) | score=10.53 |
|---|
| RGD1346860 | CDCA8 is a component of a chromosomal passenger complex required for stability of the bipolar mitotic spindle (Gassmann et al.‚ 2004 [PubMed 15249581]).[supplied by OMIM] | Chr5:143.8..143.8 Mbp (17.23 kbp) | score=10.32 |
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| RGD1344587 | SLC2A7 belongs to a family of transporters that catalyze the uptake of sugars through facilitated diffusion (Li et al.‚ 2004). This family of transporters shows conservation of 12 transmembrane helices as well as functionally significant amino acid residues (Joost and Thorens‚ 2001 [PubMed 11780753]).[supplied by OMIM] | Chr5:167.9..168 Mbp (23.05 kbp) | score=8.93 |
|---|
| RGD1313507 | Members of the F-box protein family‚ such as FBXO10‚ are characterized by an approximately 40-amino acid F-box motif. SCF complexes‚ formed by SKP1 (MIM 601434)‚ cullin (see CUL1; MIM 603134)‚ and F-box proteins‚ act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box‚ and they interact with ubiquitination targets through other protein interaction domains (Jin et al.‚ 2004 [PubMed 15520277]).[supplied by OMIM] | Chr5:61.63..61.7 Mbp (65.36 kbp) | score=8.26 |
|---|
| RGD1312431 | Members of the F-box protein family‚ such as FBXO42‚ are characterized by an approximately 40-amino acid F-box motif. SCF complexes‚ formed by SKP1 (MIM 601434)‚ cullin (see CUL1; MIM 603134)‚ and F-box proteins‚ act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box‚ and they interact with ubiquitination targets through other protein interaction domains (Jin et al.‚ 2004 [PubMed 15520277]).[supplied by OMIM] | Chr5:161..161.1 Mbp (102.4 kbp) | score=8.26 |
|---|
| RGD1322610 | Members of the ZAS family‚ such as ZAS3 (HIVEP3)‚ are large proteins that contain a ZAS domain‚ a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine -rich sequence. These proteins bind specific DNA sequences‚ including the kappa-B motif (GGGACTTTCC)‚ in the promoters and enhancer regions of several genes and viruses‚ including human immunodeficiency virus (HIV). ZAS genes span more than 150 kb and contain at least 10 exons‚ one of which is longer than 5.5 kb (Allen and Wu‚ 2004).[supplied by OMIM] | Chr5:147.6..148 Mbp (408.5 kbp) | score=7.68 |
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Matches on Chr6
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| RGD1350990 | Galactose mutarotase (aldose 1-epimerase; EC 5.1.3.3) catalyzes the conversion of beta-D-galactose to alpha-D-galactose during normal galactose metabolism (Thoden et al.‚ 2004 [PubMed 15026423]).[supplied by OMIM] | Chr6:2.869..2.937 Mbp (68.31 kbp) | score=9.50 |
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| RGD1315256 | tRNAs contain as many as 13 or 14 nucleotides that are modified posttranscriptionally by enzymes that are highly specific for particular nucleotides in the tRNA structure. TRMT5 methylates the N1 position of guanosine-37 (G37) in selected tRNAs using S-adenosyl methionine (Brule et al.‚ 2004 [PubMed 15248782]).[supplied by OMIM] | Chr6:95.64..95.65 Mbp (9.624 kbp) | score=9.18 |
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| RGD1319489 | Zinc functions as a cofactor for numerous enzymes‚ nuclear factors‚ and hormones and as an intra- and intercellular signal ion. Members of the zinc transporter (ZNT)/SLC30 subfamily of the cation diffusion facilitator family‚ such as SLC30A6‚ permit cellular efflux of zinc (Seve et al.‚ 2004 [PubMed 15154973]).[supplied by OMIM] | Chr6:17.85..17.91 Mbp (55.88 kbp) | score=8.83 |
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| RGD1316797 | Members of the F-box protein family‚ such as FBXO33‚ are characterized by an approximately 40-amino acid F-box motif. SCF complexes‚ formed by SKP1 (MIM 601434)‚ cullin (see CUL1; MIM 603134)‚ and F-box proteins‚ act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box‚ and they interact with ubiquitination targets through other protein interaction domains (Jin et al.‚ 2004 [PubMed 15520277]).[supplied by OMIM] | Chr6:79.37..79.41 Mbp (34.66 kbp) | score=8.26 |
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Matches on Chr7
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| RGD1317143 | GeneID:2004 | Chr7:27.01..27.09 Mbp (73.4 kbp) | score=11.95 |
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| RGD1345615 | OSR2 is a mammalian homolog of the Drosophila odd-skipped family of transcription factors (Lan et al.‚ 2004 [PubMed 15175245]).[supplied by OMIM] | Chr7:70.51..70.52 Mbp (7.643 kbp) | score=10.63 |
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| RGD1344275 | PIM3 belongs to a family of protooncogenes that encode serine/threonine protein kinases (Mikkers et al.‚ 2004 [PubMed 15199164]).[supplied by OMIM] | Chr7:127.8..127.8 Mbp (3.56 kbp) | score=10.42 |
|---|
| RGD736995 | SP7 is a C2H2-type zinc finger transcription factor of the SP gene family and a putative master regulator of bone cell differentiation (Gao et al.‚ 2004 [PubMed 15474293]).[supplied by OMIM] | Chr7:142.3..142.3 Mbp (9.179 kbp) | score=10.03 |
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| RGD1319222 | COL22A1‚ a member of the FACIT (fibrillar-associated collagens with interrupted triple helices) subgroup of the collagen protein family‚ specifically localizes to tissue junctions (Koch et al.‚ 2004 [PubMed 15016833]).[supplied by OMIM] | Chr7:109.2..109.5 Mbp (325.8 kbp) | score=9.75 |
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| RGD1316784 | Basic helix-loop-helix transcription factors‚ such as ASCL4‚ are essential for the determination of cell fate and the development and differentiation of numerous tissues (Jonsson et al.‚ 2004 [PubMed 15475265]).[supplied by OMIM] | Chr7:23.53..23.54 Mbp (2.254 kbp) | score=9.60 |
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| RGD1315468 | Zinc finger proteins‚ such as ZNF385A‚ are regulatory proteins that act as transcription factors‚ bind single- or double-stranded RNA‚ or interact with other proteins (Sharma et al.‚ 2004 [PubMed 15527981]).[supplied by OMIM] | Chr7:143.3..143.3 Mbp (15.56 kbp) | score=9.54 |
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| RGD1316833 | BLOC1S1 is a component of the ubiquitously expressed BLOC1 multisubunit protein complex. BLOC1 is required for normal biogenesis of specialized organelles of the endosomal-lysosomal system‚ such as melanosomes and platelet dense granules (Starcevic and Dell'Angelica‚ 2004 [PubMed 15102850]).[supplied by OMIM] | Chr7:4.881..4.885 Mbp (3.664 kbp) | score=9.09 |
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| RGD1317159 | Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes‚ and NUP37 is part of one such subcomplex‚ Nup107-160 (Loiodice et al.‚ 2004 [PubMed 15146057]).[supplied by OMIM] | Chr7:25.28..25.33 Mbp (44.39 kbp) | score=9.06 |
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| RGD1317968 | Zinc functions as a cofactor for numerous enzymes‚ nuclear factors‚ and hormones and as an intra- and intercellular signal ion. Members of the zinc transporter (ZNT)/SLC30 subfamily of the cation diffusion facilitator family‚ such as SLC30A8‚ permit cellular efflux of zinc (Seve et al.‚ 2004 [PubMed 15154973]).[supplied by OMIM] | Chr7:88.45..88.5 Mbp (41.62 kbp) | score=8.83 |
|---|
| RGD1321003 | Members of the F-box protein family‚ such as FBXO43‚ are characterized by an approximately 40-amino acid F-box motif. SCF complexes‚ formed by SKP1 (MIM 601434)‚ cullin (see CUL1; MIM 603134)‚ and F-box proteins‚ act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box‚ and they interact with ubiquitination targets through other protein interaction domains (Jin et al.‚ 2004 [PubMed 15520277]).[supplied by OMIM] | Chr7:71.7..71.72 Mbp (12.42 kbp) | score=8.26 |
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| RGD1352176 | SLC5A8 has been shown to transport iodide by a passive mechanism (Rodriguez et al.‚ 2002 [PubMed 12107270]) and monocarboxylates and short-chain fatty acids by a sodium-coupled mechanism (Gopal et al.‚ 2004 [PubMed 15322102]). In kidney‚ SLC5A8 functions as a high-affinity sodium-coupled lactate transporter involved in reabsorption of lactate and maintenance of blood lactate levels (Thangaraju et al.‚ 2006 [PubMed 16873376]).[supplied by OMIM] | Chr7:24.37..24.42 Mbp (54.72 kbp) | score=7.59 |
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Matches on Chr8
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| RGD1353628 | ADPGK (EC 2.7.1.147) catalyzes the ADP-dependent phosphorylation of glucose to glucose-6-phosphate and may play a role in glycolysis‚ possibly during ischemic conditions (Ronimus and Morgan‚ 2004 [PubMed 14975750]).[supplied by OMIM] | Chr8:62.26..62.29 Mbp (32.35 kbp) | score=9.68 |
|---|
| RGD736859 | SLC24A1 belongs to a family of potassium-dependent sodium/calcium exchangers. Members of this family have 2 large hydrophilic loops and 2 sets of multiple transmembrane-spanning segments (Schnetkamp‚ 2004 [PubMed 14770312]).[supplied by OMIM] | Chr8:71.29..71.32 Mbp (34.33 kbp) | score=9.38 |
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| RGD1602686 | The CTX (see VSIG2‚ MIM 606011) family of proteins‚ including ASAM‚ are type I transmembrane proteins within the Ig superfamily that localize to junctional complexes between endothelial and epithelial cells and may play a role in cell-cell adhesion (Raschperger et al.‚ 2004 [PubMed 14573622]).[supplied by OMIM] | Chr8:44.17..44.29 Mbp (123 kbp) | score=8.99 |
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| RGD1352427 | Members of the F-box protein family‚ such as FBXW12‚ are characterized by an approximately 40-amino acid F-box motif. SCF complexes‚ formed by SKP1 (MIM 601434)‚ cullin (see CUL1; MIM 603034)‚ and F-box proteins‚ act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box‚ and they interact with ubiquitination targets through other protein interaction domains (Jin et al.‚ 2004 [PubMed 15520277]).[supplied by OMIM] | Chr8:115..115 Mbp (22.48 kbp) | score=8.26 |
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Matches on Chr9
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| RGD1605037 | PGAP1 catalyzes the inositol deacylation of glycosylphosphatidylinositol (GPI) at an early step in GPI biosynthesis. Inositol deacylation is essential for the generation of mature GPI capable of attachment to proteins (Tanaka et al.‚ 2004 [PubMed 14734546]).[supplied by OMIM] | Chr9:53.16..53.26 Mbp (93.73 kbp) | score=9.29 |
|---|
| RGD1354473 | SLCO4C1 belongs to the organic anion transporter (OATP) family. OATPs are involved in the membrane transport of bile acids‚ conjugated steroids‚ thyroid hormone‚ eicosanoids‚ peptides‚ and numerous drugs in many tissues (Mikkaichi et al.‚ 2004 [PubMed 14993604]).[supplied by OMIM] | Chr9:96.21..96.27 Mbp (62.56 kbp) | score=9.24 |
|---|
| RGD1320045 | Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP40 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al.‚ 2004 [PubMed 14715245]).[supplied by OMIM] | Chr9:86.1..86.19 Mbp (85.7 kbp) | score=8.66 |
|---|
| RGD1344660 | TREML1 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086)‚ but it has distinct structural and functional properties. TREML1 enhances calcium signaling in an SHP2 (PTPN11; MIM 176876)-dependent manner (Allcock et al.‚ 2003 [PubMed 12645956]; Barrow et al.‚ 2004 [PubMed 15128762]).[supplied by OMIM] | Chr9:7.773..7.778 Mbp (4.729 kbp) | score=8.38 |
|---|
| RGD1317314 | Members of the F-box protein family‚ such as FBXO36‚ are characterized by an approximately 40-amino acid F-box motif. SCF complexes‚ formed by SKP1 (MIM 601434)‚ cullin (see CUL1; MIM 603134)‚ and F-box proteins‚ act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box‚ and they interact with ubiquitination targets through other protein interaction domains (Jin et al.‚ 2004 [PubMed 15520277]).[supplied by OMIM] | Chr9:84.11..84.2 Mbp (90.62 kbp) | score=8.26 |
|---|
| RGD1348950 | Members of the F-box protein family‚ such as FBXL17‚ are characterized by an approximately 40-amino acid F-box motif. SCF complexes‚ formed by SKP1 (MIM 601434)‚ cullin (see CUL1; MIM 603134)‚ and F-box proteins‚ act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box‚ and they interact with ubiquitination targets through other protein interaction domains (Jin et al.‚ 2004 [PubMed 15520277]).[supplied by OMIM] | Chr9:101.6..102.1 Mbp (521.7 kbp) | score=8.26 |
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Matches on ChrX
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| RGD1351986 | Apelin is a neuropeptide expressed in the supraoptic and paraventricular nuclei that acts on specific receptors located on vasopressinergic neurons (De Mota et al.‚ 2004) [PubMed 15231996].[supplied by OMIM] | ChrX:135.9..135.9 Mbp (9.59 kbp) | score=10.13 |
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